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Volumn 18, Issue 6, 2017, Pages 375-384

How and why do T cells and their derived cytokines affect the injured and healthy brain?

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 23;

EID: 85019167673     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn.2017.39     Document Type: Review
Times cited : (162)

References (126)
  • 1
    • 64649092338 scopus 로고    scopus 로고
    • Cytokine, sickness behavior, and depression
    • Dantzer, R. Cytokine, sickness behavior, and depression. Immunol. Allergy Clin. North Am. 29, 247-264 (2009).
    • (2009) Immunol. Allergy Clin. North Am. , vol.29 , pp. 247-264
    • Dantzer, R.1
  • 2
    • 84983048399 scopus 로고    scopus 로고
    • Multifaceted interactions between adaptive immunity and the central nervous system
    • Kipnis, J. Multifaceted interactions between adaptive immunity and the central nervous system. Science 353, 766-771 (2016).
    • (2016) Science , vol.353 , pp. 766-771
    • Kipnis, J.1
  • 4
    • 0028854369 scopus 로고
    • Lymphocytic infiltration and expression of intercellular-adhesion molecule-1 in photochemically induced ischemia of the rat cortex
    • Jander, S., Kraemer, M., Schroeter, M., Witte, O. W. & Stoll, G. Lymphocytic infiltration and expression of intercellular-adhesion molecule-1 in photochemically induced ischemia of the rat cortex. J. Cereb. Blood Flow Metab. 15, 42-51 (1995).
    • (1995) J. Cereb. Blood Flow Metab. , vol.15 , pp. 42-51
    • Jander, S.1    Kraemer, M.2    Schroeter, M.3    Witte, O.W.4    Stoll, G.5
  • 5
    • 33646454450 scopus 로고    scopus 로고
    • Role of T lymphocytes and interferon-γ in ischemic stroke
    • Yilmaz, G., Arumugam, T. V., Stokes, K. Y. & Granger, D. N. Role of T lymphocytes and interferon-γ in ischemic stroke. Circulation 113, 2105-2112 (2006).
    • (2006) Circulation , vol.113 , pp. 2105-2112
    • Yilmaz, G.1    Arumugam, T.V.2    Stokes, K.Y.3    Granger, D.N.4
  • 6
    • 35448947910 scopus 로고    scopus 로고
    • T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation
    • Hurn, P. D., et al. T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation. J. Cereb. Blood Flow Metab. 27, 1798-1805 (2007).
    • (2007) J. Cereb Blood Flow Metab. , vol.27 , pp. 1798-1805
    • Hurn, P.D.1
  • 7
    • 67650070642 scopus 로고    scopus 로고
    • Recombinant T cell receptor ligand treats experimental stroke
    • Subramanian, S., et al. Recombinant T cell receptor ligand treats experimental stroke. Stroke 40, 2539-2545 (2009).
    • (2009) Stroke , vol.40 , pp. 2539-2545
    • Subramanian, S.1
  • 8
    • 84923264361 scopus 로고    scopus 로고
    • Interleukin-33 ameliorates ischemic brain injury in experimental stroke through promoting Th2 response and suppressing Th17 response
    • Luo, Y., et al. Interleukin-33 ameliorates ischemic brain injury in experimental stroke through promoting Th2 response and suppressing Th17 response. Brain Res. 1597, 86-94 (2015).
    • (2015) Brain Res. , vol.1597 , pp. 86-94
    • Luo, Y.1
  • 9
    • 84884815486 scopus 로고    scopus 로고
    • The immunologic profile of adoptively transferred lymphocytes influences stroke outcome of recipients
    • Zierath, D., et al. The immunologic profile of adoptively transferred lymphocytes influences stroke outcome of recipients. J. Neuroimmunol. 263, 28-34 (2013).
    • (2013) J. Neuroimmunol. , vol.263 , pp. 28-34
    • Zierath, D.1
  • 10
    • 84940598082 scopus 로고    scopus 로고
    • Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation
    • Korhonen, P., et al. Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation. Brain Behav. Immun. 49, 322-336 (2015).
    • (2015) Brain Behav. Immun. , vol.49 , pp. 322-336
    • Korhonen, P.1
  • 11
    • 4243562216 scopus 로고    scopus 로고
    • Exacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient (scid) mice
    • Serpe, C. J., Kohm, A. P., Huppenbauer, C. B., Sanders, V. M. & Jones, K. J. Exacerbation of facial motoneuron loss after facial nerve transection in severe combined immunodeficient (scid) mice. J. Neurosci. 19, RC7 (1999).
    • (1999) J. Neurosci. , vol.19 , pp. RC7
    • Serpe, C.J.1    Kohm, A.P.2    Huppenbauer, C.B.3    Sanders, V.M.4    Jones, K.J.5
  • 12
    • 0038721596 scopus 로고    scopus 로고
    • Therapeutic vaccination for closed head injury
    • Kipnis, J., et al. Therapeutic vaccination for closed head injury. J. Neurotrauma 20, 559-569 (2003).
    • (2003) J. Neurotrauma , vol.20 , pp. 559-569
    • Kipnis, J.1
  • 13
    • 0033049143 scopus 로고    scopus 로고
    • Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
    • Moalem, G., et al. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat. Med. 5, 49-55 (1999).
    • (1999) Nat. Med. , vol.5 , pp. 49-55
    • Moalem, G.1
  • 14
    • 84922148661 scopus 로고    scopus 로고
    • MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4
    • Walsh, J. T., et al. MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4. J. Clin. Invest. 125, 699-714 (2015).
    • (2015) J. Clin. Invest. , vol.125 , pp. 699-714
    • Walsh, J.T.1
  • 15
    • 1642402054 scopus 로고    scopus 로고
    • Low-dose γ-irradiation promotes survival of injured neurons in the central nervous system via homeostasis-driven proliferation of T cells
    • Kipnis, J., et al. Low-dose γ-irradiation promotes survival of injured neurons in the central nervous system via homeostasis-driven proliferation of T cells. Eur. J. Neurosci. 19, 1191-1198 (2004).
