Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α

Arthritis and Rheumatology

Volumn 67, Issue 8, 2015, Pages 2141-2153

  Wang, Yun ^a   Zhao, Xianling ^b   Lotz, Martin ^c   Terkeltaub, Robert ^c   Liu Bryan, Ru ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; COLLAGENASE 3; CORE PROTEIN; GA BINDING PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTERLEUKIN 1BETA; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTIONAL FACTOR A PROTEIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; SIRTUIN 1; STROMELYSIN; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; HIGH MOBILITY GROUP PROTEIN; MITOCHONDRIAL PROTEIN; NUCLEAR RESPIRATORY FACTOR; PPARGC1A PROTEIN, HUMAN; PPARGC1A PROTEIN, MOUSE; SIRT1 PROTEIN, HUMAN; SIRT1 PROTEIN, MOUSE; TFAM PROTEIN, HUMAN; TFAM PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOGENESIS; CARTILAGE CELL; CELL AGING; CLINICAL ASSESSMENT; COMPARATIVE STUDY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; KNEE MENISCUS; MITOCHONDRIAL BIOGENESIS IMPAIRMENT; MOUSE; NONHUMAN; OSTEOARTHRITIS; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANIMAL; ARTICULAR CARTILAGE; CYTOLOGY; KNEE; KNEE OSTEOARTHRITIS; METABOLISM; MITOCHONDRION; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CARTILAGE, ARTICULAR; CHONDROCYTES; DNA-BINDING PROTEINS; HIGH MOBILITY GROUP PROTEINS; HUMANS; KNEE JOINT; MICE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NUCLEAR RESPIRATORY FACTORS; OSTEOARTHRITIS, KNEE; OXIDATIVE PHOSPHORYLATION; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SIRTUIN 1; TRANSCRIPTION FACTORS;

EID: 84938064270     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.39182     Document Type: Article

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