Fetal brain inflammation may prime hyperexcitability and behavioral dysfunction later in life

Annals of Neurology

Volumn 74, Issue 1, 2013, Pages 1-3

  Vezzani, Annamaria ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; POLYINOSINIC POLYCYTIDYLIC ACID;

AFTERDISCHARGE; BEHAVIOR DISORDER; CELL CYCLE REGULATION; CELL MIGRATION; COMORBIDITY; EDITORIAL; ENCEPHALITIS; EPILEPSY; EPILEPTOGENESIS; HIPPOCAMPUS; KINDLING; NERVE CELL DIFFERENTIATION; NERVE CELL EXCITABILITY; NERVOUS SYSTEM DEVELOPMENT; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROGENY; SEIZURE; SOCIAL INTERACTION; TONIC CLONIC SEIZURE;

ANIMALS; EPILEPSY; FEMALE; HIPPOCAMPUS; KINDLING, NEUROLOGIC; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS;

EID: 84883268673     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.23930     Document Type: Editorial

References (28)

1. Vezzani A, French J, Bartfai T, Baram TZ,. The role of inflammation in epilepsy. Nat Rev Neurol 2011; 7: 31-40.
2. Kobow K, Auvin S, Jensen F, et al. Finding a better drug for epilepsy: antiepileptogenesis targets. Epilepsia 2012; 53: 1868-1876.
3. Vezzani A, Maroso M, Balosso S, et al. IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures. Brain Behav Immun 2011; 25: 1281-1289.
4. Riazi K, Galic MA, Pittman QJ,. Contributions of peripheral inflammation to seizure susceptibility: cytokines and brain excitability. Epilepsy Res 2010; 89: 34-42.
5. Aronica E, Ravizza T, Zurolo E, Vezzani A,. Astrocyte immune response in epilepsy. Glia 2012; 60: 1258-1268.
6. Aronica E, Crino PB,. Inflammation in epilepsy: clinical observations. Epilepsia 2011; 52 (suppl 3): 26-32.
7. Graeber MB, Li W, Rodriguez ML,. Role of microglia in CNS inflammation. FEBS Lett 2011; 585: 3798-3805.
8. Ravizza T, Balosso S, Aronica E, Vezzani A,. Brain Inflammation and epilepsy. In:, Rho JM, Sankar R, Strafstrom CE, eds. Epilepsy. Mechanisms, models, and translational perspectives. Boca Raton, FL: CRC Press, 2010: 45-59.
9. Viviani B, Gardoni F, Marinovich M,. Cytokines and neuronal ion channels in health and disease. Int Rev Neurobiol 2007; 82: 247-263.
10. Kulkarni SK, Dhir A,. Cyclooxygenase in epilepsy: from perception to application. Drugs Today (Barc) 2009; 45: 135-154.
11. Morin-Brureau M, Lebrun A, Rousset MC, et al. Epileptiform activity induces vascular remodeling and zonula occludens 1 downregulation in organotypic hippocampal cultures: role of VEGF signaling pathways. J Neurosci 2011; 31: 10677-10688.
12. Librizzi L, Noè F, Vezzani A, et al. Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage. Ann Neurol 2012; 72: 82-90.
13. Braganza O, Bedner P, Huttmann K, et al. Albumin is taken up by hippocampal NG2 cells and astrocytes and decreases gap junction coupling. Epilepsia 2012; 53: 1898-1906.
14. Friedman A, Kaufer D, Heinemann U,. Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy. Epilepsy Res 2009; 85: 142-149.
15. Bilbo SD, Schwarz JM,. Early-life programming of later-life brain and behavior: a critical role for the immune system. Front Behav Neurosci 2009; 3: 14.
16. Hagberg H, Gressens P, Mallard C,. Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults. Ann Neurol 2012; 71: 444-457.
17. Auvin S, Mazarati A, Shin D,. Inflammation enhances epileptogenesis in immature rat brain. Neurobiol Dis 2010; 40: 303-310.
18. Harré EM, Galic MA, Mouihate A, et al. Neonatal inflammation produces selective behavioural deficits and alters N-methyl-D-aspartate receptor subunit mRNA in the adult rat brain. Eur J Neurosci 2008; 27: 644-653.
19. Onore C, Careaga M, Ashwood P,. The role of immune dysfunction in the pathophysiology of autism. Brain Behav Immun 2012; 26: 383-392.
20. Brooks-Kayal A,. Epilepsy and autism spectrum disorders: are there common developmental mechanisms? Brain Dev 2010; 32: 731-738.
21. Pineda E, Shin D, You SJ, et al. Maternal immune activation promotes hippocampal kindling epileptogenesis in mice. Ann Neurol 2013; 74: 11-19.
22. Garay PA, Hsiao EY, Patterson PH, McAllister AK,. Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development. Brain Behav Immun 2013; 31: 54-68.
23. Pardo CA, Vargas DL, Zimmerman AW,. Immunity, neuroglia and neuroinflammation in autism. Int Rev Psychiatry 2005; 17: 485-495.
24. Arrode-Bruses G, Bruses JL,. Maternal immune activation by poly(I:C) induces expression of cytokines IL-1beta and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain. J Neuroinflammation 2012; 9: 83.
25. Garbett KA, Hsiao EY, Kalman S, et al. Effects of maternal immune activation on gene expression patterns in the fetal brain. Transl Psychiatry 2012; 2: e98.
26. De Miranda J, Yaddanapudi K, Hornig M, et al. Induction of Toll-like receptor 3-mediated immunity during gestation inhibits cortical neurogenesis and causes behavioral disturbances. MBio 2010; 1.
27. Merrill JE,. Tumor necrosis factor alpha, interleukin 1 and related cytokines in brain development: normal and pathological. Dev Neurosci 1992; 14: 1-10.
28. Boksa P,. Effects of prenatal infection on brain development and behavior: a review of findings from animal models. Brain Behav Immun 2010; 24: 881-897.