Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability

Toxicology

Volumn 387, Issue , 2017, Pages 81-94

  Luz, Anthony L ^a   Godebo, Tewodros R ^a   Smith, Latasha L ^a   Leuthner, Tess C ^a   Maurer, Laura L ^b   Meyer, Joel N ^a  

^a DUKE UNIVERSITY   (United States)

^b EXXONMOBIL UPSTREAM RESEARCH COMPANY   (United States)

Author keywords

Arsenite; Gene environment interaction; Mitochondrial fission; Mitochondrial fusion; Mitochondrial toxicity; Mitophagy

Indexed keywords

2,4 DINITROPHENOL; ACETALDEHYDE; ACROLEIN; AFLATOXIN B1; ARSENIC TRIOXIDE; CADMIUM CHLORIDE; CISPLATIN; DOXYCYCLINE; PARAQUAT; PYRUVIC ACID; ROTENONE; TOXIC SUBSTANCE; ARSENITE SODIUM; ARSENOUS ACID DERIVATIVE; CAENORHABDITIS ELEGANS PROTEIN; DYNAMIN; DYNAMIN-RELATED PROTEIN 1, C ELEGANS; EAT-3 PROTEIN, C ELEGANS; FZO-1 PROTEIN, C ELEGANS; GUANOSINE TRIPHOSPHATASE; PARKIN; PINK1 PROTEIN, C ELEGANS; PROTEIN SERINE THREONINE KINASE; SODIUM DERIVATIVE; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CAENORHABDITIS ELEGANS; CITRIC ACID CYCLE; CONTROLLED STUDY; ENERGY METABOLISM; GENOTYPE ENVIRONMENT INTERACTION; LARVA; LETHALITY; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL TOXICITY; MITOPHAGY; NONHUMAN; PRIORITY JOURNAL; WILD TYPE; ANIMAL; AUTOPHAGY; DOSE RESPONSE; DRUG EFFECTS; EMBRYOLOGY; GENETICS; GENOTYPE; METABOLISM; MITOCHONDRION; PHENOTYPE;

ANIMALS; ARSENITES; AUTOPHAGY; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DYNAMINS; GENE-ENVIRONMENT INTERACTION; GENOTYPE; GTP PHOSPHOHYDROLASES; LARVA; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL DYNAMICS; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; SODIUM COMPOUNDS; UBIQUITIN-PROTEIN LIGASES;

EID: 85020920402     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2017.05.018     Document Type: Article

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