Clinical correlates and prognostic impact of impaired iron storage versus impaired iron transport in an international cohort of 1821 patients with chronic heart failure

International Journal of Cardiology

Volumn 243, Issue , 2017, Pages 360-366

  Moliner, Pedro ^a,c,d   Jankowska, Ewa A ^e,f   van Veldhuisen, Dirk J ^g   Farre, Nuria ^c,d   Rozentryt, Piotr ^h   Enjuanes, Cristina ^b,c,d   Polonski, Lech ^h   Meroño, Oona ^c,d   Voors, Adriaan A ^g   Ponikowski, Piotr ^e,f   Van der Meer, Peter ^g   Comin Colet, Josep ^b,c,d  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^b HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^c HOSPITAL DEL MAR   (Spain)

^d UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^e WROCLAW MEDICAL UNIVERSITY   (Poland)

^f MILITARY HOSPITAL   (Poland)

^g UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^h MEDICAL UNIVERSITY OF SILESIA   (Poland)

Author keywords

Anaemia; Heart failure; Iron deficiency; Outcomes

Indexed keywords

ALDOSTERONE ANTAGONIST; AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FERRITIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IRON; LOOP DIURETIC AGENT; TRANSFERRIN;

ADULT; AGED; ARTICLE; CARDIOVASCULAR MORTALITY; CLINICAL ASSESSMENT; CLINICAL OUTCOME; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEMOSIDEROSIS; HUMAN; HYPERTENSION; IRON TRANSPORT; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; QUALITY OF LIFE; BLOOD; CHRONIC DISEASE; CLINICAL TRIAL; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; INTERNATIONAL COOPERATION; IRON DEFICIENCY ANEMIA; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; PHYSIOLOGY; PROTEIN TRANSPORT; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANEMIA, IRON-DEFICIENCY; CHRONIC DISEASE; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; FERRITINS; HEART FAILURE; HUMANS; INTERNATIONALITY; IRON; MALE; MIDDLE AGED; PROGNOSIS; PROTEIN TRANSPORT; TRANSFERRIN;

EID: 85019192360     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2017.04.110     Document Type: Article

References (33)

