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Volumn 26, Issue 8, 2015, Pages 506-517

Therapeutic Potential of Multipotent Mesenchymal Stromal Cells and Their Extracellular Vesicles

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Indexed keywords

MICRORNA;

EID: 84939800169     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2015.072     Document Type: Review
Times cited : (146)

References (120)
  • 1
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147.
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.F.1    Mackay, A.M.2    Beck, S.C.3
  • 2
    • 84885099905 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: Sensors and switchers of inflammation
    • Bernardo ME, Fibbe WE. Mesenchymal stromal cells: sensors and switchers of inflammation. Cell Stem Cell 2013;13:392-402.
    • (2013) Cell Stem Cell , vol.13 , pp. 392-402
    • Bernardo, M.E.1    Fibbe, W.E.2
  • 3
    • 84872168547 scopus 로고    scopus 로고
    • Mesenchymal stromal cells and regulatory T cells: The Yin and Yang of peripheral tolerance?
    • Burr SP, Dazzi F, Garden OA. Mesenchymal stromal cells and regulatory T cells: the Yin and Yang of peripheral tolerance? Immunol Cell Biol 2013;91:12-18.
    • (2013) Immunol Cell Biol , vol.91 , pp. 12-18
    • Burr, S.P.1    Dazzi, F.2    Garden, O.A.3
  • 4
    • 77958467862 scopus 로고    scopus 로고
    • Immunosuppression by mesenchymal stem cells: Mechanisms and clinical applications
    • Ghannam S, Bouffi C, Djouad F, et al. Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications. Stem Cell Res Ther 2010;1:2.
    • (2010) Stem Cell Res Ther , vol.1 , pp. 2
    • Ghannam, S.1    Bouffi, C.2    Djouad, F.3
  • 5
    • 84860238652 scopus 로고    scopus 로고
    • Multipotent mesenchymal stromal cells and the innate immune system
    • Le Blanc K, Mougiakakos D. Multipotent mesenchymal stromal cells and the innate immune system. Nat Rev Immunol 2012;12:383-396.
    • (2012) Nat Rev Immunol , vol.12 , pp. 383-396
    • Le Blanc, K.1    Mougiakakos, D.2
  • 6
    • 0029867151 scopus 로고    scopus 로고
    • Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: Effects of dexamethasone and IL-1 alpha
    • Haynesworth SE, Baber MA, Caplan AI. Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL-1 alpha. J Cell Physiol 1996;166:585-592.
    • (1996) J Cell Physiol , vol.166 , pp. 585-592
    • Haynesworth, S.E.1    Baber, M.A.2    Caplan, A.I.3
  • 7
    • 77955820309 scopus 로고    scopus 로고
    • Concise review: Hitting the right spot with mesenchymal stromal cells
    • Tolar J, Le Blanc K, Keating A, et al. Concise review: hitting the right spot with mesenchymal stromal cells. Stem Cells 2010;28:1446-1455.
    • (2010) Stem Cells , vol.28 , pp. 1446-1455
    • Tolar, J.1    Le Blanc, K.2    Keating, A.3
  • 8
    • 43049103438 scopus 로고    scopus 로고
    • Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: A phase II study
    • Le Blanc K, Frassoni F, Ball L, et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008;371:1579-1586.
    • (2008) Lancet , vol.371 , pp. 1579-1586
    • Le Blanc, K.1    Frassoni, F.2    Ball, L.3
  • 9
    • 35449007194 scopus 로고    scopus 로고
    • Tissue repair using allogeneic mesenchymal stem cells for hemorrhagic cystitis, pneumomediastinum and perforated colon
    • Ringden O, Uzunel M, Sundberg B, et al. Tissue repair using allogeneic mesenchymal stem cells for hemorrhagic cystitis, pneumomediastinum and perforated colon. Leukemia 2007;21:2271-2276.
    • (2007) Leukemia , vol.21 , pp. 2271-2276
    • Ringden, O.1    Uzunel, M.2    Sundberg, B.3
  • 10
    • 34447639255 scopus 로고    scopus 로고
    • Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells
    • Le Blanc K, Samuelsson H, Gustafsson B, et al. Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells. Leukemia 2007;21:1733-1738.
