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Volumn 151, Issue 6, 2017, Pages 1229-1238

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study

Author keywords

corticosteroid; hydrocortisone; septic shock; thiamine; vitamin C

Indexed keywords

ASCORBIC ACID; HYDROCORTISONE; HYPERTENSIVE AGENT; THIAMINE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; VASOCONSTRICTOR AGENT; VITAMIN B COMPLEX;

EID: 85020886166     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1016/j.chest.2016.11.036     Document Type: Article
Times cited : (730)

References (93)
  • 1
    • 77958108729 scopus 로고    scopus 로고
    • Critical care and the global burden of critical illness in adults
    • Adhikari, N.K., Fowler, R.A., Bhagwanjee, S., et al. Critical care and the global burden of critical illness in adults. Lancet 376:9749 (2010), 1339–1346.
    • (2010) Lancet , vol.376 , Issue.9749 , pp. 1339-1346
    • Adhikari, N.K.1    Fowler, R.A.2    Bhagwanjee, S.3
  • 2
    • 84897556197 scopus 로고    scopus 로고
    • Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012
    • Kaukonen, K.M., Bailey, M., Suzuki, S., et al. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA 311 (2014), 1308–1316.
    • (2014) JAMA , vol.311 , pp. 1308-1316
    • Kaukonen, K.M.1    Bailey, M.2    Suzuki, S.3
  • 3
    • 84876665421 scopus 로고    scopus 로고
    • Benchmarking the incidence and mortality of severe sepsis in the United States
    • Gaieski, D.F., Edwards, J.M., Kallan, M.J., et al. Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med 41 (2013), 1167–1174.
    • (2013) Crit Care Med , vol.41 , pp. 1167-1174
    • Gaieski, D.F.1    Edwards, J.M.2    Kallan, M.J.3
  • 4
    • 85011593497 scopus 로고    scopus 로고
    • Estimating ten-year trends in septic shock incidence and morality in United States Academic Medical Centers using clinical data
    • Kadri, S.S., Rhee, C., Strich, J.R., et al. Estimating ten-year trends in septic shock incidence and morality in United States Academic Medical Centers using clinical data. Chest 151:2 (2017), 278–285.
    • (2017) Chest , vol.151 , Issue.2 , pp. 278-285
    • Kadri, S.S.1    Rhee, C.2    Strich, J.R.3
  • 5
    • 85010764364 scopus 로고    scopus 로고
    • Fluid administration in severe sepsis and septic shock, patterns and outcomes: an analysis of a large national database
    • [published online ahead of print January 27, ]. Intensive Care Med.
    • Marik PE, Linde-Zwirble WT, Bittner EA, et al. Fluid administration in severe sepsis and septic shock, patterns and outcomes: an analysis of a large national database [published online ahead of print January 27, 2017]. Intensive Care Med. http://dx.doi.org/10.1007/s00134-016-4675-y.
    • (2017)
    • Marik, P.E.1    Linde-Zwirble, W.T.2    Bittner, E.A.3
  • 6
    • 4344716641 scopus 로고    scopus 로고
    • Brazilian Sepsis Epidemiological Study (BASES study)
    • Silva, E., de Almeida Pedro, M., Beltrami Sogayar, A.C., et al. Brazilian Sepsis Epidemiological Study (BASES study). Crit Care 8:4 (2004), R251–R260.
    • (2004) Crit Care , vol.8 , Issue.4 , pp. R251-R260
    • Silva, E.1    de Almeida Pedro, M.2    Beltrami Sogayar, A.C.3
  • 7
    • 54049105173 scopus 로고    scopus 로고
    • Sepse Brasil: Estudo Epidemiologico da Sepse em Unidades de Terapia Intensiva Brasileiras [An epidemiological study of sepsis in intensive care units]
    • Sales, J.A., David, C.M., Hatum, R., et al., Sepsis Brazil Study. Sepse Brasil: Estudo Epidemiologico da Sepse em Unidades de Terapia Intensiva Brasileiras [An epidemiological study of sepsis in intensive care units]. Rev Bras Ter Int 18 (2006), 9–17.
    • (2006) Rev Bras Ter Int , vol.18 , pp. 9-17
    • Sales, J.A.1    David, C.M.2    Hatum, R.3
  • 8
    • 85020870961 scopus 로고    scopus 로고
    • The top 10 causes of death: the 10 leading causes of death by country income group. WHO fact sheet. Published 2016. Accessed December 15, 2016.
    • World Health Organization. The top 10 causes of death: the 10 leading causes of death by country income group 2012. WHO fact sheet. http://www.who.int/mediacentre/factsheets/fs310/en/index1.html. Published 2016. Accessed December 15, 2016.
    • (2012)
  • 9
    • 67650503830 scopus 로고    scopus 로고
    • Long-term outcome and quality-adjusted life years after severe sepsis
    • Karlsson, S., Ruokonen, E., Varpula, T., et al. Long-term outcome and quality-adjusted life years after severe sepsis. Crit Care Med 37:4 (2009), 1268–1274.
    • (2009) Crit Care Med , vol.37 , Issue.4 , pp. 1268-1274
    • Karlsson, S.1    Ruokonen, E.2    Varpula, T.3
  • 10
    • 84961231090 scopus 로고    scopus 로고
    • Long-term quality of life among survivors of severe sepsis: analyses of two international trials
    • Yende, S., Austin, S., Rhodes, A., et al. Long-term quality of life among survivors of severe sepsis: analyses of two international trials. Crit Care Med 44:8 (2016), 1461–1467.