    • (2004) Eur. J. Neurosci. , vol.19 , pp. 1191-1198
    • Kipnis, J.1
  • 16
    • 0141535147 scopus 로고    scopus 로고
    • Vaccination with dendritic cells pulsed with peptides of myelin basic protein promotes functional recovery from spinal cord injury
    • Hauben, E., et al. Vaccination with dendritic cells pulsed with peptides of myelin basic protein promotes functional recovery from spinal cord injury. J. Neurosci. 23, 8808-8819 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 8808-8819
    • Hauben, E.1
  • 17
    • 0032146068 scopus 로고    scopus 로고
    • Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration
    • Raivich, G., et al. Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration. J. Neurosci. 18, 5804-5816 (1998).
    • (1998) J. Neurosci. , vol.18 , pp. 5804-5816
    • Raivich, G.1
  • 18
    • 0037180556 scopus 로고    scopus 로고
    • Neuroprotective autoimmunity: Naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system
    • Kipnis, J., et al. Neuroprotective autoimmunity: naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system. Proc. Natl Acad. Sci. USA 26, 15620-15625 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.26 , pp. 15620-15625
    • Kipnis, J.1
  • 19
    • 0035400122 scopus 로고    scopus 로고
    • Neuronal survival after CNS insult is determined by a genetically encoded autoimmune response
    • Kipnis, J., et al. Neuronal survival after CNS insult is determined by a genetically encoded autoimmune response. J. Neurosci. 21, 4564-4571 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 4564-4571
    • Kipnis, J.1
  • 20
    • 0034667584 scopus 로고    scopus 로고
    • Kinetics of facial motoneuron loss following facial nerve transection in severe combined immunodeficient mice
    • Serpe, C. J., Sanders, V. M. & Jones, K. J. Kinetics of facial motoneuron loss following facial nerve transection in severe combined immunodeficient mice. J. Neurosci. Res. 62, 273-278 (2000).
    • (2000) J. Neurosci. Res. , vol.62 , pp. 273-278
    • Serpe, C.J.1    Sanders, V.M.2    Jones, K.J.3
  • 21
    • 0036674498 scopus 로고    scopus 로고
    • Autoreactive T cells induce neurotrophin production by immune and neural cells in injured rat optic nerve: Implications for protective autoimmunity
    • Barouch, R. & Schwartz, M. Autoreactive T cells induce neurotrophin production by immune and neural cells in injured rat optic nerve: implications for protective autoimmunity. FASEB J. 16, 1304-1306 (2002).
    • (2002) FASEB J. , vol.16 , pp. 1304-1306
    • Barouch, R.1    Schwartz, M.2
  • 22
    • 0034691136 scopus 로고    scopus 로고
    • T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: Possible therapy for optic neuropathies
    • Kipnis, J., et al. T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathies. Proc. Natl Acad. Sci. USA 97, 7446-7451 (2000).
    • (2000) Proc Natl Acad. Sci. USA , vol.97 , pp. 7446-7451
    • Kipnis, J.1
  • 23
    • 0034279106 scopus 로고    scopus 로고
    • Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion
    • Hauben, E., et al. Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion. J. Neurosci. 20, 6421-6430 (2000).
    • (2000) J. Neurosci. , vol.20 , pp. 6421-6430
    • Hauben, E.1
  • 24
    • 0035370214 scopus 로고    scopus 로고
    • Protective autoimmunity is a physiological response to CNS trauma
    • Yoles, E., et al. Protective autoimmunity is a physiological response to CNS trauma. J. Neurosci. 21, 3740-3748 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 3740-3748
    • Yoles, E.1
  • 26
    • 80053302622 scopus 로고    scopus 로고
    • Autoimmune responses to the brain after stroke are associated with worse outcome
    • Becker, K. J., et al. Autoimmune responses to the brain after stroke are associated with worse outcome. Stroke 42, 2763-2769 (2011).
    • (2011) Stroke , vol.42 , pp. 2763-2769
    • Becker, K.J.1
  • 27
    • 77953612092 scopus 로고    scopus 로고
    • CNS immune responses following experimental stroke
    • Zierath, D., et al. CNS immune responses following experimental stroke. Neurocrit. Care 12, 274-284 (2010).
    • (2010) Neurocrit. Care , vol.12 , pp. 274-284
    • Zierath, D.1
  • 28
    • 84857469217 scopus 로고    scopus 로고
    • Brain-derived antigens in lymphoid tissue of patients with acute stroke
    • Planas, A. M., et al. Brain-derived antigens in lymphoid tissue of patients with acute stroke. J. Immunol. 188, 2156-2163 (2012).
    • (2012) J. Immunol. , vol.188 , pp. 2156-2163
    • Planas, A.M.1
  • 29
    • 44449167217 scopus 로고    scopus 로고
    • Induction of immunologic tolerance to myelin basic protein prevents central nervous system autoimmunity and improves outcome after stroke
    • Gee, J. M., Kalil, A., Thullbery, M. & Becker, K. J. Induction of immunologic tolerance to myelin basic protein prevents central nervous system autoimmunity and improves outcome after stroke. Stroke 39, 1575-1582 (2008).
    • (2008) Stroke , vol.39 , pp. 1575-1582
    • Gee, J.M.1    Kalil, A.2    Thullbery, M.3    Becker, K.J.4
  • 30
    • 2942627626 scopus 로고    scopus 로고
    • Hydrophobicity: An ancient damage-associated molecular pattern that initiates innate immune responses
    • Seong, S. Y. & Matzinger, P. Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses. Nat. Rev. Immunol. 4, 469-478 (2004).
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 469-478
    • Seong, S.Y.1    Matzinger, P.2
  • 31
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: Mechanisms of differentiation and function
    • Josefowicz, S. Z., Lu, L. F. & Rudensky, A. Y. Regulatory T cells: mechanisms of differentiation and function. Annu. Rev. Immunol. 30, 531-564 (2012).
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 32
    • 59649123881 scopus 로고    scopus 로고
    • Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke
    • Liesz, A., et al. Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat. Med. 15, 192-199 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 192-199
    • Liesz, A.1
  • 33
    • 84873019070 scopus 로고    scopus 로고
    • Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature
    • Kleinschnitz, C., et al. Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood 121, 679-691 (2013).