    • (2007) Leukemia , vol.21 , pp. 1733-1738
    • Le Blanc, K.1    Samuelsson, H.2    Gustafsson, B.3
  • 11
    • 84939823410 scopus 로고    scopus 로고
    • In vivo effects of mesenchymal stromal cells in two patients with severe acute respiratory distress syndrome
    • In press
    • Simonson OE, Mougiakakos D, Heldring N, et al. In vivo effects of mesenchymal stromal cells in two patients with severe acute respiratory distress syndrome. Stem Cell Transl Med 2015. In press.
    • (2015) Stem Cell Transl Med
    • Simonson, O.E.1    Mougiakakos, D.2    Heldring, N.3
  • 12
    • 84921899603 scopus 로고    scopus 로고
    • Preserved beta-cell function in type 1 diabetes by mesenchymal stromal cells
    • Carlsson PO, Schwarcz E, Korsgren O, et al. Preserved beta-cell function in type 1 diabetes by mesenchymal stromal cells. Diabetes 2015; 64:587-592.
    • (2015) Diabetes , vol.64 , pp. 587-592
    • Carlsson, P.O.1    Schwarcz, E.2    Korsgren, O.3
  • 13
    • 50849139576 scopus 로고    scopus 로고
    • A perivascular origin for mesenchymal stem cells in multiple human organs
    • Crisan M, Yap S, Casteilla L, et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 2008;3:301-313.
    • (2008) Cell Stem Cell , vol.3 , pp. 301-313
    • Crisan, M.1    Yap, S.2    Casteilla, L.3
  • 14
    • 79959951133 scopus 로고    scopus 로고
    • The MSC: An injury drugstore
    • Caplan AI, Correa D. The MSC: an injury drugstore. Cell Stem Cell 2011;9:11-15.
    • (2011) Cell Stem Cell , vol.9 , pp. 11-15
    • Caplan, A.I.1    Correa, D.2
  • 15
    • 84906931889 scopus 로고    scopus 로고
    • The current landscape of adipose-derived stem cells in clinical applications
    • Lim MH, Ong WK, Sugii S. The current landscape of adipose-derived stem cells in clinical applications. Expert Rev Mol Med 2014;16:e8.
    • (2014) Expert Rev Mol Med , vol.16 , pp. e8
    • Lim, M.H.1    Ong, W.K.2    Sugii, S.3
  • 16
    • 36348935197 scopus 로고    scopus 로고
    • The potential of amniotic membrane/amnion-derived cells for regeneration of various tissues
    • Toda A, Okabe M, Yoshida T, et al. The potential of amniotic membrane/amnion-derived cells for regeneration of various tissues. J Pharmacol Sci 2007;105:215-228.
    • (2007) J Pharmacol Sci , vol.105 , pp. 215-228
    • Toda, A.1    Okabe, M.2    Yoshida, T.3
  • 17
    • 84877031414 scopus 로고    scopus 로고
    • Skin-derived mesenchymal stem cells: Isolation, culture, and characterization
    • Orciani M, Di Primio R. Skin-derived mesenchymal stem cells: isolation, culture, and characterization. Methods Mol Biol 2013;989: 275-283.
    • (2013) Methods Mol Biol , vol.989 , pp. 275-283
    • Orciani, M.1    Di Primio, R.2
  • 18
    • 34247510088 scopus 로고    scopus 로고
    • Isolation and characterization of postnatal stem cells from human dental tissues
    • Jo YY, Lee HJ, Kook SY, et al. Isolation and characterization of postnatal stem cells from human dental tissues. Tissue Eng 2007;13:767-773.
    • (2007) Tissue Eng , vol.13 , pp. 767-773
    • Jo, Y.Y.1    Lee, H.J.2    Kook, S.Y.3
  • 19
    • 39049164672 scopus 로고    scopus 로고
    • Islet-like clusters derived from mesenchymal stem cells in Wharton's Jelly of the human umbilical cord for transplantation to control type 1 diabetes
    • Chao KC, Chao KF, Fu YS, et al. Islet-like clusters derived from mesenchymal stem cells in Wharton's Jelly of the human umbilical cord for transplantation to control type 1 diabetes. PLoS One 2008;3:e1451.
