Efficient, Long Term Production of Monocyte-Derived Macrophages from Human Pluripotent Stem Cells under Partly-Defined and Fully-Defined Conditions

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  van Wilgenburg, Bonnie ^a   Browne, Cathy ^a   Vowles, Jane ^a   Cowley, Sally A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD16 ANTIGEN; CD163 ANTIGEN; COLONY STIMULATING FACTOR 1; DNA; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 3; INTERLEUKIN 6; INTERLEUKIN 8; LENTIVIRUS VECTOR; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; NUCLEIC ACID; RANTES; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CELL COUNT; CELL DIFFERENTIATION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; CYTOLOGY; DNA MODIFICATION; EMBRYONIC STEM CELL; GENE EXPRESSION; GENE SILENCING; GENETIC MANIPULATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MACROPHAGE; MONOCYTE; PHAGOCYTOSIS; PLURIPOTENT STEM CELL; REPRODUCIBILITY; TRANSGENE; VIRUS INFECTIVITY;

CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE; CULTURE MEDIA; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION; HIV-1; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MONOCYTES; PHAGOCYTOSIS; PHENOTYPE; PLURIPOTENT STEM CELLS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84881506946     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071098     Document Type: Article

References (45)

1. Aggarwal R, Pompili VJ, Das H, (2010) Genetic modification of ex-vivo expanded stem cells for clinical application. Frontiers in bioscience: a journal and virtual library 15: 854-871.
2. Bhattacharya B, Puri S, Puri R (2012) A Review of Gene Expression Profiling of Human Embryonic Stem Cell Lines and their Differentiated Progeny. Current Stem Cell Research & Therapy. 98-106.
3. Subramanian A, Guo B, Marsden MD, Galic Z, Kitchen S, et al. (2009) Macrophage differentiation from embryoid bodies derived from human embryonic stem cells. J Stem Cells 4: 29-45.
4. Anderson JS, Bandi S, Kaufman DS, Akkina R, (2006) Derivation of normal macrophages from human embryonic stem (hES) cells for applications in HIV gene therapy. Retrovirology 3: 24.
5. Kambal A, Mitchell G, Cary W, Gruenloh W, Jung Y, et al. (2011) Generation of HIV-1 Resistant and Functional Macrophages From Hematopoietic Stem Cell-derived Induced Pluripotent Stem Cells. Mol Ther 19: 584-593.
6. Senju S, Haruta M, Matsumura K, Matsunaga Y, Fukushima S, et al. (2011) Generation of dendritic cells and macrophages from human induced pluripotent stem cells aiming at cell therapy. Gene Ther.
7. Choi KD, Vodyanik M, Slukvin II, (2011) Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells. Nature protocols 6: 296-313.
8. Karlsson KR, Cowley S, Martinez FO, Shaw M, Minger SL, et al. (2008) Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3. Exp Hematol 36: 1167-1175.
9. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, et al. (1998) Embryonic stem cell lines derived from human blastocysts. Science 282: 1145-1147.
10. Xu C, Inokuma MS, Denham J, Golds K, Kundu P, et al. (2001) Feeder-free growth of undifferentiated human embryonic stem cells. Nature biotechnology 19: 971-974.
11. Baranov P, Regatieri C, Melo G, Clissold H, Young M (2012) Synthetic Peptide-Acrylate Surface for Self-Renewal of Human Retinal Progenitor Cells. Tissue Eng Part C Methods.
12. Ziegler-Heitbrock L, (2007) The CD14+ CD16+ blood monocytes: their role in infection and inflammation. Journal of leukocyte biology 81: 584-592.
13. Young DA, Lowe LD, Clark SC, (1990) Comparison of the effects of IL-3, granulocyte-macrophage colony-stimulating factor, and macrophage colony-stimulating factor in supporting monocyte differentiation in culture. Analysis of macrophage antibody-dependent cellular cytotoxicity. J Immunol 145: 607-615.
14. Hashimoto S, Suzuki T, Dong HY, Yamazaki N, Matsushima K, (1999) Serial analysis of gene expression in human monocytes and macrophages. Blood 94: 837-844.
15. Verreck FA, de Boer T, Langenberg DM, Hoeve MA, Kramer M, et al. (2004) Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria. Proceedings of the National Academy of Sciences of the United States of America 101: 4560-4565.
16. Akagawa KS, Komuro I, Kanazawa H, Yamazaki T, Mochida K, et al. (2006) Functional heterogeneity of colony-stimulating factor-induced human monocyte-derived macrophages. Respirology 11Suppl: S32-36.
17. Xu W, Roos A, Schlagwein N, Woltman AM, Daha MR, et al. (2006) IL-10-producing macrophages preferentially clear early apoptotic cells. Blood 107: 4930-4937.
18. Jiang Y, Cowley SA, Siler U, Melguizo D, Tilgner K, et al. (2012) Derivation and functional analysis of patient-specific induced pluripotent stem cells as an in vitro model of chronic granulomatous disease. STEM CELLS 30: 599-611.
19. Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, et al. (2004) The chemokine system in diverse forms of macrophage activation and polarization. Trends in immunology 25: 677-686.
20. Schade AE, Schieven GL, Townsend R, Jankowska AM, Susulic V, et al. (2008) Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation. Blood 111: 1366-1377.
21. Wang T, Lv M, Qian Q, Nie Y, Yu L, et al. (2011) Increased frequencies of T helper type 17 cells in tuberculous pleural effusion. Tuberculosis (Edinb) 91: 231-237.
22. Stein M, Keshav S, Harris N, Gordon S, (1992) Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med 176: 287-292.
23. Luster AD, (2002) The role of chemokines in linking innate and adaptive immunity. Current opinion in immunology 14: 129-135.
24. Cowley SA, Karlsson KR, van Wilgenburg B, Carter G, Browne C, et al. (2012) Macrophages from human Pluripotent Stem Cells. In: Takahashi R HK, editor. Macrophages: Life Cycle, Functions and Diseases. NY: Nova Science Publishers.
25. Salez L, Singer M, Balloy V, Créminon C, Chignard M, (2000) Lack of IL-10 synthesis by murine alveolar macrophages upon lipopolysaccharide exposure. Comparison with peritoneal macrophages. Journal of leukocyte biology 67: 545-552.
26. Di Marzio P, Tse J, Landau NR, (1998) Chemokine receptor regulation and HIV type 1 tropism in monocyte-macrophages. AIDS Res Hum Retroviruses 14: 129-138.
27. Bakri Y, Amzazi S, Mannioui A, Benjouad A, (2001) The susceptibility of macrophages to human immunodeficiency virus type 1 X4 isolates depends on their activation state. Biomed Pharmacother 55: 32-38.
28. Schmidtmayerova H, Alfano M, Nuovo G, Bukrinsky M, (1998) Human immunodeficiency virus type 1 T-lymphotropic strains enter macrophages via a CD4- and CXCR4-mediated pathway: replication is restricted at a postentry level. Journal of Virology 72: 4633-4642.
29. Muller FJ, Schuldt BM, Williams R, Mason D, Altun G, et al. (2011) A bioinformatic assay for pluripotency in human cells. Nat Methods 8: 315-317.
30. Verreck FA, de Boer T, Langenberg DM, van der Zanden L, Ottenhoff TH, (2006) Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-gamma- and CD40L-mediated costimulation. Journal of leukocyte biology 79: 285-293.
31. Xu W, Schlagwein N, Roos A, van den Berg TK, Daha MR, et al. (2007) Human peritoneal macrophages show functional characteristics of M-CSF-driven anti-inflammatory type 2 macrophages. Eur J Immunol 37: 1594-1599.
32. Smith W, Feldmann M, Londei M, (1998) Human macrophages induced in vitro by macrophage colony-stimulating factor are deficient in IL-12 production. Eur J Immunol 28: 2498-2507.
33. Murphy FJ, Reen DJ, (1996) Differential expression of function-related antigens on newborn and adult monocyte subpopulations. Immunology 89: 587-591.
34. Hoeffel G, Wang Y, Greter M, See P, Teo P, et al. (2012) Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac-derived macrophages. J Exp Med 209: 1167-1181.
35. Yona S, Kim KW, Wolf Y, Mildner A, Varol D, et al. (2013) Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity 38: 79-91.
36. Schulz C, Gomez Perdiguero E, Chorro L, Szabo-Rogers H, Cagnard N, et al. (2012) A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 336: 86-90.
37. Karlsson K, Cowley S, Martinez F, Shaw M, Minger S, et al. (2008) Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3. Experimental hematology 36: 1167-1175.
38. Yusa K, Rashid T, Strick-Marchand H, Varela I, Liu P-Q, et al. (2011) Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells. Nature 478: 391-394.
39. Cowan CA, Klimanskaya I, McMahon J, Atienza J, Witmyer J, et al. (2004) Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med 350: 1353-1356.
40. Zufferey R, Nagy D, Mandel RJ, Naldini L, Trono D, (1997) Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nature biotechnology 15: 871-875.
41. Demaison C, Parsley K, Brouns G, Scherr M, Battmer K, et al. (2002) High-level transduction and gene expression in hematopoietic repopulating cells using a human immunodeficiency [correction of imunodeficiency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter. Hum Gene Ther 13: 803-813.
42. Reynolds ES, (1963) The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol 17: 208-212.
43. Gartner S, Markovits P, Markovitz DM, Betts RF, Popovic M, (1986) Virus isolation from and identification of HTLV-III/LAV-producing cells in brain tissue from a patient with AIDS. JAMA: the journal of the American Medical Association 256: 2365-2371.
44. Carter GC, Bernstone L, Sangani D, Bee JW, Harder T, et al. (2009) HIV entry in macrophages is dependent on intact lipid rafts. Virology 386: 192-202.
45. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, et al. (2007) Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell 131: 861-872.