HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation

Science Signaling

Volumn 8, Issue 389, 2015, Pages

  Galvani, Sylvain ^a   Sanson, Marie ^a   Blaho, Victoria A ^a   Swendeman, Steven L ^a   Conger, Heather ^b   Dahlbäck, Björn ^c   Kono, Mari ^d   Proia, Richard L ^d   Smith, Jonathan D ^b   Hla, Timothy ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ALBUMIN; APOLIPOPROTEIN M; BETA ARRESTIN 2; CELL ADHESION MOLECULE; HIGH DENSITY LIPOPROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULAR ENDOTHELIAL CADHERIN; APOLIPOPROTEIN; APOLIPOPROTEIN M, MOUSE; APOM PROTEIN, HUMAN; ICAM1 PROTEIN, HUMAN; ICAM1 PROTEIN, MOUSE; LIPOCALIN; LYSOPHOSPHOLIPID; S1PR1 PROTEIN, HUMAN; S1PR1 PROTEIN, MOUSE; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; AORTA ENDOTHELIUM; ARTICLE; ATHEROSCLEROTIC PLAQUE; BIOTINYLATION; CAROTID ARTERY BIFURCATION; CELL CULTURE; CELL SURFACE; CHOLESTEROL BLOOD LEVEL; CIRCULATION; CONTROLLED STUDY; DESCENDING AORTA; ENDOCYTOSIS; ENDOTHELIUM CELL; ENZYME INHIBITION; GENE DELETION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHEAR STRESS; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULITIS; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; ATHEROSCLEROSIS; DISEASE MODEL; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

MUS;

ANIMALS; APOLIPOPROTEINS; ATHEROSCLEROSIS; DISEASE MODELS, ANIMAL; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LIPOCALINS; LIPOPROTEINS, HDL; LYSOPHOSPHOLIPIDS; MICE; MICE, KNOCKOUT; RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION; SPHINGOSINE; VASCULITIS;

EID: 84939201829     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.aaa2581     Document Type: Article

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