    • (2008) PLoS One , vol.3 , pp. e1451
    • Chao, K.C.1    Chao, K.F.2    Fu, Y.S.3
  • 20
    • 47249146422 scopus 로고    scopus 로고
    • Immunological properties of umbilical cord blood-derived mesenchymal stromal cells
    • Oh W, Kim DS, Yang YS, et al. Immunological properties of umbilical cord blood-derived mesenchymal stromal cells. Cell Immunol 2008;251: 116-123.
    • (2008) Cell Immunol , vol.251 , pp. 116-123
    • Oh, W.1    Kim, D.S.2    Yang, Y.S.3
  • 21
    • 84884236091 scopus 로고    scopus 로고
    • Toward the use of endometrial and menstrual blood mesenchymal stem cells for cell-based therapies
    • Ulrich D, Muralitharan R, Gargett CE. Toward the use of endometrial and menstrual blood mesenchymal stem cells for cell-based therapies. Expert Opin Biol Ther 2013;13:1387-1400.
    • (2013) Expert Opin Biol Ther , vol.13 , pp. 1387-1400
    • Ulrich, D.1    Muralitharan, R.2    Gargett, C.E.3
  • 22
    • 79955795428 scopus 로고    scopus 로고
    • Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC
    • Hass R, Kasper C, Bohm S, et al. Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC. Cell Commun Signal 2011;9:12.
    • (2011) Cell Commun Signal , vol.9 , pp. 12
    • Hass, R.1    Kasper, C.2    Bohm, S.3
  • 23
    • 84922876934 scopus 로고    scopus 로고
    • Secretion of immunoregulatory cytokines by mesenchymal stem cells
    • Kyurkchiev D, Bochev I, Ivanova-Todorova E, et al. Secretion of immunoregulatory cytokines by mesenchymal stem cells. World J Stem Cells 2014;6:552-570.
    • (2014) World J Stem Cells , vol.6 , pp. 552-570
    • Kyurkchiev, D.1    Bochev, I.2    Ivanova-Todorova, E.3
  • 24
    • 84939798072 scopus 로고    scopus 로고
    • Engineering more efficient multipotent mesenchymal stromal (stem) cells for systemic delivery as cellular therapy
    • Moll G, Le Blanc K. Engineering more efficient multipotent mesenchymal stromal (stem) cells for systemic delivery as cellular therapy. ISBT Sci Ser 2015;10:357-365.
    • (2015) ISBT Sci ser , vol.10 , pp. 357-365
    • Moll, G.1    Le Blanc, K.2
  • 26
    • 77952319188 scopus 로고    scopus 로고
    • Mesenchymal stem cell therapy: Two steps forward, one step back
    • Ankrum J, Karp JM. Mesenchymal stem cell therapy: two steps forward, one step back. Trends Mol Med 2010;16:203-209.
    • (2010) Trends Mol Med , vol.16 , pp. 203-209
    • Ankrum, J.1    Karp, J.M.2
  • 27
    • 84906230838 scopus 로고    scopus 로고
    • Fate of intravenously injected mesenchymal stem cells and significance for clinical application
    • Wagner B, Henschler R. Fate of intravenously injected mesenchymal stem cells and significance for clinical application. Adv Biochem Eng Biotechnol 2013;130:19-37.
    • (2013) Adv Biochem Eng Biotechnol , vol.130 , pp. 19-37
    • Wagner, B.1    Henschler, R.2
  • 28
    • 84878577939 scopus 로고    scopus 로고
    • Regulation of stem cell therapies under attack in Europe: For whom the bell tolls
    • Bianco P, Barker R, Brustle O, et al. Regulation of stem cell therapies under attack in Europe: for whom the bell tolls. EMBO J 2013;32:1489-1495.
    • (2013) EMBO J , vol.32 , pp. 1489-1495
    • Bianco, P.1    Barker, R.2    Brustle, O.3
  • 29
    • 84872088799 scopus 로고    scopus 로고
    • The meaning, the sense and the significance: Translating the science of mesenchymal stem cells into medicine
    • Bianco P, Cao X, Frenette PS, et al. The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine. Nat Med 2013;19:35-42.
