Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase

Free Radical Biology and Medicine

Volumn 50, Issue 7, 2011, Pages 874-882

  Fussell, Karma C ^a   Udasin, Ronald G ^a   Gray, Joshua P ^b   Mishin, Vladimir ^a   Smith, Peter J S ^c   Heck, Diane E ^d   Laskin, Jeffrey D ^e  

^a RUTGERS UNIVERSITY   (United States)

^b U S COAST GUARD ACADEMY   (United States)

^c MARINE BIOLOGICAL LABORATORY   (United States)

^d NEW YORK MEDICAL COLLEGE   (United States)

^e RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Diquat; Free radicals; Herbicides; Oxidative stress; Paraquat; Reactive oxygen species; Redox cycling

Indexed keywords

BIPYRIDINE; CATALASE; DIPHENYLIODONIUM SALT; DIQUAT; HYDROGEN PEROXIDE; HYDROXYL RADICAL; PARAQUAT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; LIVER MICROSOME; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; OXYGEN SENSING; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN EXPRESSION; WILD TYPE;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DIQUAT; FEMALE; GENE EXPRESSION; HUMANS; HYDROGEN PEROXIDE; LIVER; MICROSOMES, LIVER; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXYGEN; OXYGEN CONSUMPTION; PARAQUAT; PROTEIN CARBONYLATION; RATS; REACTIVE OXYGEN SPECIES;

CRICETULUS GRISEUS; RATTUS;

EID: 79952038479     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.12.035     Document Type: Article

References (41)