    • (2016) Crit Care Med , vol.44 , Issue.8 , pp. 1461-1467
    • Yende, S.1    Austin, S.2    Rhodes, A.3
  • 11
    • 84988984345 scopus 로고    scopus 로고
    • Long-term mortality and major adverse cardiovascular events in sepsis survivors: a nationwide population-based study
    • Ou, S.M., Chu, H., Chao, P.W., et al. Long-term mortality and major adverse cardiovascular events in sepsis survivors: a nationwide population-based study. Am J Respir Crit Care Med 194:2 (2016), 209–217.
    • (2016) Am J Respir Crit Care Med , vol.194 , Issue.2 , pp. 209-217
    • Ou, S.M.1    Chu, H.2    Chao, P.W.3
  • 12
    • 84889239723 scopus 로고    scopus 로고
    • Sepsis and scientific revolutions
    • Artenstein, A.W., Higgins, T.L., Opal, S.M., Sepsis and scientific revolutions. Crit Care Med 41:12 (2013), 2770–2772.
    • (2013) Crit Care Med , vol.41 , Issue.12 , pp. 2770-2772
    • Artenstein, A.W.1    Higgins, T.L.2    Opal, S.M.3
  • 13
    • 84908247494 scopus 로고    scopus 로고
    • Attenuation of sepsis-induced organ injury in mice by vitamin C
    • Fisher, B.J., Kraskauskas, D., Martin, E.J., et al. Attenuation of sepsis-induced organ injury in mice by vitamin C. JPEN 38:7 (2014), 825–839.
    • (2014) JPEN , vol.38 , Issue.7 , pp. 825-839
    • Fisher, B.J.1    Kraskauskas, D.2    Martin, E.J.3
  • 14
    • 79957646019 scopus 로고    scopus 로고
    • Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury
    • Fisher, B.J., Seropian, I.M., Masanori, Y., et al. Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury. Crit Care Med 39:6 (2011), 1454–1460.
    • (2011) Crit Care Med , vol.39 , Issue.6 , pp. 1454-1460
    • Fisher, B.J.1    Seropian, I.M.2    Masanori, Y.3
  • 15
    • 84863229258 scopus 로고    scopus 로고
    • Ascorbate protects against vascular leakage in cecal ligation and puncture-induced septic peritonitis
    • Zhou, G., Kamenos, G., Pendem, S., et al. Ascorbate protects against vascular leakage in cecal ligation and puncture-induced septic peritonitis. Am J Physiol Regulatory Integrative Comp Physiol 302:4 (2012), R409–R416.
    • (2012) Am J Physiol Regulatory Integrative Comp Physiol , vol.302 , Issue.4 , pp. R409-R416
    • Zhou, G.1    Kamenos, G.2    Pendem, S.3
  • 16
    • 84893162337 scopus 로고    scopus 로고
    • Phase 1 safety trial of intravenous ascorbic acid in patients with severe sepsis
    • Fowler, A.A., Syed, A.A., Knowlson, S., et al. Phase 1 safety trial of intravenous ascorbic acid in patients with severe sepsis. J Transl Med, 12, 2014, 32.
    • (2014) J Transl Med , vol.12 , pp. 32
    • Fowler, A.A.1    Syed, A.A.2    Knowlson, S.3
  • 17
    • 0034019327 scopus 로고    scopus 로고
    • Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized, prospective study
    • Tanaka, H., Matsuda, T., Miyagantani, Y., et al. Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized, prospective study. Arch Surg 135:3 (2000), 326–331.
    • (2000) Arch Surg , vol.135 , Issue.3 , pp. 326-331
    • Tanaka, H.1    Matsuda, T.2    Miyagantani, Y.3
  • 18
    • 0037297449 scopus 로고    scopus 로고
    • Ascorbic acid dynamics in the seriously ill and injured
    • Long, C.L., Maull, K.L., Krishman, R.S., et al. Ascorbic acid dynamics in the seriously ill and injured. J Surg Res 109:2 (2003), 144–148.
    • (2003) J Surg Res , vol.109 , Issue.2 , pp. 144-148
    • Long, C.L.1    Maull, K.L.2    Krishman, R.S.3
  • 19
    • 85020842120 scopus 로고    scopus 로고
    • Pharmacokinetics of four high-dose regime[n]s of intravenous vitamin C in critically ill patients
    • [abstract]
    • de Grooth, H.J., Choo, W.P., Spoelstra-de Man, A.M., et al. Pharmacokinetics of four high-dose regime[n]s of intravenous vitamin C in critically ill patients. [abstract] Intensive Care Med Exp, 4(suppl 1), 2016, A52.
    • (2016) Intensive Care Med Exp , vol.4 , pp. A52
    • de Grooth, H.J.1    Choo, W.P.2    Spoelstra-de Man, A.M.3
  • 20
    • 1842435160 scopus 로고    scopus 로고
    • Vitamin C pharmacokinetics: implications for oral and intravenous use
    • Padayatty, S.J., Sun, H., Wang, Y., et al. Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann Intern Med 140:7 (2004), 533–537.
    • (2004) Ann Intern Med , vol.140 , Issue.7 , pp. 533-537
    • Padayatty, S.J.1    Sun, H.2    Wang, Y.3
  • 21
    • 0036895263 scopus 로고    scopus 로고
    • Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients
    • Nathens, A.B., Neff, M.J., Jurkovich, G.J., et al. Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients. Ann Surg 236:6 (2002), 814–822.
    • (2002) Ann Surg , vol.236 , Issue.6 , pp. 814-822
    • Nathens, A.B.1    Neff, M.J.2    Jurkovich, G.J.3
  • 22
    • 84991276508 scopus 로고    scopus 로고
    • Effect of high-dose ascorbic acid on vasopressor requirement in septic shock
    • Zabet, M.H., Mohammadi, M., Ramezani, M., et al. Effect of high-dose ascorbic acid on vasopressor requirement in septic shock. J Res Pharm Pract 5:2 (2016), 94–100.
