A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response

Stem Cell Reports

Volumn 8, Issue 6, 2017, Pages 1727-1742

  Haenseler, Walther ^a   Sansom, Stephen N ^b   Buchrieser, Julian ^a   Newey, Sarah E ^c   Moore, Craig S ^d   Nicholls, Francesca J ^e   Chintawar, Satyan ^f   Schnell, Christian ^g   Antel, Jack P ^h   Allen, Nicholas D ^g   Cader, M Zameel ^f   Wade Martins, Richard ^c   James, William S ^a   Cowley, Sally A ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^e WARNEFORD HOSPITAL   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g CARDIFF UNIVERSITY   (United Kingdom)

^h MCGILL UNIVERSITY   (Canada)

Author keywords

Alzheimer's disease; cortical neurons; human; induced pluripotent stem cell; iPSC; macrophage; microglia; neurodegeneration; neuroinflammation; Parkinson's disease

Indexed keywords

ADULT; ARTICLE; CELL MATURATION; CELL MIGRATION; COCULTURE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOWN REGULATION; EMBRYO; FETUS; HUMAN; HUMAN CELL; IN VITRO STUDY; INDUCED PLURIPOTENT STEM CELL; MACROPHAGE; MICROGLIA; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM INFLAMMATION; PHAGOCYTE; PRIORITY JOURNAL; YOLK SAC; BIOLOGICAL MODEL; CELL CULTURE; CYTOLOGY; GENETICS; METABOLISM; NERVE CELL; PATHOLOGY; PHAGOCYTOSIS; PLURIPOTENT STEM CELL;

CD135 ANTIGEN; CYTOKINE; FLT3 PROTEIN, HUMAN; PROTEIN C MYB; TRANSCRIPTOME;

CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINES; DOWN-REGULATION; FMS-LIKE TYROSINE KINASE 3; HUMANS; MACROPHAGES; MICROGLIA; MODELS, BIOLOGICAL; NEURODEGENERATIVE DISEASES; NEURONS; PHAGOCYTOSIS; PLURIPOTENT STEM CELLS; PROTO-ONCOGENE PROTEINS C-MYB; TRANSCRIPTOME;

EID: 85020263129     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2017.05.017     Document Type: Article

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