-
2
-
-
84883705437
-
Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance
-
Kumashiro N, Beddow SA, Vatner DF, et al. Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance. Diabetes 2013;62:2183-2194
-
(2013)
Diabetes
, vol.62
, pp. 2183-2194
-
-
Kumashiro, N.1
Beddow, S.A.2
Vatner, D.F.3
-
3
-
-
84930589309
-
Acetyl coenzyme A: A central metabolite and second messenger
-
Pietrocola F, Galluzzi L, Bravo-San Pedro JM, Madeo F, Kroemer G. Acetyl coenzyme A: A central metabolite and second messenger. Cell Metab 2015;21:805-821
-
(2015)
Cell Metab
, vol.21
, pp. 805-821
-
-
Pietrocola, F.1
Galluzzi, L.2
Bravo-San Pedro, J.M.3
Madeo, F.4
Kroemer, G.5
-
4
-
-
84922709227
-
Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes
-
Perry RJ, Camporez JP, Kursawe R, et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell 2015; 160:745-758
-
(2015)
Cell
, vol.160
, pp. 745-758
-
-
Perry, R.J.1
Camporez, J.P.2
Kursawe, R.3
-
6
-
-
32244447570
-
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
-
Zhang Y, Lee FY, Barrera G, et al. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci U S A 2006;103:1006-1011
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 1006-1011
-
-
Zhang, Y.1
Lee, F.Y.2
Barrera, G.3
-
7
-
-
84873342775
-
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist
-
Sayin SI, Wahlström A, Felin J, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab 2013;17:225-235
-
(2013)
Cell Metab
, vol.17
, pp. 225-235
-
-
Sayin, S.I.1
Wahlström, A.2
Felin, J.3
-
8
-
-
84887960056
-
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
-
Li F, Jiang C, Krausz KW, et al. Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity. Nat Commun 2013;4:2384
-
(2013)
Nat Commun
, vol.4
, pp. 2384
-
-
Li, F.1
Jiang, C.2
Krausz, K.W.3
-
9
-
-
84920401295
-
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
-
Jiang C, Xie C, Li F, et al. Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. J Clin Invest 2015;125:386-402
-
(2015)
J Clin Invest
, vol.125
, pp. 386-402
-
-
Jiang, C.1
Xie, C.2
Li, F.3
-
10
-
-
84897621880
-
Discovery of bile salt hydrolase inhibitors using an efficient high-Throughput screening system
-
Smith K, Zeng X, Lin J. Discovery of bile salt hydrolase inhibitors using an efficient high-Throughput screening system. PLoS One 2014;9:e85344
-
(2014)
PLoS One
, vol.9
, pp. e85344
-
-
Smith, K.1
Zeng, X.2
Lin, J.3
-
11
-
-
37249015421
-
Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
-
Kim I, Ahn SH, Inagaki T, et al. Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J Lipid Res 2007; 48:2664-2672
-
(2007)
J Lipid Res
, vol.48
, pp. 2664-2672
-
-
Kim, I.1
Ahn, S.H.2
Inagaki, T.3
-
12
-
-
84867888478
-
Caffeic acid phenethyl ester reduces the activation of the nuclear factor kB pathway by high-fat diet-induced obesity in mice
-
Bezerra RM, Veiga LF, Caetano AC, et al. Caffeic acid phenethyl ester reduces the activation of the nuclear factor kB pathway by high-fat diet-induced obesity in mice. Metabolism 2012;61:1606-1614
-
(2012)
Metabolism
, vol.61
, pp. 1606-1614
-
-
Bezerra, R.M.1
Veiga, L.F.2
Caetano, A.C.3
-
13
-
-
80053406579
-
Inflammation is necessary for long-Term but not short-Term high-fat diet-induced insulin resistance