    • (2013) Nat Med , vol.19 , pp. 35-42
    • Bianco, P.1    Cao, X.2    Frenette, P.S.3
  • 30
    • 84875468183 scopus 로고    scopus 로고
    • The mesenchymal stromal cells dilemma-does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?
    • Galipeau J. The mesenchymal stromal cells dilemma-does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road? Cytotherapy 2013;15:2-8.
    • (2013) Cytotherapy , vol.15 , pp. 2-8
    • Galipeau, J.1
  • 31
    • 79951679002 scopus 로고    scopus 로고
    • Coinfusion of ex vivo-expanded, parental MSCs prevents life-threatening acute GVHD, but does not reduce the risk of graft failure in pediatric patients undergoing allogeneic umbilical cord blood transplantation
    • Bernardo ME, Ball LM, Cometa AM, et al. Coinfusion of ex vivo-expanded, parental MSCs prevents life-threatening acute GVHD, but does not reduce the risk of graft failure in pediatric patients undergoing allogeneic umbilical cord blood transplantation. Bone Marrow Transplant 2011;46:200-207.
    • (2011) Bone Marrow Transplant , vol.46 , pp. 200-207
    • Bernardo, M.E.1    Ball, L.M.2    Cometa, A.M.3
  • 32
    • 67149093649 scopus 로고    scopus 로고
    • Adult human mesenchymal stem cells added to corticosteroid therapy for the treatment of acute graft-versushost disease
    • Kebriaei P, Isola L, Bahceci E, et al. Adult human mesenchymal stem cells added to corticosteroid therapy for the treatment of acute graft-versushost disease. Biol Blood Marrow Transplant 2009;15:804-811.
    • (2009) Biol Blood Marrow Transplant , vol.15 , pp. 804-811
    • Kebriaei, P.1    Isola, L.2    Bahceci, E.3
  • 33
    • 33744913533 scopus 로고    scopus 로고
    • Mesenchymal stem cells for treatment of therapyresistant graft-versus-host disease
    • Ringden O, Uzunel M, Rasmusson I, et al. Mesenchymal stem cells for treatment of therapyresistant graft-versus-host disease. Transplantation 2006;81:1390-1397.
    • (2006) Transplantation , vol.81 , pp. 1390-1397
    • Ringden, O.1    Uzunel, M.2    Rasmusson, I.3
  • 34
    • 84858080480 scopus 로고    scopus 로고
    • Longterm complications, immunologic effects, and role of passage for outcome in mesenchymal stromal cell therapy
    • von Bahr L, Sundberg B, Lonnies L, et al. Longterm complications, immunologic effects, and role of passage for outcome in mesenchymal stromal cell therapy. Biol Blood Marrow Transplant 2012;18:557-564.
    • (2012) Biol Blood Marrow Transplant , vol.18 , pp. 557-564
    • Von Bahr, L.1    Sundberg, B.2    Lonnies, L.3
  • 35
    • 84862900149 scopus 로고    scopus 로고
    • Are therapeutic human mesenchymal stromal cells compatible with human blood?
    • Moll G, Rasmusson-Duprez I, von Bahr L, et al. Are therapeutic human mesenchymal stromal cells compatible with human blood? Stem Cells 2012;30:1565-1574.
    • (2012) Stem Cells , vol.30 , pp. 1565-1574
    • Moll, G.1    Rasmusson-Duprez, I.2    Von Bahr, L.3
  • 36
    • 84055164238 scopus 로고    scopus 로고
    • Tissueengineered airway: A regenerative solution
    • Jungebluth P, Moll G, Baiguera S, et al. Tissueengineered airway: a regenerative solution. Clin Pharmacol Ther 2012;91:81-93.
    • (2012) Clin Pharmacol Ther , vol.91 , pp. 81-93
    • Jungebluth, P.1    Moll, G.2    Baiguera, S.3
  • 37
    • 33646078934 scopus 로고    scopus 로고
    • Bloodstream cells phenotypically identical to human mesenchymal bone marrow stem cells circulate in large amounts under the influence of acute large skin damage: New evidence for their use in regenerative medicine
    • Mansilla E, Marin GH, Drago H, et al. Bloodstream cells phenotypically identical to human mesenchymal bone marrow stem cells circulate in large amounts under the influence of acute large skin damage: new evidence for their use in regenerative medicine. Transplant Proc 2006;38: 967-969.
