Mitochondrial dysfunction as an arrhythmogenic substrate: A translational proof-of-concept study in patients with metabolic syndrome in whom post-operative atrial fibrillation develops

Journal of the American College of Cardiology

Volumn 62, Issue 16, 2013, Pages 1466-1473

  Montaigne, David ^a,b   Marechal, Xavier ^a   Lefebvre, Philippe ^a   Modine, Thomas ^b   Fayad, Georges ^b   Dehondt, Helene ^a   Hurt, Christopher ^a   Coisne, Augustin ^a,b   Koussa, Mohamed ^b   Remy Jouet, Isabelle ^c   Zerimech, Farid ^b   Boulanger, Eric ^a   Lacroix, Dominique ^b   Staels, Bart ^a   Neviere, Remi ^a  

^a UNIV LILLE   (France)

^b LILLE UNIVERSITY HOSPITAL   (France)

^c UNIVERSITY OF ROUEN   (France)

Author keywords

atrial fibrillation cardiac surgery diabetes gene expression mitochondria

Indexed keywords

ADENOSINE DIPHOSPHATE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PALMITOYLCARNITINE;

ADULT; AGED; ARTICLE; BODY MASS; CAUSAL ATTRIBUTION; CORONARY ARTERY BYPASS GRAFT; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; DRUG USE; FEMALE; GENE CLUSTER; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; HEART ARRHYTHMIA; HEART ATRIUM; HEART ATRIUM FIBRILLATION; HEART RATE; HEART SURGERY; HIGH RISK POPULATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL RESPIRATION; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; POSTOPERATIVE ATRIAL FIBRILLATION; POSTOPERATIVE COMPLICATION; PREOPERATIVE PERIOD; PRIORITY JOURNAL; SINUS RHYTHM; UPREGULATION;

ADENOSINE DIPHOSPHATE; ADENOSINE DIPHOSPHATE-STIMULATED RESPIRATION SUPPORTED BY PALMITOYL-L-CARNITINE; ADENOSINE TRIPHOSPHATE; ADP; AF; ATP; ATRIAL FIBRILLATION; BMI; BODY MASS INDEX; CABG; CARDIAC SURGERY; COMPLEX IV-RELATED UNCOUPLED MAXIMUM RESPIRATION; CORONARY ARTERY BYPASS GRAFT; DIABETES; GENE EXPRESSION; MANGANESE SUPEROXIDE DISMUTASE; MCRC; MITOCHONDRIA; MITOCHONDRIAL CALCIUM RETENTION CAPACITY; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MNSOD; MPTP; OXIDATIVE PHOSPHORYLATION; OXPHOS; POAF; POST-OPERATIVE ATRIAL FIBRILLATION; REACTIVE OXYGEN SPECIES; ROS; SINUS RHYTHM; SR; V(COX); V(PALM+ADP);

AGED; ATRIAL FIBRILLATION; CORONARY ARTERY BYPASS; FEMALE; HEART ATRIA; HUMANS; LOGISTIC MODELS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MITOCHONDRIA, HEART; OXIDATIVE STRESS; POSTOPERATIVE COMPLICATIONS; PREOPERATIVE CARE; PROSPECTIVE STUDIES; RISK FACTORS; TRANSLATIONAL MEDICAL RESEARCH; TREATMENT OUTCOME;

EID: 84885436693     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.03.061     Document Type: Article

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