메뉴 건너뛰기




Volumn 41, Issue 6, 2016, Pages 386-394

Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 33; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; KYNURENINE; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR; MESSENGER RNA;

EID: 84992499908     PISSN: 11804882     EISSN: 14882434     Source Type: Journal    
DOI: 10.1503/jpn.150226     Document Type: Article
Times cited : (75)

References (61)
  • 1
    • 79953662385 scopus 로고    scopus 로고
    • Immune system to brain signaling: Neuropsychopharmacological implications
    • Capuron L, Miller AH. Immune system to brain signaling: neuropsychopharmacological implications. Pharmacol Ther 2011;130: 226-38.
    • (2011) Pharmacol Ther , vol.130 , pp. 226-238
    • Capuron, L.1    Miller, A.H.2
  • 2
    • 84856111463 scopus 로고    scopus 로고
    • Psychoneuroimmunology meets neuropsychopharmacology: Translational implications of the impact of inflammation on behavior
    • Haroon E, Raison CL, Miller AH. Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 2012;37:137-62.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 137-162
    • Haroon, E.1    Raison, C.L.2    Miller, A.H.3
  • 3
    • 84876079221 scopus 로고    scopus 로고
    • Cytokine targets in the brain: Impact on neurotransmitters and neurocircuits
    • Miller AH, Haroon E, Raison CL, et al. Cytokine targets in the brain: impact on neurotransmitters and neurocircuits. Depress Anxiety 2013;30:297-306
    • (2013) Depress Anxiety , vol.30 , pp. 297-306
    • Miller, A.H.1    Haroon, E.2    Raison, C.L.3
  • 4
    • 84878155936 scopus 로고    scopus 로고
    • Malaise, melancholia and madness: The evolutionary legacy of an inflammatory bias
    • Raison CL, Miller AH. Malaise, melancholia and madness: the evolutionary legacy of an inflammatory bias. Brain Behav Immun 2013; 31:1-8.
    • (2013) Brain Behav Immun , vol.31 , pp. 1-8
    • Raison, C.L.1    Miller, A.H.2
  • 5
    • 84866332726 scopus 로고    scopus 로고
    • Indoleamine 2,3­­dioxygenase activation and depressive symptoms: Results from the Young Finns Study
    • Elovainio M, Hurme M, Jokela M, et al. Indoleamine 2,3­­dioxygenase activation and depressive symptoms: results from the Young Finns Study. Psychosom Med 2012;74:675-81.
    • (2012) Psychosom Med , vol.74 , pp. 675-681
    • Elovainio, M.1    Hurme, M.2    Jokela, M.3
  • 6
    • 73649114218 scopus 로고    scopus 로고
    • The kynurenine pathway in adolescent depression: Preliminary findings from a proton MR spectroscopy study
    • Gabbay V, Liebes L, Katz Y, et al. The kynurenine pathway in adolescent depression: preliminary findings from a proton MR spectroscopy study. Prog Neuropsychopharmacol Biol Psychiatry 2010;34:37-44.
    • (2010) Prog Neuropsychopharmacol Biol Psychiatry , vol.34 , pp. 37-44
    • Gabbay, V.1    Liebes, L.2    Katz, Y.3
  • 7
    • 84864772397 scopus 로고    scopus 로고
    • Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression
    • Kim H, Chen L, Lim G, et al. Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression. J Clin Invest 2012;122:2940-54.
    • (2012) J Clin Invest , vol.122 , pp. 2940-2954
    • Kim, H.1    Chen, L.2    Lim, G.3
  • 8
    • 37849027118 scopus 로고    scopus 로고
    • The immune effects of TRYCATs (Tryptophan catabolites along the IDO pathway): Relevance for depression and other conditions characterized by tryptophan depletion induced by inflammation
    • Maes M, Mihaylova I, Ruyter MD, et al. The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression and other conditions characterized by tryptophan depletion induced by inflammation. Neuroendocrinol Lett 2007;28:826-31.
    • (2007) Neuroendocrinol Lett , vol.28 , pp. 826-831
    • Maes, M.1    Mihaylova, I.2    Ruyter, M.D.3
  • 9
    • 34547794475 scopus 로고    scopus 로고
    • The immune-mediated alteration of serotonin and glutamate: Towards an integrated view of depression
    • Müller N, Schwarz MJ. The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression. Mol Psychiatry 2007;12:988-1000.
