Impaired barrier function in patients with house dust mite-induced allergic rhinitis is accompanied by decreased occludin and zonula occludens-1 expression

Journal of Allergy and Clinical Immunology

Volumn 137, Issue 4, 2016, Pages 1043-1053.e5

  Steelant, Brecht ^a   Farré, Ricard ^a   Wawrzyniak, Paulina ^b   Belmans, Jochen ^a   Dekimpe, Emily ^a,c   Vanheel, Hanne ^a   Van Gerven, Laura ^a,c   Kortekaas Krohn, Inge ^a   Bullens, Dominique M A ^a   Ceuppens, Jan L ^a   Akdis, Cezmi A ^b   Boeckxstaens, Guy ^a   Seys, Sven F ^a   Hellings, Peter W ^a,c,d,e  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d GHENT UNIVERSITY HOSPITAL   (Belgium)

^e UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Allergic rhinitis; epithelial permeability; epithelial resistance; fluticasone propionate; IL 4; leak pathway; tight junctions

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE DEXTRAN; FLUTICASONE PROPIONATE; GAMMA INTERFERON; INTERLEUKIN 4; OCCLUDIN; PROTEIN ZO1; ANTIINFLAMMATORY AGENT; BIOLOGICAL MARKER; DEXTRAN; FLUORESCEIN ISOTHIOCYANATE; FLUTICASONE; OCLN PROTEIN, HUMAN;

ADULT; ALLERGIC AIRWAY DISEASE; ALLERGIC DISEASE; ALLERGIC RHINITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DERMATOPHAGOIDES; EX VIVO STUDY; EXPLANT; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IN VITRO STUDY; INVESTIGATIVE PROCEDURES; MALE; MOUSE; NASAL EPITHELIAL CELL; NONHUMAN; NOSE MUCOSA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY TRACT DISEASE; TIGHT JUNCTION; TRANSEPITHELIAL RESISTANCE; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CASE CONTROL STUDY; CLINICAL TRIAL; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PERMEABILITY; PYROGLYPHIDAE; RHINITIS, ALLERGIC, PERENNIAL;

ADULT; ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOMARKERS; CASE-CONTROL STUDIES; DEXTRANS; FEMALE; FLUORESCEIN-5-ISOTHIOCYANATE; FLUTICASONE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MIDDLE AGED; NASAL MUCOSA; OCCLUDIN; PERMEABILITY; PYROGLYPHIDAE; REAL-TIME POLYMERASE CHAIN REACTION; RHINITIS, ALLERGIC, PERENNIAL; TIGHT JUNCTIONS; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84956686307     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.10.050     Document Type: Article

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