    • (2016) J Res Pharm Pract , vol.5 , Issue.2 , pp. 94-100
    • Zabet, M.H.1    Mohammadi, M.2    Ramezani, M.3
  • 23
    • 85020924967 scopus 로고    scopus 로고
    • Ascorbic acid injection
    • Updated November 18, 2016. Accessed December 15.
    • Ascorbic acid injection. Torrance Company. http://medlibrary.org/lib/rx/meds/ascorbic-acid-5/. Updated November 18, 2016. Accessed December 15, 2016.
    • (2016)
  • 24
    • 64949179184 scopus 로고    scopus 로고
    • High-dose vitamin C (ascorbic acid) therapy in the treatment of patients with advanced cancer
    • Ohno, S., Ohno, Y., Suzuki, N., et al. High-dose vitamin C (ascorbic acid) therapy in the treatment of patients with advanced cancer. Anticancer Res 29:3 (2009), 809–815.
    • (2009) Anticancer Res , vol.29 , Issue.3 , pp. 809-815
    • Ohno, S.1    Ohno, Y.2    Suzuki, N.3
  • 25
    • 84879794983 scopus 로고    scopus 로고
    • Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer
    • Stephenson, C.M., Levin, R.D., Spector, T., et al. Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer. Cancer Chemother Pharmacol 72:1 (2013), 139–146.
    • (2013) Cancer Chemother Pharmacol , vol.72 , Issue.1 , pp. 139-146
    • Stephenson, C.M.1    Levin, R.D.2    Spector, T.3
  • 26
    • 45149105776 scopus 로고    scopus 로고
    • Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine
    • Marik, P.E., Pastores, S.M., Annane, D., et al. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 36:6 (2008), 1937–1949.
    • (2008) Crit Care Med , vol.36 , Issue.6 , pp. 1937-1949
    • Marik, P.E.1    Pastores, S.M.2    Annane, D.3
  • 27
    • 84969222300 scopus 로고    scopus 로고
    • “Vitamin S” (steroids) and vitamin C for the treatment of severe sepsis and septic shock!
    • Marik, P.E., “Vitamin S” (steroids) and vitamin C for the treatment of severe sepsis and septic shock!. Crit Care Med 44:6 (2016), 1228–1229.
    • (2016) Crit Care Med , vol.44 , Issue.6 , pp. 1228-1229
    • Marik, P.E.1
  • 28
    • 84973386990 scopus 로고    scopus 로고
    • Integrating randomized comparative effectiveness research with patient care
    • Fiore, L.D., Lavori, P.W., Integrating randomized comparative effectiveness research with patient care. N Engl J Med 374:22 (2016), 2152–2158.
    • (2016) N Engl J Med , vol.374 , Issue.22 , pp. 2152-2158
    • Fiore, L.D.1    Lavori, P.W.2
  • 29
    • 84876708502 scopus 로고    scopus 로고
    • Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis
    • Wacker, C., Prkno, A., Brunkhorst, F.M., et al. Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis 13:5 (2013), 426–435.
    • (2013) Lancet Infect Dis , vol.13 , Issue.5 , pp. 426-435
    • Wacker, C.1    Prkno, A.2    Brunkhorst, F.M.3
  • 30
    • 84879076980 scopus 로고    scopus 로고
    • Procalcitonin decrease over 72 hours in US critical care units predicts fatal outcome in sepsis patients
    • Schuetz, P., Maurer, P., Punjabi, V., et al. Procalcitonin decrease over 72 hours in US critical care units predicts fatal outcome in sepsis patients. Crit Care, 17(3), 2013, R115.
    • (2013) Crit Care , vol.17 , Issue.3 , pp. R115
    • Schuetz, P.1    Maurer, P.2    Punjabi, V.3
  • 31
    • 64049119735 scopus 로고    scopus 로고
    • Procalcitonin kinetics within the first days of sepsis: relationship with the appropriateness of antibiotic therapy and outcome
    • Charles, P.E., Tinel, C., Barbar, S., et al. Procalcitonin kinetics within the first days of sepsis: relationship with the appropriateness of antibiotic therapy and outcome. Crit Care, 13(2), 2016, R38.
    • (2016) Crit Care , vol.13 , Issue.2 , pp. R38
    • Charles, P.E.1    Tinel, C.2    Barbar, S.3
  • 32
    • 84866553484 scopus 로고    scopus 로고
    • Longitudinal changes in procalcitonin in a heterogeneous group of critically ill patients
    • Reynolds, S.C., Shorr, A.F., Muscedere, J., et al. Longitudinal changes in procalcitonin in a heterogeneous group of critically ill patients. Crit Care Med 40:10 (2012), 2781–2787.
    • (2012) Crit Care Med , vol.40 , Issue.10 , pp. 2781-2787
    • Reynolds, S.C.1    Shorr, A.F.2    Muscedere, J.3
  • 33
    • 84937894169 scopus 로고    scopus 로고
    • Procalcitonin levels in survivors and non survivors of sepsis: systematic review and meta-analysis
    • Arora, S., Singh, P., Singh, P.M., et al. Procalcitonin levels in survivors and non survivors of sepsis: systematic review and meta-analysis. Shock 43:3 (2015), 212–221.
    • (2015) Shock , vol.43 , Issue.3 , pp. 212-221
    • Arora, S.1    Singh, P.2    Singh, P.M.3
  • 34
    • 84926344321 scopus 로고    scopus 로고
    • Prognostic value of procalcitonin in respiratory tract infections across clinical settings
    • Kutz, A., Briel, M., Christ-Crain, M., et al. Prognostic value of procalcitonin in respiratory tract infections across clinical settings. Crit Care, 19, 2015, 74.