1. Klip, I.T., Comin-Colet, J., Voors, A.A., et al. Iron deficiency in chronic heart failure: an international pooled analysis. Am. Heart J. 165:4 (April 2013), 575–582.
2. Comin-Colet, J., Ruiz, S., Cladellas, M., Rizzo, M., Torres, A., Bruguera, J., A pilot evaluation of the long-term effect of combined therapy with intravenous iron sucrose and erythropoietin in elderly patients with advanced chronic heart failure and cardio-renal anemia syndrome: influence on neurohormonal activation and clinical outcomes. J. Card. Fail. 15:9 (2009), 727–735.
3. Jankowska, E.A., Rozentryt, P., Witkowska, et al. Iron deficiency predicts impaired exercise capacity in patients with systolic chronic heart failure. J. Card. Fail. 17:11 (November 2011), 899–906.
4. Enjuanes, C., Klip, I.T., Bruguera, J., et al. Iron deficiency and health-related quality of life in chronic heart failure: results from a multicenter European study. Int. J. Cardiol. 174:2 (2014), 268–275.
5. van Veldhuisen, D.J., Anker, S.D., Ponikowski, P., Macdougall, I.C., Anemia and iron deficiency in heart failure: mechanisms and therapeutic approaches. Nat. Rev. Cardiol. 8:9 (May 31 2011), 485–493.
6. Anker, S.D., Comin-Colet, J., Filippatos, et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N. Engl. J. Med. 361:25 (December 17 2009), 2436–2448.
7. Comin-Colet, J., Lainscak, M., Dickstein, K., Filippatos, G.S., et al. The effect of intravenous ferric carboxymaltose on health-related quality of life in patients with chronic heart failure and iron deficiency: a subanalysis of the FAIR-HF study. Eur. Heart J. 34:1 (January 2013), 30–38.
8. Filippatos, G., Farmakis, D., Colet, J.C., et al. Intravenous ferric carboxymaltose in iron-deficient chronic heart failure patients with and without anaemia: a subanalysis of the FAIR-HF trial. Eur. J. Heart Fail. 15:11 (November 2013), 1267–1276.
9. Ponikowski, P., van Veldhuisen, D.J., Comin-Colet, J., et al. Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency. Eur. Heart J. 36:11 (March 14 2015), 657–668.
10. Jankowska, E.A., von, H.S., Anker, S.D., Macdougall, I.C., Ponikowski, P., Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives. Eur. Heart J. 34:11 (March 2013), 816–829.
11. Kilp, T., Jankowska, E.A., Enjuanes, C., et al. The additive burden of iron deficiency in the cardiorenal-anaemia axis: scope of a problem and its consequences. Eur. J. Heart Fail. 16 (2014), 655–662.
12. van der Wal, H.H., Comin-Colet, J., Klip, I.T., et al. Vitamin B12 and folate deficiency in chronic heart failure. Heart 101:4 (Feb 2015), 302–310.
13. Suominen, P., Punnonen, K., Rajamäki, A., Irjala, K., Serum transferrin receptor and transferrin receptor-ferritin index identify healthy subjects with subclinical iron deficits. Blood 92:8 (Oct 15 1998), 2934–2939.
14. Yusuf, S., Pfeffer, M.A., Swedberg, K., et al. Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial. Lancet 362:9386 (2003), 777–781.
15. Comín-Colet, J., Enjuanes, C., Gonzalez-Robledo, G., et al. Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status. Eur. J. Heart Fail. 15:10 (2013), 1164–1172.
16. Jankowska, E.A., Rozentryt, P., Witkowska, A., et al. Iron deficiency: an ominous sign in patients with systolic chronic heart failure. Eur. Heart J. 31:15 (2010), 1872–1880.
17. Bruggink-Andre de la Porte, P.W., Lok, D.J., van, W.J., et al. Heart failure programmes in countries with a primary care-based health care system. Are additional trials necessary? Design of the DEAL-HF study. Eur. J. Heart Fail. 7:5 (2005), 910–920.
18. Willemsen, S., Hartog, J.W., Hummel, Y.M., et al. Effects of alagebrium, an advanced glycation end-product breaker, in patients with chronic heart failure: study design and baseline characteristics of the BENEFICIAL trial. Eur. J. Heart Fail. 12:3 (2010), 294–300.
19. Beilby, J., Olynyk, J., Ching, S., et al. Transferrin index: an alternative method for calculating the iron saturation of transferrin. Clin. Chem. 38:10 (1992), 2078–2081.
20. Nutritional anaemias. Report of a WHO scientific group. World Health Organ. Tech. Rep. Ser., 405, 1968, 5–37.
21. Chen, C., Paw, B.H., Cellular and mitochondrial iron homeostasis in vertebrates. Biochim. Biophys. Acta 1823:9 (September 2012), 1459–1467.
22. Anderson, G.J., Vulpe, C.D., Mammalian iron transport. Cell. Mol. Life Sci. 66:20 (October 2009), 3241–3261.
23. Richardson, D.R., Lane, D.J., Becker, E.M., et al. Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol. Proc. Natl. Acad. Sci. U. S. A. 107:24 (June 15 2010), 10775–10782.
24. Bayeva, M., Ardehali, H., Mitochondrial dysfunction and oxidative damage to sarcomeric proteins. Curr. Hypertens. Rep. 12:6 (December 2010), 426–432.
25. Bayeva, M., Gheorghiade, M., Ardehali, H., Mitochondria as a therapeutic target in heart failure. J. Am. Coll. Cardiol. 61:6 (February 12 2013), 599–610.
26. Naito, Y., Tsujino, T., Matsumoto, M., Sakoda, T., Ohyanagi, M., Masuyama, T., Adaptive response of the heart to long-term anemia induced by iron deficiency. Am. J. Physiol. Heart Circ. Physiol. 296:3 (March 2009), H585–H593.
27. Tanne, Z., Coleman, R., Nahir, M., Shomrat, D., Finberg, J.P., Youdim, M.B., Ultrastructural and cytochemical changes in the heart of iron-deficient rats. Biochem. Pharmacol. 47:10 (May 18 1994), 1759–1766.
28. Maeder, M.T., Khammy, O., dos, R.C., Kaye, D.M., Myocardial and systemic iron depletion in heart failure implications for anemia accompanying heart failure. J. Am. Coll. Cardiol. 58:5 (July 26 2011), 474–480.
29. Leszek, P., Sochanowicz, B., Szperl, M., et al. Myocardial iron homeostasis in advanced chronic heart failure patients. Int. J. Cardiol. 159:1 (August 9 2012), 47–52.
30. Weiss, G., Goodnough, L.T., Anemia of chronic disease. N. Engl. J. Med. 352:10 (March 10 2005), 1011–1023.
31. Nemeth, E., Rivera, S., Gabayan, V., et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J. Clin. Invest. 113:9 (May 2004), 1271–1276.
32. Collins, J.F., Wessling-Resnick, M., Knutson, M.D., Hepcidin regulation of iron transport. J. Nutr. 138:11 (November 2008), 2284–2288.
33. Beck-da-Silva, L., Piardi, D., Soder, S., et al. IRON-HF study: a randomized trial to assess the effects of iron in heart failure patients with anemia. Int. J. Cardiol. 168:4 (2013), 3439–3442.