Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study

Critical Care Medicine

Volumn 44, Issue 2, 2016, Pages 360-367

  Donnino, Michael W ^a   Andersen, Lars W ^a,b   Chase, Maureen ^a   Berg, Katherine M ^a   Tidswell, Mark ^c   Giberson, Tyler ^a   Wolfe, Richard ^a   Moskowitz, Ari ^a   Smithline, Howard ^c   Ngo, Long ^a   Cocchi, Michael N ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c BAYSTATE MEDICAL CENTER   (United States)

Author keywords

lactate; metabolism; sepsis; septic shock; thiamine; thiamine deficiency

Indexed keywords

LACTIC ACID; PLACEBO; THIAMINE;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CARDIOVASCULAR MORTALITY; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HOSPITAL DISCHARGE; HUMAN; MAJOR CLINICAL STUDY; MALE; MITOCHONDRIAL RESPIRATION; MULTICENTER STUDY; OUTCOME ASSESSMENT; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REDUCTION KINETICS; SEPTIC SHOCK; SHOCK; THIAMINE DEFICIENCY; TIME TO TREATMENT; BLOOD; CLINICAL TRIAL; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; SHOCK, SEPTIC; VERY ELDERLY;

AGED; AGED, 80 AND OVER; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LACTIC ACID; MALE; MIDDLE AGED; PILOT PROJECTS; SEVERITY OF ILLNESS INDEX; SHOCK, SEPTIC; THIAMINE; THIAMINE DEFICIENCY;

EID: 84954349075     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000001572     Document Type: Article

References (41)