    • (2013) Blood , vol.121 , pp. 679-691
    • Kleinschnitz, C.1
  • 34
    • 84910136028 scopus 로고    scopus 로고
    • Regulatory T cells in central nervous system injury: A double-edged sword
    • Walsh, J. T., et al. Regulatory T cells in central nervous system injury: A double-edged sword. J. Immunol. 193, 5013-5022 (2014).
    • (2014) J. Immunol. , vol.193 , pp. 5013-5022
    • Walsh, J.T.1
  • 35
    • 80053574871 scopus 로고    scopus 로고
    • Regulatory T cells in CNS injury: The simple, the complex and the confused
    • Walsh, J. T. & Kipnis, J. Regulatory T cells in CNS injury: The simple, the complex and the confused. Trends Mol. Med. 17, 541-547 (2011).
    • (2011) Trends Mol. Med. , vol.17 , pp. 541-547
    • Walsh, J.T.1    Kipnis, J.2
  • 36
    • 79960141471 scopus 로고    scopus 로고
    • The immunology of stroke: From mechanisms to translation
    • Iadecola, C. & Anrather, J. The immunology of stroke: from mechanisms to translation. Nat. Med. 17, 796-808 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 796-808
    • Iadecola, C.1    Anrather, J.2
  • 37
    • 84924988052 scopus 로고    scopus 로고
    • The glia-derived alarmin IL-33 orchestrates the immune response and promotes recovery following CNS injury
    • Gadani, S. P., Walsh, J. T., Smirnov, I., Zheng, J. & Kipnis, J. The glia-derived alarmin IL-33 orchestrates the immune response and promotes recovery following CNS injury. Neuron 85, 703-709 (2015).
    • (2015) Neuron , vol.85 , pp. 703-709
    • Gadani, S.P.1    Walsh, J.T.2    Smirnov, I.3    Zheng, J.4    Kipnis, J.5
  • 38
    • 46049087379 scopus 로고    scopus 로고
    • Adaptive immunity affects learning behavior in mice
    • Brynskikh, A., Warren, T., Zhu, J. & Kipnis, J. Adaptive immunity affects learning behavior in mice. Brain Behav. Immun. 22, 861-869 (2008).
    • (2008) Brain Behav. Immun. , vol.22 , pp. 861-869
    • Brynskikh, A.1    Warren, T.2    Zhu, J.3    Kipnis, J.4
  • 39
    • 2542596271 scopus 로고    scopus 로고
    • T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions
    • Kipnis, J., Cohen, H., Cardon, M., Ziv, Y. & Schwartz, M. T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions. Proc. Natl Acad. Sci. USA 101, 8180-8185 (2004).
    • (2004) Proc Natl Acad. Sci. USA , vol.101 , pp. 8180-8185
    • Kipnis, J.1    Cohen, H.2    Cardon, M.3    Ziv, Y.4    Schwartz, M.5
  • 40
    • 84888880129 scopus 로고    scopus 로고
    • Brain antigenreactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire
    • Radjavi, A., Smirnov, I. & Kipnis, J. Brain antigenreactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire. Brain Behav. Immun. 35, 58-63 (2014).
    • (2014) Brain Behav. Immun. , vol.35 , pp. 58-63
    • Radjavi, A.1    Smirnov, I.2    Kipnis, J.3
  • 41
    • 84978160816 scopus 로고    scopus 로고
    • Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour
    • Filiano, A. J., et al. Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Nature 535, 425-429 (2016).
    • (2016) Nature , vol.535 , pp. 425-429
    • Filiano, A.J.1
  • 42
    • 4644373224 scopus 로고    scopus 로고
    • Sociability and preference for social novelty in five inbred strains: An approach to assess autistic-like behavior in mice
    • Moy, S. S., et al. Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice. Genes Brain Behav. 3, 287-302 (2004).
    • (2004) Genes Brain Behav. , vol.3 , pp. 287-302
    • Moy, S.S.1
  • 43
    • 35648932799 scopus 로고    scopus 로고
    • Maladaptation to mental stress mitigated by the adaptive immune system via depletion of naturally occurring regulatory CD4+CD25+ cells
    • Cohen, H., et al. Maladaptation to mental stress mitigated by the adaptive immune system via depletion of naturally occurring regulatory CD4+CD25+ cells. J. Neurobiol. 66, 552-563 (2006).
    • (2006) J. Neurobiol. , vol.66 , pp. 552-563
    • Cohen, H.1
  • 44
    • 84930400347 scopus 로고    scopus 로고
    • Immune deficiency influences juvenile social behavior and maternal behavior
    • Quinnies, K. M., Cox, K. H. & Rissman, E. F. Immune deficiency influences juvenile social behavior and maternal behavior. Behav. Neurosci. 129, 331-338 (2015).
    • (2015) Behav. Neurosci. , vol.129 , pp. 331-338
    • Quinnies, K.M.1    Cox, K.H.2    Rissman, E.F.3
  • 45
    • 84890341272 scopus 로고    scopus 로고
    • CD4+ but not CD8+ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice
    • Rattazzi, L., et al. CD4+ but not CD8+ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice. Transl Psychiatry 3, e280 (2013).
    • (2013) Transl Psychiatry , vol.3 , pp. e280
    • Rattazzi, L.1
  • 46
    • 77952311924 scopus 로고    scopus 로고
    • Regulation of learning and memory by meningeal immunity: A key role for IL-4
    • Derecki, N. C., et al. Regulation of learning and memory by meningeal immunity: A key role for IL-4. J. Exp. Med. 207, 1067-1080 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1067-1080
    • Derecki, N.C.1
  • 47
    • 64249134817 scopus 로고    scopus 로고
    • CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis
    • Wolf, S. A., et al. CD4-positive T lymphocytes provide a neuroimmunological link in the control of adult hippocampal neurogenesis. J. Immunol. 182, 3979-3984 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 3979-3984
    • Wolf, S.A.1
  • 48
    • 84899488296 scopus 로고    scopus 로고
    • Dynamics of the meningeal CD4+ T-cell repertoire are defined by the cervical lymph nodes and facilitate cognitive task performance in mice
    • Radjavi, A., Smirnov, I., Derecki, N. & Kipnis, J. Dynamics of the meningeal CD4+ T-cell repertoire are defined by the cervical lymph nodes and facilitate cognitive task performance in mice. Mol. Psychiatry 19, 531-533 (2014).
