Hypoxia-induced inhibition of epithelial Na+ channels in the lung: Role of Nedd4-2 and the ubiquitin-proteasome pathway

American Journal of Respiratory Cell and Molecular Biology

Volumn 50, Issue 3, 2014, Pages 526-537

  Gille, Thomas ^a,f   Randrianarison Pellan, Nadia ^a   Goolaerts, Arnaud ^b   Dard, Nicolas ^a   Uzunhan, Yurdagül ^a,f   Ferrary, Evelyne ^c,d   Hummler, Edith ^e   Clerici, Christine ^b,d,f   Planès, Carole ^a,f  

^a AP HP   (France)

^b CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

^c INSERM   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e UNIVERSITY OF LAUSANNE   (Switzerland)

^f ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

Alveolar fluid clearance; Antioxidant; Membrane trafficking; Nedd4 2; Ubiquitination

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; EPITHELIAL SODIUM CHANNEL; LACTACYSTIN; PROTEASOME; REACTIVE OXYGEN METABOLITE; UBIQUITIN PROTEIN LIGASE NEDD4;

ALVEOLAR FLUID CLEARANCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; APICAL MEMBRANE; ARTICLE; CONTROLLED STUDY; ENDOCYTOSIS; ENZYME INHIBITION; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; LUNG; LUNG ALVEOLUS EPITHELIUM; LUNG CLEARANCE; LUNG HOMOGENATE; MALE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN SUBUNIT; SHORT CIRCUIT CURRENT; SODIUM TRANSPORT; UBIQUITINATION;

ANIMALS; ANOXIA; ANTIOXIDANTS; CELL HYPOXIA; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOCYTOSIS; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; EPITHELIAL CELLS; EPITHELIAL SODIUM CHANNELS; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUCOCILIARY CLEARANCE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY; SODIUM; SODIUM CHANNEL BLOCKERS; TIME FACTORS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 84895540215     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2012-0518OC     Document Type: Article

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