    • (2006) Transplant Proc , vol.38 , pp. 967-969
    • Mansilla, E.1    Marin, G.H.2    Drago, H.3
  • 38
    • 80051779199 scopus 로고    scopus 로고
    • Impact of enhanced mobilization of bone marrow derived cells to site of injury
    • discussion 289-291
    • Hannoush EJ, Sifri ZC, Elhassan IO, et al. Impact of enhanced mobilization of bone marrow derived cells to site of injury. J Trauma 2011;71: 283-289; discussion 289-291.
    • (2011) J Trauma , vol.71 , pp. 283-289
    • Hannoush, E.J.1    Sifri, Z.C.2    Elhassan, I.O.3
  • 39
    • 33845983611 scopus 로고    scopus 로고
    • Concise review: Multipotent mesenchymal stromal cells in blood
    • He Q, Wan C, Li G. Concise review: multipotent mesenchymal stromal cells in blood. Stem Cells 2007;25:69-77.
    • (2007) Stem Cells , vol.25 , pp. 69-77
    • He, Q.1    Wan, C.2    Li, G.3
  • 40
    • 0028881201 scopus 로고
    • Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): Implications for therapeutic use
    • Lazarus HM, Haynesworth SE, Gerson SL, et al. Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use. Bone Marrow Transplant 1995;16:557-564.
    • (1995) Bone Marrow Transplant , vol.16 , pp. 557-564
    • Lazarus, H.M.1    Haynesworth, S.E.2    Gerson, S.L.3
  • 41
    • 0033977382 scopus 로고    scopus 로고
    • Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and cultureexpanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy
    • Koc ON, Gerson SL, Cooper BW, et al. Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and cultureexpanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol 2000;18: 307-316.
    • (2000) J Clin Oncol , vol.18 , pp. 307-316
    • Koc, O.N.1    Gerson, S.L.2    Cooper, B.W.3
  • 42
    • 17444379357 scopus 로고    scopus 로고
    • Immunobiology of human mesenchymal stem cells and future use in hematopoietic stem cell transplantation
    • Le Blanc K, Ringden O. Immunobiology of human mesenchymal stem cells and future use in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2005;11:321-334.
    • (2005) Biol Blood Marrow Transplant , vol.11 , pp. 321-334
    • Le Blanc, K.1    Ringden, O.2
  • 43
    • 0141484485 scopus 로고    scopus 로고
    • HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells
    • Le Blanc K, Tammik C, Rosendahl K, et al. HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells. Exp Hematol 2003;31:890-896.
    • (2003) Exp Hematol , vol.31 , pp. 890-896
    • Le Blanc, K.1    Tammik, C.2    Rosendahl, K.3
  • 44
    • 0032883638 scopus 로고    scopus 로고
    • Incompatibility between human blood and isolated islets of Langerhans: A finding with implications for clinical intraportal islet transplantation?
    • Bennet W, Sundberg B, Groth CG, et al. Incompatibility between human blood and isolated islets of Langerhans: a finding with implications for clinical intraportal islet transplantation? Diabetes 1999;48:1907-1914.
    • (1999) Diabetes , vol.48 , pp. 1907-1914
    • Bennet, W.1    Sundberg, B.2    Groth, C.G.3
  • 45
    • 73149108627 scopus 로고    scopus 로고
    • Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition?
    • Nilsson B, Korsgren O, Lambris JD, et al. Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition? Trends Immunol 2010;31:32-38.
    • (2010) Trends Immunol , vol.31 , pp. 32-38
    • Nilsson, B.1    Korsgren, O.2    Lambris, J.D.3
  • 46
    • 81255168048 scopus 로고    scopus 로고
    • Control of instant blood-mediated inflammatory reaction to improve islets of Langerhans engraftment
    • Nilsson B, Ekdahl KN, Korsgren O. Control of instant blood-mediated inflammatory reaction to improve islets of Langerhans engraftment. Curr Opin Organ Transplant 2011;16:620-626.