    • (2015) Crit Care , vol.19 , pp. 74
    • Kutz, A.1    Briel, M.2    Christ-Crain, M.3
  • 35
    • 0026874127 scopus 로고
    • American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis
    • Society of Critical Care Medicine Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20:6 (1992), 864–874.
    • (1992) Crit Care Med , vol.20 , Issue.6 , pp. 864-874
  • 36
    • 84883502696 scopus 로고    scopus 로고
    • Tolerability and safety of enteral nutrition in critically ill patients receiving intravenous vasopressor therapy
    • Mancl, E.E., Muzevich, K.M., Tolerability and safety of enteral nutrition in critically ill patients receiving intravenous vasopressor therapy. JPEN 37:5 (2013), 641–651.
    • (2013) JPEN , vol.37 , Issue.5 , pp. 641-651
    • Mancl, E.E.1    Muzevich, K.M.2
  • 37
    • 40049109098 scopus 로고    scopus 로고
    • Vasopressin versus norepinephrine infusion in patients with septic shock
    • Russell, J.A., Walley, K.R., Singer, J., et al. Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med 358:9 (2008), 877–887.
    • (2008) N Engl J Med , vol.358 , Issue.9 , pp. 877-887
    • Russell, J.A.1    Walley, K.R.2    Singer, J.3
  • 38
    • 84873522208 scopus 로고    scopus 로고
    • Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1)
    • Kellum, J.A., Lameire, N., Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1). Crit Care, 17(1), 2013, 204.
    • (2013) Crit Care , vol.17 , Issue.1 , pp. 204
    • Kellum, J.A.1    Lameire, N.2
  • 39
    • 0022256529 scopus 로고
    • APACHE II: a severity of disease classification system
    • Knaus, W.A., Draper, E.A., Wagner, D.P., et al. APACHE II: a severity of disease classification system. Crit Care Med 13:10 (1985), 818–828.
    • (1985) Crit Care Med , vol.13 , Issue.10 , pp. 818-828
    • Knaus, W.A.1    Draper, E.A.2    Wagner, D.P.3
  • 40
    • 33646592518 scopus 로고    scopus 로고
    • Acute Physiology and Chronic Health Evaluation (APACHE) IV: hospital mortality assessment for today's critically ill patients
    • Zimmerman, J.E., Kramer, A.A., McNair, D.S., et al. Acute Physiology and Chronic Health Evaluation (APACHE) IV: hospital mortality assessment for today's critically ill patients. Crit Care Med 34:5 (2006), 1297–1310.
    • (2006) Crit Care Med , vol.34 , Issue.5 , pp. 1297-1310
    • Zimmerman, J.E.1    Kramer, A.A.2    McNair, D.S.3
  • 41
    • 0030015661 scopus 로고    scopus 로고
    • The SOFA (Sepsis-Related Organ Failure Assessment) score to describe organ dysfunction/failure
    • Vincent, J.L., Moreno, R., Takala, J., et al., Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. The SOFA (Sepsis-Related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Med 22:7 (1996), 707–710.
    • (1996) Intensive Care Med , vol.22 , Issue.7 , pp. 707-710
    • Vincent, J.L.1    Moreno, R.2    Takala, J.3
  • 42
    • 84901824865 scopus 로고    scopus 로고
    • Early management of severe sepsis: current concepts and controversies
    • Marik, P.E., Early management of severe sepsis: current concepts and controversies. Chest 145:6 (2014), 1407–1418.
    • (2014) Chest , vol.145 , Issue.6 , pp. 1407-1418
    • Marik, P.E.1
  • 43
    • 84941368693 scopus 로고    scopus 로고
    • Corticosteroid therapy for patients hospitalized with community-acquired pneumonia: a systematic review and meta-analysis
    • Siemieniuk, R.A., Meade, M.P., Alonso-Coello, P., et al. Corticosteroid therapy for patients hospitalized with community-acquired pneumonia: a systematic review and meta-analysis. Ann Intern Med 163:7 (2015), 519–528.
    • (2015) Ann Intern Med , vol.163 , Issue.7 , pp. 519-528
    • Siemieniuk, R.A.1    Meade, M.P.2    Alonso-Coello, P.3
  • 44
    • 84891026537 scopus 로고    scopus 로고
    • De-escalation of emperical therapy is associated with lower mortality in patients with severe sepsis and septic shock
    • Garnacho-Montero, J., Gutierrez-Pizarraya, A., Escoresca-Ortega, A., et al. De-escalation of emperical therapy is associated with lower mortality in patients with severe sepsis and septic shock. Intensive Care Med 40:1 (2014), 32–40.
    • (2014) Intensive Care Med , vol.40 , Issue.1 , pp. 32-40
    • Garnacho-Montero, J.1    Gutierrez-Pizarraya, A.2    Escoresca-Ortega, A.3
  • 45
    • 84960378046 scopus 로고    scopus 로고
    • A rational apprach to fluid therapy in sepsis
    • Marik, P., Bellomo, R., A rational apprach to fluid therapy in sepsis. Br J Anaesth 116:3 (2016), 339–349.
    • (2016) Br J Anaesth , vol.116 , Issue.3 , pp. 339-349
    • Marik, P.1    Bellomo, R.2
  • 46
    • 84947087478 scopus 로고    scopus 로고
    • Fluid responsiveness and the six guiding principles of fluid resuscitation
    • Marik, P.E., Fluid responsiveness and the six guiding principles of fluid resuscitation. Crit Care Med 44:10 (2016), 1920–1922.
    • (2016) Crit Care Med , vol.44 , Issue.10 , pp. 1920-1922
    • Marik, P.E.1
  • 47
    • 0343893748 scopus 로고    scopus 로고
    • Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome
    • Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:18 (2000), 1301–1308.
