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Volumn 111, Issue 3, 2014, Pages E374-E383

TGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury

Author keywords

Alveolar epithelium; Fluid homeostasis

Indexed keywords

2 (5 CHLORO 2 FLUOROPHENYL) 4 (4 PYRIDINYLAMINO)PTERIDINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALPHA EPITHELIAL SODIUM CHANNEL; BETA EPITHELIAL SODIUM CHANNEL; BLEOMYCIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; EPITHELIAL SODIUM CHANNEL; GAMMA EPITHELIAL SODIUM CHANNEL; MESSENGER RNA; PHOSPHATIDYLINOSITOL 4 PHOSPHATE 5 KINASE 1ALPHA; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE; PHOSPHOLIPASE D1; PROTEIN KINASE C IOTA; PROTEIN KINASE C ZETA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMAD2 PROTEIN; SMAD3 PROTEIN; SODIUM 22; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN PROTEIN LIGASE NEDD4; UNCLASSIFIED DRUG; 1-PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE; ADENOSINE TRIPHOSPHATASE; ION; PHOSPHOLIPASE D; PHOSPHOTRANSFERASE;

EID: 84892922505     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1306798111     Document Type: Article
Times cited : (106)

References (73)
  • 1
    • 0034604129 scopus 로고    scopus 로고
    • The acute respiratory distress syndrome
    • Ware LB, Matthay MA (2000) The acute respiratory distress syndrome. N Engl J Med 342(18):1334-1349.
    • (2000) N Engl J Med , vol.342 , Issue.18 , pp. 1334-1349
    • Ware, L.B.1    Matthay, M.A.2
  • 2
    • 67650447649 scopus 로고    scopus 로고
    • What makes a good lung?
    • Weibel ER (2009) What makes a good lung? Swiss Med Wkly 139(27-28):375-386.
    • (2009) Swiss Med Wkly , vol.139 , Issue.27-28 , pp. 375-386
    • Weibel, E.R.1
  • 3
    • 34447128929 scopus 로고    scopus 로고
    • Alveolar epithelium and Na, K-ATPase in acute lung injury
    • Vadász I, Raviv S, Sznajder JI (2007) Alveolar epithelium and Na, K-ATPase in acute lung injury. Intensive Care Med 33(7):1243-1251.
    • (2007) Intensive Care Med , vol.33 , Issue.7 , pp. 1243-1251
    • Vadász, I.1    Raviv, S.2    Sznajder, J.I.3
  • 4
    • 67651173244 scopus 로고    scopus 로고
    • The contribution of epithelial sodium channels to alveolar function in health and disease
    • Eaton DC, Helms MN, Koval M, Bao HF, Jain L (2009) The contribution of epithelial sodium channels to alveolar function in health and disease. Annu Rev Physiol 71:403-423.
    • (2009) Annu Rev Physiol , vol.71 , pp. 403-423
    • Eaton, D.C.1    Helms, M.N.2    Koval, M.3    Bao, H.F.4    Jain, L.5
  • 5
    • 0033066855 scopus 로고    scopus 로고
    • Sodium channels in alveolar epithelial cells: Molecular characterization, biophysical properties, and physiological significance
    • Matalon S, O'Brodovich H (1999) Sodium channels in alveolar epithelial cells: Molecular characterization, biophysical properties, and physiological significance. Annu Rev Physiol 61:627-661.
    • (1999) Annu Rev Physiol , vol.61 , pp. 627-661
    • Matalon, S.1    O'Brodovich, H.2
  • 6
    • 0036784957 scopus 로고    scopus 로고
    • Invited review: Active fluid clearance from the distal air spaces of the lung
    • (1985)
    • Matthay MA, Clerici C, Saumon G (2002) Invited review: Active fluid clearance from the distal air spaces of the lung. J Appl Physiol (1985) 93(4):1533-1541.
    • (2002) J Appl Physiol , vol.93 , Issue.4 , pp. 1533-1541
    • Matthay, M.A.1    Clerici, C.2    Saumon, G.3
  • 7
    • 0036941270 scopus 로고    scopus 로고
    • Alveolar fluid clearance in patients with ARDS: Does it make a difference?
