메뉴 건너뛰기




Volumn 29, Issue 3, 2009, Pages 809-816

High-dose vitamin C (ascorbic acid) therapy in the treatment of patients with advanced cancer

Author keywords

Ascorbate; Ascorbic acid; Cancer; Complementary and alternative medicine; Cytotoxicity; Intravenous; Plasma concentration; Review; Vitamin C

Indexed keywords

ASCORBIC ACID; DOXORUBICIN;

EID: 64949179184     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (123)

References (56)
  • 1
    • 0025790311 scopus 로고
    • Epidemiologic evidence regarding vitamin C and cancer
    • Block G: Epidemiologic evidence regarding vitamin C and cancer. Am J Clin Nutr 54: 1310S-1314S, 1991.
    • (1991) Am J Clin Nutr , vol.54
    • Block, G.1
  • 2
    • 0006171777 scopus 로고
    • Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer
    • Cameron E and Pauling L: Supplemental ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer. Proc Natl Acad Sci USA 73: 3685-3689, 1976.
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 3685-3689
    • Cameron, E.1    Pauling, L.2
  • 3
    • 0012375577 scopus 로고
    • Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer
    • Cameron E and Pauling L: Supplemental ascorbate in the supportive treatment of cancer: reevaluation of prolongation of survival times in terminal human cancer. Proc Natl Acad Sci USA 75: 4538-4542, 1978.
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 4538-4542
    • Cameron, E.1    Pauling, L.2
  • 4
    • 0020006414 scopus 로고
    • Prolongation of survival times of terminal cancer patients by administration of large doses of ascorbate
    • Murata A, Morishige F and Yamaguchi H: Prolongation of survival times of terminal cancer patients by administration of large doses of ascorbate. Int J Vitam Nutr Res Suppl 23: 103- 113, 1982.
    • (1982) Int J Vitam Nutr Res Suppl , vol.23 , pp. 103-113
    • Murata, A.1    Morishige, F.2    Yamaguchi, H.3
  • 5
    • 0026409224 scopus 로고
    • Reticulum cell sarcoma: Two complete 'spontaneous' regressions, in response to high- dose ascorbic acid therapy. A report on subsequent progress
    • Campbell A, Jack T and Cameron E: Reticulum cell sarcoma: two complete 'spontaneous' regressions, in response to high- dose ascorbic acid therapy. A report on subsequent progress. Oncology 48: 495-497, 1991.
    • (1991) Oncology , vol.48 , pp. 495-497
    • Campbell, A.1    Jack, T.2    Cameron, E.3
  • 6
    • 0018669229 scopus 로고
    • Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial
    • Creagan ET, Moertel CG, O'Fallon JR, Schutt AJ, O'Connell MJ, Rubin J and Frytak S: Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial. N Engl J Med 301: 687-690, 1979.
    • (1979) N Engl J Med , vol.301 , pp. 687-690
    • Creagan, E.T.1    Moertel, C.G.2    O'Fallon, J.R.3    Schutt, A.J.4    O'Connell, M.J.5    Rubin, J.6    Frytak, S.7
  • 7
    • 0021955675 scopus 로고
    • High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison
    • Moertel CG, Fleming TR, Creagan ET, Rubin J, O'Connell MJ and Ames MM: High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison. N Engl J Med 312: 137-141, 1985.
    • (1985) N Engl J Med , vol.312 , pp. 137-141
    • Moertel, C.G.1    Fleming, T.R.2    Creagan, E.T.3    Rubin, J.4    O'Connell, M.J.5    Ames, M.M.6
  • 10
    • 0033883604 scopus 로고    scopus 로고
    • Reevaluation of ascorbate in cancer treatment: Emerging evidence, open minds and serendipity
    • Padayatty SJ and Levine M: Reevaluation of ascorbate in cancer treatment: emerging evidence, open minds and serendipity. J Am Coll Nutr 19: 423-425, 2000.
    • (2000) J Am Coll Nutr , vol.19 , pp. 423-425
    • Padayatty, S.J.1    Levine, M.2
  • 11
    • 84891421720 scopus 로고
    • Cancer: The preconditioning factor in pathogenesis; a new etiologic approach
    • McCormick WJ: Cancer: the preconditioning factor in pathogenesis; a new etiologic approach. Arch Pediatr 71: 313- 322, 1954.
