Iron deficiency and health-related quality of life in chronic heart failure: Results from a multicenter European study

International Journal of Cardiology

Volumn 174, Issue 2, 2014, Pages 268-275

  Enjuanes, Cristina ^a,b   Klip, Ijsbrand T ^c   Bruguera, Jordi ^a   Cladellas, Merce ^a,b   Ponikowski, Piotr ^d,e   Banasiak, Waldemar ^d   Van Veldhuisen, Dirk J ^c   Van Der Meer, Peter ^c   Jankowska, Ewa A ^d,e   Comín Colet, Josep ^a,b  

^a HOSPITAL DEL MAR   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^d MILITARY HOSPITAL   (Poland)

^e WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

Anaemia; Health related quality of life; Iron deficiency

Indexed keywords

ALDOSTERONE ANTAGONIST; AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FERRITIN; HEMOGLOBIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IRON; LOOP DIURETIC AGENT; TRANSFERRIN;

AGED; ANEMIA; ARTICLE; BLOOD OXYGEN TENSION; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DESCRIPTIVE RESEARCH; DISEASE COURSE; ETHNIC GROUP; EUROPEAN; FEMALE; FERRITIN BLOOD LEVEL; GLOMERULUS FILTRATION RATE; HEALTH IMPACT ASSESSMENT; HEALTH STATUS; HEART EJECTION FRACTION; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; IRON BINDING CAPACITY; IRON BLOOD LEVEL; IRON DEFICIENCY; IRON METABOLISM; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MEDICAL INFORMATION; MINNESOTA LIVING WITH HEART FAILURE QUESTIONNAIRE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NEW YORK HEART ASSOCIATION CLASS; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; SCORING SYSTEM; UNIVARIATE ANALYSIS; VERY ELDERLY; ANEMIA, IRON-DEFICIENCY; CHRONIC DISEASE; CLINICAL TRIAL; COMPLICATION; DEFICIENCY; EUROPE; IRON METABOLISM DISORDER; MULTICENTER STUDY;

AGED; ANEMIA, IRON-DEFICIENCY; CHRONIC DISEASE; CROSS-SECTIONAL STUDIES; EUROPE; FEMALE; HEART FAILURE; HUMANS; IRON; IRON METABOLISM DISORDERS; MALE; QUALITY OF LIFE;

EID: 84901244523     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2014.03.169     Document Type: Article

References (44)

