Alogliptin, a dipeptidyl peptidase-4 inhibitor, alleviates atrial remodeling and improves mitochondrial function and biogenesis in diabetic rabbits

Journal of the American Heart Association

Volumn 6, Issue 5, 2017, Pages

  Zhang, Xiaowei ^a   Zhang, Zhiwei ^a   Zhao, Yungang ^b   Jiang, Ning ^b   Qiu, Jiuchun ^a   Yang, Yajuan ^a   Li, Jian ^a   Liang, Xue ^a   Wang, Xinghua ^a   Tse, Gary ^c   Li, Guangping ^a   Liu, Tong ^a  

^a SECOND HOSPITAL OF TIANJIN MEDICAL UNIVERSITY   (China)

^b TIANJIN UNIVERSITY OF SPORT   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Atrial fibrillation; Dipeptidyl peptidase 4 inhibitors; Mitochondrial biogenesis; Mitochondrial function

Indexed keywords

ADIPONECTIN; ALLOXAN; ALOGLIPTIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCAGON LIKE PEPTIDE 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; MITOCHONDRIAL PROTEIN; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR A; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; PIPERIDINE DERIVATIVE; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR RELA; URACIL;

ALLOXAN-INDUCED DIABETES MELLITUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATRIAL FIBRILLATION; CONTROLLED STUDY; DIABETES MELLITUS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG MECHANISM; ECHOCARDIOGRAPHY; ENZYME REGULATION; HEART ATRIUM ENLARGEMENT; HEART ATRIUM REMODELING; HEART ELECTROPHYSIOLOGY; HEART HEMODYNAMICS; HEART LEFT VENTRICLE HYPERTROPHY; IN VIVO STUDY; INFLAMMATION; ISOLATED HEART; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL BIOGENESIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION SWELLING; NONHUMAN; ORYCTOLAGUS CUNICULUS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TREATMENT DURATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; FIBROSIS; GENETICS; HEART ATRIUM; HEART MITOCHONDRION; HEART RATE; HEART VENTRICLE FUNCTION; LEPORIDAE; METABOLISM; ORGANELLE BIOGENESIS; PATHOLOGY; PATHOPHYSIOLOGY; TIME FACTOR;

ANIMALS; ATRIAL FIBRILLATION; ATRIAL REMODELING; DIABETES MELLITUS, EXPERIMENTAL; DIPEPTIDYL-PEPTIDASE IV INHIBITORS; FIBROSIS; HEART ATRIA; HEART RATE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, HEART; NF-E2-RELATED FACTOR 1; ORGANELLE BIOGENESIS; OXIDATIVE STRESS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; PIPERIDINES; RABBITS; TIME FACTORS; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA1; URACIL; VENTRICULAR FUNCTION;

EID: 85019378087     PISSN: None     EISSN: 20479980     Source Type: Journal    
DOI: 10.1161/JAHA.117.005945     Document Type: Article

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