Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 7, 2016, Pages 1827-1830

  Meza Aviña, Maria Elena ^a   Lingerfelt, Mary A ^a   Console Bram, Linda M ^b   Gamage, Thomas F ^b   Sharir, Haleli ^b   Gettys, Kristen E ^a   Hurst, Dow P ^a   Kotsikorou, Evangelia ^c   Shore, Derek M ^a   Caron, Marc G ^d   Rao, Narasinga ^a   Barak, Larry S ^d   Abood, Mary E ^b   Reggio, Patricia H ^a   Croatt, Mitchell P ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^b TEMPLE UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS PAN AMERICAN   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Antagonist; Cancer; GPCR; GPR55; Neuropathic pain

Indexed keywords

1,3,4 OXADIAZOLE DERIVATIVE; BETA ARRESTIN; CYCLOPROPANE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 55; PIPERIDINE DERIVATIVE; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; 1,3,4-OXADIAZOL-2(3H)-ONE; GPR55 PROTEIN, HUMAN; OXADIAZOLE DERIVATIVE; RETINA S ANTIGEN;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SUBSTITUTION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR DOCKING; NEUROPATHIC PAIN; STRUCTURE ACTIVITY RELATION; U2OS CELL LINE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CHO CELL LINE; CRICETULUS; METABOLISM; SYNTHESIS;

ANIMALS; ARRESTINS; BETA-ARRESTINS; CHO CELLS; CRICETULUS; DRUG DESIGN; HUMANS; MOLECULAR DOCKING SIMULATION; OXADIAZOLES; PIPERIDINES; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85006096995     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.02.030     Document Type: Article

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