Voluntary exercise promotes glymphatic clearance of amyloid beta and reduces the activation of astrocytes and microglia in aged mice

Frontiers in Molecular Neuroscience

Volumn 10, Issue , 2017, Pages

  He, Xiao Fei ^a   Liu, Dong Xu ^a   Zhang, Qun ^a   Liang, Feng Ying ^a   Dai, Guang Yan ^a   Zeng, Jin Sheng ^a   Pei, Zhong ^a   Xu, Guang Qing ^a   Lan, Yue ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Aging; Inflammation; Interstitial fluid; Paravascular space; Spatial memory; Wheel running

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AQUAPORIN 4; FLUORESCEIN ISOTHIOCYANATE; GLIAL FIBRILLARY ACIDIC PROTEIN; GREEN FLUORESCENT PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95;

AGED; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; CELL ACTIVATION; CELL LOSS; COGNITION; CONFOCAL LASER SCANNING MICROSCOPY; CONTROLLED STUDY; DENDRITE; DENDRITIC SPINE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXERCISE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HISTOLOGY; IMAGING; INTERSTITIAL FLUID; MALE; MICROGLIA; MORRIS WATER MAZE TEST; MOUSE; NONHUMAN; PROTEIN CLEARANCE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; RUNNING; SPATIAL MEMORY; SPINAL GANGLION; SWIMMING; TRANSGENIC MOUSE;

EID: 85021326764     PISSN: 16625099     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnmol.2017.00144     Document Type: Article

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