    • (2000) N Engl J Med , vol.342 , Issue.18 , pp. 1301-1308
  • 48
    • 84997525112 scopus 로고    scopus 로고
    • Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: the oxygen-ICU randomized clinical trial
    • Girardis, M., Busani, S., Damiani, E., et al. Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: the oxygen-ICU randomized clinical trial. JAMA 316:15 (2016), 1583–1589.
    • (2016) JAMA , vol.316 , Issue.15 , pp. 1583-1589
    • Girardis, M.1    Busani, S.2    Damiani, E.3
  • 49
    • 84872087535 scopus 로고    scopus 로고
    • Clinical practice guidelines for the management of pain, agitation and delirium in adult patients in the intensive care unit
    • Barr, J., Fraser, G.L., Puntillo, K., et al. Clinical practice guidelines for the management of pain, agitation and delirium in adult patients in the intensive care unit. Crit Care Med 41:1 (2013), 263–306.
    • (2013) Crit Care Med , vol.41 , Issue.1 , pp. 263-306
    • Barr, J.1    Fraser, G.L.2    Puntillo, K.3
  • 50
    • 84930934362 scopus 로고    scopus 로고
    • Feeding critically ill patients the right “whey”: thinking outside of the box: a personal view
    • Marik, P.E., Feeding critically ill patients the right “whey”: thinking outside of the box: a personal view. Ann Intensive Care, 5(1), 2015, 51.
    • (2015) Ann Intensive Care , vol.5 , Issue.1 , pp. 51
    • Marik, P.E.1
  • 51
    • 84957438720 scopus 로고    scopus 로고
    • Is early starvation beneficial for the critically ill patient?
    • Marik, P.E., Is early starvation beneficial for the critically ill patient?. Curr Opin Clin Nutr Metab Care 19:2 (2016), 155–160.
    • (2016) Curr Opin Clin Nutr Metab Care , vol.19 , Issue.2 , pp. 155-160
    • Marik, P.E.1
  • 52
    • 84966669953 scopus 로고    scopus 로고
    • Tight glycemic control in acutely ill patients: low evidence of benefit, high evidence of harm!
    • Marik, P.E., Tight glycemic control in acutely ill patients: low evidence of benefit, high evidence of harm!. Intensive Care Med 42:9 (2016), 1475–1477.
    • (2016) Intensive Care Med , vol.42 , Issue.9 , pp. 1475-1477
    • Marik, P.E.1
  • 53
    • 84988431176 scopus 로고    scopus 로고
    • Stress ulcer prophylaxis de-adoption: what is the barrier?
    • Marik, P.E., Stress ulcer prophylaxis de-adoption: what is the barrier?. Crit Care Med 44:10 (2016), 1939–1941.
    • (2016) Crit Care Med , vol.44 , Issue.10 , pp. 1939-1941
    • Marik, P.E.1
  • 54
    • 38049110809 scopus 로고    scopus 로고
    • Hydrocortisone therapy for patients with septic shock
    • Sprung, C.L., Annane, D., Keh, D., et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 358:2 (2008), 111–124.
    • (2008) N Engl J Med , vol.358 , Issue.2 , pp. 111-124
    • Sprung, C.L.1    Annane, D.2    Keh, D.3
  • 55
    • 78149425934 scopus 로고    scopus 로고
    • Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study
    • Karlsson, S., Heikkinen, M., Pettila, V., et al. Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study. Crit Care, 14(6), 2010, R205.
    • (2010) Crit Care , vol.14 , Issue.6 , pp. R205
    • Karlsson, S.1    Heikkinen, M.2    Pettila, V.3
  • 56
    • 0035840891 scopus 로고    scopus 로고
    • Serial evaluation of the SOFA score to predict outcome in critically ill patients
    • Ferreira, F.L., Bota, D.P., Bross, A., et al. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 286:14 (2001), 1754–1758.
    • (2001) JAMA , vol.286 , Issue.14 , pp. 1754-1758
    • Ferreira, F.L.1    Bota, D.P.2    Bross, A.3
  • 57
    • 84920593314 scopus 로고    scopus 로고
    • Prognostic evaluation of severe sepsis and septic shock: procalcitonin clearance vs Δ Sequential Organ Failure Assessment
    • 219-212
    • de Azevedo, J.R., Torres, O.J., Beraldi, R.A., et al. Prognostic evaluation of severe sepsis and septic shock: procalcitonin clearance vs Δ Sequential Organ Failure Assessment. J Crit Care, 30(1), 2015 219-212.
    • (2015) J Crit Care , vol.30 , Issue.1
    • de Azevedo, J.R.1    Torres, O.J.2    Beraldi, R.A.3
  • 58
    • 81755166344 scopus 로고    scopus 로고
    • Dynamic change of procalcitonin, rather than concentration itself, is predictive of survival in septic shock patients when beyond 10 ng/mL
    • Guan, J., Lin, Z., Lue, H., Dynamic change of procalcitonin, rather than concentration itself, is predictive of survival in septic shock patients when beyond 10 ng/mL. Shock 36:6 (2011), 570–574.
    • (2011) Shock , vol.36 , Issue.6 , pp. 570-574
    • Guan, J.1    Lin, Z.2    Lue, H.3
  • 59
    • 84865993732 scopus 로고    scopus 로고
    • Usefulness of procalcitonin clearance as a prognostic biomarker in septic shock: a prospective pilot study
    • Ruiz-Rodriguez, J.C., Caballero, J., Ruiz-Sanmartin, A., et al. Usefulness of procalcitonin clearance as a prognostic biomarker in septic shock: a prospective pilot study. Medicina Intensiva 36:7 (2012), 475–480.