    • (2014) Mol. Psychiatry , vol.19 , pp. 531-533
    • Radjavi, A.1    Smirnov, I.2    Derecki, N.3    Kipnis, J.4
  • 49
    • 9444247527 scopus 로고    scopus 로고
    • Interleukin-6: A cytokine to forget
    • Balschun, D., et al. Interleukin-6: A cytokine to forget. FASEB J. 18, 1788-1790 (2004).
    • (2004) FASEB J. , vol.18 , pp. 1788-1790
    • Balschun, D.1
  • 50
    • 84887559106 scopus 로고    scopus 로고
    • Brain hyperconnectivity in children with autism and its links to social deficits
    • Supekar, K., et al. Brain hyperconnectivity in children with autism and its links to social deficits. Cell Rep. 5, 738-747 (2013).
    • (2013) Cell Rep. , vol.5 , pp. 738-747
    • Supekar, K.1
  • 51
    • 80052563319 scopus 로고    scopus 로고
    • Neocortical excitation/inhibition balance in information processing and social dysfunction
    • Yizhar, O., et al. Neocortical excitation/inhibition balance in information processing and social dysfunction. Nature 477, 171-178 (2011).
    • (2011) Nature , vol.477 , pp. 171-178
    • Yizhar, O.1
  • 52
    • 0028363251 scopus 로고
    • Morphology and spatial distribution of GABAergic neurons in cat primary auditory cortex (AI)
    • Prieto, J. J., Peterson, B. A. & Winer, J. A. Morphology and spatial distribution of GABAergic neurons in cat primary auditory cortex (AI). J. Comp. Neurol. 344, 349-382 (1994).
    • (1994) J. Comp. Neurol. , vol.344 , pp. 349-382
    • Prieto, J.J.1    Peterson, B.A.2    Winer, J.A.3
  • 53
    • 84992499908 scopus 로고    scopus 로고
    • Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals
    • Clark, S. M., et al. Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals. J. Psychiatry Neurosci. 41, 386-394 (2016).
    • (2016) J. Psychiatry Neurosci. , vol.41 , pp. 386-394
    • Clark, S.M.1
  • 54
    • 84901237501 scopus 로고    scopus 로고
    • The plasma levels of various cytokines are increased during ongoing depression and are reduced to normal levels after recovery
    • Dahl, J., et al. The plasma levels of various cytokines are increased during ongoing depression and are reduced to normal levels after recovery. Psychoneuroendocrinology 45, 77-86 (2014).
    • (2014) Psychoneuroendocrinology , vol.45 , pp. 77-86
    • Dahl, J.1
  • 55
    • 0032078663 scopus 로고    scopus 로고
    • Th1-and Th2-like cytokines in CD4+ and CD8+ T cells in autism
    • Gupta, S., Aggarwal, S., Rashanravan, B. & Lee, T. Th1-and Th2-like cytokines in CD4+ and CD8+ T cells in autism. J. Neuroimmunol. 85, 106-109 (1998).
    • (1998) J. Neuroimmunol. , vol.85 , pp. 106-109
    • Gupta, S.1    Aggarwal, S.2    Rashanravan, B.3    Lee, T.4
  • 56
    • 60149103359 scopus 로고    scopus 로고
    • Elevated immune response in the brain of autistic patients
    • Li, X., et al. Elevated immune response in the brain of autistic patients. J. Neuroimmunol. 207, 111-116 (2009).
    • (2009) J. Neuroimmunol. , vol.207 , pp. 111-116
    • Li, X.1
  • 57
    • 84926168759 scopus 로고    scopus 로고
    • Cytokine aberrations in autism spectrum disorder: A systematic review and metaanalysis
    • Masi, A., et al. Cytokine aberrations in autism spectrum disorder: A systematic review and metaanalysis. Mol. Psychiatry 20, 440-446 (2015).
    • (2015) Mol. Psychiatry , vol.20 , pp. 440-446
    • Masi, A.1
  • 58
    • 70350575737 scopus 로고    scopus 로고
    • An autistic endophenotype results in complex immune dysfunction in healthy siblings of autistic children
    • Saresella, M., et al. An autistic endophenotype results in complex immune dysfunction in healthy siblings of autistic children. Biol. Psychiatry 66, 978-984 (2009).
    • (2009) Biol. Psychiatry , vol.66 , pp. 978-984
    • Saresella, M.1
  • 59
    • 79960574244 scopus 로고    scopus 로고
    • Aberrant immune responses in a mouse with behavioral disorders
    • Heo, Y., Zhang, Y., Gao, D., Miller, V. M. & Lawrence, D. A. Aberrant immune responses in a mouse with behavioral disorders. PLoS ONE 6, e20912 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e20912
    • Heo, Y.1    Zhang, Y.2    Gao, D.3    Miller, V.M.4    Lawrence, D.A.5
  • 60
    • 84950261621 scopus 로고    scopus 로고
    • Immune endophenotypes in children with autism spectrum disorder
    • Careaga, M., et al. Immune endophenotypes in children with autism spectrum disorder. Biol. Psychiatry 81, 434-441 (2015).
    • (2015) Biol. Psychiatry , vol.81 , pp. 434-441
    • Careaga, M.1
  • 61
    • 83255171042 scopus 로고    scopus 로고
    • Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition
    • Zhu, P. J., et al. Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition. Cell 147, 1384-1396 (2011).
    • (2011) Cell , vol.147 , pp. 1384-1396
    • Zhu, P.J.1
  • 62
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-γ: An overview of signals, mechanisms and functions
    • Schroder, K., Hertzog, P. J., Ravasi, T. & Hume, D. A. Interferon-γ: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 75, 163-189 (2004).
    • (2004) J. Leukoc. Biol. , vol.75 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 63
    • 0036734498 scopus 로고    scopus 로고
    • Sensitization of IFN-γ Jak-STAT signaling during macrophage activation
    • Hu, X., et al. Sensitization of IFN-γ Jak-STAT signaling during macrophage activation. Nat. Immunol. 3, 859-866 (2002).
    • (2002) Nat. Immunol. , vol.3 , pp. 859-866
    • Hu, X.1
  • 64
    • 77958161312 scopus 로고    scopus 로고
    • Interferon gamma licensing of human dendritic cells in T-helper-independent CD8+ alloimmunity
    • Lemoine, R., et al. Interferon gamma licensing of human dendritic cells in T-helper-independent CD8+ alloimmunity. Blood 116, 3089-3098 (2010).