    • (1954) Arch Pediatr , vol.71 , pp. 313-322
    • McCormick, W.J.1
  • 12
    • 0008465610 scopus 로고
    • Cancer: A collagen disease, secondary to a nutritional deficiency
    • McCormick WJ: Cancer: a collagen disease, secondary to a nutritional deficiency. Arch Pediatr 76: 166-171, 1959.
    • (1959) Arch Pediatr , vol.76 , pp. 166-171
    • McCormick, W.J.1
  • 13
    • 0015493510 scopus 로고
    • Ascorbic acid, cell proliferation, and cancer
    • Cameron E and Rotman D: Ascorbic acid, cell proliferation, and cancer. Lancet 1: 542, 1972.
    • (1972) Lancet 1 , vol.542
    • Cameron, E.1    Rotman, D.2
  • 14
    • 0015544986 scopus 로고
    • Ascorbic acid and the glycosaminoglycans. An orthomolecular approach to cancer and other diseases
    • Cameron E and Pauling L: Ascorbic acid and the glycosaminoglycans. An orthomolecular approach to cancer and other diseases. Oncology 27: 181-192, 1973.
    • (1973) Oncology , vol.27 , pp. 181-192
    • Cameron, E.1    Pauling, L.2
  • 15
    • 0016275402 scopus 로고
    • The orthomolecular treatment of cancer. II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer
    • Cameron E and Campbell A: The orthomolecular treatment of cancer. II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer. Chem Biol Interact 9: 285-315, 1974.
    • (1974) Chem Biol Interact , vol.9 , pp. 285-315
    • Cameron, E.1    Campbell, A.2
  • 16
    • 0026315317 scopus 로고
    • Innovation vs. quality control: An 'unpublishable' clinical trial of supplemental ascorbate in incurable cancer
    • Cameron E and Campbell A: Innovation vs. quality control: an 'unpublishable' clinical trial of supplemental ascorbate in incurable cancer. Med Hypotheses 36: 185-189, 1991.
    • (1991) Med Hypotheses , vol.36 , pp. 185-189
    • Cameron, E.1    Campbell, A.2
  • 20
    • 0023934968 scopus 로고
    • Quantitative determination of water-soluble scavengers in neoplastic and non- neoplastic human breast tissue
    • Honegger CG, Torhorst J, Langemann H, Kabiersch A and Krenger W: Quantitative determination of water-soluble scavengers in neoplastic and non- neoplastic human breast tissue. Int J Cancer 41: 690-694, 1988.
    • (1988) Int J Cancer , vol.41 , pp. 690-694
    • Honegger, C.G.1    Torhorst, J.2    Langemann, H.3    Kabiersch, A.4    Krenger, W.5
  • 21
    • 0024399787 scopus 로고
    • Quantitative determination of water- and lipid- soluble antioxidants in neoplastic and non-neoplastic human breast tissue
    • Langemann H, Torhorst J, Kabiersch A, Krenger W and Honegger CG: Quantitative determination of water- and lipid- soluble antioxidants in neoplastic and non-neoplastic human breast tissue. Int J Cancer 43: 1169-1173, 1989.
    • (1989) Int J Cancer , vol.43 , pp. 1169-1173
    • Langemann, H.1    Torhorst, J.2    Kabiersch, A.3    Krenger, W.4    Honegger, C.G.5
  • 22
    • 0033567885 scopus 로고    scopus 로고
    • Stromal cell oxidation: A mechanism by which tumors obtain vitamin C
    • Agus DB, Vera JC and Golde DW: Stromal cell oxidation: a mechanism by which tumors obtain vitamin C. Cancer Res 59: 4555-4558, 1999.
    • (1999) Cancer Res , vol.59 , pp. 4555-4558
    • Agus, D.B.1    Vera, J.C.2    Golde, D.W.3
  • 23
    • 0033590959 scopus 로고    scopus 로고
    • Criteria and recommendations for vitamin C intake
    • Levine M, Rumsey SC, Daruwala R, Park JB and Wang Y: Criteria and recommendations for vitamin C intake. JAMA 281: 1415-1423, 1999.
