A single supplement of a standardised bilberry (Vaccinium myrtillus L.) extract (36 % wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes controlled by diet and lifestyle

Journal of Nutritional Science

Volumn 2, Issue , 2013, Pages 1-9

  Hoggard, Nigel ^a   Cruickshank, Morven ^a   Moar, Kim Marie ^a   Bestwick, Charles ^a   Holst, Jens J ^b   Russell, Wendy ^a   Horgan, Graham ^c  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c BIOMATHEMATICS AND STATISTICS SCOTLAND   (United Kingdom)

Author keywords

Anthocyanins; Bilberries; Glycaemic response; Type 2 diabetes

Indexed keywords

EID: 85019295844     PISSN: 20486790     EISSN: None     Source Type: Journal    
DOI: 10.1017/jns.2013.16     Document Type: Article

References (46)

1. Ceriello A & Testa R (2009) Antioxidant anti-inflammatory treatment in type 2 diabetes. Diabetes Care 32, Suppl. 2, S232-S236.
2. Zafra-Stone S, Yasmin T, Bagchi M, et al. (2007) Berry anthocyanins as novel antioxidants in human health and disease prevention. Mol Nutr Food Res 51, 675-683.
3. Tsuda T (2008) Regulation of adipocyte function by anthocyanins; possibility of preventing the metabolic syndrome. J Agric Food Chem 56, 642-646.
4. Neto CC (2007) Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases. Mol Nutr Food Res 51, 652-664.
5. Basu A, Du M, Leyva MJ, et al. (2010) Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutr 140, 1582-1587.
6. Stull AJ, Cash KC, Johnson WD, et al. (2010) Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women. J Nutr 140, 1764-1768.
7. Karlsen A, Paur I, Bøhn SK, et al. (2010) Bilberry juice modulates plasma concentration of NF-κB related inflammatory markers in subjects at increased risk of CVD. Eur J Nutr 49, 345-355.
8. Prior RL, Wilkes SE, Rogers TR, et al. (2010) Purified blueberry anthocyanins and blueberry juice alter development of obesity in mice fed an obesogenic high-fat diet. J Agric Food Chem 58, 3970-3976.
9. DeFuria J, Bennett G, Strissel KJ, et al. (2009) Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae. J Nutr 139, 1510-1516.
10. Prior RL, Wu X, Gu L, et al. (2008) Whole berries versus berry anthocyanins: interactions with dietary fat levels in the C57BL/6J mouse model of obesity. J Agric Food Chem 56, 647-653.
11. Guo H, Li D, Ling W, et al. (2011) Anthocyanin inhibits high glucose-induced hepatic mtGPAT1 activation and prevents fatty acid synthesis through PKCζ. J Lipid Res 52, 908-922.
12. Jayaprakasam B, Olson LK, Schutzki RE, et al. (2006) Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). J Agric Food Chem 54, 243-248.
13. Welsch CA, Lachance PA & Wasserman BP (1989) Dietary phenolic compounds: inhibition of Na+-dependent D-glucose uptake in rat intestinal brush border membrane vesicles. J Nutr 119, 1698-1704.
14. Matsui T, Tanaka T, Tamura S, et al. (2007) α-Glucosidase inhibitory profile of catechins and theaflavins. J Agric Food Chem 55, 99-105.
15. Hanamura T (2006) Antihyperglycemic effect of polyphenols from acerola (Malpighia emarginata DC.) fruit. Biosci Biotechnol Biochem 70, 1813-1820.
16. Hanamura T, Hagiwara T & Kawagishi H (2005) Structural and functional characterization of polyphenols isolated from acerola (Malpighia emarginata DC.) fruit. Biosci Biotechnol Biochem 69, 280-286.
17. Iwai K, Kim M, Onodera A, et al. (2006) α-Glucosidase inhibitory and antihyperglycemic effects of polyphenols in the fruit of Viburnum dilatatum Thunb. J Agric Food Chem 54, 4588-4592.
18. Kobayashi Y, Suzuki M, Satsu H, et al. (2000) Green tea polyphenols inhibit the sodium-dependent glucose transporter of intestinal epithelial cells by a competitive mechanism. J Agric Food Chem 48, 5618-5623.
19. Song J, Kwon O, Chen S, et al. (2002) Flavonoid inhibition of sodium-dependent vitamin C transporter 1 (SVCT1) and glucose transporter isoform 2 (GLUT2), intestinal transporters for vitamin C and glucose. J Biol Chem 277, 15252-15260.
20. Cermak R, Landgraf S & Wolffram S (2004) Quercetin glucosides inhibit glucose uptake into brush-border-membrane vesicles of porcine jejunum. Br J Nutr 91, 849-855.
21. Johnston K, Sharp P, Clifford M, et al. (2005) Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells. FEBS Lett 579, 1653-1657.
