In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis

Haematologica

Volumn 100, Issue 2, 2015, Pages 157-166

  Vanhee, Stijn ^a   De Mulder, Katrien ^a   Van Caeneghem, Yasmine ^a   Verstichel, Greet ^a   Van Roy, Nadine ^b   Menten, Björn ^b   Velghe, Imke ^a   Philippé, Jan ^b   De Bleser, Dominique ^c   Lambrecht, Bart N ^a,b   Taghon, Tom ^a   Leclercq, Georges ^a   Kerre, Tessa ^a   Vandekerckhove, Bart ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c Red Cross Flanders   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; INTERLEUKIN 3; INTERLEUKIN 6; LEUKOSIALIN; PROTEIN MYB;

ARTICLE; CELL DIFFERENTIATION; CELL SELECTION; CONTROLLED STUDY; DOWN REGULATION; EMBRYONIC STEM CELL; EMBRYONIC STEM CELL HEMATOPOIESIS; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HEMATOPOIESIS; HUMAN; HUMAN CELL; PHENOTYPE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; YOLK SAC; YOLK SAC HEMATOPOIESIS;

EID: 84964285616     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2014.112144     Document Type: Article

References (33)

1. Medvinsky A, Dzierzak E. Definitive hematopoiesis is autonomously initiated by the AGM region. Cell. 1996;86(6):897-906.
2. Palis J, Robertson S, Kennedy M, Wall C, Keller G. Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development. 1999;126(22):5073-5084.
3. Tober J, McGrath KE, Palis J. Primitive ery-thropoiesis and megakaryopoiesis in the yolk sac are independent of c-myb. Blood. 2008;111(5):2636-2639.
4. Mucenski ML, McLain K, Kier AB, et al. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell. 1991;65(4):677-689.
5. Bertrand JY, Chi NC, Santoso B, Teng S, Stainier DY, Traver D. Haematopoietic stem cells derive directly from aortic endothelium during development. Nature. 2010;464(7285):108-111.
6. Lieu YK, Reddy EP. Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation. Proc Natl Acad Sci USA. 2009;106(51): 21689-21694.
7. Lieu YK, Reddy E P. Impaired adult myeloid progenitor CMP and GMP cell function in conditional c-myb-knockout mice. Cell Cycle. 2012;11(18):3504-3512.
8. Schulz C, Gomez Perdiguero E, Chorro L, et al. A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science. 2012;336(6077):86-90.
9. Kyba M, Perlingeiro RC, Daley GQ. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell. 2002;109(1):29-37.
10. Ng ES, Davis RP, Azzola L, Stanley EG, Elefanty AG. Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation. Blood. 2005;106(5):1601-1603.
11. Vodyanik MA, Thomson JA, Slukvin, II. Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures. Blood. 2006; 108(6):2095-2105.
12. Notta F, Doulatov S, Laurenti E, Poeppl A, Jurisica I, Dick JE. Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment. Science. 2011;333(6039):218-221.
13. Qiu C, Olivier EN, Velho M, Bouhassira EE. Globin switches in yolk sac-like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells. Blood. 2008;111(4):2400-2408.
14. Gaur M, Kamata T, Wang S, Moran B, Shattil SJ, Leavitt AD. Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function. J Thromb Haemost. 2006;4(2): 436-442.
15. Choi KD, Vodyanik MA, Slukvin, II. Generation of mature human myelomono-cytic cells through expansion and differentiation of pluripotent stem cell-derived lin-CD34+CD43+CD45+ progenitors. J Clin Invest. 2009;119(9):2818-2829.
16. Woll PS, Martin CH, Miller JS, Kaufman DS. Human embryonic stem cell-derived NK cells acquire functional receptors and cytolytic activity. J Immunol. 2005; 175(8):5095-5103.
17. Timmermans F, Velghe I, Vanwalleghem L, et al. Generation of T cells from human embryonic stem cell-derived hematopoietic zones. J Immunol. 2009;182(11):6879-6888.
18. Kennedy M, Awong G, Sturgeon CM, et al. T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures. Cell Rep. 2012; 2(6):1722-1735.
19. Yoshimoto M, Porayette P, Glosson NL, et al. Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence. Blood. 2012; 119(24):5706-5714.
20. Ramond C, Berthault C, Burlen-Defranoux O, et al. Two waves of distinct hematopoi-etic progenitor cells colonize the fetal thy-mus. Nat Immunol. 2014;15(1):27-35.
21. Ledran MH, Krassowska A, Armstrong L, et al. Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches. Cell Stem Cell. 2008;3(1):85-98.
22. Wang L, Menendez P, Shojaei F, et al. Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression. J Exp Med. 2005;201(10):1603-1614.
23. Amabile G, Welner RS, Nombela-Arrieta C, et al. In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells. Blood. 2013; 121(8):1255-1264.
24. Doulatov S, Vo LT, Chou SS, et al. Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors. Cell Stem Cell. 2013;13(4):459-470.
25. Pereira CF, Chang B, et al. Induction of a hemogenic program in mouse fibroblasts. Cell Stem Cell. 2013;13(2):205-218.
26. Riddell J, Gazit R, Garrison BS, et al. Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors. Cell. 2014;157(3):549-564.
27. Rollini P, Kaiser S, Faes-van't Hull E, Kapp U, Leyvraz S. Long-term expansion of trans-plantable human fetal liver hematopoietic stem cells. Blood. 2004; 103(3):1166-1170.
28. Huang J, Nguyen-McCarty M, Hexner EO, Danet-Desnoyers G, Klein PS. Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways. Nat Med. 2012;18(12):1778-1785.
29. Conneally E, Cashman J, Petzer A, Eaves C. Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic-scid/scid mice. Proc Natl Acad Sci USA. 1997;94(18):9836-9841.
30. Sakamoto H, Dai G, Tsujino K, et al. Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development. Blood. 2006;108(3):896-903.
31. Clarke D, Vegiopoulos A, Crawford A, Mucenski M, Bonifer C, Frampton J. In vitro differentiation of c-myb(-/-) ES cells reveals that the colony forming capacity of unilineage macrophage precursors and myeloid progenitor commitment are c-Myb independent. Oncogene. 2000; 19(30):3343-3351.
32. Ziegler-Heitbrock HW, Fingerle G, Strobel M, et al. The novel subset of CD14+/CD16+ blood monocytes exhibits features of tissue macrophages. Eur J Immunol. 1993;23(9): 2053-2058.
33. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 2005;5(12):953-964.