1. J.S. Bus, and J.E. Gibson Paraquat: model for oxidant-initiated toxicity Environ. Health Perspect. 55 1984 37 46 (Pubitemid 14094796)
2. R.J. Dinis-Oliveira, J.A. Duarte, A. Sanchez-Navarro, F. Remiao, M.L. Bastos, and F. Carvalho Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment Crit. Rev. Toxicol. 38 2008 13 71
3. R. Franco, S. Li, H. Rodriguez-Rocha, M. Burns, and M.I. Panayiotidis Molecular mechanisms of pesticide-induced neurotoxicity: relevance to Parkinson's disease Chem. Biol. Interact. 188 2010 289 300
4. G.M. Jones, and J.A. Vale Mechanisms of toxicity, clinical features, and management of diquat poisoning: a review J. Toxicol. Clin. Toxicol. 38 2000 123 128 (Pubitemid 30212833)
5. H.P. Onyeama, and F.W. Oehme A literature review of paraquat toxicity Vet. Hum. Toxicol. 26 1984 494 502 (Pubitemid 15195529)
6. A. Pasi The Toxicology of Paraquat, Diquat and Morfamquat 1978 H. Huber Bern
7. T.R. Van Vleet, and R.G. Schnellmann Toxic nephropathy: environmental chemicals Semin. Nephrol. 23 2003 500 508 (Pubitemid 37176695)
8. B. Halliwell, and J.M.C. Gutteridge Free Radicals in Biology and Medicine 2007 Oxford Univ. Press Oxford/New York
9. J.C. Gage The action of paraquat and diquat on the respiration of liver cell fractions Biochem. J. 109 1968 757 761
10. J.P. Gray, D.E. Heck, V. Mishin, P.J.S. Smith, J.Y. Hong, M. Thiruchelvam, D.A. Cory-Slechta, D.L. Laskin, and J.D. Laskin Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase J. Biol. Chem. 282 2007 7939 7949 (Pubitemid 47093577)
11. R.P. Mason Redox cycling of radical anion metabolites of toxic chemicals and drugs and the Marcus theory of electron transfer Environ. Health Perspect. 87 1990 237 243 (Pubitemid 20316923)
12. P.A. Ward Oxidative stress: acute and progressive lung injury Ann. NY Acad. Sci. 1203 2010 53 59
13. A. Adam, L.L. Smith, and G.M. Cohen An evaluation of the redox cycling potencies of paraquat and nitrofurantoin in microsomal and lung slice systems Biochem. Pharmacol. 40 1990 1533 1539 (Pubitemid 20310570)
14. A. Adam, L.L. Smith, and G.M. Cohen An assessment of the role of redox cycling in mediating the toxicity of paraquat and nitrofurantoin Environ. Health Perspect. 85 1990 113 117 (Pubitemid 20315289)
15. H.M. Hassan, and I. Fridovich Regulation of the synthesis of superoxide dismutase in Escherichia coli: induction by methyl viologen J. Biol. Chem. 252 1977 7667 7672 (Pubitemid 8211018)
16. H.M. Hassan, and I. Fridovich Superoxide radical and the oxygen enhancement of the toxicity of paraquat in Escherichia coli J. Biol. Chem. 253 1978 8143 8148 (Pubitemid 9086297)
17. D.J. Rossouw, and F.M. Engelbrecht The effect of paraquat on the respiration of lung cell fractions S. Afr. Med. J. 54 1978 1101 1104
18. 14C-glucose oxidation of rabbit alveolar macrophages and lung slices S. Afr. Med. J. 55 1979 558 560 (Pubitemid 9167437)
19. D.J. Rossouw, and F.M. Engelbrecht The effect of paraquat on the aerobic metabolism of rabbit alveolar macrophages and lung fibroblasts S. Afr. Med. J. 55 1979 20 23 (Pubitemid 9116136)
20. Y. Wang, J.P. Gray, V. Mishin, D.E. Heck, D.L. Laskin, and J.D. Laskin Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity Free Radic. Biol. Med. 44 2008 1169 1179
21. M. Zhou, Z. Diwu, N. Panchuk-Voloshina, and R.P. Haugland A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: applications in detecting the activity of phagocyte NADPH oxidase and other oxidases Anal. Biochem. 253 1997 162 168 (Pubitemid 27508167)
22. V.M. Mishin, and P.E. Thomas Characterization of hydroxyl radical formation by microsomal enzymes using a water-soluble trap, terephthalate Biochem. Pharmacol. 68 2004 747 752 (Pubitemid 38953456)
23. R.P. Baumann, P.G. Penketh, H.A. Seow, K. Shyam, and A.C. Sartorelli Generation of oxygen deficiency in cell culture using a two-enzyme system to evaluate agents targeting hypoxic tumor cells Radiat. Res. 170 2008 651 660
24. M.Y. Aksenov, M.V. Aksenova, D.A. Butterfield, J.W. Geddes, and W.R. Markesbery Protein oxidation in the brain in Alzheimer's disease Neuroscience 103 2001 373 383 (Pubitemid 32201924)
25. L.H. Long, A. Hoi, and B. Halliwell Instability of, and generation of hydrogen peroxide by, phenolic compounds in cell culture media Arch. Biochem. Biophys. 501 2010 162 169
26. P.J.S. Smith, R.S. Sanger, and M.A. Messerli Principles of development and applications of self-referencing electrochemical microelectrodes to the determination of fluxes at cell membrane A.C. Michael, Methods and New Frontiers in Neuroscience 2007 CRC Press Boca Raton, FL 373 405
27. M.A. Messerli, K.R. Robinson, and P.J.S. Smith Electrochemical sensor applications to the study of molecular physiology and analyte flux in plants A.G. Volkov, Plant Electrophysiology-Theory and Methods 2006 Springer New York
28. S. Djordjevic, D.L. Roberts, M. Wang, T. Shea, M.G. Camitta, B.S. Masters, and J.J. Kim Crystallization and preliminary X-ray studies of NADPH-cytochrome P450 reductase Proc. Natl Acad. Sci. USA 92 1995 3214 3218
29. C. Schwarzer, B. Illek, J.H. Suh, S.J. Remington, H. Fischer, and T.E. Machen Organelle redox of CF and CFTR-corrected airway epithelia Free Radic. Biol. Med. 43 2007 300 316 (Pubitemid 46977166)
30. S.C. Land, D.M. Porterfield, R.H. Sanger, and P.J. Smith The self-referencing oxygen-selective microelectrode: detection of transmembrane oxygen flux from single cells J. Exp. Biol. 202 1999 211 218 (Pubitemid 29083815)
31. G.C. Mees Experiments on the herbicidal action of 1,1′-ethylene-2, 2′-dipyridylium dibromide Ann. Appl. Biol. 48 1960 601 612
32. J.F. Han, S.L. Wang, X.Y. He, C.Y. Liu, and J.Y. Hong Effect of genetic variation on human cytochrome P450 reductase-mediated paraquat cytotoxicity Toxicol. Sci. 91 2006 42 48
33. M. Saito, C.E. Thomas, and S.D. Aust Paraquat and ferritin-dependent lipid peroxidation J. Free Radic. Biol. Med. 1 1985 179 185 (Pubitemid 16145605)
34. Y. Wang, J.P. Gray, V. Mishin, D.E. Heck, D.L. Laskin, and J.D. Laskin Distinct roles of cytochrome P450 reductase in mitomycin C redox cycling and cytotoxicity Mol. Cancer Ther. 9 2010 1852 1863
35. E. Lewinsohn, and J. Gressel Benzyl viologen-mediated counteraction of diquat and paraquat phytotoxicities Plant Physiol. 76 1984 125 130
36. R.L. Levine, D. Garland, C.N. Oliver, A. Amici, I. Climent, A.G. Lenz, B.W. Ahn, S. Shaltiel, and E.R. Stadtman Determination of carbonyl content in oxidatively modified proteins Methods Enzymol. 186 1990 464 478 (Pubitemid 20279989)
37. A.F. Fell, D.R. Jarvie, and M.J. Stewart Analysis for paraquat by second- and fourth-derivative spectroscopy Clin. Chem. 27 1981 286 292 (Pubitemid 11117435)
38. P. Hantson, P. Wallemacq, and P. Mahieu A case of fatal diquat poisoning: toxicokinetic data and autopsy findings J. Toxicol. Clin. Toxicol. 38 2000 149 152 (Pubitemid 30212837)
39. J.H. Kim, H.W. Gil, J.O. Yang, E.Y. Lee, and S.Y. Hong Effect of glutathione administration on serum levels of reactive oxygen metabolites in patients with paraquat intoxication: a pilot study Korean J. Intern. Med. 25 2010 282 287
40. M.H. Litchfield, J.W. Daniel, and S. Longshaw The tissue distribution of the bipyridylium herbicides diquat and paraquat in rats and mice Toxicology 1 1973 155 165
41. M.S. Rose, and L.L. Smith Tissue uptake of paraquat and diquat Gen. Pharmacol. 8 1977 173 176 (Pubitemid 8160208)