    • (2010) Blood , vol.116 , pp. 3089-3098
    • Lemoine, R.1
  • 65
    • 77249104532 scopus 로고    scopus 로고
    • Inhibitory role for GABA in autoimmune inflammation
    • Bhat, R., et al. Inhibitory role for GABA in autoimmune inflammation. Proc. Natl Acad. Sci. USA 107, 2580-2585 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 2580-2585
    • Bhat, R.1
  • 66
    • 0033103608 scopus 로고    scopus 로고
    • Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation?
    • Kerschensteiner, M., et al. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation? J. Exp. Med. 189, 865-870 (1999).
    • (1999) J. Exp. Med. , vol.189 , pp. 865-870
    • Kerschensteiner, M.1
  • 67
    • 34147125008 scopus 로고    scopus 로고
    • Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor
    • Leon-Ponte, M., Ahern, G. P. & O'Connell, P. J. Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor. Blood 109, 3139-3146 (2007).
    • (2007) Blood , vol.109 , pp. 3139-3146
    • Leon-Ponte, M.1    Ahern, G.P.2    O'Connell, P.J.3
  • 68
    • 84865123660 scopus 로고    scopus 로고
    • A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β
    • Iliff, J. J., et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci. Transl Med. 4, 147ra111 (2012).
    • (2012) Sci. Transl Med. , vol.4 , pp. 147ra111
    • Iliff, J.J.1
  • 69
    • 0034736220 scopus 로고    scopus 로고
    • Diffusion and action of intracerebroventricularly injected interleukin-1 in the CNS
    • Konsman, J. P., Tridon, V. & Dantzer, R. Diffusion and action of intracerebroventricularly injected interleukin-1 in the CNS. Neuroscience 101, 957-967 (2000).
    • (2000) Neuroscience , vol.101 , pp. 957-967
    • Konsman, J.P.1    Tridon, V.2    Dantzer, R.3
  • 70
    • 0033653668 scopus 로고    scopus 로고
    • Cytokine signals propagate through the brain
    • Vitkovic, L., et al. Cytokine signals propagate through the brain. Mol. Psychiatry 5, 604-615 (2000).
    • (2000) Mol. Psychiatry , vol.5 , pp. 604-615
    • Vitkovic, L.1
  • 71
    • 84897138296 scopus 로고    scopus 로고
    • Role of the microbiota in immunity and inflammation
    • Belkaid, Y. & Hand, T. W. Role of the microbiota in immunity and inflammation. Cell 157, 121-141 (2014).
    • (2014) Cell , vol.157 , pp. 121-141
    • Belkaid, Y.1    Hand, T.W.2
  • 72
    • 84944070146 scopus 로고    scopus 로고
    • The impact of gut microbiota on brain and behaviour: Implications for psychiatry
    • Dinan, T. G. & Cryan, J. F. The impact of gut microbiota on brain and behaviour: implications for psychiatry. Curr. Opin. Clin. Nutr. Metab. Care 18, 552-558 (2015).
    • (2015) Curr. Opin. Clin. Nutr. Metab. Care , vol.18 , pp. 552-558
    • Dinan, T.G.1    Cryan, J.F.2
  • 73
    • 0037293972 scopus 로고    scopus 로고
    • Cytokine-induced sickness behavior
    • Kelley, K. W., et al. Cytokine-induced sickness behavior. Brain Behav. Immun. 17 (Suppl. 1), S112-S118 (2003).
    • (2003) Brain Behav. Immun. , vol.17 , pp. S112-S118
    • Kelley, K.W.1
  • 74
    • 0033830170 scopus 로고    scopus 로고
    • Role of IL-6 in cytokine-induced sickness behavior: A study with IL-6 deficient mice
    • Bluthé, R. M., Michaud, B., Poli, V. & Dantzer, R. Role of IL-6 in cytokine-induced sickness behavior: A study with IL-6 deficient mice. Physiol. Behav. 70, 367-373 (2000).
    • (2000) Physiol. Behav. , vol.70 , pp. 367-373
    • Bluthé, R.M.1    Michaud, B.2    Poli, V.3    Dantzer, R.4
  • 75
    • 0028279551 scopus 로고
    • Synergy between tumor necrosis factor alpha and interleukin-1 in the induction of sickness behavior in mice
    • Bluthé, R. M., et al. Synergy between tumor necrosis factor alpha and interleukin-1 in the induction of sickness behavior in mice. Psychoneuroendocrinology 19, 197-207 (1994).
    • (1994) Psychoneuroendocrinology , vol.19 , pp. 197-207
    • Bluthé, R.M.1
  • 76
    • 84964330538 scopus 로고    scopus 로고
    • Brain endothelial-and epithelial-specific interferon receptor chain 1 drives virus-induced sickness behavior and cognitive impairment
    • Blank, T., et al. Brain endothelial-and epithelial-specific interferon receptor chain 1 drives virus-induced sickness behavior and cognitive impairment. Immunity 44, 901-912 (2016).
    • (2016) Immunity , vol.44 , pp. 901-912
    • Blank, T.1
  • 77
    • 0032891837 scopus 로고    scopus 로고
    • Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat
    • Quan, N., Stern, E. L., Whiteside, M. B. & Herkenham, M. Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat. J. Neuroimmunol. 93, 72-80 (1999).
    • (1999) J. Neuroimmunol. , vol.93 , pp. 72-80
    • Quan, N.1    Stern, E.L.2    Whiteside, M.B.3    Herkenham, M.4
  • 78
    • 27244450859 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha, interleukin-1 beta, interleukin-6 and major histocompatibility complex molecules in the normal brain and after peripheral immune challenge
    • Tonelli, L. H. & Postolache, T. T. Tumor necrosis factor alpha, interleukin-1 beta, interleukin-6 and major histocompatibility complex molecules in the normal brain and after peripheral immune challenge. Neurol. Res. 27, 679-684 (2005).
    • (2005) Neurol. Res. , vol.27 , pp. 679-684
    • Tonelli, L.H.1    Postolache, T.T.2
  • 79
    • 0026726031 scopus 로고
    • Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: A pathway for the induction of non-specific symptoms of sickness?