    • Matthay MA (2002) Alveolar fluid clearance in patients with ARDS: Does it make a difference? Chest 122(6, Suppl):340S-343S.
    • (2002) Chest , vol.122 , Issue.6 , pp. 340-343
    • Matthay, M.A.1
  • 8
    • 0034992884 scopus 로고    scopus 로고
    • Alveolar edema must be cleared for the acute respiratory distress syndrome patient to survive
    • Sznajder JI (2001) Alveolar edema must be cleared for the acute respiratory distress syndrome patient to survive. Am J Respir Crit Care Med 163(6):1293-1294.
    • (2001) Am J Respir Crit Care Med , vol.163 , Issue.6 , pp. 1293-1294
    • Sznajder, J.I.1
  • 9
    • 0034977190 scopus 로고    scopus 로고
    • TGF-β is a critical mediator of acute lung injury
    • Pittet JF, et al. (2001) TGF-β is a critical mediator of acute lung injury. J Clin Invest 107(12):1537-1544.
    • (2001) J Clin Invest , vol.107 , Issue.12 , pp. 1537-1544
    • Pittet, J.F.1
  • 10
    • 33745183811 scopus 로고    scopus 로고
    • 6 integrin-dependent TGF-β activation and promotes acute lung injury
    • 6 integrin-dependent TGF-β activation and promotes acute lung injury. J Clin Invest 116(6):1606-1614.
    • (2006) J Clin Invest , vol.116 , Issue.6 , pp. 1606-1614
    • Jenkins, R.G.1
  • 11
    • 12944304176 scopus 로고    scopus 로고
    • Active transforming growth factor-beta1 activates the procollagen I promoter in patients with acute lung injury
    • Budinger GR, et al. (2005) Active transforming growth factor-beta1 activates the procollagen I promoter in patients with acute lung injury. Intensive Care Med 31(1): 121-128.
    • (2005) Intensive Care Med , vol.31 , Issue.1 , pp. 121-128
    • Budinger, G.R.1
  • 12
    • 0037383998 scopus 로고    scopus 로고
    • The acute respiratory distress syndrome: A role for transforming growth factor-beta 1
    • Fahy RJ, et al. (2003) The acute respiratory distress syndrome: A role for transforming growth factor-beta 1. Am J Respir Cell Mol Biol 28(4):499-503.
    • (2003) Am J Respir Cell Mol Biol , vol.28 , Issue.4 , pp. 499-503
    • Fahy, R.J.1
  • 13
    • 0242666876 scopus 로고    scopus 로고
    • Transforming growth factor-β1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism
    • Frank J, et al. (2003) Transforming growth factor-β1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem 278(45):43939-43950.
    • (2003) J Biol Chem , vol.278 , Issue.45 , pp. 43939-43950
    • Frank, J.1
  • 14
    • 0345138996 scopus 로고    scopus 로고
    • Modulation of ion conductance and active transport by TGF-β 1 in alveolar epithelial cell monolayers
    • Willis BC, et al. (2003) Modulation of ion conductance and active transport by TGF-β 1 in alveolar epithelial cell monolayers. Am J Physiol Lung Cell Mol Physiol 285(6): L1192-L1200.
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.285 , Issue.6 , pp. L1192-L1200
    • Willis, B.C.1
  • 15
    • 77951193038 scopus 로고    scopus 로고
    • Transforming growth factor β1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism
    • Roux J, et al. (2010) Transforming growth factor β1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism. J Biol Chem 285(7):4278-4290.
    • (2010) J Biol Chem , vol.285 , Issue.7 , pp. 4278-4290
    • Roux, J.1
  • 16
    • 84866742560 scopus 로고    scopus 로고
    • TGFβ signalling in context
    • Massagué J (2012) TGFβ signalling in context. Nat Rev Mol Cell Biol 13(10):616-630.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , Issue.10 , pp. 616-630
    • Massagué, J.1
  • 17
    • 0022204452 scopus 로고
    • Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution
    • (1985)
    • Rennard SI, et al. (1986) Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution. J Appl Physiol (1985) 60(2):532-538.
