NRF2 induction supporting breast cancer cell survival is enabled by oxidative stress-induced DPP3-KEAP1 interaction

Cancer Research

Volumn 77, Issue 11, 2017, Pages 2881-2892

  Lu, Kevin ^a   Alcivar, Allen L ^a,c   Ma, Jianglin ^a,d   Foo, Tzeh Keong ^a   Zywea, Susan ^a   Mahdi, Amar ^a   Huo, Yanying ^a   Kensler, Thomas W ^b   Gatza, Michael L ^a   Xia, Bing ^a  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

^d CELGENE CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL PEPTIDASE 3; HYDROGEN PEROXIDE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MESSENGER RNA; PEPTIDE HYDROLASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; DIPEPTIDYL PEPTIDASE; DPP3 PROTEIN, HUMAN; KEAP1 PROTEIN, HUMAN;

ARTICLE; BIOACCUMULATION; BREAST CANCER; CANCER PROGNOSIS; CELL NUCLEUS; CELL SURVIVAL; CONTROLLED STUDY; DPP3 GENE; ESTROGEN RECEPTOR POSITIVE BREAST CANCER; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MCF-7 CELL LINE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; BREAST TUMOR; FEMALE; GENETIC TRANSFECTION; GENETICS; HELA CELL LINE; METABOLISM; MORTALITY; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS;

BREAST NEOPLASMS; CELL SURVIVAL; DIPEPTIDYL-PEPTIDASES AND TRIPEPTIDYL-PEPTIDASES; FEMALE; HELA CELLS; HUMANS; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; MCF-7 CELLS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS; TRANSFECTION;

EID: 85020743035     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-16-2204     Document Type: Article

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