    • (2007) Mol Psychiatry , vol.12 , pp. 988-1000
    • Müller, N.1    Schwarz, M.J.2
  • 10
    • 77950022119 scopus 로고    scopus 로고
    • CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: Elationship to CNS immune responses and depression
    • Raison CL, Dantzer R, Kelley KW, et al. CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: elationship to CNS immune responses and depression. Mol Psychiatry 2010;15:393-403 10.1038/mp.2009.116.
    • (2010) Mol Psychiatry , vol.15 , pp. 393-403
    • Raison, C.L.1    Dantzer, R.2    Kelley, K.W.3
  • 11
    • 21244495606 scopus 로고    scopus 로고
    • IDO and interferon-alpha-induced depressive symptoms: A shift in hypothesis from tryptophan depletion to neurotoxicity
    • Wichers MC, Koek GH, Robaeys G, et al. IDO and interferon-alpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity. Mol Psychiatry 2005;10:538-44.
    • (2005) Mol Psychiatry , vol.10 , pp. 538-544
    • Wichers, M.C.1    Koek, G.H.2    Robaeys, G.3
  • 12
    • 84857627249 scopus 로고    scopus 로고
    • Kynurenic acid: A metabolite with multiple actions and multiple targets in brain and periphery
    • Moroni F, Cozzi A, Sili M, et al. Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery. J Neural Transm (Vienna) 2012;119:133-9.
    • (2012) J Neural Transm (Vienna) , vol.119 , pp. 133-139
    • Moroni, F.1    Cozzi, A.2    Sili, M.3
  • 13
    • 80052710746 scopus 로고    scopus 로고
    • Fluctuations in endo­genous kynurenic acid control hippocampal glutamate and memory
    • Pocivavsek A, Wu HQ, Potter MC, et al. Fluctuations in endo­genous kynurenic acid control hippocampal glutamate and memory. Neuropsychopharmacology 2011;36:2357-67.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 2357-2367
    • Pocivavsek, A.1    Wu, H.Q.2    Potter, M.C.3
  • 14
    • 84862603083 scopus 로고    scopus 로고
    • Kynurenines in the mammalian brain: When physiology meets pathology
    • Schwarcz R, Bruno JP, Muchowski PJ, et al. Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci 2012;13:465-77.
    • (2012) Nat Rev Neurosci , vol.13 , pp. 465-477
    • Schwarcz, R.1    Bruno, J.P.2    Muchowski, P.J.3
  • 15
    • 75049085333 scopus 로고    scopus 로고
    • The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex
    • Wu HQ, Pereira EF, Bruno JP, et al. The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex. J Mol Neurosci 2010;40:204-10.
    • (2010) J Mol Neurosci , vol.40 , pp. 204-210
    • Wu, H.Q.1    Pereira, E.F.2    Bruno, J.P.3
  • 16
    • 84880684441 scopus 로고    scopus 로고
    • New paradigms for treatment-resistant depression
    • Zarate C, Duman RS, Liu G, et al. New paradigms for treatment-resistant depression. Ann N Y Acad Sci 2013;1292:21-31.
    • (2013) Ann N Y Acad Sci , vol.1292 , pp. 21-31
    • Zarate, C.1    Duman, R.S.2    Liu, G.3
  • 17
    • 84862779106 scopus 로고    scopus 로고
    • Neurobehavioral effects of interferon-alpha in patients with hepatitis-C: Symptom dimensions and responsiveness to paroxetine
    • McNutt MD, Liu S, Manatunga A, et al. Neurobehavioral effects of interferon-alpha in patients with hepatitis-C: symptom dimensions and responsiveness to paroxetine. Neuropsychopharmacology 2012; 37:1444-54.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 1444-1454
    • McNutt, M.D.1    Liu, S.2    Manatunga, A.3
  • 18
    • 0142250797 scopus 로고    scopus 로고
    • Interferon-alpha-induced changes in tryptophan metabolism. Relationship to depression and paroxetine treatment
    • Capuron L, Neurauter G, Musselman DL, et al. Interferon-alpha-induced changes in tryptophan metabolism. Relationship to depression and paroxetine treatment. Biol Psychiatry 2003;54:906-14.
    • (2003) Biol Psychiatry , vol.54 , pp. 906-914
    • Capuron, L.1    Neurauter, G.2    Musselman, D.L.3
  • 20
    • 0036429451 scopus 로고    scopus 로고
    • Low levels of circulating inflammatory cytokines — Do they affect human brain functions?
