Hypercapnia impairs ENaC cell surface stability by promoting phosphorylation, polyubiquitination and endocytosis of β-ENac in a human alveolar epithelial cell line

Frontiers in Immunology

Volumn 8, Issue MAY, 2017, Pages

  Gwoździńska, Paulina ^a   Buchbinder, Benno A ^a   Mayer, Konstantin ^a   Herold, Susanne ^a   Morty, Rory E ^a,b   Seeger, Werner ^a,b   Vadász, István ^a  

^a JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

^b MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

Author keywords

Alveolar epithelium; Alveolar fluid clearance; Carbon dioxide; Epithelial sodium channel; Mitogen activated protein kinase signaling; Sodium transport; Ubiquitination

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CARBON DIOXIDE; EPITHELIAL SODIUM CHANNEL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ACTIVATOR; INTERLEUKIN 1BETA; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE 3; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; UBIQUITIN PROTEIN LIGASE NEDD4;

ARTICLE; BIOTINYLATION; CELL CULTURE; CELL SURFACE; CONTROLLED STUDY; ENDOCYTOSIS; FLUID BALANCE; HUMAN; HUMAN CELL; HYPERCAPNIA; INTERNALIZATION; LUNG ALVEOLUS EPITHELIUM CELL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RECEPTOR DOWN REGULATION; SITE DIRECTED MUTAGENESIS; SODIUM TRANSPORT; TRANSIENT TRANSFECTION; UBIQUITINATION;

EID: 85020037953     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2017.00591     Document Type: Article

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