    • (2012) Medicina Intensiva , vol.36 , Issue.7 , pp. 475-480
    • Ruiz-Rodriguez, J.C.1    Caballero, J.2    Ruiz-Sanmartin, A.3
  • 60
    • 3543135271 scopus 로고    scopus 로고
    • Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group
    • D'Agostino, R.B., Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. Stat Med 17:19 (1998), 2265–2281.
    • (1998) Stat Med , vol.17 , Issue.19 , pp. 2265-2281
    • D'Agostino, R.B.1
  • 61
    • 43249131152 scopus 로고    scopus 로고
    • Selection bias negates conclusions from the CORTICUS study?
    • Marik, P.E., Pastores, S.M., Kavanaugh, B.P., Selection bias negates conclusions from the CORTICUS study?. N Engl J Med 358 (2008), 2069–2070.
    • (2008) N Engl J Med , vol.358 , pp. 2069-2070
    • Marik, P.E.1    Pastores, S.M.2    Kavanaugh, B.P.3
  • 62
    • 84924930847 scopus 로고
    • The treatment of poliomyelitis and other virus diseases with vitamin C
    • Klenner, F.R., The treatment of poliomyelitis and other virus diseases with vitamin C. South Med Surg 111:7 (1949), 209–214.
    • (1949) South Med Surg , vol.111 , Issue.7 , pp. 209-214
    • Klenner, F.R.1
  • 63
    • 0002350578 scopus 로고
    • The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone: compound E) and the pituitary adenocorticotrophic hormone on rheumatoid arthritis: preliminary report
    • Hench, P.S., Kendall, E.C., Slocumb, C.H., et al. The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone: compound E) and the pituitary adenocorticotrophic hormone on rheumatoid arthritis: preliminary report. Ann Rheum Dis 8:2 (1949), 97–104.
    • (1949) Ann Rheum Dis , vol.8 , Issue.2 , pp. 97-104
    • Hench, P.S.1    Kendall, E.C.2    Slocumb, C.H.3
  • 64
    • 84954349075 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of thiamine as a metabolic resuscitator in septic shock: a pilot study
    • Donnino, M.W., Andersen, L.W., Chase, M., et al. Randomized, double-blind, placebo-controlled trial of thiamine as a metabolic resuscitator in septic shock: a pilot study. Crit Care Med 44:2 (2016), 360–367.
    • (2016) Crit Care Med , vol.44 , Issue.2 , pp. 360-367
    • Donnino, M.W.1    Andersen, L.W.2    Chase, M.3
  • 65
    • 17044422667 scopus 로고    scopus 로고
    • Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis
    • Gibot, S., Cravoisy, A., Kolopp-Sarda, M.N., et al. Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis. Crit Care Med 33:4 (2005), 792–796.
    • (2005) Crit Care Med , vol.33 , Issue.4 , pp. 792-796
    • Gibot, S.1    Cravoisy, A.2    Kolopp-Sarda, M.N.3
  • 66
    • 84982132621 scopus 로고    scopus 로고
    • Effect of early vasopressin vs norepinephrine on kidney failure in patients with septic shock: the VANISH randomized clinical trial
    • Gordon, A.C., Mason, A.J., Thirunavukkarasu, N., et al. Effect of early vasopressin vs norepinephrine on kidney failure in patients with septic shock: the VANISH randomized clinical trial. JAMA 316:5 (2016), 509–518.
    • (2016) JAMA , vol.316 , Issue.5 , pp. 509-518
    • Gordon, A.C.1    Mason, A.J.2    Thirunavukkarasu, N.3
  • 67
    • 0026676920 scopus 로고
    • Symmetrical peripheral gangrene: association with noradrenaline administration
    • Hayes, M.A., Yau, E.H., Hinds, C.J., et al. Symmetrical peripheral gangrene: association with noradrenaline administration. Intensive Care Med 18:7 (1992), 433–436.
    • (1992) Intensive Care Med , vol.18 , Issue.7 , pp. 433-436
    • Hayes, M.A.1    Yau, E.H.2    Hinds, C.J.3
  • 68
    • 33646241086 scopus 로고    scopus 로고
    • Ischemic skin lesions and microcirculatory collapse during vasopressin therapy: a possible role of the microcirculation?
    • Dunser, M.W., Wenzel, V., Hasibeder, W.R., Ischemic skin lesions and microcirculatory collapse during vasopressin therapy: a possible role of the microcirculation?. Acta Anaesthesiol Scand 50:5 (2006), 637–638.
    • (2006) Acta Anaesthesiol Scand , vol.50 , Issue.5 , pp. 637-638
    • Dunser, M.W.1    Wenzel, V.2    Hasibeder, W.R.3
  • 69
    • 84988822454 scopus 로고    scopus 로고
    • Potentially inadvertant immunomodulation: norepinephrine use in sepsis
    • Stolk, R.F., van der Poll, T., Angus, D.C., et al. Potentially inadvertant immunomodulation: norepinephrine use in sepsis. Am J Respir Crit Care Med 194:5 (2016), 550–558.
    • (2016) Am J Respir Crit Care Med , vol.194 , Issue.5 , pp. 550-558
    • Stolk, R.F.1    van der Poll, T.2    Angus, D.C.3
  • 70
    • 84890489475 scopus 로고    scopus 로고
    • Role of vitamin C in the function of the vascular endothelium
    • May, J.M., Role of vitamin C in the function of the vascular endothelium. Antioxid Redox Signal 19:17 (2013), 2068–2083.
    • (2013) Antioxid Redox Signal , vol.19 , Issue.17 , pp. 2068-2083
    • May, J.M.1
  • 71
    • 84886432847 scopus 로고    scopus 로고
    • Evaluation of vitamin C for adjuvant sepsis therapy
    • Wilson, J.X., Evaluation of vitamin C for adjuvant sepsis therapy. Antioxid Redox Signal 19:17 (2013), 2129–2140.
