Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients

Journal of Allergy and Clinical Immunology

Volumn 141, Issue 1, 2018, Pages 300-310.e11

  Sugita, Kazunari ^a,b,c   Steer, Catherine A ^d   Martinez Gonzalez, Itziar ^d   Altunbulakli, Can ^a,b   Morita, Hideaki ^a,b,e   Castro Giner, Francesc ^a,b   Kubo, Terufumi ^a,b   Wawrzyniak, Paulina ^a,b   Rückert, Beate ^a,b   Sudo, Katsuko ^f   Nakae, Susumu ^g,h   Matsumoto, Kenji ^e   O'Mahony, Liam ^a,b   Akdis, Mübeccel ^a,b   Takei, Fumio ^d   Akdis, Cezmi A ^a,b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b Hochgebirgsklinik Children s Allergy and Asthma Hospital   (Switzerland)

^c TOTTORI UNIVERSITY   (Japan)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^f TOKYO MEDICAL UNIVERSITY   (Japan)

^g UNIVERSITY OF TOKYO   (Japan)

^h JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

barrier; bronchial epithelium; IL 13; Innate lymphoid cell; tight junction

Indexed keywords

ALPHA 2 MACROGLOBULIN; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; INTERLEUKIN 13; INTERLEUKIN 33; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; MUCIN 5AC; MUCIN 5B; OCCLUDIN; PROTEIN ZO1; RAG2 PROTEIN; RETINOID RELATED ORPHAN RECEPTOR ALPHA; TIGHT JUNCTION PROTEIN; TRANSCRIPTION FACTOR GATA 3; TRANSFERRIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BONE MARROW TRANSPLANTATION; BRONCHIAL EPITHELIAL BARRIER; BRONCHUS EPITHELIUM; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; IN VIVO STUDY; INNATE IMMUNITY; LUNG FUNCTION; LYMPHOID CELL; MOUSE; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; PROCEDURES; PROTEIN EXPRESSION; RESPIRATORY TRACT INFLAMMATION; TH2 CELL; TIGHT JUNCTION; TRANSEPITHELIAL RESISTANCE; TYPE 2 INNATE LYMPHOID CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; EPITHELIUM CELL; IMMUNOLOGY; LYMPHOCYTE SUBPOPULATION; METABOLISM; MUCUS; PATHOLOGY; RESPIRATORY MUCOSA; TRANSGENIC MOUSE;

ANIMALS; ASTHMA; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-13; LYMPHOCYTE SUBSETS; MICE; MICE, TRANSGENIC; MUCUS; RESPIRATORY MUCOSA; TIGHT JUNCTIONS;

EID: 85019159369     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2017.02.038     Document Type: Article

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