    • (1999) JAMA , vol.281 , pp. 1415-1423
    • Levine, M.1    Rumsey, S.C.2    Daruwala, R.3    Park, J.B.4    Wang, Y.5
  • 24
  • 25
    • 0014442953 scopus 로고
    • Synergistic killing of Ehrlich ascites carcinoma cells by ascorbate and 3-amino-l,2,4,-triazole
    • Benade L, Howard T and Burk D: Synergistic killing of Ehrlich ascites carcinoma cells by ascorbate and 3-amino-l,2,4,-triazole. Oncology 23: 33-43, 1969.
    • (1969) Oncology , vol.23 , pp. 33-43
    • Benade, L.1    Howard, T.2    Burk, D.3
  • 27
    • 0027195067 scopus 로고
    • Cytotoxic effect of ascorbate and its derivatives on cultured malignant and nonmalignant cell lines
    • Leung PY, Miyashita K, Young M and Tsao CS: Cytotoxic effect of ascorbate and its derivatives on cultured malignant and nonmalignant cell lines. Anticancer Res 13: 475-480, 1993.
    • (1993) Anticancer Res , vol.13 , pp. 475-480
    • Leung, P.Y.1    Miyashita, K.2    Young, M.3    Tsao, C.S.4
  • 28
    • 26444521256 scopus 로고    scopus 로고
    • Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a prodrug to deliver hydrogen peroxide to tissues
    • Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E and Levine M: Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a prodrug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci USA 102: 13604-13609, 2005.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 13604-13609
    • Chen, Q.1    Espey, M.G.2    Krishna, M.C.3    Mitchell, J.B.4    Corpe, C.P.5    Buettner, G.R.6    Shacter, E.7    Levine, M.8
  • 30
    • 0019819468 scopus 로고
    • Ascorbate is detectably mutagenic in the L5178Y TK+/- cell mutation assay
    • Amacher DE and Paillet SC: Ascorbate is detectably mutagenic in the L5178Y TK+/- cell mutation assay. Cancer Lett 14: 151- 158, 1981.
    • (1981) Cancer Lett , vol.14 , pp. 151-158
    • Amacher, D.E.1    Paillet, S.C.2
  • 31
    • 0022826402 scopus 로고
    • Enhancement of ascorbate cytotoxicity by chelation with ferrous ions through prolonged duration of the action
    • Miwa N, Yamazaki H and Ikari Y: Enhancement of ascorbate cytotoxicity by chelation with ferrous ions through prolonged duration of the action. Anticancer Res 6: 1033-1036, 1986.
    • (1986) Anticancer Res , vol.6 , pp. 1033-1036
    • Miwa, N.1    Yamazaki, H.2    Ikari, Y.3
  • 32
    • 0034674055 scopus 로고    scopus 로고
    • 2 gradients across biomembranes. FEBS Lett 475: 121-126, 2000.
    • 2 gradients across biomembranes. FEBS Lett 475: 121-126, 2000.
  • 33
    • 0022355344 scopus 로고
    • Glutathione cycle activity and pyridine nucleotide levels in oxidant- induced injury of cells
    • Schraufstatter IU, Hinshaw DB, Hyslop PA, Spragg RG and Cochrane CG: Glutathione cycle activity and pyridine nucleotide levels in oxidant- induced injury of cells. J Clin Invest 76: 1131- 1139,1985.
    • (1985) J Clin Invest , vol.76 , pp. 1131-1139
    • Schraufstatter, I.U.1    Hinshaw, D.B.2    Hyslop, P.A.3    Spragg, R.G.4    Cochrane, C.G.5
  • 34
    • 0022553195 scopus 로고
    • Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate- ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide
    • Schraufstatter IU, Hinshaw DB, Hyslop PA, Spragg RG and Cochrane CG: Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate- ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide. J Clin Invest 77: 1312-1320, 1986.
    • (1986) J Clin Invest , vol.77 , pp. 1312-1320
    • Schraufstatter, I.U.1    Hinshaw, D.B.2    Hyslop, P.A.3    Spragg, R.G.4    Cochrane, C.G.5
  • 35
    • 0023874677 scopus 로고
    • Mechanisms of oxidant- mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide
    • Hyslop PA, Hinshaw DB, Halsey WA Jr, Schraufstatter IU, Sauerheber RD, Spragg RG, Jackson JH and Cochrane CG: Mechanisms of oxidant- mediated cell injury. The glycolytic and mitochondrial pathways of ADP phosphorylation are major intracellular targets inactivated by hydrogen peroxide. J Biol Chem 263: 1665-1675, 1988.