    • (2013) Antioxid Redox Signal , vol.19 , Issue.17 , pp. 2129-2140
    • Wilson, J.X.1
  • 72
    • 65549141156 scopus 로고    scopus 로고
    • Mechanism of action of vitamin C in sepsis: ascorbate modulates redox signaling in endothelium
    • Wilson, J.X., Mechanism of action of vitamin C in sepsis: ascorbate modulates redox signaling in endothelium. Biofactors 35:1 (2009), 5–13.
    • (2009) Biofactors , vol.35 , Issue.1 , pp. 5-13
    • Wilson, J.X.1
  • 73
    • 74349087513 scopus 로고    scopus 로고
    • Ascorbate protects endothelial barrier function during septic insult: role of protein phosphatase type 2A
    • Han, M., Pendem, S., Teh, S.L., et al. Ascorbate protects endothelial barrier function during septic insult: role of protein phosphatase type 2A. Free Radic Biol Med 48:1 (2010), 128–135.
    • (2010) Free Radic Biol Med , vol.48 , Issue.1 , pp. 128-135
    • Han, M.1    Pendem, S.2    Teh, S.L.3
  • 74
    • 2542469730 scopus 로고    scopus 로고
    • Antioxidant-independent ascorbate enhancement of catecholamine-induced contractions of vascular smooth muscle
    • Dillon, P.F., Root-Bernstein, R.S., Lieder, C.M., Antioxidant-independent ascorbate enhancement of catecholamine-induced contractions of vascular smooth muscle. Am J Physiol Heart Circ Physiol 286:6 (2004), H2353–H2360.
    • (2004) Am J Physiol Heart Circ Physiol , vol.286 , Issue.6 , pp. H2353-H2360
    • Dillon, P.F.1    Root-Bernstein, R.S.2    Lieder, C.M.3
  • 75
    • 58249105731 scopus 로고    scopus 로고
    • Critical illness related corticosteroid insufficiency
    • Marik, P.E., Critical illness related corticosteroid insufficiency. Chest 135:1 (2009), 181–193.
    • (2009) Chest , vol.135 , Issue.1 , pp. 181-193
    • Marik, P.E.1
  • 76
    • 0015272596 scopus 로고
    • Prolonged skin allograft survival in vitamin C-deficient guinea-pigs: preliminary communication
    • Kalden, J.R., Prolonged skin allograft survival in vitamin C-deficient guinea-pigs: preliminary communication. Eur Surg Res 4:2 (1972), 114–119.
    • (1972) Eur Surg Res , vol.4 , Issue.2 , pp. 114-119
    • Kalden, J.R.1
  • 77
    • 84929708263 scopus 로고    scopus 로고
    • Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals
    • Kim, S.R., Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals. Biochem Pharmacol 95:4 (2015), 279–289.
    • (2015) Biochem Pharmacol , vol.95 , Issue.4 , pp. 279-289
    • Kim, S.R.1
  • 78
    • 84890481336 scopus 로고    scopus 로고
    • Vitamin C promotes maturation of T-cells
    • Manning, J., Mitchell, B., Appadurai, D.A., et al. Vitamin C promotes maturation of T-cells. Antioxid Redox Signal 19:17 (2013), 2054–2067.
    • (2013) Antioxid Redox Signal , vol.19 , Issue.17 , pp. 2054-2067
    • Manning, J.1    Mitchell, B.2    Appadurai, D.A.3
  • 79
    • 29844447526 scopus 로고    scopus 로고
    • Corticosteroid sparing effects of vitamin C and magnesium in asthma: a randomised trial
    • Fogarty, A., Scrivener, S.L., Antoniak, M., et al. Corticosteroid sparing effects of vitamin C and magnesium in asthma: a randomised trial. Respir Med 100:1 (2006), 174–179.
    • (2006) Respir Med , vol.100 , Issue.1 , pp. 174-179
    • Fogarty, A.1    Scrivener, S.L.2    Antoniak, M.3
  • 80
    • 0021355753 scopus 로고
    • Sulfhydryl-modifying reagents reversibly inhibit binding of glucocorticoid-receptor complexes to DNA-cellulose
    • Bodwell, J.E., Holbrook, N.J., Munck, A., Sulfhydryl-modifying reagents reversibly inhibit binding of glucocorticoid-receptor complexes to DNA-cellulose. Biochemistry 23:7 (1984), 1392–1398.
    • (1984) Biochemistry , vol.23 , Issue.7 , pp. 1392-1398
    • Bodwell, J.E.1    Holbrook, N.J.2    Munck, A.3
  • 81
    • 0033538027 scopus 로고    scopus 로고
    • Redox-dependent regulation of nuclear import of the glucocorticoid receptor
    • Okamoto, K., Tanaka, H., Ogawa, H., et al. Redox-dependent regulation of nuclear import of the glucocorticoid receptor. J Biol Chem 274:15 (1999), 10363–10371.
    • (1999) J Biol Chem , vol.274 , Issue.15 , pp. 10363-10371
    • Okamoto, K.1    Tanaka, H.2    Ogawa, H.3
  • 82
    • 0031750979 scopus 로고    scopus 로고
    • Restoration of the glucocorticoid receptor function by the phosphodiester compound of vitamins C and E, EPC-K1 (l-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl hydrogen phosphate] potassium salt), via a redox-dependent mechanism
    • Okamoto, K., Tanaka, H., Makino, Y., et al. Restoration of the glucocorticoid receptor function by the phosphodiester compound of vitamins C and E, EPC-K1 (l-ascorbic acid 2-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl hydrogen phosphate] potassium salt), via a redox-dependent mechanism. Biochem Pharmacol 56:1 (1998), 79–86.
