Design, synthesis and biological evaluation of GPR55 agonists

Bioorganic and Medicinal Chemistry

Volumn 25, Issue 16, 2017, Pages 4355-4367

  Fakhouri, Lara ^a   Cook, Christopher D ^a   Al Huniti, Mohammed H ^a   Console Bram, Linda M ^b   Hurst, Dow P ^a   Spano, Michael B S ^a   Nasrallah, Daniel J ^a   Caron, Marc G ^c   Barak, Larry S ^c   Reggio, Patricia H ^a   Abood, Mary E ^b   Croatt, Mitchell P ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; GPR55; Homology model; Thiourea; Arrestin recruitment assay

Indexed keywords

3 (2 METHOXYPHENYL) N [[4 (NPHENYLSULFAMOYL)PHENYL]CARBAMOTHIOYL]ACRYLAMIDE; 3 (2 METHOXYPHENYL) N [[4 [N METHYL N (PYRIDIN 4 YL)SULFAMOYL]PHENYL]CARBAMOTHIOYL]ACRYLAMIDE; 3 (2 METHOXYPHENYL) N [[4 [N PHENYL N (PYRIDIN 4 YLMETHYL)SULFAMOYL]PHENYL]CARBAMOTHIOYL]ACRYLAMIDE; 3 (2 METHOXYPHENYL)N [[4 (N METHYL N PHENYLSULFAMOYL)PHENYL]CARBAMOTHIOYL]ACRYLAMIDE; 6 (2 HYDROXYETHYL) N [[4 (M METHYL N PHENYLSULFAMOYL)PHENYL]CARBAMOTHIOYL] 2 NAPHTHAMIDE; 6 (2 HYDROXYETHYL) N [[4 [N (2 HYDROXYETHYL) N PHENYLSULFAMOYL]PHENYL]CARBAMOTHIOYL] 2 NAPHTHAMIDE; 6 (2 HYDROXYETHYL) N [[4 [N [[5 (HYDROXYMETHYL)FURAN 2 YL]METHYL] N PHENYLSULFAMOYL]PHENYL]CARBAMOTHIOYL] 2 NAPHTHAMIDE; 6 (HYDROXYMETHYL) N [[4 (M METHYL N PHENYLSULFAMOYL)PHENYL]CARBAMOTHIOYL] 2 NAPHTHAMIDE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; G PROTEIN COUPLED RECEPTOR AGONIST DERIVATIVE; N [[4 (N METHYL N PHENYLSULFAMOYL)PHENYL]CARBAMOTHIOYL]QUINOLINE 3 CARBOXAMIDE; N [[4 (N METHYL N PHENYLSULFAMOYL)PHENYL]CARBAMOTHIOYL]QUINOLINE 7 CARBOXAMIDE; N [[4 [N (2 HYDROXYBENZYL) N PHENYLSULFAMOYL]PHENYL]CARBAMOTHIOYL] 3 (2 METHOXYPHENYL)ACRYLAMIDE; N [[4 [N (2 HYDROXYETHYL) N PHENYLSULFAMOYL]PHENYL]CARBAMOTHIOYL] 3 (2 METHOXYPHENYL)ACRYLAMIDE; N [[4 [N (2 HYDROXYETHYL) N PHENYLSULFAMOYL]PHENYL]CARBAMOTHIOYL]QUINOLINE 7 CARBOXAMIDE; N [[4 [N (2 HYDROXYETHYL)SULFAMOYL]PHENYL]CARBAMOTHIOYL] 3 (2 METHOXYPHENYL)ACRYLAMIDE; N [[4 [N (2,3 DIHYDROXYPROPYL)SULFAMOYL]PHENYL]CARBAMOTHIOYL] 3 (2 METHOXYPHENYL)ACRYLAMIDE; N [[4 [N (3 HYDROXYBENZYL) N PHENYLSULFAMOYL]PHENYL]CARBAMOTHIOYL] 3 (2 METHOXYPHENYL)ACRYLAMIDE; N [[4 [N (3,4 DIMETHYLISOXAZOL 5 YL)SULFAMOYL]PHENYL]CARBAMOTHIOYL] 3 (2 METHOXYPHENYL)ACRYLAMIDE; N [[4 [N (4 HYDROXYBENZYL) N PHENYLSULFAMOYL]PHENYL]CARBAMOTHIOYL] 3 (2 METHOXYPHENYL)ACRYLAMIDE; N [[4 [N (4 HYDROXYBENZYL) N PHENYLSULFAMOYL]PHENYL]CARBAMOTHIOYL]QUINOLINE 7 CARBOXAMIDE; N [[4 [N PHENYL N (PYRIDIN 4 YLMETHYL)SULFAMOYL]PHENYL]CARBAMOTHIOYL]QUINOLINE 7 CARBOXAMIDE; N [[4 [N [[5 (HYDROXYMETHYL)FURAN 2 YL]METHYL] N PHENYLSULFAMOYL]PHENYL]CARBAMOTHIOYL] 3 (2 METHOXYPHENYL)ACRYLAMIDE; N [[4 [N [[5 (HYDROXYMETHYL)FURAN 2 YL]METHYL] N PHENYLSULFAMOYL]PHENYL]CARBAMOTHIOYL]QUINOLINE 7 CARBOXAMIDE; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; GPR55 PROTEIN, HUMAN; THIOUREA;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; STRUCTURE ACTIVITY RELATION; AGONISTS; ANALOGS AND DERIVATIVES; CHEMICAL STRUCTURE; DOSE RESPONSE; HUMAN; SYNTHESIS;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA;

EID: 85021693802     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2017.06.016     Document Type: Article

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