    • (1988) J Biol Chem , vol.263 , pp. 1665-1675
    • Hyslop, P.A.1    Hinshaw, D.B.2    Halsey Jr, W.A.3    Schraufstatter, I.U.4    Sauerheber, R.D.5    Spragg, R.G.6    Jackson, J.H.7    Cochrane, C.G.8
  • 36
    • 0030865646 scopus 로고    scopus 로고
    • Dual regulation of caspase activity by hydrogen peroxide: Implications for apoptosis
    • Hampton MB and Orrenius S: Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis. FEBS Lett 414: 552-556, 1997.
    • (1997) FEBS Lett , vol.414 , pp. 552-556
    • Hampton, M.B.1    Orrenius, S.2
  • 37
    • 0033538451 scopus 로고    scopus 로고
    • Oxidative stress inhibits apoptosis in human lymphoma cells
    • Lee YJ and Shacter E: Oxidative stress inhibits apoptosis in human lymphoma cells. J Biol Chem 274: 19792-19798, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 19792-19798
    • Lee, Y.J.1    Shacter, E.2
  • 38
    • 0037403615 scopus 로고    scopus 로고
    • Apoptosis is induced by decline of mitochondrial ATP synthesis in erythroleukemia cells
    • Comelli M, Di Pancrazio F and Mavelli I: Apoptosis is induced by decline of mitochondrial ATP synthesis in erythroleukemia cells. Free Radic Biol Med 34: 1190-1199, 2003.
    • (2003) Free Radic Biol Med , vol.34 , pp. 1190-1199
    • Comelli, M.1    Di Pancrazio, F.2    Mavelli, I.3
  • 39
    • 20044361991 scopus 로고    scopus 로고
    • 2 mediate glucose deprivation-induced stress in human cancer cells. J Biol Chem 280: 4254-4263, 2005.
    • 2 mediate glucose deprivation-induced stress in human cancer cells. J Biol Chem 280: 4254-4263, 2005.
  • 41
    • 0027996576 scopus 로고
    • Modification of the effect of tamoxifen, cis- platin, DTIC, and interferon- alpha 2b on human melanoma cells in culture by a mixture of vitamins
    • Prasad KN, Hernandez C, Edwards- Prasad J, Nelson J, Bonis T and Robinson WA: Modification of the effect of tamoxifen, cis- platin, DTIC, and interferon- alpha 2b on human melanoma cells in culture by a mixture of vitamins. Nutr Cancer 22: 233-245, 1994.
    • (1994) Nutr Cancer , vol.22 , pp. 233-245
    • Prasad, K.N.1    Hernandez, C.2    Edwards- Prasad, J.3    Nelson, J.4    Bonis, T.5    Robinson, W.A.6
  • 42
    • 0029986515 scopus 로고    scopus 로고
    • Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro
    • Kurbacher CM, Wagner U, Kolster B, Andreotti PE, Krebs D and Bruckner HW: Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro. Cancer Lett 103: 183- 189, 1996.
    • (1996) Cancer Lett , vol.103 , pp. 183-189
    • Kurbacher, C.M.1    Wagner, U.2    Kolster, B.3    Andreotti, P.E.4    Krebs, D.5    Bruckner, H.W.6
  • 43
    • 0023618556 scopus 로고
    • Non-toxic potentiation of cancer chemotherapy by combined C and K3 vitamin pre- treatment
    • Taper HS, de Gerlache J, Lans M and Roberfroid M: Non-toxic potentiation of cancer chemotherapy by combined C and K3 vitamin pre- treatment. Int J Cancer 40: 575-579, 1987.
    • (1987) Int J Cancer , vol.40 , pp. 575-579
    • Taper, H.S.1    de Gerlache, J.2    Lans, M.3    Roberfroid, M.4
  • 44
    • 0032580628 scopus 로고    scopus 로고
    • Scurvy in patients with cancer
    • Fain O, Mathieu E and Thomas M: Scurvy in patients with cancer. BMJ 316: 1661-1662, 1998.
