Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 17, 2017, Pages E3536-E3545

  Longa, Qianfa ^a,c   Upadhya, Dinesh ^a,b,d   Hattiangady, Bharathi ^a,b   Kim, Dong Ki ^a   An, Su Yeon ^a   Shuai, Bing ^a,b   Prockop, Darwin J ^a   Shetty, Ashok K ^a,b  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c XI'AN JIAOTONG UNIVERSITY   (China)

^d MANIPAL UNIVERSITY   (India)

Author keywords

Adult neurogenesis; Exosomes; Memory dysfunction; Neuroinflammation; Status epilepticus

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; PILOCARPINE; PLATELET DERIVED GROWTH FACTOR B; STEM CELL FACTOR; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; BRAIN CORTEX; COGNITION; COGNITIVE DEFECT; COMPARATIVE STUDY; CONTROLLED STUDY; DENTATE HILUS; EPILEPTIC STATE; EXOSOME; EXPERIMENTAL EPILEPSY; GABAERGIC SYSTEM; GLUTAMATERGIC SYNAPSE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; HUMAN; HUMAN CELL; INTERNEURON; INTRANASAL MESENCHYMAL STEM CELL DERIVED A1 EXOSOME TRANSPLANTATION; MEMORY; MEMORY DISORDER; MICROGLIA; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; UPREGULATION; ANIMAL; CELL LINE; INTRANASAL DRUG ADMINISTRATION; MALE; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; TRANSPLANTATION;

ADMINISTRATION, INTRANASAL; ANIMALS; CELL LINE; EXOSOMES; HUMANS; MALE; MEMORY DISORDERS; MESENCHYMAL STROMAL CELLS; MICE; NEUROGENESIS; STATUS EPILEPTICUS;

EID: 85018805183     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1703920114     Document Type: Article

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