-
1
-
-
0033771951
-
Concordance of the toxicity of pharmaceuticals in humans and in animals
-
Olson, H. et al. Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul. Toxicol. Pharmacol. 32, 56-67 (2000).
-
(2000)
Regul. Toxicol. Pharmacol.
, vol.32
, pp. 56-67
-
-
Olson, H.1
-
2
-
-
0842312531
-
Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants
-
Nelson, D. R. et al. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics 14, 1-18 (2004).
-
(2004)
Pharmacogenetics
, vol.14
, pp. 1-18
-
-
Nelson, D.R.1
-
3
-
-
79960657926
-
Orphans in the human cytochrome P450 superfamily: Approaches to discovering functions and relevance in pharmacology
-
Guengerich, F. P. & Cheng, Q. Orphans in the human cytochrome P450 superfamily: approaches to discovering functions and relevance in pharmacology. Pharmacol. Rev. 63, 684-699 (2011).
-
(2011)
Pharmacol. Rev.
, vol.63
, pp. 684-699
-
-
Guengerich, F.P.1
Cheng, Q.2
-
4
-
-
17944379233
-
Hepatitis C virus replication in mice with chimeric human livers
-
Mercer, D. F. et al. Hepatitis C virus replication in mice with chimeric human livers. Nat. Med. 7, 927-933 (2001).
-
(2001)
Nat. Med.
, vol.7
, pp. 927-933
-
-
Mercer, D.F.1
-
5
-
-
38049164210
-
Repopulation of adult and neonatal mice with human hepatocytes: A chimeric animal model
-
Bissig, K. D., Le, T. T., Woods, N. B. & Verma, I. M. Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model. Proc. Natl Acad. Sci. USA 104, 20507-20511 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 20507-20511
-
-
Bissig, K.D.1
Le, T.T.2
Woods, N.B.3
Verma, I.M.4
-
6
-
-
17744378552
-
Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus
-
Dandri, M. et al. Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus. Hepatology 33, 981-988 (2001).
-
(2001)
Hepatology
, vol.33
, pp. 981-988
-
-
Dandri, M.1
-
8
-
-
79951576827
-
The reconstituted 'humanized liver' in TK-NOG mice is mature and functional
-
Hasegawa, M. et al. The reconstituted 'humanized liver' in TK-NOG mice is mature and functional. Biochem. Biophys. Res. Commun. 405, 405-410 (2011).
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.405
, pp. 405-410
-
-
Hasegawa, M.1
-
9
-
-
79953196869
-
A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease
-
Washburn, M. L. et al. A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease. Gastroenterology 140, 1334-1344 (2011).
-
(2011)
Gastroenterology
, vol.140
, pp. 1334-1344
-
-
Washburn, M.L.1
-
11
-
-
0025144417
-
Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator
-
Heckel, J. L., Sandgren, E. P., Degen, J. L., Palmiter, R. D. & Brinster, R. L. Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator. Cell 62, 447-456 (1990).
-
(1990)
Cell
, vol.62
, pp. 447-456
-
-
Heckel, J.L.1
Sandgren, E.P.2
Degen, J.L.3
Palmiter, R.D.4
Brinster, R.L.5
-
12
-
-
4344574035
-
Near completely humanized liver in mice shows human-type metabolic responses to drugs
-
Tateno, C. et al. Near completely humanized liver in mice shows human-type metabolic responses to drugs. Am. J. Pathol. 165, 901-912 (2004).
-
(2004)
Am. J. Pathol.
, vol.165
, pp. 901-912
-
-
Tateno, C.1
-
13
-
-
84893106390
-
Troglitazone metabolism and transporter effects in chimeric mice: A comparison between chimeric humanized and chimeric murinized FRG mice
-
Samuelsson, K. et al. Troglitazone metabolism and transporter effects in chimeric mice: a comparison between chimeric humanized and chimeric murinized FRG mice. Xenobiotica 44, 186-195 (2014).
-
(2014)
Xenobiotica
, vol.44
, pp. 186-195
-
-
Samuelsson, K.1
-
14
-
-
77953441312
-
Steroid metabolism in chimeric mice with humanized liver
-
Lootens, L. et al. Steroid metabolism in chimeric mice with humanized liver. Drug Test Anal. 1, 531-537 (2009).
-
(2009)
Drug Test Anal.
, vol.1
, pp. 531-537
-
-
Lootens, L.1
-
15
-
-
84870043730
-
Differential effect of troglitazone on the human bile acid transporters, MRP2 and BSEP, in the PXB hepatic chimeric mouse
-
Foster, J. R. et al. Differential effect of troglitazone on the human bile acid transporters, MRP2 and BSEP, in the PXB hepatic chimeric mouse. Toxicol. Pathol. 40, 1106-1116 (2012).