    • Pollmächer T, Haack M, Schuld A, et al. Low levels of circulating inflammatory cytokines — Do they affect human brain functions? Brain Behav Immun 2002;16:525-32.
    • (2002) Brain Behav Immun , vol.16 , pp. 525-532
    • Pollmächer, T.1    Haack, M.2    Schuld, A.3
  • 21
    • 84875211649 scopus 로고    scopus 로고
    • Connecting inflammation with glutamate agonism in suicidality
    • Erhardt S, Lim CK, Linderholm KR, et al. Connecting inflammation with glutamate agonism in suicidality. Neuropsychopharmacology 2013;38:743-52.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 743-752
    • Erhardt, S.1    Lim, C.K.2    Linderholm, K.R.3
  • 22
    • 84857627727 scopus 로고    scopus 로고
    • The possible role of the kynurenine pathway in anhedonia in adolescents
    • Gabbay V, Ely BA, Babb J, et al. The possible role of the kynurenine pathway in anhedonia in adolescents. J Neural Transm (Vienna) 2012;119:253-60.
    • (2012) J Neural Transm (Vienna) , vol.119 , pp. 253-260
    • Gabbay, V.1    Ely, B.A.2    Babb, J.3
  • 23
    • 77954509277 scopus 로고    scopus 로고
    • The possible role of the kynurenine pathway in adolescent depression with melancholic features
    • Gabbay V, Klein RG, Katz Y, et al. The possible role of the kynurenine pathway in adolescent depression with melancholic features. J Child Psychol Psychiatry 2010;51:935-43.
    • (2010) J Child Psychol Psychiatry , vol.51 , pp. 935-943
    • Gabbay, V.1    Klein, R.G.2    Katz, Y.3
  • 24
    • 84866333507 scopus 로고    scopus 로고
    • Neuroinflammation and depression: The role of indoleamine 2,3-dioxygenase (IDO) as a molecular pathway
    • Sublette ME, Postolache TT. Neuroinflammation and depression: the role of indoleamine 2,3-dioxygenase (IDO) as a molecular pathway. Psychosom Med 2012;74:668-72.
    • (2012) Psychosom Med , vol.74 , pp. 668-672
    • Sublette, M.E.1    Postolache, T.T.2
  • 25
    • 84863858002 scopus 로고    scopus 로고
    • Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation
    • Hughes MM, Carballedo A, McLoughlin DM, et al. Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation. Brain Behav Immun 2012;26:979-87.
    • (2012) Brain Behav Immun , vol.26 , pp. 979-987
    • Hughes, M.M.1    Carballedo, A.2    McLoughlin, D.M.3
  • 26
    • 84901228336 scopus 로고    scopus 로고
    • Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms?
    • Quak J, Doornbos B, Roest AM, et al. Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms? Psychoneuroendocrinology 2014;45:202-10.
    • (2014) Psychoneuroendocrinology , vol.45 , pp. 202-210
    • Quak, J.1    Doornbos, B.2    Roest, A.M.3
  • 27
    • 84919402536 scopus 로고    scopus 로고
    • A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality
    • Bay-Richter C, Linderholm KR, Lim CK, et al. A role for inflammatory metabolites as modulators of the glutamate N-methyl-d-aspartate receptor in depression and suicidality. Brain Behav Immun 2015;43:110-7.
    • (2015) Brain Behav Immun , vol.43 , pp. 110-117
    • Bay-Richter, C.1    Linderholm, K.R.2    Lim, C.K.3
  • 28
    • 40949098991 scopus 로고    scopus 로고
    • Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder
    • Miller CL, Llenos IC, Cwik M, et al. Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder. Neurochem Int 2008;52:1297-303.
    • (2008) Neurochem Int , vol.52 , pp. 1297-1303
    • Miller, C.L.1    Llenos, I.C.2    Cwik, M.3
  • 29
    • 33644963618 scopus 로고    scopus 로고
    • Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder
    • Miller CL, Llenos IC, Dulay JR, et al. Upregulation of the initiating step of the kynurenine pathway in postmortem anterior cingulate cortex from individuals with schizophrenia and bipolar disorder. Brain Res 2006;1073-1074:25-37.
    • (2006) Brain Res , vol.1073-1074 , pp. 25-37
    • Miller, C.L.1    Llenos, I.C.2    Dulay, J.R.3
  • 30
    • 81155157520 scopus 로고    scopus 로고
    • Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?
    • Steiner J, Walter M, Gos T, et al. Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission? J Neuroinflammation 2011;8:94.