    • (1986) J Appl Physiol , vol.60 , Issue.2 , pp. 532-538
    • Rennard, S.I.1
  • 18
    • 0036300549 scopus 로고    scopus 로고
    • Lung epithelial fluid transport and the resolution of pulmonary edema
    • Matthay MA, Folkesson HG, Clerici C (2002) Lung epithelial fluid transport and the resolution of pulmonary edema. Physiol Rev 82(3):569-600.
    • (2002) Physiol Rev , vol.82 , Issue.3 , pp. 569-600
    • Matthay, M.A.1    Folkesson, H.G.2    Clerici, C.3
  • 19
    • 0035498491 scopus 로고    scopus 로고
    • Re-evaluating the Na(+) conductance of adult rat alveolar type II pneumocytes: Evidence for the involvement of cGMP-activated cation channels
    • Kemp PJ, Kim KJ, Borok Z, Crandall ED (2001) Re-evaluating the Na(+) conductance of adult rat alveolar type II pneumocytes: Evidence for the involvement of cGMP-activated cation channels. J Physiol 536(Pt 3):693-701.
    • (2001) J Physiol , vol.536 , pp. 693-701
    • Kemp, P.J.1    Kim, K.J.2    Borok, Z.3    Crandall, E.D.4
  • 20
    • 0034009507 scopus 로고    scopus 로고
    • Biophysical properties and molecular characterization of amiloride-sensitive sodium channels in A549 cells
    • Lazrak A, Samanta A, Matalon S (2000) Biophysical properties and molecular characterization of amiloride-sensitive sodium channels in A549 cells. Am J Physiol Lung Cell Mol Physiol 278(4):L848-L857.
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.278 , Issue.4 , pp. L848-L857
    • Lazrak, A.1    Samanta, A.2    Matalon, S.3
  • 21
    • 0346668344 scopus 로고    scopus 로고
    • Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells
    • Planès C, et al. (2002) Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells. J Biol Chem 277(49): 47318-47324.
    • (2002) J Biol Chem , vol.277 , Issue.49 , pp. 47318-47324
    • Planès, C.1
  • 22
    • 70949103175 scopus 로고    scopus 로고
    • Carbon monoxide rapidly impairs alveolar fluid clearance by inhibiting epithelial sodium channels
    • Althaus M, et al. (2009) Carbon monoxide rapidly impairs alveolar fluid clearance by inhibiting epithelial sodium channels. Am J Respir Cell Mol Biol 41(6):639-650.
    • (2009) Am J Respir Cell Mol Biol , vol.41 , Issue.6 , pp. 639-650
    • Althaus, M.1
  • 23
    • 68949094195 scopus 로고    scopus 로고
    • ENaC at the cutting edge: Regulation of epithelial sodium channels by proteases
    • Kleyman TR, Carattino MD, Hughey RP (2009) ENaC at the cutting edge: Regulation of epithelial sodium channels by proteases. J Biol Chem 284(31):20447-20451.
    • (2009) J Biol Chem , vol.284 , Issue.31 , pp. 20447-20451
    • Kleyman, T.R.1    Carattino, M.D.2    Hughey, R.P.3
  • 24
    • 0027958441 scopus 로고
    • + channel is made of three homologous subunits
    • + channel is made of three homologous subunits. Nature 367(6462):463-467.
    • (1994) Nature , vol.367 , Issue.6462 , pp. 463-467
    • Canessa, C.M.1
  • 25
    • 34547830212 scopus 로고    scopus 로고
    • The PY motif of ENaC, mutated in liddle syndrome, regulates channel internalization, sorting and mobilization from subapical pool
    • Lu C, Pribanic S, Debonneville A, Jiang C, Rotin D (2007) The PY motif of ENaC, mutated in Liddle syndrome, regulates channel internalization, sorting and mobilization from subapical pool. Traffic 8(9):1246-1264.