-
Lee YS, Li P, Huh JY, et al. Inflammation is necessary for long-Term but not short-Term high-fat diet-induced insulin resistance. Diabetes 2011;60:2474-2483
-
(2011)
Diabetes
, vol.60
, pp. 2474-2483
-
-
Lee, Y.S.1
Li, P.2
Huh, J.Y.3
-
14
-
-
84925581335
-
Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity
-
Arruda AP, Pers BM, Parlakgöl G, Göney E, Inouye K, Hotamisligil GS. Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Nat Med 2014;20:1427-1435
-
(2014)
Nat Med
, vol.20
, pp. 1427-1435
-
-
Arruda, A.P.1
Pers, B.M.2
Parlakgöl, G.3
Göney, E.4
Inouye, K.5
Hotamisligil, G.S.6
-
15
-
-
84899482356
-
Glucose-lowering effects of intestinal bile acid sequestration through enhancement of splanchnic glucose utilization
-
Prawitt J, Caron S, Staels B. Glucose-lowering effects of intestinal bile acid sequestration through enhancement of splanchnic glucose utilization. Trends Endocrinol Metab 2014;25:235-244
-
(2014)
Trends Endocrinol Metab
, vol.25
, pp. 235-244
-
-
Prawitt, J.1
Caron, S.2
Staels, B.3
-
16
-
-
84949932843
-
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
-
Jiang C, Xie C, Lv Y, et al. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat Commun 2015;6:10166
-
(2015)
Nat Commun
, vol.6
, pp. 10166
-
-
Jiang, C.1
Xie, C.2
Lv, Y.3
-
17
-
-
33645509321
-
Farnesoid X receptor is essential for normal glucose homeostasis
-
Ma K, Saha PK, Chan L, Moore DD. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest 2006;116:1102-1109
-
(2006)
J Clin Invest
, vol.116
, pp. 1102-1109
-
-
Ma, K.1
Saha, P.K.2
Chan, L.3
Moore, D.D.4
-
18
-
-
33645531297
-
The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice
-
Cariou B, van Harmelen K, Duran-Sandoval D, et al. The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. J Biol Chem 2006;281:11039-11049
-
(2006)
J Biol Chem
, vol.281
, pp. 11039-11049
-
-
Cariou, B.1
Van Harmelen, K.2
Duran-Sandoval, D.3
-
19
-
-
77950613528
-
FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats
-
Cipriani S, Mencarelli A, Palladino G, Fiorucci S. FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats. J Lipid Res 2010;51:771-784
-
(2010)
J Lipid Res
, vol.51
, pp. 771-784
-
-
Cipriani, S.1
Mencarelli, A.2
Palladino, G.3
Fiorucci, S.4
-
20
-
-
84880664792
-
Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
-
Mudaliar S, Henry RR, Sanyal AJ, et al. Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology 2013;145:574.e1-582.e1
-
(2013)
Gastroenterology
, vol.145
, pp. 574e1-582e1
-
-
Mudaliar, S.1
Henry, R.R.2
Sanyal, A.J.3
-
21
-
-
84929266699
-
Farnesoid X nuclear receptor ligand obeticholic acid for noncirrhotic non-Alcoholic steatohepatitis (FLINT): A multicentre randomised placebo-controlled trial
-
NASH Clinical Research Network
-
Neuschwander-Tetri BA, Loomba R, Sanyal AJ, et al.; NASH Clinical Research Network. Farnesoid X nuclear receptor ligand obeticholic acid for noncirrhotic, non-Alcoholic steatohepatitis (FLINT): A multicentre, randomised, placebo-controlled trial. Lancet 2015;385:956-965
-
(2015)
Lancet
, vol.385
, pp. 956-965
-
-
Neuschwander-Tetri, B.A.1
Loomba, R.2
Sanyal, A.J.3
-
22
-
-
79960695556
-
Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure
-
Watanabe M, Horai Y, Houten SM, et al. Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. J Biol Chem 2011;286:26913-26920
-
(2011)
J Biol Chem
, vol.286
, pp. 26913-26920
-
-
Watanabe, M.1
Horai, Y.2
Houten, S.M.3
-
23
-
-
84937675715
-
Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery
-
Flynn CR, Albaugh VL, Cai S, et al. Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery. Nat Commun 2015;6:7715
-
(2015)
Nat Commun
, vol.6
, pp. 7715
-
-
Flynn, C.R.1
Albaugh, V.L.2
Cai, S.3
-
24
-
-
0034664729
-
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
-
Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, Gonzalez FJ. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 2000;102:731-744
-
(2000)
Cell
, vol.102
, pp. 731-744
-
-
Sinal, C.J.1
Tohkin, M.2
Miyata, M.3
Ward, J.M.4
Lambert, G.5
Gonzalez, F.J.6
-
25
-
-
84946088116
-
Farnesoid X receptor inhibits glucagonlike peptide-1 production by enteroendocrine L cells
-
Trabelsi MS, Daoudi M, Prawitt J, et al. Farnesoid X receptor inhibits glucagonlike peptide-1 production by enteroendocrine L cells. Nat Commun 2015;6:7629
-
(2015)
Nat Commun
, vol.6
, pp. 7629
-
-
Trabelsi, M.S.1
Daoudi, M.2
Prawitt, J.3
-
26
-
-
80555124939
-
Ceramides as modulators of cellular and wholebody metabolism
-
Bikman BT, Summers SA. Ceramides as modulators of cellular and wholebody metabolism. J Clin Invest 2011;121:4222-4230
-
(2011)
J Clin Invest
, vol.121
, pp. 4222-4230
-
-
Bikman, B.T.1
Summers, S.A.2
-
27
-
-
84907978697
-
Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance
-
Turpin SM, Nicholls HT, Willmes DM, et al. Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab 2014;20:678-686
-
(2014)
Cell Metab
, vol.20
, pp. 678-686
-
-
Turpin, S.M.1
Nicholls, H.T.2
Willmes, D.M.3
-
28
-
-
84907984591
-
CerS2 haploinsufficiency inhibits b-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance [published correction appears in Cell Metab 2014;20:919]
-
Raichur S, Wang ST, Chan PW, et al. CerS2 haploinsufficiency inhibits b-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. [published correction appears in Cell Metab 2014;20:919]. Cell Metab 2014;20:687-695
-
(2014)
Cell Metab
, vol.20
, pp. 687-695
-
-
Raichur, S.1
Wang, S.T.2
Chan, P.W.3
-
29
-
-
84938569966
-
Targeted induction of ceramide degradation leads to improved systemic metabolism and reduced hepatic steatosis
-
Xia JY, Holland WL, Kusminski CM, et al. Targeted induction of ceramide degradation leads to improved systemic metabolism and reduced hepatic steatosis. Cell Metab 2015;22:266-278
-
(2015)
Cell Metab
, vol.22
, pp. 266-278
-
-
Xia, J.Y.1
Holland, W.L.2
Kusminski, C.M.3
-
30
-
-
84860482342
-
A ceramide-centric view of insulin resistance
-
Chavez JA, Summers SA. A ceramide-centric view of insulin resistance. Cell Metab 2012;15:585-594
-
(2012)
Cell Metab
, vol.15
, pp. 585-594
-
-
Chavez, J.A.1
Summers, S.A.2
-
31
-
-
84864396455
-
Roles of ceramide and sphingolipids in pancreatic b-cell function and dysfunction
-
Boslem E, Meikle PJ, Biden TJ. Roles of ceramide and sphingolipids in pancreatic b-cell function and dysfunction. Islets 2012;4:177-187
-
(2012)
Islets
, vol.4