    • van Dam, A. M., Brouns, M., Louisse, S. & Berkenbosch, F. Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: A pathway for the induction of non-specific symptoms of sickness? Brain Res. 588, 291-296 (1992).
    • (1992) Brain Res. , vol.588 , pp. 291-296
    • Van Dam, A.M.1    Brouns, M.2    Louisse, S.3    Berkenbosch, F.4
  • 80
    • 0026599095 scopus 로고
    • Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat
    • Bluthe, R. M., Dantzer, R. & Kelley, K. W. Effects of interleukin-1 receptor antagonist on the behavioral effects of lipopolysaccharide in rat. Brain Res. 573, 318-320 (1992).
    • (1992) Brain Res. , vol.573 , pp. 318-320
    • Bluthe, R.M.1    Dantzer, R.2    Kelley, K.W.3
  • 81
    • 0024159821 scopus 로고
    • Biological basis of the behavior of sick animals
    • Hart, B. L. Biological basis of the behavior of sick animals. Neurosci. Biobehav Rev. 12, 123-137 (1988).
    • (1988) Neurosci. Biobehav Rev. , vol.12 , pp. 123-137
    • Hart, B.L.1
  • 82
    • 84946048123 scopus 로고    scopus 로고
    • Why do we feel sick when infected - can altruism play a role?
    • Shakhar, K. & Shakhar, G. Why do we feel sick when infected - can altruism play a role? PLoS Biol. 13, e1002276 (2015).
    • (2015) PLoS Biol. , vol.13 , pp. e1002276
    • Shakhar, K.1    Shakhar, G.2
  • 85
    • 0042383459 scopus 로고    scopus 로고
    • Parasite manipulation of the proximate mechanisms that mediate social behavior in vertebrates
    • Klein, S. L. Parasite manipulation of the proximate mechanisms that mediate social behavior in vertebrates. Physiol. Behav. 79, 441-449 (2003).
    • (2003) Physiol. Behav. , vol.79 , pp. 441-449
    • Klein, S.L.1
  • 86
    • 77956238949 scopus 로고    scopus 로고
    • Change in human social behavior in response to a common vaccine
    • Reiber, C., et al. Change in human social behavior in response to a common vaccine. Ann. Epidemiol. 20, 729-733 (2010).
    • (2010) Ann. Epidemiol. , vol.20 , pp. 729-733
    • Reiber, C.1
  • 87
    • 77956094385 scopus 로고    scopus 로고
    • Transgenic models for cytokine-induced neurological disease
    • Campbell, I. L., Hofer, M. J. & Pagenstecher, A. Transgenic models for cytokine-induced neurological disease. Biochim. Biophys. Acta 1802, 903-917 (2010).
    • (2010) Biochim. Biophys. Acta , vol.1802 , pp. 903-917
    • Campbell, I.L.1    Hofer, M.J.2    Pagenstecher, A.3
  • 88
    • 84946569137 scopus 로고    scopus 로고
    • Opposing roles of interferon-gamma on cells of the central nervous system in autoimmune neuroinflammation
    • Ottum, P. A., Arellano, G., Reyes, L. I., Iruretagoyena, M. & Naves, R. Opposing roles of interferon-gamma on cells of the central nervous system in autoimmune neuroinflammation. Front. Immunol. 6, 539 (2015).
    • (2015) Front. Immunol. , vol.6 , pp. 539
    • Ottum, P.A.1    Arellano, G.2    Reyes, L.I.3    Iruretagoyena, M.4    Naves, R.5
  • 89
    • 0036889113 scopus 로고    scopus 로고
    • The role of IFN-γ in immune responses to viral infections of the central nervous system
    • Chesler, D. A. & Reiss, C. S. The role of IFN-γ in immune responses to viral infections of the central nervous system. Cytokine Growth Factor Rev. 13, 441-454 (2002).
    • (2002) Cytokine Growth Factor Rev. , vol.13 , pp. 441-454
    • Chesler, D.A.1    Reiss, C.S.2
  • 90
    • 0004131381 scopus 로고    scopus 로고
    • (eds Coffin, J. M., Hughes, S. H. & Varmus, H. E.) (Cold Spring Harbor Laboratory Press)
    • Boeke, J. D. & Stoye, J. P. in Retroviruses (eds Coffin, J. M., Hughes, S. H. & Varmus, H. E.) (Cold Spring Harbor Laboratory Press,1997).
    • (1997) Retroviruses
    • Boeke, J.D.1    Stoye, J.P.2
  • 91
    • 1542563409 scopus 로고    scopus 로고
    • Initial sequencing and comparative analysis of the mouse genome
    • Mouse Genome Sequencing Consortium et al
    • Mouse Genome Sequencing Consortium et al. Initial sequencing and comparative analysis of the mouse genome. Nature 420, 520-562 (2002).
    • (2002) Nature , vol.420 , pp. 520-562
  • 92
    • 0342545919 scopus 로고    scopus 로고
    • Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis
    • Mi, S., et al. Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature 403, 785-789 (2000).
    • (2000) Nature , vol.403 , pp. 785-789
    • Mi, S.1
  • 93
    • 84920923006 scopus 로고    scopus 로고
    • TRIM28 represses transcription of endogenous retroviruses in neural progenitor cells
    • Fasching, L., et al. TRIM28 represses transcription of endogenous retroviruses in neural progenitor cells. Cell Rep. 10, 20-28 (2015).
    • (2015) Cell Rep. , vol.10 , pp. 20-28
    • Fasching, L.1
  • 94
    • 23844464762 scopus 로고    scopus 로고
    • Human endogenous retrovirus expression profiles in samples from brains of patients with schizophrenia and bipolar disorders
    • Frank, O., et al. Human endogenous retrovirus expression profiles in samples from brains of patients with schizophrenia and bipolar disorders. J. Virol. 79, 10890-10901 (2005).
    • (2005) J. Virol. , vol.79 , pp. 10890-10901
    • Frank, O.1
  • 95
    • 84969410014 scopus 로고    scopus 로고
    • Human endogenous retroviruses in neurologic disease
    • Christensen, T. Human endogenous retroviruses in neurologic disease. APMIS 124, 116-126 (2016).