    • (1998) Biochem Pharmacol , vol.56 , Issue.1 , pp. 79-86
    • Okamoto, K.1    Tanaka, H.2    Makino, Y.3
  • 83
    • 84870179553 scopus 로고    scopus 로고
    • Functional and physiological role of vitamin C transporters
    • Burzle, M., Hediger, M.A., Functional and physiological role of vitamin C transporters. Curr Top Membr 70 (2012), 357–375.
    • (2012) Curr Top Membr , vol.70 , pp. 357-375
    • Burzle, M.1    Hediger, M.A.2
  • 84
    • 5644225578 scopus 로고    scopus 로고
    • Functional expression of sodium-dependent vitamin C transporter 2 in human endothelial cells
    • Seno, T., Inoue, N., Matsui, K., et al. Functional expression of sodium-dependent vitamin C transporter 2 in human endothelial cells. J Vasc Res 41:4 (2004), 345–351.
    • (2004) J Vasc Res , vol.41 , Issue.4 , pp. 345-351
    • Seno, T.1    Inoue, N.2    Matsui, K.3
  • 85
    • 0034888127 scopus 로고    scopus 로고
    • Dexamethasone induces sodium-dependant vitamin C transporter in a mouse osteoblastic cell line MC3T3-E1
    • Fujita, I., Hirano, J., Itoh, N., et al. Dexamethasone induces sodium-dependant vitamin C transporter in a mouse osteoblastic cell line MC3T3-E1. Br J Nutr 86:2 (2001), 145–149.
    • (2001) Br J Nutr , vol.86 , Issue.2 , pp. 145-149
    • Fujita, I.1    Hirano, J.2    Itoh, N.3
  • 86
    • 85020901764 scopus 로고    scopus 로고
    • Hydrocortisone and ascorbic acid synergistically protect against LPS-induced pulmonary endothelial barrier dysfunction
    • Chest. In press.
    • Barabutis N, Khangoora V, Marik PE, et al. Hydrocortisone and ascorbic acid synergistically protect against LPS-induced pulmonary endothelial barrier dysfunction. Chest. In press.
    • Barabutis, N.1    Khangoora, V.2    Marik, P.E.3
  • 87
    • 84997287919 scopus 로고    scopus 로고
    • Effect of hydrocortisone on development of shock among patients with severe sepsis: the HYPRESS Randomized Clinical Trial
    • Keh, D., Trips, E., Marx, G., et al., SepNet-Critical Care Trials Group. Effect of hydrocortisone on development of shock among patients with severe sepsis: the HYPRESS Randomized Clinical Trial. JAMA 316:17 (2016), 1775–1785.
    • (2016) JAMA , vol.316 , Issue.17 , pp. 1775-1785
    • Keh, D.1    Trips, E.2    Marx, G.3
  • 88
    • 65449188293 scopus 로고    scopus 로고
    • The effects of steroids during sepsis depend on dose and severity of illness: an updated meta-analysis
    • Minneci, P.C., Deans, K.J., Eichacker, P.Q., et al. The effects of steroids during sepsis depend on dose and severity of illness: an updated meta-analysis. Clin Microbiol Infect 15:4 (2009), 308–318.
    • (2009) Clin Microbiol Infect , vol.15 , Issue.4 , pp. 308-318
    • Minneci, P.C.1    Deans, K.J.2    Eichacker, P.Q.3
  • 89
    • 22144484168 scopus 로고    scopus 로고
    • Ascorbate increases human oxaluria and kidney stone risk
    • Massey, L.K., Ascorbate increases human oxaluria and kidney stone risk. J Nutr 135:7 (2005), 1673–1677.
    • (2005) J Nutr , vol.135 , Issue.7 , pp. 1673-1677
    • Massey, L.K.1
  • 90
    • 0028266613 scopus 로고
    • Effect of high dose vitamin C on urinary oxalate levels
    • Wandzilak, T.R., Effect of high dose vitamin C on urinary oxalate levels. J Urol 151:4 (1994), 834–837.
    • (1994) J Urol , vol.151 , Issue.4 , pp. 834-837
    • Wandzilak, T.R.1
  • 91
    • 67349122278 scopus 로고    scopus 로고
    • The primary hyperoxalurias
    • Hoppe, B., Beck, B.B., Milliner, D., The primary hyperoxalurias. Kidney Int 75:12 (2009), 1264–1271.
    • (2009) Kidney Int , vol.75 , Issue.12 , pp. 1264-1271
    • Hoppe, B.1    Beck, B.B.2    Milliner, D.3
  • 92
    • 0023491596 scopus 로고
    • Oxalate metabolism in thiamine-deficient rats
    • Sidhu, H., Gupta, R., Thind, S.K., et al. Oxalate metabolism in thiamine-deficient rats. Ann Nutr Metab 31:6 (1987), 354–361.
    • (1987) Ann Nutr Metab , vol.31 , Issue.6 , pp. 354-361
    • Sidhu, H.1    Gupta, R.2    Thind, S.K.3
  • 93
    • 79955613592 scopus 로고    scopus 로고
    • Pyridoxine and dietary counseling for the management of idiopathic hyperoxaluria in stone-forming patients
    • Ortiz-Alvarado, O., Muyaoka, R., Kriedberg, C., et al. Pyridoxine and dietary counseling for the management of idiopathic hyperoxaluria in stone-forming patients. Urology 77:5 (2011), 1054–1058.
    • (2011) Urology , vol.77 , Issue.5 , pp. 1054-1058
    • Ortiz-Alvarado, O.1    Muyaoka, R.2    Kriedberg, C.3


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