    • (2007) Traffic , vol.8 , Issue.9 , pp. 1246-1264
    • Lu, C.1    Pribanic, S.2    Debonneville, A.3    Jiang, C.4    Rotin, D.5
  • 26
    • 0035009443 scopus 로고    scopus 로고
    • Expression of highly selective sodium channels in alveolar type II cells is determined by culture conditions
    • Jain L, Chen XJ, Ramosevac S, Brown LA, Eaton DC (2001) Expression of highly selective sodium channels in alveolar type II cells is determined by culture conditions. Am J Physiol Lung Cell Mol Physiol 280(4):L646-L658.
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.280 , Issue.4 , pp. L646-L658
    • Jain, L.1    Chen, X.J.2    Ramosevac, S.3    Brown, L.A.4    Eaton, D.C.5
  • 27
    • 34250206316 scopus 로고    scopus 로고
    • Cellular origin of pro-coagulant and (anti)-fibrinolytic factors in bleomycin-injured lungs
    • Wygrecka M, et al. (2007) Cellular origin of pro-coagulant and (anti)-fibrinolytic factors in bleomycin-injured lungs. Eur Respir J 29(6):1105-1114.
    • (2007) Eur Respir J , vol.29 , Issue.6 , pp. 1105-1114
    • Wygrecka, M.1
  • 28
    • 38849159502 scopus 로고    scopus 로고
    • AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis
    • Vadász I, et al. (2008) AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis. J Clin Invest 118(2):752-762.
    • (2008) J Clin Invest , vol.118 , Issue.2 , pp. 752-762
    • Vadász, I.1
  • 29
    • 0037380667 scopus 로고    scopus 로고
    • Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-ζ
    • Dada LA, et al. (2003) Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-ζ. J Clin Invest 111(7):1057-1064.
    • (2003) J Clin Invest , vol.111 , Issue.7 , pp. 1057-1064
    • Dada, L.A.1
  • 30
    • 70450246902 scopus 로고    scopus 로고
    • 2 synthesis: Regulation and cellular functions
    • 2 synthesis: Regulation and cellular functions. J Cell Sci 122(Pt 21):3837-3850.
    • (2009) J Cell Sci , vol.122 , pp. 3837-3850
    • Van Den-Bout, I.1    Divecha, N.2
  • 31
    • 34548652014 scopus 로고    scopus 로고
    • Regulation of the epithelial sodium channel by phosphatidylinositides: Experiments, implications, and speculations
    • Ma HP, Chou CF, Wei SP, Eaton DC (2007) Regulation of the epithelial sodium channel by phosphatidylinositides: Experiments, implications, and speculations. Pflugers Arch 455(1):169-180.
    • (2007) Pflugers Arch , vol.455 , Issue.1 , pp. 169-180
    • Ma, H.P.1    Chou, C.F.2    Wei, S.P.3    Eaton, D.C.4
  • 32
    • 37548999808 scopus 로고    scopus 로고
    • Phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (ENaC) in cultured collecting duct cells
    • Weixel KM, et al. (2007) Phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (ENaC) in cultured collecting duct cells. J Biol Chem 282(50):36534-36542.
    • (2007) J Biol Chem , vol.282 , Issue.50 , pp. 36534-36542
    • Weixel, K.M.1
  • 34
    • 78650638452 scopus 로고    scopus 로고
    • Nitric oxide inhibits highly selective sodium channels and the Na+/K+-ATPase in H441 cells
    • Althaus M, et al. (2011) Nitric oxide inhibits highly selective sodium channels and the Na+/K+-ATPase in H441 cells. Am J Respir Cell Mol Biol 44(1):53-65.
    • (2011) Am J Respir Cell Mol Biol , vol.44 , Issue.1 , pp. 53-65
    • Althaus, M.1
  • 35
    • 0344927165 scopus 로고    scopus 로고
    • Regulation of ion channel structure and function by reactive oxygen-nitrogen species
    • Matalon S, et al. (2003) Regulation of ion channel structure and function by reactive oxygen-nitrogen species. Am J Physiol Lung Cell Mol Physiol 285(6):L1184-L1189.
