Elevated CO2 levels cause mitochondrial dysfunction and impair cell proliferation

Journal of Biological Chemistry

Volumn 286, Issue 43, 2011, Pages 37067-37076

  Vohwinkel, Christine U ^a,b   Lecuona, Emilia ^a   Sun, Haying ^a   Sommer, Natascha ^c   Vadász, István ^c   Chandel, Navdeep S ^a   Sznajder, Jacob I ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALVEOLAR EPITHELIAL CELLS; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; CYSTIC FIBROSIS; ELEVATED CO; ELEVATED CO2; ELEVATED LEVEL; GLUCOSE 6 PHOSPHATES; HYPERCAPNIA; ISOCITRATE DEHYDROGENASE; ISOMERASES; KETOGLUTARATE; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL FUNCTION; MUSCULAR DYSTROPHY; OVER-EXPRESSION;

CELL CULTURE; CELL PROLIFERATION; GLUCOSE; MITOCHONDRIA; PULMONARY DISEASES;

CARBON DIOXIDE;

2 OXOGLUTARIC ACID; ADENOSINE TRIPHOSPHATE; CARBON DIOXIDE; GALACTOSE; GLUCOSE 6 PHOSPHATE ISOMERASE; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE ISOENZYME; MICRORNA; MICRORNA 183; OXYGEN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ISOCITRATE DEHYDROGENASE 2, HUMAN; MIRN183 MICRORNA, HUMAN;

ACIDOSIS; ARTICLE; CARBON DIOXIDE BLOOD LEVEL; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; ENZYME INHIBITION; FIBROBLAST; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPERCAPNIA; HYPOXIA; LUNG ALVEOLUS EPITHELIUM; NUCLEIC ACID SYNTHESIS; OXYGEN CONSUMPTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; UPREGULATION; CELL LINE; DRUG EFFECT; LUNG DISEASE; METABOLISM; MITOCHONDRION; MUSCULAR DYSTROPHY; PATHOLOGY;

CARBON DIOXIDE; CELL LINE; CELL PROLIFERATION; HUMANS; HYPERCAPNIA; ISOCITRATE DEHYDROGENASE; KETOGLUTARIC ACIDS; LUNG DISEASES; MICRORNAS; MITOCHONDRIA; MUSCULAR DYSTROPHIES; UP-REGULATION;

EID: 80054805268     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.290056     Document Type: Article

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