    • (2011) J Neuroinflammation , vol.8 , pp. 94
    • Steiner, J.1    Walter, M.2    Gos, T.3
  • 31
    • 37049029415 scopus 로고    scopus 로고
    • Orbitofrontal cortex function and structure in depression
    • Drevets WC. Orbitofrontal cortex function and structure in depression. Ann N Y Acad Sci 2007;1121:499-527.
    • (2007) Ann N Y Acad Sci , vol.1121 , pp. 499-527
    • Drevets, W.C.1
  • 32
    • 67349122031 scopus 로고    scopus 로고
    • The functional neuroanatomy of depression: Distinct roles for ventromedial and dorsolateral prefrontal cortex
    • Koenigs M, Grafman J. The functional neuroanatomy of depression: distinct roles for ventromedial and dorsolateral prefrontal cortex. Behav Brain Res 2009;201:239-43.
    • (2009) Behav Brain Res , vol.201 , pp. 239-243
    • Koenigs, M.1    Grafman, J.2
  • 33
    • 84855312099 scopus 로고    scopus 로고
    • Neural circuits underlying the pathophysiology of mood disorders
    • Price JL, Drevets WC. Neural circuits underlying the pathophysiology of mood disorders. Trends Cogn Sci 2012;16:61-71.
    • (2012) Trends Cogn Sci , vol.16 , pp. 61-71
    • Price, J.L.1    Drevets, W.C.2
  • 34
    • 3543136066 scopus 로고    scopus 로고
    • Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls
    • Neumeister A, Nugent AC, Waldeck T, et al. Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls. Arch Gen Psychiatry 2004;61:765-73.
    • (2004) Arch Gen Psychiatry , vol.61 , pp. 765-773
    • Neumeister, A.1    Nugent, A.C.2    Waldeck, T.3
  • 35
    • 0142153196 scopus 로고    scopus 로고
    • Neurobiology of suicidal behaviour
    • Mann JJ. Neurobiology of suicidal behaviour. Nat Rev Neurosci 2003;4:819-28.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 819-828
    • Mann, J.J.1
  • 36
    • 0031590825 scopus 로고    scopus 로고
    • Postmortem findings in suicide victims. Implications for in vivo imaging studies
    • Arango V, Underwood MD, Mann JJ. Postmortem findings in suicide victims. Implications for in vivo imaging studies. Ann N Y Acad Sci 1997;836:269-87.
    • (1997) Ann N Y Acad Sci , vol.836 , pp. 269-287
    • Arango, V.1    Underwood, M.D.2    Mann, J.J.3
  • 37
    • 84862686203 scopus 로고    scopus 로고
    • Neuron density and serotonin receptor binding in prefrontal cortex in suicide
    • Underwood MD, Kassir SA, Bakalian MJ, et al. Neuron density and serotonin receptor binding in prefrontal cortex in suicide. Int J Neuropsychopharmacol 2012;15:435-47.
    • (2012) Int J Neuropsychopharmacol , vol.15 , pp. 435-447
    • Underwood, M.D.1    Kassir, S.A.2    Bakalian, M.J.3
  • 38
    • 38849185889 scopus 로고    scopus 로고
    • Elevated cytokine expression in the orbitofrontal cortex of victims of suicide
    • Tonelli LH, Stiller J, Rujescu D, et al. Elevated cytokine expression in the orbitofrontal cortex of victims of suicide. Acta psychiatrica Scandinavica 2008;117:198-206.
    • (2008) Acta Psychiatrica Scandinavica , vol.117 , pp. 198-206
    • Tonelli, L.H.1    Stiller, J.2    Rujescu, D.3
  • 39
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative C(T) method
    • Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008;3:1101-8.
    • (2008) Nat Protoc , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 40
    • 84862785742 scopus 로고    scopus 로고
    • Gas chromatography/tandem mass spectrometry detection of extracellular kynurenine and related metabolites in normal and lesioned rat brain
    • Notarangelo FM, Wu HQ, Macherone A, et al. Gas chromatography/tandem mass spectrometry detection of extracellular kynurenine and related metabolites in normal and lesioned rat brain. Anal Biochem 2012;421:573-81.
    • (2012) Anal Biochem , vol.421 , pp. 573-581
    • Notarangelo, F.M.1    Wu, H.Q.2    Macherone, A.3
  • 41
    • 33751558659 scopus 로고    scopus 로고
    • Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry
    • Guidetti P, Hoffman GE, Melendez-Ferro M, et al. Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry. Glia 2007;55:78-92.