    • (2011) Curr Opin Organ Transplant , vol.16 , pp. 620-626
    • Nilsson, B.1    Ekdahl, K.N.2    Korsgren, O.3
  • 47
    • 0034721255 scopus 로고    scopus 로고
    • Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    • Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000;343:230-238.
    • (2000) N Engl J Med , vol.343 , pp. 230-238
    • Shapiro, A.M.1    Lakey, J.R.2    Ryan, E.A.3
  • 48
    • 84906275192 scopus 로고    scopus 로고
    • Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties?
    • Moll G, Alm JJ, Davies LC, et al. Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties? Stem Cells 2014;32:2430-2442.
    • (2014) Stem Cells , vol.32 , pp. 2430-2442
    • Moll, G.1    Alm, J.J.2    Davies, L.C.3
  • 49
    • 84877769576 scopus 로고    scopus 로고
    • Safety and efficacy of intravenous infusion of allogeneic cryopreserved mesenchymal stem cells for treatment of chronic kidney disease in cats: Results of three sequential pilot studies
    • Quimby JM, Webb TL, Habenicht LM, et al. Safety and efficacy of intravenous infusion of allogeneic cryopreserved mesenchymal stem cells for treatment of chronic kidney disease in cats: results of three sequential pilot studies. Stem Cell Res Ther 2013;4:48.
    • (2013) Stem Cell Res Ther , vol.4 , pp. 48
    • Quimby, J.M.1    Webb, T.L.2    Habenicht, L.M.3
  • 50
    • 84873470211 scopus 로고    scopus 로고
    • Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolism
    • Tatsumi K, Ohashi K, Matsubara Y, et al. Tissue factor triggers procoagulation in transplanted mesenchymal stem cells leading to thromboembolism. Biochem Biophys Res Commun 2013; 431:203-209.
    • (2013) Biochem Biophys Res Commun , vol.431 , pp. 203-209
    • Tatsumi, K.1    Ohashi, K.2    Matsubara, Y.3
  • 51
    • 0034670009 scopus 로고    scopus 로고
    • Limited engraftment capacity of bone marrow-derived mesenchymal cells following T-cell-depleted hematopoietic stem cell transplantation
    • Cilloni D, Carlo-Stella C, Falzetti F, et al. Limited engraftment capacity of bone marrow-derived mesenchymal cells following T-cell-depleted hematopoietic stem cell transplantation. Blood 2000;96:3637-3643.
    • (2000) Blood , vol.96 , pp. 3637-3643
    • Cilloni, D.1    Carlo-Stella, C.2    Falzetti, F.3
  • 52
    • 33745215431 scopus 로고    scopus 로고
    • Donor multipotent mesenchymal stromal cells may engraft in pediatric patients given either cord blood or bone marrow transplantation
    • Pozzi S, Lisini D, Podesta M, et al. Donor multipotent mesenchymal stromal cells may engraft in pediatric patients given either cord blood or bone marrow transplantation. Exp Hematol 2006;34:934-942.
    • (2006) Exp Hematol , vol.34 , pp. 934-942
    • Pozzi, S.1    Lisini, D.2    Podesta, M.3
  • 53
    • 84862835586 scopus 로고    scopus 로고
    • Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation
    • von Bahr L, Batsis I, Moll G, et al. Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation. Stem Cells 2012;30:1575-1578.
    • (2012) Stem Cells , vol.30 , pp. 1575-1578
    • Von Bahr, L.1    Batsis, I.2    Moll, G.3
  • 54
    • 80053614471 scopus 로고    scopus 로고
    • In vivo tracking of 111In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis
    • Gholamrezanezhad A, Mirpour S, Bagheri M, et al. In vivo tracking of 111In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis. Nucl Med Biol 2011;38:961-967.
    • (2011) Nucl Med Biol , vol.38 , pp. 961-967
    • Gholamrezanezhad, A.1    Mirpour, S.2    Bagheri, M.3
  • 55
    • 84872139846 scopus 로고    scopus 로고
    • Antidonor immune responses elicited by allogeneic mesenchymal stem cells: What have we learned so far?