-
(2012)
Toxicol. Pathol.
, vol.40
, pp. 1106-1116
-
-
Foster, J.R.1
-
16
-
-
84900460907
-
Fialuridine induces acute liver failure in chimeric TK-NOG mice: A model for detecting hepatic drug toxicity prior to human testing
-
Xu, D. et al. Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing. PLoS Med. 11, e1001628 (2014).
-
(2014)
PLoS Med.
, vol.11
, pp. e1001628
-
-
Xu, D.1
-
17
-
-
84901011638
-
Application of chimeric mice with humanized liver for study of human-specific drug metabolism
-
Bateman, T. J., Reddy, V. G., Kakuni, M., Morikawa, Y. & Kumar, S. Application of chimeric mice with humanized liver for study of human-specific drug metabolism. Drug Metab. Dispos. 42, 1055-1065 (2014).
-
(2014)
Drug Metab. Dispos.
, vol.42
, pp. 1055-1065
-
-
Bateman, T.J.1
Reddy, V.G.2
Kakuni, M.3
Morikawa, Y.4
Kumar, S.5
-
18
-
-
84872743384
-
Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction
-
Nishimura, T. et al. Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J. Pharmacol. Exp. Ther. 344, 388-396 (2013).
-
(2013)
J. Pharmacol. Exp. Ther.
, vol.344
, pp. 388-396
-
-
Nishimura, T.1
-
19
-
-
84885159847
-
Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes
-
Tanoue, C. et al. Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes. Xenobiotica 43, 956-962 (2013).
-
(2013)
Xenobiotica
, vol.43
, pp. 956-962
-
-
Tanoue, C.1
-
20
-
-
77949725830
-
Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment
-
Bissig, K. D. et al. Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. J. Clin. Invest. 120, 924-930 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 924-930
-
-
Bissig, K.D.1
-
21
-
-
16244415868
-
Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera
-
Meuleman, P. et al. Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera. Hepatology 41, 847-856 (2005).
-
(2005)
Hepatology
, vol.41
, pp. 847-856
-
-
Meuleman, P.1
-
22
-
-
84940394133
-
Development of murine cyp3a knockout chimeric mice with humanized liver
-
Kato, K. et al. Development of murine Cyp3a knockout chimeric mice with humanized liver. Drug Metab. Dispos. 43, 1208-1217 (2015).
-
(2015)
Drug Metab. Dispos.
, vol.43
, pp. 1208-1217
-
-
Kato, K.1
-
23
-
-
84957309060
-
Murine cyp3a knockout chimeric mice with humanized liver: Prediction of the metabolic profile of nefazodone in humans
-
Nakada N. et al. Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans. Biopharm. Drug Dispos. 37, 3-14 (2016).
-
(2016)
Biopharm. Drug Dispos.
, vol.37
, pp. 3-14
-
-
Nakada, N.1
-
24
-
-
0037155271
-
Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase
-
Shen, A. L., O'Leary, K. A. & Kasper, C. B. Association of multiple developmental defects and embryonic lethality with loss of microsomal NADPH-cytochrome P450 oxidoreductase. J. Biol. Chem. 277, 6536-6541 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 6536-6541
-
-
Shen, A.L.1
O'Leary, K.A.2
Kasper, C.B.3
-
25
-
-
10744224118
-
Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene
-
Wu, L. et al. Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene. Genesis 36, 177-181 (2003).
-
(2003)
Genesis
, vol.36
, pp. 177-181
-
-
Wu, L.1
-
26
-
-
0037790603
-
Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase
-
Henderson, C. J. et al. Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. J. Biol. Chem. 278, 13480-13486 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13480-13486
-
-
Henderson, C.J.1
-
27
-
-
0038507099
-
Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: Impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase
-
Gu, J. et al. Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase. J. Biol. Chem. 278, 25895-25901 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 25895-25901
-
-
Gu, J.1
-
28
-
-
0023646810
-
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
-
Thomas, K. R. & Capecchi, M. R. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51, 503-512 (1987).
-
(1987)
Cell
, vol.51
, pp. 503-512
-
-
Thomas, K.R.1
Capecchi, M.R.2
-
29
-
-
79959210305
-
A conditional knockout resource for the genome-wide study of mouse gene function
-
Skarnes, W. C. et al. A conditional knockout resource for the genome-wide study of mouse gene function. Nature 474, 337-342 (2011).