    • (2007) Glia , vol.55 , pp. 78-92
    • Guidetti, P.1    Hoffman, G.E.2    Melendez-Ferro, M.3
  • 42
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A new and powerful approach to multiple testing
    • Benjamini YH. Controlling the false discovery rate: a new and powerful approach to multiple testing. J R Stat Soc Ser A Stat Soc 1995;57:1289-300.
    • (1995) J R Stat Soc Ser a Stat Soc , vol.57 , pp. 1289-1300
    • Benjamini, Y.H.1
  • 43
    • 79959588892 scopus 로고    scopus 로고
    • Mechanism of acute tryptophan depletion: Is it only serotonin?
    • van Donkelaar EL, Blokland A, Ferrington L, et al. Mechanism of acute tryptophan depletion: Is it only serotonin? Mol Psychiatry 2011;16:695-713.
    • (2011) Mol Psychiatry , vol.16 , pp. 695-713
    • Van Donkelaar, E.L.1    Blokland, A.2    Ferrington, L.3
  • 44
    • 84939941566 scopus 로고    scopus 로고
    • Acute tryptophan depletion reduces kynurenine levels: Implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome
    • Kennedy PJ, Allen AP, O’Neill A, et al. Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome. Psychopharmacology (Berl) 2015;232:1357-71.
    • (2015) Psychopharmacology (Berl) , vol.232 , pp. 1357-1371
    • Kennedy, P.J.1    Allen, A.P.2    O’Neill, A.3
  • 45
    • 79960266118 scopus 로고    scopus 로고
    • Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder
    • Sublette ME, Galfalvy HC, Fuchs D, et al. Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder. Brain Behav Immun 2011;25:1272-8.
    • (2011) Brain Behav Immun , vol.25 , pp. 1272-1278
    • Sublette, M.E.1    Galfalvy, H.C.2    Fuchs, D.3
  • 46
    • 84927712616 scopus 로고    scopus 로고
    • Ongoing episode of major depressive disorder is not associated with elevated plasma levels of kynurenine pathway markers
    • Dahl J, Andreassen OA, Verkerk R, et al. Ongoing episode of major depressive disorder is not associated with elevated plasma levels of kynurenine pathway markers. Psychoneuroendocrinology 2015;56:12-22.
    • (2015) Psychoneuroendocrinology , vol.56 , pp. 12-22
    • Dahl, J.1    Reassen, O.A.2    Verkerk, R.3
  • 47
    • 84928824523 scopus 로고    scopus 로고
    • Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder
    • Savitz J, Drevets WC, Wurfel BE, et al. Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder. Brain Behav Immun 2015; 46:55-9.
    • (2015) Brain Behav Immun , vol.46 , pp. 55-59
    • Savitz, J.1    Drevets, W.C.2    Wurfel, B.E.3
  • 48
    • 84937990984 scopus 로고    scopus 로고
    • Decreased quinolinic acid in the hippocampus of depressive patients: Evidence for local antiinflammatory and neuroprotective responses?
    • Busse M, Busse S, Myint AM, et al. Decreased quinolinic acid in the hippocampus of depressive patients: Evidence for local antiinflammatory and neuroprotective responses? Eur Arch Psychiatry Clin Neurosci 2015;265:321-9.
    • (2015) Eur Arch Psychiatry Clin Neurosci , vol.265 , pp. 321-329
    • Busse, M.1    Busse, S.2    Myint, A.M.3
  • 49
    • 84879410148 scopus 로고    scopus 로고
    • Different changes in cortical tumor necrosis factor-alpha-related pathways in schizophrenia and mood disorders
    • Dean B, Gibbons AS, Tawadros N, et al. Different changes in cortical tumor necrosis factor-alpha-related pathways in schizophrenia and mood disorders. Mol Psychiatry 2013;18:767-73.
    • (2013) Mol Psychiatry , vol.18 , pp. 767-773
    • Dean, B.1    Gibbons, A.S.2    Tawadros, N.3
  • 50
    • 71649086548 scopus 로고    scopus 로고
    • Regionally-specific changes in levels of tumour necrosis factor in the dorsolateral prefrontal cortex obtained postmortem from subjects with major depressive disorder
    • Dean B, Tawadros N, Scarr E, et al. Regionally-specific changes in levels of tumour necrosis factor in the dorsolateral prefrontal cortex obtained postmortem from subjects with major depressive disorder. J Affect Disord 2010;120:245-8.
