Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling

Nature

Volumn 546, Issue 7657, 2017, Pages 307-311

  Brockmann, Markus ^a   Blomen, Vincent A ^a   Nieuwenhuis, Joppe ^a   Stickel, Elmer ^a   Raaben, Matthijs ^a   Bleijerveld, Onno B ^a   Altelaar, A F Maarten ^a,b   Jae, Lucas T ^a,e   Brummelkamp, Thijn R ^a,c,d  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^d Cancer GenomiCsnl   (Netherlands)

^e UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; INTERFERON REGULATORY FACTOR 1; KCTD5 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; WNT PROTEIN; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; HISTONE; INTERFERON; KCTD5 PROTEIN, HUMAN; POTASSIUM CHANNEL;

CANCER; CHEMORECEPTION; ENVIRONMENTAL CUE; ENZYME ACTIVITY; GENE EXPRESSION; HOMINID; MOLECULAR ANALYSIS; MUTATION; PHENOTYPE; PROTEIN; SUBSTRATE;

ARTICLE; EPIGENETIC REPRESSION; GENE INTERACTION; GENE MAPPING; HISTONE METHYLATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SPLICING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMISTRY; DEFICIENCY; GENETICS; HAPLOIDY; HUMAN; METABOLISM; MUTAGENESIS; PHOSPHORYLATION; PROCEDURES; SINGLE CELL ANALYSIS; WNT SIGNALING;

CELLS, CULTURED; HAPLOIDY; HETEROTRIMERIC GTP-BINDING PROTEINS; HISTONES; HUMANS; INTERFERONS; MITOGEN-ACTIVATED PROTEIN KINASES; MUTAGENESIS; PHENOTYPE; PHOSPHORYLATION; POTASSIUM CHANNELS; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SINGLE-CELL ANALYSIS; WNT SIGNALING PATHWAY;

EID: 85020486879     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature22376     Document Type: Article

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