22. Matsui T, Ebuchi S, Kobayashi M, et al. (2002) Anti-hyperglycemic effect of diacylated anthocyanin derived from Ipomoea batatas cultivar Ayamurasaki can be achieved through the α-glucosidase inhibitory action. J Agric Food Chem 50, 7244-7248.
23. Törrönen R, Sarkkinen E, Tapola N, et al. (2010) Berries modify the postprandial plasma glucose response to sucrose in healthy subjects. Br J Nutr 103, 1094-1097.
24. Wilson T, Singh AP, Vorsa N, et al. (2008) Human glycemic response and phenolic content of unsweetened cranberry juice. J Med Food 11, 46-54.
25. Orskov C, Rabenhoj L, Wettergren A, et al. (1994) Tissue and plasma concentrations of amidated and glycine-extended glucagonlike peptide I in humans. Diabetes 43, 535-539.
26. Benzie IF & Strain JJ (1996) The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem 239, 70-76.
27. Dragsted LO, Pedersen A, Hermetter A, et al. (2004) The 6-a-day study: effects of fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy nonsmokers. Am J Clin Nutr 79, 1060-1072.
28. Törrönen R, Kolehmainen M, Sarkkinen E, et al. (2012) Postprandial glucose, insulin, and free fatty acid responses to sucrose consumed with blackcurrants and lingonberries in healthy women. Am J Clin Nutr 96, 527-533.
29. Johnston KL, Clifford MN & Morgan LM (2002) Possible role for apple juice phenolic compounds in the acute modification of glucose tolerance and gastrointestinal hormone secretion in humans. J Sci Food Agric 82, 1800-1805.
30. Törrönen R, Sarkkinen E, Niskanen T, et al. (2012) Postprandial glucose, insulin and glucagon-like peptide 1 responses to sucrose ingested with berries in healthy subjects. Br J Nutr 107, 1445-1451.
31. Panee J (2012) Monocyte chemoattractant protein 1 (MCP-1) in obesity and diabetes. Cytokine 60, 1-12.
32. Adisakwattana S, Ngamrojanavanich N, Kalampakorn K, et al. (2004) Inhibitory activity of cyanidin-3-rutinoside on α-glucosidase. J Enzyme Inhib Med Chem 19, 313-316.
33. Akkarachiyasit S, Yibchok-Anun S, Wacharasindhu S, et al. (2011) In vitro inhibitory effects of cyandin-3-rutinoside on pancreatic α-amylase and its combined effect with acarbose. Molecules 16, 2075-2083.
34. Adisakwattana S, Charoenlertkul P & Yibchok-Anun S (2009) α-Glucosidase inhibitory activity of cyanidin-3-galactoside and synergistic effect with acarbose. J Enzyme Inhib Med Chem 24, 65-69.
35. Buchert J, Koponen JM, Suutarinen M, et al. (2005) Effect of enzyme-aided pressing on anthocyanin yield and profiles in bilberry and blackcurrant juices. J Sci Food Agric 85, 2548-2556.
36. Schäfer A & Högger P (2007) Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol®) effectively inhibit α-glucosidase. Diabetes Res Clin Pract 77, 41-46.
37. Kumar S, Narwal S, Kumar V, et al. (2011) α-Glucosidase inhibitors from plants: a natural approach to treat diabetes. Pharmacogn Rev 5, 19-29.
38. Cai H, Thomasset SC, Berry DP, et al. (2011) Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract. Biomed Chromatogr 25, 660-663.
39. Cooke DN, Thomasset S, Boocock DJ, et al. (2006) Development of analyses by high-performance liquid chromatography and liquid chromatography/tandem mass spectrometry of bilberry (Vaccinium myrtilus) anthocyanins in human plasma and urine. J Agric Food Chem 54, 7009-7013.
40. Levin RJ (1994) Digestion and absorption of carbohydrates - from molecules and membranes to humans. Am J Clin Nutr 59, Suppl. 3, 690S-698S.
41. Määttä-Riihinen KR, Kamal-Eldin A, Mattila PH, et al. (2004) Distribution and contents of phenolic compounds in eighteen Scandinavian berry species. J Agric Food Chem 52, 4477-4486.
42. Määttä-Riihinen KR, Kamal-Eldin A & Törrönen AR (2004) Identification and quantification of phenolic compounds in berries of Fragaria and Rubus species (family Rosaceae). J Agric Food Chem 52, 6178-6187.
43. Mattila P, Hellström J & Törrönen R (2006) Phenolic acids in berries, fruits, and beverages. J Agric Food Chem 54, 7193-7199.
44. Wood PJ (2007) Cereal β-glucans in diet and health. J Cereal Sci 46, 230-238.
45. Thom E (2007) The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people. J Int Med Res 35, 900-908.
46. Johnston KL, Clifford MN & Morgan LM (2003) Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. Am J Clin Nutr 78, 728-733.