-
(2011)
Nature
, vol.474
, pp. 337-342
-
-
Skarnes, W.C.1
-
30
-
-
0034487368
-
Widespread recombinase expression using FLPeR (flipper) mice
-
Farley, F. W., Soriano, P., Steffen, L. S. & Dymecki, S. M. Widespread recombinase expression using FLPeR (flipper) mice. Genesis 28, 106-110 (2000).
-
(2000)
Genesis
, vol.28
, pp. 106-110
-
-
Farley, F.W.1
Soriano, P.2
Steffen, L.S.3
Dymecki, S.M.4
-
31
-
-
34248400310
-
A guild of 45 CRISPRassociated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes
-
Haft, D. H., Selengut, J., Mongodin, E. F. & Nelson, K. E. A guild of 45 CRISPRassociated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes. PLoS Comput. Biol. 1, e60 (2005).
-
(2005)
PLoS Comput. Biol.
, vol.1
, pp. e60
-
-
Haft, D.H.1
Selengut, J.2
Mongodin, E.F.3
Nelson, K.E.4
-
32
-
-
84865070369
-
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
-
Jinek, M. et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816-821 (2012).
-
(2012)
Science
, vol.337
, pp. 816-821
-
-
Jinek, M.1
-
33
-
-
0036267740
-
Identification of genes that are associated with DNA repeats in prokaryotes
-
Jansen, R., Embden, J. D., Gaastra, W. & Schouls, L. M. Identification of genes that are associated with DNA repeats in prokaryotes. Mol. Microbiol. 43, 1565-1575 (2002).
-
(2002)
Mol. Microbiol.
, vol.43
, pp. 1565-1575
-
-
Jansen, R.1
Embden, J.D.2
Gaastra, W.3
Schouls, L.M.4
-
34
-
-
84935897836
-
Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model
-
Bissig-Choisat, B. et al. Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model. Nat. Commun. 6, 7339 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 7339
-
-
Bissig-Choisat, B.1
-
35
-
-
24744466284
-
Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype
-
Weng, Y., DiRusso, C. C., Reilly, A. A., Black, P. N. & Ding, X. Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype. J. Biol. Chem. 280, 31686-31698 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 31686-31698
-
-
Weng, Y.1
DiRusso, C.C.2
Reilly, A.A.3
Black, P.N.4
Ding, X.5
-
36
-
-
6944221357
-
Drug-drug interactions for UDP-glucuronosyltransferase substrates: A pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios
-
Williams, J. A. et al. Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab. Dispos. 32, 1201-1208 (2004).
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 1201-1208
-
-
Williams, J.A.1
-
37
-
-
0035939330
-
Studies leading to the identification of ZD1839 (IRESSA): An orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer
-
Barker, A. J. et al. Studies leading to the identification of ZD1839 (IRESSA): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer. Bioorg. Med. Chem. Lett. 11, 1911-1914 (2001).
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 1911-1914
-
-
Barker, A.J.1
-
38
-
-
10344239413
-
Gefitinib-A novel targeted approach to treating cancer
-
Herbst, R. S., Fukuoka, M. & Baselga, J. Gefitinib-a novel targeted approach to treating cancer. Nat. Rev. Cancer 4, 956-965 (2004).
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 956-965
-
-
Herbst, R.S.1
Fukuoka, M.2
Baselga, J.3
-
39
-
-
84939574759
-
Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism
-
Liu, X. et al. Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism. Biochem. Pharmacol. 97, 111-121 (2015).
-
(2015)
Biochem. Pharmacol.
, vol.97
, pp. 111-121
-
-
Liu, X.1
-
40
-
-
10644261348
-
Metabolic disposition of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in rat, dog and man
-
McKillop, D. et al. Metabolic disposition of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in rat, dog and man. Xenobiotica 34, 917-934 (2004).
-
(2004)
Xenobiotica
, vol.34
, pp. 917-934
-
-
McKillop, D.1
-
41
-
-
79955919708
-
Clinical pharmacokinetics of tyrosine kinase inhibitors: Focus on 4-anilinoquinazolines
-
Scheffler, M., Di Gion, P., Doroshyenko, O., Wolf, J. & Fuhr, U. Clinical pharmacokinetics of tyrosine kinase inhibitors: focus on 4-anilinoquinazolines. Clin. Pharmacokinet. 50, 371-403 (2011).
-
(2011)
Clin. Pharmacokinet.
, vol.50
, pp. 371-403
-
-
Scheffler, M.1
Di Gion, P.2
Doroshyenko, O.3
Wolf, J.4
Fuhr, U.5
-
42
-
-
79951869899
-
CYP3A-mediated generation of aldehyde and hydrazine in atazanavir metabolism
-
Li, F., Lu, J., Wang, L. & Ma, X. CYP3A-mediated generation of aldehyde and hydrazine in atazanavir metabolism. Drug Metab. Dispos. 39, 394-401 (2011).