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.285 , Issue.6 , pp. L1184-L1189
    • Matalon, S.1
  • 36
    • 38549138327 scopus 로고    scopus 로고
    • Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant
    • Heumüller S, et al. (2008) Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 51(2):211-217.
    • (2008) Hypertension , vol.51 , Issue.2 , pp. 211-217
    • Heumüller, S.1
  • 37
    • 78149239505 scopus 로고    scopus 로고
    • NADPH oxidase-4 mediates protection against chronic loadinduced stress in mouse hearts by enhancing angiogenesis
    • Zhang M, et al. (2010) NADPH oxidase-4 mediates protection against chronic loadinduced stress in mouse hearts by enhancing angiogenesis. Proc Natl Acad Sci USA 107(42):18121-18126.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.42 , pp. 18121-18126
    • Zhang, M.1
  • 38
    • 84873872745 scopus 로고    scopus 로고
    • Ethanol alters alveolar fluid balance via nadph oxidase (NOX) signaling to epithelial sodium channels (ENaC) in the lung
    • Downs CA, et al. (2013) Ethanol alters alveolar fluid balance via Nadph oxidase (NOX) signaling to epithelial sodium channels (ENaC) in the lung. PLoS ONE 8(1):e54750.
    • (2013) PLoS ONE , vol.8 , Issue.1 , pp. e54750
    • Downs, C.A.1
  • 39
    • 0033614019 scopus 로고    scopus 로고
    • Mutational analysis of cysteine-rich domains of the epithelium sodium channel (ENaC). Identification of cysteines essential for channel expression at the cell surface
    • Firsov D, Robert-Nicoud M, Gruender S, Schild L, Rossier BC (1999) Mutational analysis of cysteine-rich domains of the epithelium sodium channel (ENaC). Identification of cysteines essential for channel expression at the cell surface. J Biol Chem 274(5): 2743-2749.
    • (1999) J Biol Chem , vol.274 , Issue.5 , pp. 2743-2749
    • Firsov, D.1    Robert-Nicoud, M.2    Gruender, S.3    Schild, L.4    Rossier, B.C.5
  • 40
    • 14844320055 scopus 로고    scopus 로고
    • Intracellular thiol-mediated modulation of epithelial sodium channel activity
    • Kellenberger S, Gautschi I, Pfister Y, Schild L (2005) Intracellular thiol-mediated modulation of epithelial sodium channel activity. J Biol Chem 280(9):7739-7747.
    • (2005) J Biol Chem , vol.280 , Issue.9 , pp. 7739-7747
    • Kellenberger, S.1    Gautschi, I.2    Pfister, Y.3    Schild, L.4
  • 41
    • 0033105864 scopus 로고    scopus 로고
    • Defective regulation of the epithelial Na+ channel by nedd4 in Liddle's syndrome
    • Abriel H, et al. (1999) Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome. J Clin Invest 103(5):667-673.
    • (1999) J Clin Invest , vol.103 , Issue.5 , pp. 667-673
    • Abriel, H.1
  • 42
    • 0037267232 scopus 로고    scopus 로고
    • The role of individual nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels
    • Fotia AB, et al. (2003) The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. FASEB J 17(1):70-72.
    • (2003) FASEB J , vol.17 , Issue.1 , pp. 70-72
    • Fotia, A.B.1
  • 43
    • 0035161876 scopus 로고    scopus 로고
    • A novel mouse nedd4 protein suppresses the activity of the epithelial Na+ channel
    • Kamynina E, Debonneville C, Bens M, Vandewalle A, Staub O (2001) A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel. FASEB J 15(1): 204-214.
    • (2001) FASEB J , vol.15 , Issue.1 , pp. 204-214
    • Kamynina, E.1    Debonneville, C.2    Bens, M.3    Vandewalle, A.4    Staub, O.5
  • 44
    • 0035958908 scopus 로고    scopus 로고
    • Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human nedd4
    • Snyder PM, Olson DR, McDonald FJ, Bucher DB (2001) Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4. J Biol Chem 276(30):28321-28326.