    • (2010) J Affect Disord , vol.120 , pp. 245-248
    • Dean, B.1    Tawadros, N.2    Scarr, E.3
  • 51
    • 81855198982 scopus 로고    scopus 로고
    • Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims
    • Pandey GN, Rizavi HS, Ren X, et al. Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims. J Psychiatr Res 2012;46:57-63.
    • (2012) J Psychiatr Res , vol.46 , pp. 57-63
    • Pandey, G.N.1    Rizavi, H.S.2    Ren, X.3
  • 52
    • 47749100389 scopus 로고    scopus 로고
    • Gene expression analysis in the human hypothalamus in depression by laser micro­ dissection and real-time PCR: The presence of multiple receptor imbalances
    • Wang SS, Kamphuis W, Huitinga I, et al. Gene expression analysis in the human hypothalamus in depression by laser micro­ dissection and real-time PCR: the presence of multiple receptor imbalances. Mol Psychiatry 2008;13:786-99.
    • (2008) Mol Psychiatry , vol.13 , pp. 786-799
    • Wang, S.S.1    Kamphuis, W.2    Huitinga, I.3
  • 53
    • 79959611025 scopus 로고    scopus 로고
    • Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression
    • Shelton RC, Claiborne J, Sidoryk-Wegrzynowicz M, et al. Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression. Mol Psychiatry 2011;16:751-62.
    • (2011) Mol Psychiatry , vol.16 , pp. 751-762
    • Shelton, R.C.1    Claiborne, J.2    Sidoryk-Wegrzynowicz, M.3
  • 54
    • 1542614040 scopus 로고    scopus 로고
    • Minor depression: Risk profiles, functional disability, health care use and risk of developing major depression
    • Cuijpers P, de Graaf R, van Dorsselaer S. Minor depression: risk profiles, functional disability, health care use and risk of developing major depression. J Affect Disord 2004;79:71-9.
    • (2004) J Affect Disord , vol.79 , pp. 71-79
    • Cuijpers, P.1    De Graaf, R.2    Van Dorsselaer, S.3
  • 55
    • 84925357658 scopus 로고    scopus 로고
    • Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes
    • Setiawan E, Wilson AA, Mizrahi R, et al. Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes. JAMA Psychiatry 2015;72:268-75.
    • (2015) JAMA Psychiatry , vol.72 , pp. 268-275
    • Setiawan, E.1    Wilson, A.A.2    Mizrahi, R.3
  • 56
    • 84901253775 scopus 로고    scopus 로고
    • Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis
    • Kreisel T, Frank MG, Licht T, et al. Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis. Mol Psychiatry 2014;19:699-709.
    • (2014) Mol Psychiatry , vol.19 , pp. 699-709
    • Kreisel, T.1    Frank, M.G.2    Licht, T.3
  • 58
    • 84908617290 scopus 로고    scopus 로고
    • Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides
    • Torres-Platas SG, Cruceanu C, Chen GG, et al. Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides. Brain Behav Immun 2014;42:50-9.
    • (2014) Brain Behav Immun , vol.42 , pp. 50-59
    • Torres-Platas, S.G.1    Cruceanu, C.2    Chen, G.G.3
  • 59
    • 33646548627 scopus 로고    scopus 로고
    • A new chapter opens in anti-inflammatory treatments: The antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice
    • Brustolim D, Ribeiro-dos-Santos R, Kast RE, et al. A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice. Int Immunopharmacol 2006;6:903-7.
    • (2006) Int Immunopharmacol , vol.6 , pp. 903-907
    • Brustolim, D.1    Ribeiro-Dos-Santos, R.2    Kast, R.E.3
  • 60
    • 51049098119 scopus 로고    scopus 로고
    • Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants
    • Hwang J, Zheng LT, Ock J, et al. Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants. Neuropharmacology 2008;55:826-34.
    • (2008) Neuropharmacology , vol.55 , pp. 826-834
    • Hwang, J.1    Zheng, L.T.2    Ock, J.3
  • 61
    • 0035107338 scopus 로고    scopus 로고
    • Anti-Inflammatory effects of antide­pressants through suppression of the interferon-gamma/interleukin-10 production ratio
    • Kubera M, Lin AH, Kenis G, et al. Anti-Inflammatory effects of antide­pressants through suppression of the interferon-gamma/interleukin-10 production ratio. J Clin Psychopharmacol 2001;21:199-206.
    • (2001) J Clin Psychopharmacol , vol.21 , pp. 199-206
    • Kubera, M.1    Lin, A.H.2    Kenis, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.