1. Frank RA, Leeper FJ, Luisi BF, Structure, mechanism and catalytic duality of thiamine-dependent enzymes. Cell Mol Life Sci 2007 64 892 905
2. Victor M, Adams R, Collins G., The Wernicke-Korsakoff Syndrome and Related Neurologic Disorders Due to Alcoholism and Malnutrition 1989 2 ed Quest-Meridien Ltd.
3. Donnino MW, Vega J, Miller J, Myths and misconceptions of Wernicke's encephalopathy: what every emergency physician should know. Ann Emerg Med 2007 50 715 721
4. Chisolm-Straker M, Cherkas D, Altered and unstable: wet beriberi, a clinical review. J Emerg Med 2013 45 341 344
5. Rao SN, Chandak GR, Cardiac beriberi: often a missed diagnosis. J Trop Pediatr 2010 56 284 285
6. Kitamura K, Yamaguchi T, Tanaka H, TPN-induced fulminant beriberi: a report on our experience and a review of the literature. Surg Today 1996 26 769 776
7. Betrosian AP, Thireos E, Toutouzas K, Occidental beriberi and sudden death. Am J Med Sci 2004 327 250 252
8. Attas M, Hanley HG, Stultz D, Fulminant beriberi heart disease with lactic acidosis: presentation of a case with evaluation of left ventricular function and review of pathophysiologic mechanisms. Circulation 1978 58 566 572
9. Kountchev J, Bijuklic K, Bellmann R, A patient with severe lactic acidosis and rapidly evolving multiple organ failure: a case of shoshin beri-beri. Intensive Care Med 2005 31 1004
10. Panichewa S, Hathirat S, Fulminant cardiac beriberi with severe acidosis. J Med Assoc Thai 1982 65 566 569
11. Manzanares W, Hardy G, Thiamine supplementation in the critically ill. Curr Opin Clin Nutr Metab Care 2011 14 610 617
12. Thauvin-Robinet C, Faivre L, Barbier ML, Severe lactic acidosis and acute thiamin deficiency: a report of 11 neonates with unsupplemented total parenteral nutrition. J Inherit Metab Dis 2004 27 700 704
13. Kleiner-Baumgarten A, Sidi A, Abu-Shakra M, [Thiamine deficiency among Chinese workers in Israel]. Harefuah 2003 142 5 329 331, 400, 399
14. Busani S, Bonvecchio C, Gaspari A, Wernicke's encephalopathy in a malnourished surgical patient: a difficult diagnosis. BMC Res Notes 2014 7 718
15. Campos L, Masclans JR, Ortega A, Neurological disturbances and hyperdynamic shock in a patient with esophagocoloplasty. Intensive Care Med 1997 23 590 592
16. Campbell CH, The severe lacticacidosis of thiamine deficiency: acute pernicious or fulminating beriberi. Lancet 1984 2 446 449
17. Donnino MW, Carney E, Cocchi MN, Thiamine deficiency in critically ill patients with sepsis. J Crit Care 2010 25 576 581
18. Lima LF, Leite HP, Taddei JA, Low blood thiamine concentrations in children upon admission to the intensive care unit: risk factors and prognostic significance. Am J Clin Nutr 2011 93 57 61
19. Seear M, Lockitch G, Jacobson B, Thiamine, riboflavin, and pyridoxine deficiencies in a population of critically ill children. J Pediatr 1992 121 533 538
20. Cruickshank AM, Telfer AB, Shenkin A, Thiamine deficiency in the critically ill. Intensive Care Med 1988 14 384 387
21. Costa NA, Gut AL, de Souza Dorna M, Serum thiamine concentration and oxidative stress as predictors of mortality in patients with septic shock. J Crit Care 2014 29 249 252
22. Andersen LW, Mackenhauer J, Roberts JC, Etiology and therapeutic approach to elevated lactate levels. Mayo Clin Proc 2013 88 1127 1140
23. Donnino MW, Andersen LW, Giberson T, National Post-Arrest Research Consortium Initial lactate and lactate change in post-cardiac arrest: a multicenter validation study. Crit Care Med 2014 42 1804 1811
24. Knaus WA, Draper EA, Wagner DP, APACHE II: a severity of disease classification system. Crit Care Med 1985 13 818 829
25. Vincent JL, Moreno R, Takala J, The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996 22 707 710
26. Fergusson D, Aaron SD, Guyatt G, Post-randomisation exclusions: the intention to treat principle and excluding patients from analysis. BMJ 2002 325 652 654
27. Fine J, Gray R., A proportional hazards model for the subdistribution of a competing risk. Journal of the American Statistical Association 1999 94 496 509
28. Moskowitz A, Graver A, Giberson T, The relationship between lactate and thiamine levels in patients with diabetic ketoacidosis. J Crit Care 2014 29 182.e5 182.e8
29. Thornalley PJ, Babaei-Jadidi R, Al Ali H, High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease. Diabetologia 2007 50 2164 2170
30. Boniol S, Boyd M, Koreth R, Wernicke encephalopathy complicating lymphoma therapy: case report and literature review. South Med J 2007 100 717 719
31. Lakhani SV, Shah HN, Alexander K, Small intestinal bacterial overgrowth and thiamine deficiency after Roux-en-Y gastric bypass surgery in obese patients. Nutr Res 2008 28 293 298
32. Kotha VK, De Souza A, Wernicke's encephalopathy following Hyperemesis gravidarum. A report of three cases. Neuroradiol J 2013 26 35 40
33. Wierzbicka-Chmiel J, Wierzbicki K, Kajdaniuk D, Wernicke-Korsakoff syndrome in the course of thyrotoxicosis-a case report. Endokrynol Pol 2011 62 178 180
34. Renthal W, Marin-Valencia I, Evans PA, Thiamine deficiency secondary to anorexia nervosa: an uncommon cause of peripheral neuropathy and Wernicke encephalopathy in adolescence. Pediatr Neurol 2014 51 100 103
35. Giacalone M, Martinelli R, Abramo A, Rapid reversal of severe lactic acidosis after thiamine administration in critically ill adults: a report of 3 cases. Nutr Clin Pract 2015 30 104 110
36. Donnino MW, Cocchi MN, Smithline H, Coronary artery bypass graft surgery depletes plasma thiamine levels. Nutrition 2010 26 133 136
37. Kim WY, Kwak MK, Ko BS, Factors associated with the occurrence of cardiac arrest after emergency tracheal intubation in the emergency department. PLoS One 2014 9 e112779
38. Investigators A, Group ACT Peake SL, Investigators A, Group ACT Goal-directed resuscitation for patients with early septic shock. N Engl J Med 2014 371 16 1496 1506
39. Mouncey PR, Osborn TM, Power GS, ProMISe Trial Investigators Trial of early, goal-directed resuscitation for septic shock. N Engl J Med 2015 372 1301 1311
40. Process Investigators Yealy DM, Kellum JA, Process Investigators A randomized trial of protocol-based care for early septic shock. N Engl J Med 2014 370 18 1683 1693
41. Casserly B, Phillips GS, Schorr C, Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Crit Care Med 2015 43 567 573