    • (2001) J Biol Chem , vol.276 , Issue.30 , pp. 28321-28326
    • Snyder, P.M.1    Olson, D.R.2    McDonald, F.J.3    Bucher, D.B.4
  • 45
    • 79955052957 scopus 로고    scopus 로고
    • Respiratory distress and perinatal lethality in nedd4-2-deficient mice
    • Boase NA, et al. (2011) Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nat Commun 2:287.
    • (2011) Nat Commun , vol.2 , pp. 287
    • Boase, N.A.1
  • 46
    • 79952764514 scopus 로고    scopus 로고
    • Deletion of the ubiquitin ligase nedd4l in lung epithelia causes cystic fibrosis-like disease
    • Kimura T, et al. (2011) Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease. Proc Natl Acad Sci USA 108(8):3216-3221.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.8 , pp. 3216-3221
    • Kimura, T.1
  • 47
    • 70350785179 scopus 로고    scopus 로고
    • Ubiquitin ligase nedd4l targets activated smad2/3 to limit TGFbeta signaling
    • Gao S, et al. (2009) Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGFbeta signaling. Mol Cell 36(3):457-468.
    • (2009) Mol Cell , vol.36 , Issue.3 , pp. 457-468
    • Gao, S.1
  • 48
    • 84984856193 scopus 로고    scopus 로고
    • Hypoxia-induced inhibition of ENaC in the lung: Role of nedd4-2 and the ubiquitin-proteasome pathway
    • in press
    • Gille T, et al. (2013) Hypoxia-induced inhibition of ENaC in the lung: Role of Nedd4-2 and the ubiquitin-proteasome pathway. Am J Respir Cell Mol Biol, in press.
    • (2013) Am J Respir Cell Mol Biol
    • Gille, T.1
  • 49
    • 0028942671 scopus 로고
    • Transforming growth factor-β1 circulates in normal human plasma and is unchanged in advanced metastatic breast cancer
    • Wakefield LM, et al. (1995) Transforming growth factor-β1 circulates in normal human plasma and is unchanged in advanced metastatic breast cancer. Clin Cancer Res 1(1):129-136.
    • (1995) Clin Cancer Res , vol.1 , Issue.1 , pp. 129-136
    • Wakefield, L.M.1
  • 50
    • 0141617559 scopus 로고    scopus 로고
    • Pleural fluid transforming growth factor-beta1 correlates with pleural fibrosis in experimental empyema
    • Sasse SA, Jadus MR, Kukes GD (2003) Pleural fluid transforming growth factor-beta1 correlates with pleural fibrosis in experimental empyema. Am J Respir Crit Care Med 168(6):700-705.
    • (2003) Am J Respir Crit Care Med , vol.168 , Issue.6 , pp. 700-705
    • Sasse, S.A.1    Jadus, M.R.2    Kukes, G.D.3
  • 51
    • 42949101343 scopus 로고    scopus 로고
    • Altered ENaC expression leads to impaired sodium absorption in the noninflamed intestine in Crohn's disease
    • Zeissig S, et al. (2008) Altered ENaC expression leads to impaired sodium absorption in the noninflamed intestine in Crohn's disease. Gastroenterology 134(5):1436-1447.
    • (2008) Gastroenterology , vol.134 , Issue.5 , pp. 1436-1447
    • Zeissig, S.1
  • 52
    • 0025314386 scopus 로고
    • Cellular basis for defective electrolyte transport in inflamed human colon
    • Sandle GI, et al. (1990) Cellular basis for defective electrolyte transport in inflamed human colon. Gastroenterology 99(1):97-105.
    • (1990) Gastroenterology , vol.99 , Issue.1 , pp. 97-105
    • Sandle, G.I.1
  • 53
    • 58149335369 scopus 로고    scopus 로고
    • Physiologic regulation of the epithelial sodium channel by phosphatidylinositides
    • Pochynyuk O, Bugaj V, Stockand JD (2008) Physiologic regulation of the epithelial sodium channel by phosphatidylinositides. Curr Opin Nephrol Hypertens 17(5): 533-540.