-
(2011)
Drug Metab. Dispos.
, vol.39
, pp. 394-401
-
-
Li, F.1
Lu, J.2
Wang, L.3
Ma, X.4
-
43
-
-
33746255370
-
Future of toxicology-metabolic activation and drug design: Challenges and opportunities in chemical toxicology
-
Baillie, T. A. Future of toxicology-metabolic activation and drug design: challenges and opportunities in chemical toxicology. Chem. Res. Toxicol. 19, 889-893 (2006).
-
(2006)
Chem. Res. Toxicol.
, vol.19
, pp. 889-893
-
-
Baillie, T.A.1
-
44
-
-
34047266790
-
Applying mechanisms of chemical toxicity to predict drug safety
-
Guengerich, F. P. & MacDonald, J. S. Applying mechanisms of chemical toxicity to predict drug safety. Chem. Res. Toxicol. 20, 344-369 (2007).
-
(2007)
Chem. Res. Toxicol.
, vol.20
, pp. 344-369
-
-
Guengerich, F.P.1
MacDonald, J.S.2
-
45
-
-
62249093071
-
Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites
-
Dalvie, D. et al. Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites. Chem. Res. Toxicol. 22, 357-368 (2009).
-
(2009)
Chem. Res. Toxicol.
, vol.22
, pp. 357-368
-
-
Dalvie, D.1
-
46
-
-
62249183036
-
Predicting circulating human metabolites: How good are we?
-
Anderson, S., Luffer-Atlas, D. & Knadler, M. P. Predicting circulating human metabolites: how good are we? Chem. Res. Toxicol. 22, 243-256 (2009).
-
(2009)
Chem. Res. Toxicol.
, vol.22
, pp. 243-256
-
-
Anderson, S.1
Luffer-Atlas, D.2
Knadler, M.P.3
-
47
-
-
67649574240
-
Agouti C57BL/6N embryonic stem cells for mouse genetic resources
-
Pettitt, S. J. et al. Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat. Methods 6, 493-495 (2009).
-
(2009)
Nat. Methods
, vol.6
, pp. 493-495
-
-
Pettitt, S.J.1
-
48
-
-
84921598229
-
COSMID: A web-based tool for identifying and validating CRISPR/Cas off-target sites
-
Cradick, T. J., Qiu, P., Lee, C. M., Fine, E. J. & Bao, G. COSMID: a web-based tool for identifying and validating CRISPR/Cas off-target sites. Mol. Ther. Nucleic Acids 3, e214 (2014).
-
(2014)
Mol. Ther. Nucleic Acids
, vol.3
, pp. e214
-
-
Cradick, T.J.1
Qiu, P.2
Lee, C.M.3
Fine, E.J.4
Bao, G.5
-
49
-
-
84874617789
-
Efficient genome editing in zebrafish using a CRISPR-Cas system
-
Hwang, W. Y. et al. Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat. Biotechnol. 31, 227-229 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 227-229
-
-
Hwang, W.Y.1
-
50
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819-823 (2013).
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
-
51
-
-
0026031297
-
Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation
-
Ponder, K. P. et al. Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation. Proc. Natl Acad. Sci. USA 88, 1217-1221 (1991).
-
(1991)
Proc. Natl Acad. Sci. USA
, vol.88
, pp. 1217-1221
-
-
Ponder, K.P.1
-
52
-
-
79961123152
-
RSEM: Accurate transcript quantification from RNA-Seq data with or without a reference genome
-
Li, B. & Dewey, C. N. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC. Bioinformatics 12, 323 (2011).
-
(2011)
BMC. Bioinformatics
, vol.12
, pp. 323
-
-
Li, B.1
Dewey, C.N.2
-
53
-
-
84859210032
-
Fast gapped-read alignment with bowtie 2
-
Langmead, B. & Salzberg, S. L. Fast gapped-read alignment with Bowtie 2. Nat. Methods 9, 357-359 (2012).
-
(2012)
Nat. Methods
, vol.9
, pp. 357-359
-
-
Langmead, B.1
Salzberg, S.L.2
-
54
-
-
84884416048
-
Human housekeeping genes, revisited
-
Eisenberg, E. & Levanon, E. Y. Human housekeeping genes, revisited. Trends Genet. 29, 569-574 (2013).
-
(2013)
Trends Genet.
, vol.29
, pp. 569-574
-
-
Eisenberg, E.1
Levanon, E.Y.2
|