Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK- PGC-1α signaling contributing to increased vulnerability in diabetic heart

Basic Research in Cardiology

Volumn 108, Issue 3, 2013, Pages

  Yan, Wenjun ^a   Zhang, Haifeng ^a   Liu, Peilin ^a   Wang, Han ^a   Liu, Jingyi ^a   Gao, Chao ^a   Liu, Yi ^a   Lian, Kun ^a   Yang, Lu ^a   Sun, Lu ^a   Guo, Yunping ^a   Zhang, Lijian ^a   Dong, Ling ^b   Lau, Wayne Bond ^c   Gao, Erhe ^c   Gao, Feng ^b   Xiong, Lize ^a   Wang, Haichang ^a   Qu, Yan ^a   Tao, Ling ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Adiponectin; AMPK; Diabetes; Mitochondrial biogenesis dysfunction; Myocardial ischemia; PGC 1

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; ADENYLATE KINASE INHIBITOR; ADIPONECTIN; CITRATE SYNTHASE; CYTOCHROME C OXIDASE; ENZYME INHIBITOR; FAT; GLUCOSE; MESSENGER RNA; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF1; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; DISEASE EXACERBATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA CONTENT; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE SILENCING; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HYPOADIPONECTINEMIA; IMPAIRED MITOCHONDRIAL BIOGENESIS; MALE; MITOCHONDRION; MITOCHONDRION SWELLING; MOUSE; MOUSE STRAIN; NONHUMAN; PROTEIN BLOOD LEVEL; REOXYGENATION; SIGNAL TRANSDUCTION; SURVIVAL RATE;

EID: 84874397857     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-013-0329-1     Document Type: Article

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