    • (2008) Curr Opin Nephrol Hypertens , vol.17 , Issue.5 , pp. 533-540
    • Pochynyuk, O.1    Bugaj, V.2    Stockand, J.D.3
  • 54
    • 64149083549 scopus 로고    scopus 로고
    • Activation of the epithelial sodium channel (ENaC) by serine proteases
    • Rossier BC, Stutts MJ (2009) Activation of the epithelial sodium channel (ENaC) by serine proteases. Annu Rev Physiol 71:361-379.
    • (2009) Annu Rev Physiol , vol.71 , pp. 361-379
    • Rossier, B.C.1    Stutts, M.J.2
  • 55
    • 54049130846 scopus 로고    scopus 로고
    • Mechanisms of ENaC regulation and clinical implications
    • Bhalla V, Hallows KR (2008) Mechanisms of ENaC regulation and clinical implications. J Am Soc Nephrol 19(10):1845-1854.
    • (2008) J Am Soc Nephrol , vol.19 , Issue.10 , pp. 1845-1854
    • Bhalla, V.1    Hallows, K.R.2
  • 57
    • 0029918734 scopus 로고    scopus 로고
    • Liddle disease caused by a missense mutation of β subunit of the epithelial sodium channel gene
    • Tamura H, et al. (1996) Liddle disease caused by a missense mutation of β subunit of the epithelial sodium channel gene. J Clin Invest 97(7):1780-1784.
    • (1996) J Clin Invest , vol.97 , Issue.7 , pp. 1780-1784
    • Tamura, H.1
  • 58
    • 0030731428 scopus 로고    scopus 로고
    • + channel (ENaC) by ubiquitination
    • + channel (ENaC) by ubiquitination. EMBO J 16(21):6325-6336.
    • (1997) EMBO J , vol.16 , Issue.21 , pp. 6325-6336
    • Staub, O.1
  • 59
    • 0026744154 scopus 로고
    • Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase
    • Moritz A, De Graan PN, Gispen WH, Wirtz KW (1992) Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase. J Biol Chem 267(11):7207-7210.
    • (1992) J Biol Chem , vol.267 , Issue.11 , pp. 7207-7210
    • Moritz, A.1    De Graan, P.N.2    Gispen, W.H.3    Wirtz, K.W.4
  • 60
    • 57349116981 scopus 로고    scopus 로고
    • Phosphatidylinositol (4,5)-bisphosphate modulates nox5 localization via an N-terminal polybasic region
    • Kawahara T, Lambeth JD (2008) Phosphatidylinositol (4,5)-bisphosphate modulates Nox5 localization via an N-terminal polybasic region. Mol Biol Cell 19(10):4020-4031.
    • (2008) Mol Biol Cell , vol.19 , Issue.10 , pp. 4020-4031
    • Kawahara, T.1    Lambeth, J.D.2
  • 61
    • 33846794822 scopus 로고    scopus 로고
    • The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
    • Bedard K, Krause KH (2007) The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology. Physiol Rev 87(1):245-313.
    • (2007) Physiol Rev , vol.87 , Issue.1 , pp. 245-313
    • Bedard, K.1    Krause, K.H.2
  • 62
    • 0036833387 scopus 로고    scopus 로고
    • Acute lung injury in experimental pancreatitis in rats: Pulmonary protective effects of crotapotin and N-acetylcysteine
    • Leme AS, Lichtenstein A, Arantes-Costa FM, Landucci EC, Martins MA (2002) Acute lung injury in experimental pancreatitis in rats: Pulmonary protective effects of crotapotin and N-acetylcysteine. Shock 18(5):428-433.
    • (2002) Shock , vol.18 , Issue.5 , pp. 428-433
    • Leme, A.S.1    Lichtenstein, A.2    Arantes-Costa, F.M.3    Landucci, E.C.4    Martins, M.A.5
  • 63
    • 0029680965 scopus 로고    scopus 로고
    • Role of oxidant stress in the adult respiratory distress syndrome: Evaluation of a novel antioxidant strategy in a porcine model of endotoxin-induced acute lung injury
    • Gonzalez PK, et al. (1996) Role of oxidant stress in the adult respiratory distress syndrome: Evaluation of a novel antioxidant strategy in a porcine model of endotoxin-induced acute lung injury. Shock 6(Suppl 1):S23-S26.
