Defective epithelial barrier in chronic rhinosinusitis: The regulation of tight junctions by IFN-γ and IL-4

Journal of Allergy and Clinical Immunology

Volumn 130, Issue 5, 2012, Pages 1087-1096.e10

  Soyka, Michael B ^a,b   Wawrzyniak, Paulina ^a   Eiwegger, Thomas ^a,c   Holzmann, David ^b   Treis, Angela ^a   Wanke, Kerstin ^a   Kast, Jeannette I ^a   Akdis, Cezmi A ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Chronic rhinosinusitis; chronic sinusitis; claudin; cytokines; leaky epithelium; occludin; regulation; tight junctions; zonula occludens

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 4; OCCLUDIN; PROTEIN ZO1;

ARTICLE; ASTHMA; CHRONIC RHINOSINUSITIS; CONTROLLED STUDY; ENTERITIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; NOSE POLYP; PARANASAL SINUS; PATHOGENESIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SKIN DISEASE; TIGHT JUNCTION; WESTERN BLOTTING;

EID: 84869147350     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2012.05.052     Document Type: Article

References (44)

1. B.F. Marple, J.A. Stankiewicz, F.M. Baroody, J.M. Chow, D.B. Conley, and J.P. Corey Diagnosis and management of chronic rhinosinusitis in adults Postgrad Med 121 2009 121 139
2. W. Fokkens, V. Lund, and J. Mullol EP3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. A summary for otorhinolaryngologists Rhinology 45 2007 97 101
3. P. Van Cauwenberge, and J.B. Watelet Epidemiology of chronic rhinosinusitis Thorax 55 suppl 2 2000 S20 S21
4. N. Van Bruaene, C. Pérez-Novo, T.M. Basinski, T. Van Zele, G. Holtappels, and N. De Ruyck T-cell regulation in chronic paranasal sinus disease J Allergy Clin Immunol 121 2008 1435 1441 e1-3
5. T. Van Zele, S. Claeys, P. Gevaert, G. Van Maele, G. Holtappels, and P. Van Cauwenberge Differentiation of chronic sinus diseases by measurement of inflammatory mediators Allergy 61 2006 1280 1289 (Pubitemid 44465587)
6. H. Chiba, M. Osanai, M. Murata, T. Kojima, and N. Sawada Transmembrane proteins of tight junctions Biochim Biophys Acta 1778 2008 588 600 (Pubitemid 351317799)
7. J.D. Schulzke, S. Ploeger, M. Amasheh, A. Fromm, S. Zeissig, and H. Troeger Epithelial tight junctions in intestinal inflammation Ann N Y Acad Sci 1165 2009 294 300
8. A. De Benedetto, N.M. Rafaels, L.Y. McGirt, A.I. Ivanaov, S.N. Georas, and C. Cheadle Tight junction defects in patients with atopic dermatitis J Allergy Clin Immunol 127 2011 773 786 e1-7
9. N. Kirschner, P. Houdek, M. Fromm, I. Moll, and J. Brandner Tight junctions form a barrier in human epidermis Eur J Cell Biol 89 2010 839 842
10. S. Holgate Epithelium dysfunction in asthma J Allergy Clin Immunol 120 2007 1233 1246
11. C. Xiao, S.M. Puddicombe, S. Field, J. Haywood, V. Broughton-Head, and I. Puxeddu Defective epithelial barrier function in asthma J Allergy Clin Immunol 128 2011 549 556 e1-12
12. D.D. Tieu, R.C. Kern, and R.P. Schleimer Alterations in epithelial barrier function and host defense responses in chronic rhinosinusitis J Allergy Clin Immunol 124 2009 37 42
13. U. Sajjan, Q. Wang, Y. Zhao, D.C. Gruenert, and M.B. Hershenson Rhinovirus disrupts the barrier function of polarized airway epithelial cells Am J Respir Crit Care Med 178 2008 1271 1281
14. Y.J. Jang, H.G. Kim, T.W. Koo, and P.S. Chung Localization of ZO-1 and E-cadherin in the nasal polyp epithelium Eur Arch Otorhinolaryngol 259 2002 465 469
15. J.D. Zuckerman, W.Y. Lee, J.M. DelGaudio, C.E. Moore, P. Nava, and A. Nusrat Pathophysiology of nasal polyposis: the role of desmosomal junctions Am J Rhinol 22 2008 589 597
16. M. Akdis, S. Burgler, R. Crameri, T. Eiwegger, H. Fujita, and E. Gomez Interleukins, from 1 to 37, and interferon-gamma: receptors, functions, and roles in diseases J Allergy Clin Immunol 127 2011 701 721 e1-70
17. S. Klunker, M.M. Chong, P.Y. Mantel, O. Palomares, C. Bassin, and M. Ziegler Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells J Exp Med 206 2009 2701 2715
18. V. Asgrimsson, T. Gudjonsson, G.H. Gudmundsson, and O. Baldursson Novel effects of azithromycin on tight junction proteins in human airway epithelia Antimicrob Agents Chemother 50 2006 1805 1812
19. W. de Boer, H. Sharma, S. Baelemans, H. Hoogsteden, B. Lambrecht, and G. Braunstahl Altered expression of epithelial junctional proteins in atopic asthma: possible role in inflammation Can J Physiol Pharmacol 86 2008 105 112 (Pubitemid 351536459)
20. J. Koizumi, T. Kojima, R. Kamekura, M. Kurose, A. Harimaya, and M. Murata Changes of gap and tight junctions during differentiation of human nasal epithelial cells using primary human nasal epithelial cells and primary human nasal fibroblast cells in a noncontact coculture system J Membr Biol 218 2007 1 7 (Pubitemid 350132116)