    • (2016) APMIS , vol.124 , pp. 116-126
    • Christensen, T.1
  • 96
    • 84942938334 scopus 로고    scopus 로고
    • Human endogenous retrovirus-K contributes to motor neuron disease
    • Li, W., et al. Human endogenous retrovirus-K contributes to motor neuron disease. Sci. Transl Med. 7, 307ra153 (2015).
    • (2015) Sci. Transl Med. , vol.7 , pp. 307ra153
    • Li, W.1
  • 97
    • 84964659793 scopus 로고    scopus 로고
    • Human endogenous retroviruses as pathogenic factors in the development of schizophrenia
    • Slokar, G. & Hasler, G. Human endogenous retroviruses as pathogenic factors in the development of schizophrenia. Front. Psychiatry 6, 183 (2015).
    • (2015) Front. Psychiatry , vol.6 , pp. 183
    • Slokar, G.1    Hasler, G.2
  • 98
    • 66149157654 scopus 로고    scopus 로고
    • Human-specific modulation of transcriptional activity provided by endogenous retroviral insertions
    • Gogvadze, E., Stukacheva, E., Buzdin, A. & Sverdlov, E. Human-specific modulation of transcriptional activity provided by endogenous retroviral insertions. J. Virol. 83, 6098-6105 (2009).
    • (2009) J. Virol. , vol.83 , pp. 6098-6105
    • Gogvadze, E.1    Stukacheva, E.2    Buzdin, A.3    Sverdlov, E.4
  • 99
    • 84901651635 scopus 로고    scopus 로고
    • Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance
    • Fort, A., et al. Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance. Nat. Genet. 46, 558-566 (2014).
    • (2014) Nat. Genet. , vol.46 , pp. 558-566
    • Fort, A.1
  • 100
    • 84863458292 scopus 로고    scopus 로고
    • Embryonic stem cell potency fluctuates with endogenous retrovirus activity
    • Macfarlan, T. S., et al. Embryonic stem cell potency fluctuates with endogenous retrovirus activity. Nature 487, 57-63 (2012).
    • (2012) Nature , vol.487 , pp. 57-63
    • Macfarlan, T.S.1
  • 101
    • 84960194716 scopus 로고    scopus 로고
    • Regulatory evolution of innate immunity through co-option of endogenous retroviruses
    • Chuong, E. B., Elde, N. C. & Feschotte, C. Regulatory evolution of innate immunity through co-option of endogenous retroviruses. Science 351, 1083-1087 (2016).
    • (2016) Science , vol.351 , pp. 1083-1087
    • Chuong, E.B.1    Elde, N.C.2    Feschotte, C.3
  • 102
    • 72849115174 scopus 로고    scopus 로고
    • Origin and evolution of the adaptive immune system: Genetic events and selective pressures
    • Flajnik, M. F. & Kasahara, M. Origin and evolution of the adaptive immune system: genetic events and selective pressures. Nat. Rev. Genet. 11, 47-59 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 47-59
    • Flajnik, M.F.1    Kasahara, M.2
  • 103
    • 84976871257 scopus 로고    scopus 로고
    • Discovery of an active RAG transposon illuminates the origins of V(D)J recombination
    • Huang, S., et al. Discovery of an active RAG transposon illuminates the origins of V(D)J recombination. Cell 166, 102-114 (2016).
    • (2016) Cell , vol.166 , pp. 102-114
    • Huang, S.1
  • 104
    • 72949113702 scopus 로고    scopus 로고
    • How did our complex immune system evolve?
    • Cooper, M. D. & Herrin, B. R. How did our complex immune system evolve? Nat. Rev. Immunol. 10, 2-3 (2010).
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 2-3
    • Cooper, M.D.1    Herrin, B.R.2
  • 105
    • 84880979966 scopus 로고    scopus 로고
    • In the company of cowbirds, Molothrus ater ater: Robust patterns of sociability predict reproductive performance
    • Kohn, G. M., King, A. P., Dohme, R., Meredith, G. R. & West, M. J. In the company of cowbirds, Molothrus ater ater: robust patterns of sociability predict reproductive performance. J. Comp. Psychol. 127, 40-48 (2013).
    • (2013) J. Comp. Psychol. , vol.127 , pp. 40-48
    • Kohn, G.M.1    King, A.P.2    Dohme, R.3    Meredith, G.R.4    West, M.J.5
  • 106
    • 17344362313 scopus 로고    scopus 로고
    • Ligand recognition by αβ T cell receptors
    • Davis, M. M., et al. Ligand recognition by αβ T cell receptors. Annu. Rev. Immunol. 16, 523-544 (1998).
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 523-544
    • Davis, M.M.1
  • 107
    • 0042696999 scopus 로고    scopus 로고
    • Antigen presentation to naive CD4 T cells in the lymph node
    • Itano, A. A. & Jenkins, M. K. Antigen presentation to naive CD4 T cells in the lymph node. Nat. Immunol. 4, 733-739 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 733-739
    • Itano, A.A.1    Jenkins, M.K.2
  • 108
    • 77649220954 scopus 로고    scopus 로고
    • Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
    • O'Shea, J. J. & Paul, W. E. Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 327, 1098-1102 (2010).
    • (2010) Science , vol.327 , pp. 1098-1102
    • O'Shea, J.J.1    Paul, W.E.2
  • 109
    • 0028966206 scopus 로고
    • Evidence that cytokine-mediated immune interactions induced by Schistosoma mansoni alter disease outcome in mice concurrently infected with Trichuris muris
    • Curry, A. J., et al. Evidence that cytokine-mediated immune interactions induced by Schistosoma mansoni alter disease outcome in mice concurrently infected with Trichuris muris. J. Exp. Med. 181, 769-774 (1995).
    • (1995) J. Exp. Med. , vol.181 , pp. 769-774
    • Curry, A.J.1
  • 111
    • 84959020187 scopus 로고    scopus 로고
    • Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid
    • Schlager, C., et al. Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid. Nature 530, 349-353 (2016).