, pp. 177-187
-
-
Boslem, E.1
Meikle, P.J.2
Biden, T.J.3
-
32
-
-
84907970671
-
Central ceramideinduced hypothalamic lipotoxicity and ER stress regulate energy balance
-
Contreras C, González-García I, Martínez-Sánchez N, et al. Central ceramideinduced hypothalamic lipotoxicity and ER stress regulate energy balance. Cell Reports 2014;9:366-377
-
(2014)
Cell Reports
, vol.9
, pp. 366-377
-
-
Contreras, C.1
González-García, I.2
Martínez-Sánchez, N.3
-
33
-
-
26044480175
-
Calcium overload increases oxidative stress in old rat gastrocnemius muscle
-
Capel F, Demaison L, Maskouri F, et al. Calcium overload increases oxidative stress in old rat gastrocnemius muscle. J Physiol Pharmacol 2005;56:369-380
-
(2005)
J Physiol Pharmacol
, vol.56
, pp. 369-380
-
-
Capel, F.1
Demaison, L.2
Maskouri, F.3
-
34
-
-
85006765148
-
Farnesoid X receptor signaling shapes the gut microbiota and controls hepatic lipid metabolism
-
Zhang L, Xie C, Nichols RG, et al. Farnesoid X receptor signaling shapes the gut microbiota and controls hepatic lipid metabolism. mSystems 2016; 1:e00070-16
-
(2016)
MSystems
, vol.1
, pp. e00070-16
-
-
Zhang, L.1
Xie, C.2
Nichols, R.G.3
-
35
-
-
84982957860
-
Caffeic acid phenethyl ester: A review of its antioxidant activity, protective effects against ischemia-reperfusion injury and drug adverse reactions
-
Tolba MF, Omar HA, Azab SS, Khalifa AE, Abdel-Naim AB, Abdel-Rahman SZ. Caffeic acid phenethyl ester: A review of its antioxidant activity, protective effects against ischemia-reperfusion injury and drug adverse reactions. Crit Rev Food Sci Nutr 2016;56:2183-2190
-
(2016)
Crit Rev Food Sci Nutr
, vol.56
, pp. 2183-2190
-
-
Tolba, M.F.1
Omar, H.A.2
Azab, S.S.3
Khalifa, A.E.4
Abdel-Naim, A.B.5
Abdel-Rahman, S.Z.6
-
36
-
-
84902169175
-
Caffeic acid phenethyl ester and therapeutic potentials
-
Murtaza G, Karim S, Akram MR, et al. Caffeic acid phenethyl ester and therapeutic potentials. Biomed Res Int 2014;2014:145342
-
(2014)
Biomed Res Int
, vol.2014
, pp. 145342
-
-
Murtaza, G.1
Karim, S.2
Akram, M.R.3
-
37
-
-
84903648273
-
Caffeic acid phenethyl ester as a protective agent against nephrotoxicity and/or oxidative kidney damage: A detailed systematic review
-
Akyol S, Ugurcu V, Altuntas A, Hasgul R, Cakmak O, Akyol O. Caffeic acid phenethyl ester as a protective agent against nephrotoxicity and/or oxidative kidney damage: A detailed systematic review. Scientific World Journal 2014; 2014:561971
-
(2014)
Scientific World Journal
, vol.2014
, pp. 561971
-
-
Akyol, S.1
Ugurcu, V.2
Altuntas, A.3
Hasgul, R.4
Cakmak, O.5
Akyol, O.6
-
38
-
-
84994876898
-
An intestinal microbiota-farnesoid x receptor axis modulates metabolic disease
-
Gonzalez FJ, Jiang C, Patterson AD. An intestinal microbiota-farnesoid x receptor axis modulates metabolic disease. Gastroenterology 2016;151:845-859
-
(2016)
Gastroenterology
, vol.151
, pp. 845-859
-
-
Gonzalez, F.J.1
Jiang, C.2
Patterson, A.D.3
-
39
-
-
84925507991
-
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
-
Fang S, Suh JM, Reilly SM, et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med 2015;21: 159-165
-
(2015)
Nat Med
, vol.21
, pp. 159-165
-
-
Fang, S.1
Suh, J.M.2
Reilly, S.M.3
|