    • (1996) Shock , vol.6 , pp. S23-S26
    • Gonzalez, P.K.1
  • 64
    • 37149042709 scopus 로고    scopus 로고
    • ENaC alpha-subunit variants are expressed in lung epithelial cells and are suppressed by oxidative stress
    • Xu H, Chu S (2007) ENaC alpha-subunit variants are expressed in lung epithelial cells and are suppressed by oxidative stress. Am J Physiol Lung Cell Mol Physiol 293(6): L1454-L1462.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.293 , Issue.6 , pp. L1454-L1462
    • Xu, H.1    Chu, S.2
  • 67
    • 3242712276 scopus 로고    scopus 로고
    • Redox signaling: Thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers
    • Forman HJ, Fukuto JM, Torres M (2004) Redox signaling: Thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers. Am J Physiol Cell Physiol 287(2):C246-C256.
    • (2004) Am J Physiol Cell Physiol , vol.287 , Issue.2 , pp. C246-C256
    • Forman, H.J.1    Fukuto, J.M.2    Torres, M.3
  • 68
    • 79957518453 scopus 로고    scopus 로고
    • A key role for NOX4 in epithelial cell death during development of lung fibrosis
    • Carnesecchi S, et al. (2011) A key role for NOX4 in epithelial cell death during development of lung fibrosis. Antioxid Redox Signal 15(3):607-619.
    • (2011) Antioxid Redox Signal , vol.15 , Issue.3 , pp. 607-619
    • Carnesecchi, S.1
  • 69
    • 0035148871 scopus 로고    scopus 로고
    • Alteration of fatty acid profiles in different pulmonary surfactant phospholipids in acute respiratory distress syndrome and severe pneumonia
    • Schmidt R, et al. (2001) Alteration of fatty acid profiles in different pulmonary surfactant phospholipids in acute respiratory distress syndrome and severe pneumonia. Am J Respir Crit Care Med 163(1):95-100.
    • (2001) Am J Respir Crit Care Med , vol.163 , Issue.1 , pp. 95-100
    • Schmidt, R.1
  • 70
    • 15944371874 scopus 로고    scopus 로고
    • Oleic acid inhibits alveolar fluid reabsorption: A role in acute respiratory distress syndrome?
    • Vadász I, et al. (2005) Oleic acid inhibits alveolar fluid reabsorption: A role in acute respiratory distress syndrome? Am J Respir Crit Care Med 171(5):469-479.
    • (2005) Am J Respir Crit Care Med , vol.171 , Issue.5 , pp. 469-479
    • Vadász, I.1
  • 71
    • 26244432616 scopus 로고    scopus 로고
    • Thrombin impairs alveolar fluid clearance by promoting endocytosis of Na+,K+-ATPase
    • Vadász I, et al. (2005) Thrombin impairs alveolar fluid clearance by promoting endocytosis of Na+,K+-ATPase. Am J Respir Cell Mol Biol 33(4):343-354.
    • (2005) Am J Respir Cell Mol Biol , vol.33 , Issue.4 , pp. 343-354
    • Vadász, I.1
  • 72
    • 4444321508 scopus 로고    scopus 로고
    • Elastase mediates the release of growth factors from lung in vivo
    • Buczek-Thomas JA, et al. (2004) Elastase mediates the release of growth factors from lung in vivo. Am J Respir Cell Mol Biol 31(3):344-350.
    • (2004) Am J Respir Cell Mol Biol , vol.31 , Issue.3 , pp. 344-350
    • Buczek-Thomas, J.A.1
  • 73
    • 71949128382 scopus 로고    scopus 로고
    • Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1
    • Zhou G, et al. (2009) Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1. Am J Physiol Lung Cell Mol Physiol 297(6):L1120-L1130.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297 , Issue.6 , pp. L1120-L1130
    • Zhou, G.1


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