    • (2016) Nature , vol.530 , pp. 349-353
    • Schlager, C.1
  • 112
    • 0037816192 scopus 로고    scopus 로고
    • Human cerebrospinal fluid central memory CD4+ T cells: Evidence for trafficking through choroid plexus and meninges via P-selectin
    • Kivisakk, P., et al. Human cerebrospinal fluid central memory CD4+ T cells: evidence for trafficking through choroid plexus and meninges via P-selectin. Proc. Natl Acad. Sci. USA 100, 8389-8394 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 8389-8394
    • Kivisakk, P.1
  • 113
    • 84942469639 scopus 로고    scopus 로고
    • A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
    • Aspelund, A., et al. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J. Exp. Med. 212, 991-999 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 991-999
    • Aspelund, A.1
  • 114
    • 84936871460 scopus 로고    scopus 로고
    • Structural and functional features of central nervous system lymphatic vessels
    • Louveau, A., et al. Structural and functional features of central nervous system lymphatic vessels. Nature 523, 337-341 (2015).
    • (2015) Nature , vol.523 , pp. 337-341
    • Louveau, A.1
  • 115
    • 84869885852 scopus 로고    scopus 로고
    • Capture, crawl, cross: The T cell code to breach the blood-brain barriers
    • Engelhardt, B. & Ransohoff, R. M. Capture, crawl, cross: The T cell code to breach the blood-brain barriers. Trends Immunol. 33, 579-589 (2012).
    • (2012) Trends Immunol. , vol.33 , pp. 579-589
    • Engelhardt, B.1    Ransohoff, R.M.2
  • 116
    • 0036166387 scopus 로고    scopus 로고
    • Chemokines and the tissue-specific migration of lymphocytes
    • Kunkel, E. J. & Butcher, E. C. Chemokines and the tissue-specific migration of lymphocytes. Immunity 16, 1-4 (2002).
    • (2002) Immunity , vol.16 , pp. 1-4
    • Kunkel, E.J.1    Butcher, E.C.2
  • 117
    • 0026506799 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin
    • Yednock, T. A., et al. Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin. Nature 356, 63-66 (1992).
    • (1992) Nature , vol.356 , pp. 63-66
    • Yednock, T.A.1
  • 118
    • 0017816680 scopus 로고
    • Eosinophilic granulocytes in cerebrospinal fluid: Analysis of 94 cerebrospinal fluid specimens and review of the literature
    • Bosch, I. & Oehmichen, M. Eosinophilic granulocytes in cerebrospinal fluid: analysis of 94 cerebrospinal fluid specimens and review of the literature. J. Neurol. 219, 93-105 (1978).
    • (1978) J. Neurol. , vol.219 , pp. 93-105
    • Bosch, I.1    Oehmichen, M.2
  • 119
    • 84978066752 scopus 로고    scopus 로고
    • Increased prevalence of lymphoid tissue inducer cells in the cerebrospinal fluid of patients with early multiple sclerosis
    • Degn, M., et al. Increased prevalence of lymphoid tissue inducer cells in the cerebrospinal fluid of patients with early multiple sclerosis. Mult. Scler. 22, 1013-1020 (2016).
    • (2016) Mult. Scler. , vol.22 , pp. 1013-1020
    • Degn, M.1
  • 120
    • 85012254755 scopus 로고    scopus 로고
    • Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury
    • Gadani, S. P., Smirnov, I., Smith, A. T., Overall, C. C. & Kipnis, J. Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury. J. Exp. Med. 214, 285-296 (2016).
    • (2016) J. Exp. Med. , vol.214 , pp. 285-296
    • Gadani, S.P.1    Smirnov, I.2    Smith, A.T.3    Overall, C.C.4    Kipnis, J.5
  • 121
    • 84895074713 scopus 로고    scopus 로고
    • Immune cell subtyping in the cerebrospinal fluid of patients with neurological diseases
    • Kowarik, M. C., et al. Immune cell subtyping in the cerebrospinal fluid of patients with neurological diseases. J. Neurol. 261, 130-143 (2014).
    • (2014) J. Neurol. , vol.261 , pp. 130-143
    • Kowarik, M.C.1
  • 122
    • 84873575370 scopus 로고    scopus 로고
    • Two-photon microscopy imaging of thy1GFP-M transgenic mice: A novel animal model to investigate brain dendritic cell subsets in vivo
    • Laperchia, C., et al. Two-photon microscopy imaging of thy1GFP-M transgenic mice: A novel animal model to investigate brain dendritic cell subsets in vivo. PLoS ONE 8, e56144 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e56144
    • Laperchia, C.1
  • 123
    • 79955458125 scopus 로고    scopus 로고
    • Illuminating viral infections in the nervous system
    • McGavern, D. B. & Kang, S. S. Illuminating viral infections in the nervous system. Nat. Rev. Immunol. 11, 318-329 (2011).
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 318-329
    • McGavern, D.B.1    Kang, S.S.2
  • 124
    • 0035211232 scopus 로고    scopus 로고
    • Delayed inflammation in rat meninges: Implications for migraine pathophysiology
    • Reuter, U., et al. Delayed inflammation in rat meninges: implications for migraine pathophysiology. Brain 124, 2490-2502 (2001).
    • (2001) Brain , vol.124 , pp. 2490-2502
    • Reuter, U.1
  • 125
    • 77953639372 scopus 로고    scopus 로고
    • Meningeal mast cells affect early T cell central nervous system infiltration and blood-brain barrier integrity through TNF: A role for neutrophil recruitment?
    • Sayed, B. A., Christy, A. L., Walker, M. E. & Brown, M. A. Meningeal mast cells affect early T cell central nervous system infiltration and blood-brain barrier integrity through TNF: A role for neutrophil recruitment? J. Immunol. 184, 6891-6900 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 6891-6900
    • Sayed, B.A.1    Christy, A.L.2    Walker, M.E.3    Brown, M.A.4
  • 126
    • 84978766827 scopus 로고    scopus 로고
    • Cytokine and growth factor activation in vivo and in vitro after spinal cord injury
    • Garcia, E., Aguilar-Cevallos, J., Silva-Garcia, R. & Ibarra, A. Cytokine and growth factor activation in vivo and in vitro after spinal cord injury. Mediators Inflamm. 2016, 9476020 (2016).
    • (2016) Mediators Inflamm. , vol.2016 , pp. 9476020
    • Garcia, E.1    Aguilar-Cevallos, J.2    Silva-Garcia, R.3    Ibarra, A.4


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