The HELLGH motif of rat liver dipeptidyl peptidase III is involved in zinc coordination and the catalytic activity of the enzyme

Biochemistry

Volumn 38, Issue 26, 1999, Pages 8299-8303

  Fukasawa, Katsuhiko ^a   Fukasawa, Kayoko M ^a   Iwamoto, Hiroyuki ^b   Hirose, Junzo ^b   Harada, Minoru ^a  

^a MATSUMOTO DENTAL UNIVERSITY   (Japan)

^b FUKUYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AMINOPEPTIDASE; COMPLEMENTARY DNA; DIPEPTIDYL PEPTIDASE; DIPEPTIDYL PEPTIDASE III; MUTANT PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BINDING AFFINITY; ENZYME ACTIVITY; ENZYME ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; CATALYSIS; DIPEPTIDYL PEPTIDASES; DNA, COMPLEMENTARY; ENZYME ACTIVATION; ESCHERICHIA COLI; GLUTAMIC ACID; HISTIDINE; HUMANS; LEUCINE; LIVER; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; RATS; RECOMBINANT PROTEINS; ZINC;

ESCHERICHIA COLI;

EID: 0033614807     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9904959     Document Type: Article

References (20)

1. Mattews, B. W., Jansonius, J. N., Colman, P. M., Schoenborn, B. P., and Dupourque, D. (1972) Nat. New Biol. 238, 37-41.
2. Vallee, B. L., and Auld, D. S. (1990) Biochemistry 29, 5647-5659.
3. Rawlings, N. D., and Barrett, A. J. (1995) Methods Enzymol. 248, 183-228.
4. Bode, W., Gomis-Rüth, F. X., Huber, R., Zwilling, R., and Stöcker, W. (1992) Nature 358, 164-167.
5. Gomis-Rüth, F. X., Kress, L. F., and Bode, W. (1993) EMBO J. 72, 4151-4157.
6. Bode, W., Gomis-Rüth, F. X., and Stöcker, W. (1993) FEBS Lett. 331, 134-140.
7. Hooper, N. M. (1994) FEBS Lett. 354, 1-6.
8. Fukasawa, K., Fukasawa, K. M., Kanai, M., Fujii, S., Hirose, J., and Harada, M. (1998) Biochem. J. 329, 275-282.
9. Fukasawa, K., Fukasawa, K. M., and Harada, M. (1997) FASEB J. 11, A1019.
10. Sanger, F., Nicklen, S., and Coulson, A. R. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 5463-5467.
11. Hartree, E. F. (1972) Anal. Biochem. 48, 422-427.
12. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254.
13. Wu, Q., Li, L., Cooper, M. D., Pierres, M., and Gorvel, J. P. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 676-680.
14. Medina, J. F., Wetterholm, A., Rådmark, O., Shapiro, R., Haeggström, J. Z., Vallee, B. L., and Samuelsson, B. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 7620-7624.
15. Fukasawa, K. M., Fukasawa, K., Kanai, M., Fujii, S., and Harada, M. (1996) J. Biol. Chem. 271, 30731-30735.
16. Gibbs, B. S., Wojchowski, D., and Benkovic, S. J. (1993) J. Biol. Chem. 268, 8046-8052.
17. Erlandsen, H., Fusetti, F., Martinez, A., Hough, E., Flatmark, T., and Stevens, R. C. (1997) Nat. Struct. Biol. 4, 995-1000.
18. Monzingo, A. F., and Matthews, B. W. (1984) Biochemistry 23, 5724-5729.
19. Goodwill, K. E., Sabatier, C., Marks, C., Raag, R., Fitzpatrick, P. F., and Stevens, R. C. (1997) Nat. Struct. Biol. 4, 578-585.
20. Rees, D. C., Howard, J. B., Chakrabarti, P., Yeates, T., Hsu, B. T., Hardman, K. D., and Lipscomb, W. N. (1986) in Zinc Enzymes (Bertini, I., Luchinat, C., Maret, W., and Zeppezauer, M., Eds.) pp 155-166, Birkhaeuser Boston, Secaucus, NJ.