1. J. Juenger, D. Schellberg, and S. Kraemer et al. Health related quality of life in patients with congestive heart failure: comparison with other chronic diseases and relation to functional variables Heart 87 3 2002 235 241
2. M. Jessup, and S. Brozena Heart failure N Engl J Med 348 20 2003 2007 2018
3. I.C. Macdougall, B. Canaud, and A.L. de Francisco et al. Beyond the cardiorenal anaemia syndrome: recognizing the role of iron deficiency Eur J Heart Fail 14 8 2012 882 886
4. I. Ekman, A. Wolf, and L.E. Olsson et al. Effects of person-centred care in patients with chronic heart failure: the PCC-HF study Eur Heart J 33 9 2012 1112 1119
5. M.R. Cowie Person-centred care: more than just improving patient satisfaction? Eur Heart J 33 9 2012 1037 1039
6. S.D. Anker, C.J. Comín, and G. Filippatos et al. Ferric carboxymaltose in patients with heart failure and iron deficiency N Engl J Med 361 25 2009 2436 2448
7. M.D. Sullivan, W.C. Levy, J.E. Russo, B. Crane, and J.A. Spertus Summary health status measures in advanced heart failure: relationship to clinical variables and outcome J Card Fail 13 7 2007 560 568
8. J. Myers, N. Zaheer, S. Quaglietti, R. Madhavan, V. Froelicher, and P. Heidenreich Association of functional and health status measures in heart failure J Card Fail 12 6 2006 439 445
9. S. Heo, T.A. Lennie, C. Okoli, and D.K. Moser Quality of life in patients with heart failure: ask the patients Heart Lung 38 2 2009 100 108
10. T. Jaarsma, J.M. Beattie, and M. Ryder et al. Palliative care in heart failure: a position statement from the palliative care workshop of the Heart Failure Association of the European Society of Cardiology Eur J Heart Fail 11 5 2009 433 443
11. L.W. Stevenson, A.S. Hellkamp, and C.V. Leier et al. Changing preferences for survival after hospitalization with advanced heart failure J Am Coll Cardiol 52 21 2008 1702 1708
12. E.A. Jankowska, P. Rozentryt, and A. Witkowska et al. Iron deficiency: an ominous sign in patients with systolic chronic heart failure Eur Heart J 31 15 2010 1872 1880
13. E.A. Jankowska, P. Rozentryt, and A. Witkowska et al. Iron deficiency predicts impaired exercise capacity in patients with systolic chronic heart failure J Card Fail 17 11 2011 899 906
14. I.T. Klip, J. Comín-Colet, and A.A. Voors et al. Iron deficiency in chronic heart failure: an international pooled analysis Am Heart J 165 4 2013 575 582
15. D.O. Okonko, A.K. Mandal, C.G. Missouris, and P.A. Poole-Wilson Disordered iron homeostasis in chronic heart failure: prevalence, predictors, and relation to anemia, exercise capacity, and survival J Am Coll Cardiol 58 12 2011 1241 1251
16. J. Comín-Colet, M. Lainscak, and K. Dickstein et al. The effect of intravenous ferric carboxymaltose on health-related quality of life in patients with chronic heart failure and iron deficiency: a subanalysis of the FAIR-HF study Eur Heart J 34 1 2013 30 38
17. G. Filippatos, D. Farmakis, and J.C. Colet et al. Intravenous ferric carboxymaltose in iron-deficient chronic heart failure patients with and without anaemia: a subanalysis of the FAIR-HF trial Eur J Heart Fail 15 11 2013 1267 1276
18. L. Beck-da-Silva, D. Piardi, and S. Soder et al. IRON-HF study: a randomized trial to assess the effects of iron in heart failure patients with anemia Int J Cardiol 168 4 2013 3439 3442
19. D.O. Okonko, A. Grzeslo, and T. Witkowski et al. Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial J Am Coll Cardiol 51 2 2008 103 112
20. E.A. Jankowska, and P. Ponikowski Molecular changes in myocardium in the course of anemia or iron deficiency Heart Fail Clin 6 3 2010 295 304
21. J. Comín-Colet, C. Enjuanes, and G. Gonzalez-Robledo et al. Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status Eur J Heart Fail 15 10 2013 1164 1172
22. S. Yusuf, M.A. Pfeffer, and K. Swedberg et al. Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial Lancet 362 9386 2003 777 781
23. P.W. Bruggink-Andre de la Porte, D.J. Lok, and W.J. van et al. Heart failure programmes in countries with a primary care-based health care system. Are additional trials necessary? Design of the DEAL-HF study Eur J Heart Fail 7 5 2005 910 920
24. S. Willemsen, J.W. Hartog, and Y.M. Hummel et al. Effects of alagebrium, an advanced glycation end-product breaker, in patients with chronic heart failure: study design and baseline characteristics of the BENEFICIAL trial Eur J Heart Fail 12 3 2010 294 300
25. Nutritional anaemias. Report of a WHO scientific group World Health Organ Tech Rep Ser 405 1968 5 37
26. J. Beilby, J. Olynyk, and S. Ching et al. Transferrin index: an alternative method for calculating the iron saturation of transferrin Clin Chem 38 10 1992 2078 2081
27. C. Thomas, and L. Thomas Biochemical markers and hematologic indices in the diagnosis of functional iron deficiency Clin Chem 48 7 2002 1066 1076
28. C. Brugnara, and N. Mohandas Red cell indices in classification and treatment of anemias: from M.M. Wintrobes's original 1934 classification to the third millennium Curr Opin Hematol 20 3 2013 222 230
29. G. Weiss Monitoring iron therapy in chronic heart failure Eur J Heart Fail 15 7 2013 711 712
30. E.M. Van Craenenbroeck, V.M. Conraads, and N. Greenlaw et al. The effect of intravenous ferric carboxymaltose on red cell distribution width: a subanalysis of the FAIR-HF study Eur J Heart Fail 15 7 2013 756 762
31. T.S. Rector, S.H. Kubo, and J.N. Cohn Patient's self-assessment of their congestive heart failure. Part 2: content, reliability and validity of a new measure, the Minnesota living with heart failure questionnaire Heart Fail 3 1987 198 209
32. T. Brownlie, V. Utermohlen, P.S. Hinton, and J.D. Haas Tissue iron deficiency without anemia impairs adaptation in endurance capacity after aerobic training in previously untrained women Am J Clin Nutr 79 3 2004 437 443
33. L.T. Goodnough, E. Nemeth, and T. Ganz Detection, evaluation, and management of iron-restricted erythropoiesis Blood 116 23 2010 4754 4761
34. J.D. Haas, and T. Brownlie Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship J Nutr 131 2S-2 2001 676S 688S
35. P. Leszek, B. Sochanowicz, and M. Szperl et al. Myocardial iron homeostasis in advanced chronic heart failure patients Int J Cardiol 159 1 2012 47 52
36. M.T. Maeder, O. Khammy, C. dos Remedios, and D.M. Kaye Myocardial and systemic iron depletion in heart failure implications for anemia accompanying heart failure J Am Coll Cardiol 58 5 2011 474 480
37. J. Comín-Colet, O. Garin, and J. Lupon et al. Validation of the Spanish version of the Kansas city cardiomyopathy questionnaire Rev Esp Cardiol 64 1 2011 51 58
38. R. Gaber, N.A. Kotb, M. Ghazy, H. Nagy, M. Salama, and A. Elhendy Tissue Doppler and strain rate imaging detect improvement of myocardial function in iron deficient patients with congestive heart failure after iron replacement therapy Echocardiography 29 1 2012 13 18
39. J.E. Toblli, A. Lombrana, P. Duarte, and G.F. Di Intravenous iron reduces NT-pro-brain natriuretic peptide in anemic patients with chronic heart failure and renal insufficiency J Am Coll Cardiol 50 17 2007 1657 1665
40. R.I. Usmanov, E.B. Zueva, D.S. Silverberg, and M. Shaked Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency J Nephrol 21 2 2008 236 242
41. M. Kasner, A.S. Aleksandrov, and D. Westermann et al. Functional iron deficiency and diastolic function in heart failure with preserved ejection fraction Int J Cardiol 168 5 2013 4652 4657
42. J.B. Wish Assessing iron status: beyond serum ferritin and transferrin Clin J Am Soc Nephrol Suppl. 1 2006 S4 S8
43. N. Aung, H.Z. Ling, and A.S. Cheng et al. Expansion of the red cell distribution width and evolving iron deficiency as predictors of poor outcome in chronic heart failure Int J Cardiol 168 3 2013 1997 2002
44. R.R. van Kimmenade, A.A. Mohammed, S. Uthamalingam, P. van der Meer, G.M. Felker, and J.L. Januzzi Jr. Red blood cell distribution width and 1-year mortality in acute heart failure Eur J Heart Fail 12 2 2010 129 136