    • (1998) BMJ , vol.316 , pp. 1661-1662
    • Fain, O.1    Mathieu, E.2    Thomas, M.3
  • 45
    • 0842281425 scopus 로고    scopus 로고
    • Impact of nutritional status and nutrient supplements on immune responses and incidence of infection in older individuals
    • Chandra RK: Impact of nutritional status and nutrient supplements on immune responses and incidence of infection in older individuals. Ageing Res Rev 3: 91-104, 2004.
    • (2004) Ageing Res Rev , vol.3 , pp. 91-104
    • Chandra, R.K.1
  • 46
    • 0012422745 scopus 로고
    • Vitamin C and immune responses
    • Bendich A: Vitamin C and immune responses. Food Technol 41: 112-114,1987.
    • (1987) Food Technol , vol.41 , pp. 112-114
    • Bendich, A.1
  • 47
    • 0020434606 scopus 로고
    • On the biochemical similarities of ascorbic acid and interferon
    • Scott JA: On the biochemical similarities of ascorbic acid and interferon. J Theor Biol 98: 235-238, 1982.
    • (1982) J Theor Biol , vol.98 , pp. 235-238
    • Scott, J.A.1
  • 48
    • 64949182949 scopus 로고    scopus 로고
    • Vitamin Toxicities and Therapeutic Monitoring
    • and, eds, St. Louis, Churchill Livingstone Elsevier, pp
    • Murray MT and Bongiorno PB: Vitamin Toxicities and Therapeutic Monitoring. Pizzorno JE and Murray MT (eds.). St. Louis, Churchill Livingstone Elsevier, pp. 1389-1393, 2006.
    • (2006) , pp. 1389-1393
    • Murray, M.T.1    Bongiorno, P.B.2
  • 50
    • 0028488607 scopus 로고
    • Acute oxalate nephropathy after a massive intravenous dose of vitamin C
    • Wong K, Thomson C, Bailey RR, McDiarmid S and Gardner J: Acute oxalate nephropathy after a massive intravenous dose of vitamin C. Aust N Z J Med 24: 410-411, 1994.
    • (1994) Aust N Z J Med , vol.24 , pp. 410-411
    • Wong, K.1    Thomson, C.2    Bailey, R.R.3    McDiarmid, S.4    Gardner, J.5
  • 51
    • 0018742112 scopus 로고
    • Acute reactions to mega ascorbic acid therapy in malignant disease
    • Campbell A and Jack T: Acute reactions to mega ascorbic acid therapy in malignant disease. Scott Med J 24: 151-153, 1979.
    • (1979) Scott Med J , vol.24 , pp. 151-153
    • Campbell, A.1    Jack, T.2
  • 52
    • 0023062974 scopus 로고
    • Safety of high-level vitamin C ingestion
    • Rivers JM: Safety of high-level vitamin C ingestion. Ann NY Acad Sci 498: 445-454, 1987.
    • (1987) Ann NY Acad Sci , vol.498 , pp. 445-454
    • Rivers, J.M.1
  • 53
    • 34547197625 scopus 로고    scopus 로고
    • Impact of antioxidant supplementation on chemotherapeutic efficacy: A systematic review of the evidence from randomized controlled trials
    • Block KI, Koch AC, Mead MN, Tothy PK, Newman RA and Gyllenhaal C: Impact of antioxidant supplementation on chemotherapeutic efficacy: a systematic review of the evidence from randomized controlled trials. Cancer Treat Rev 33: 407- 418, 2007.
    • (2007) Cancer Treat Rev , vol.33 , pp. 407-418
    • Block, K.I.1    Koch, A.C.2    Mead, M.N.3    Tothy, P.K.4    Newman, R.A.5    Gyllenhaal, C.6
  • 54
    • 0036972112 scopus 로고    scopus 로고
    • Complementary and alternative medicine research: A National Cancer Institute perspective
    • White JD: Complementary and alternative medicine research: a National Cancer Institute perspective. Semin Oncol 29: 546-551, 2002.
    • (2002) Semin Oncol , vol.29 , pp. 546-551
    • White, J.D.1
  • 55
    • 0036970437 scopus 로고    scopus 로고
    • Use of the best case series to evaluate complementary and alternative therapies for cancer: A systematic review
    • Nahin RL: Use of the best case series to evaluate complementary and alternative therapies for cancer: a systematic review. Semin Oncol 29: 552-562, 2002.
    • (2002) Semin Oncol , vol.29 , pp. 552-562
    • Nahin, R.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.