21. D.I. Sun, Y.H. Joo, H.J. Auo, and J.M. Kang Clinical significance of eosinophilic cationic protein levels in nasal secretions of patients with nasal polyposis Eur Arch Otorhinolaryngol 266 2009 981 986
22. 2LEN study Allergy 64 2009 520 533
23. A.M. Marchiando, W.V. Graham, and J.R. Turner Epithelial barriers in homeostasis and disease Annu Rev Pathol 5 2010 119 144
24. J.A. Guttman, and B.B. Finlay Tight junctions as targets of infectious agents Biochim Biophys Acta 1788 2009 832 841
25. T. Masaki, T. Kojima, T. Okabayashi, N. Ogasawara, T. Ohkuni, and K. Obata A nuclear factor-kappaB signaling pathway via protein kinase C delta regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells Mol Biol Cell 22 2011 2144 2156
26. S. Nash, J. Stafford, and J.L. Madara Effects of polymorphonuclear leukocyte transmigration on the barrier function of cultured intestinal epithelial monolayers J Clin Invest 80 1987 1104 1113 (Pubitemid 18075649)
27. S.T. Holgate, H.S. Arshad, G.C. Roberts, P.H. Howarth, P. Thurner, and D.E. Davies A new look at the pathogenesis of asthma Clin Sci (Lond) 118 2010 439 450
28. G.A. Settipane Epidemiology of nasal polyps Allergy Asthma Proc 17 1996 231 236 (Pubitemid 26403402)
29. J.M. Bernstein, J. Gorfien, B. Noble, and J.R. Yankaskas Nasal polyposis: immunohistochemistry and bioelectrical findings (a hypothesis for the development of nasal polyps) J Allergy Clin Immunol 99 1997 165 175 (Pubitemid 27091563)
30. K. Dejima, S.H. Randell, M.J. Stutts, B.A. Senior, and R.C. Boucher Potential role of abnormal ion transport in the pathogenesis of chronic sinusitis Arch Otolaryngol Head Neck Surg 132 2006 1352 1362 (Pubitemid 44956616)
31. H. Fujita, M. Chalubinski, C. Rhyner, P. Indermitte, N. Meyer, and R. Ferstl Claudin-1 expression in airway smooth muscle exacerbates airway remodeling in asthmatic subjects J Allergy Clin Immunol 127 2011 1612 1621 e8
32. X.H. Zhang, Y.N. Zhang, H.B. Li, C.Y. Hu, N. Wang, and P.P. Cao Overexpression of miR-125b, a novel regulator of innate immunity, in eosinophilic chronic rhinosinusitis with nasal polyps Am J Respir Crit Care Med 185 2012 140 151
33. R.M. Naclerio, C. Bachert, and J.N. Baraniuk Pathophysiology of nasal congestion Int J Gen Med 3 2010 47 57
34. J.B. Watelet, C. Bachert, C. Claeys, and P. Van Cauwenberge Matrix metalloproteinases MMP-7, MMP-9 and their tissue inhibitor TIMP-1: expression in chronic sinusitis vs nasal polyposis Allergy 59 2004 54 60 (Pubitemid 38167952)
35. P.D. Vermeer, J. Denker, M. Estin, T.O. Moninger, S. Keshavjee, and P. Karp MMP9 modulates tight junction integrity and cell viability in human airway epithelia Am J Physiol Lung Cell Mol Physiol 296 2009 L751 L762
36. M. Lischper, S. Beuck, G. Thanabalasundaram, C. Pieper, and H.J. Galla Metalloproteinase mediated occludin cleavage in the cerebral microcapillary endothelium under pathological conditions Brain Res 1326 2010 114 127
37. K. Kanai, K. Asano, T. Hisamitsu, and H. Suzaki Suppression of matrix metalloproteinase production from nasal fibroblasts by macrolide antibiotics in vitro Eur Respir J 23 2004 671 678 (Pubitemid 38618134)
38. C.T. Capaldo, and A. Nusrat Cytokine regulation of tight junctions Biochim Biophys Acta 1788 2009 864 871
39. T.M. Basinski, D. Holzmann, T. Eiwegger, M. Zimmermann, S. Klunker, and N. Meyer Dual nature of T cell-epithelium interaction in chronic rhinosinusitis J Allergy Clin Immunol 124 2009 74 80 e1-8
40. N. Meyer, M. Zimmermann, S. Burgler, C. Bassin, S. Woehri, and K. Mortiz IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis J Allergy Clin Immunol 125 2010 858 865 e10
41. M. Zimmermann, A. Koreck, N. Meyer, T. Basinski, F. Meiler, and B. Simone TNF-like weak inducer of apoptosis (TWEAK) and TNF-alpha cooperate in the induction of keratinocyte apoptosis J Allergy Clin Immunol 127 2011 200 207 e1-10
42. F. Sachse, K. Becker, C. von Eiff, D. Metze, and C. Rudack Staphylococcus aureus invades the epithelium in nasal polyposis and induces IL-6 in nasal epithelial cells in vitro Allergy 65 2010 1430 1437
43. S. Runswick, T. Mitchell, P. Davies, C. Robinson, and D.R. Garrod Pollen proteolytic enzymes degrade tight junctions Respirology 12 2007 834 842 (Pubitemid 350045730)
44. X.H. Zhang, Y.N. Zhang, H.B. Li, C.Y. Hu, N. Wang, and P.P. Cao Overexpression of miR-125b, a novel regulator of innate immunity, in eosinophilic chronic rhinosinusitis with nasal polyps Am J Respir Crit Care Med 185 2012 140 151