    • Griffin MD, Ryan AE, Alagesan S, et al. Antidonor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far? Immunol Cell Biol 2013;91:40-51.
    • (2013) Immunol Cell Biol , vol.91 , pp. 40-51
    • Griffin, M.D.1    Ryan, A.E.2    Alagesan, S.3
  • 56
    • 84887825747 scopus 로고    scopus 로고
    • Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: Role of secretome and exosomes
    • Maumus M, Jorgensen C, Noel D. Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: role of secretome and exosomes. Biochimie 2013;95:2229-2234.
    • (2013) Biochimie , vol.95 , pp. 2229-2234
    • Maumus, M.1    Jorgensen, C.2    Noel, D.3
  • 57
    • 77955646193 scopus 로고    scopus 로고
    • Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
    • Mendez-Ferrer S, Michurina TV, Ferraro F, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010;466:829-834.
    • (2010) Nature , vol.466 , pp. 829-834
    • Mendez-Ferrer, S.1    Michurina, T.V.2    Ferraro, F.3
  • 58
    • 84865980440 scopus 로고    scopus 로고
    • Methylation of arsenic by recombinant human wild-type arsenic ( + 3 oxidation state) methyltransferase and its methionine 287 threonine (M287T) polymorph: Role of glutathione
    • Ding L, Saunders RJ, Drobna Z, et al. Methylation of arsenic by recombinant human wild-type arsenic ( + 3 oxidation state) methyltransferase and its methionine 287 threonine (M287T) polymorph: role of glutathione. Toxicol Appl Pharmacol 2012;264:121-130.
    • (2012) Toxicol Appl Pharmacol , vol.264 , pp. 121-130
    • Ding, L.1    Saunders, R.J.2    Drobna, Z.3
  • 59
    • 84874997081 scopus 로고    scopus 로고
    • CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance
    • Greenbaum A, Hsu YM, Day RB, et al. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature 2013;495:227-230.
    • (2013) Nature , vol.495 , pp. 227-230
    • Greenbaum, A.1    Hsu, Y.M.2    Day, R.B.3
  • 60
    • 33746424373 scopus 로고    scopus 로고
    • Mesenchymal stem cells as trophic mediators
    • Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem 2006;98: 1076-1084.
    • (2006) J Cell Biochem , vol.98 , pp. 1076-1084
    • Caplan, A.I.1    Dennis, J.E.2
  • 61
    • 50249158511 scopus 로고    scopus 로고
    • Mesenchymal stem cells in health and disease
    • Uccelli A, Moretta L, Pistoia V. Mesenchymal stem cells in health and disease. Nat Rev Immunol 2008;8:726-736.
    • (2008) Nat Rev Immunol , vol.8 , pp. 726-736
    • Uccelli, A.1    Moretta, L.2    Pistoia, V.3
  • 62
    • 84862534451 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: New directions
    • Keating A. Mesenchymal stromal cells: new directions. Cell Stem Cell 2012;10:709-716.
    • (2012) Cell Stem Cell , vol.10 , pp. 709-716
    • Keating, A.1
  • 63
    • 84856973179 scopus 로고    scopus 로고
    • Mesenchymal stem/stromal cells (MSCs): Role as guardians of inflammation
    • Prockop DJ, Oh JY. Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation. Mol Ther 2012;20:14-20.
    • (2012) Mol Ther , vol.20 , pp. 14-20
    • Prockop, D.J.1    Oh, J.Y.2
  • 64
    • 84894226176 scopus 로고    scopus 로고
    • Concise review: The immune status of mesenchymal stem cells and its relevance for therapeutic application
    • Knaan-Shanzer S. Concise review: the immune status of mesenchymal stem cells and its relevance for therapeutic application. Stem Cells 2014;32:603-608.
    • (2014) Stem Cells , vol.32 , pp. 603-608
    • Knaan-Shanzer, S.1
  • 65
    • 84925883417 scopus 로고    scopus 로고
    • Mesenchymal stem cell therapy and acute graft-versus-host disease: A review
    • Amorin B, Alegretti AP, Valim V, et al. Mesenchymal stem cell therapy and acute graft-versus-host disease: a review. Hum Cell 2014;27:137-150.
    • (2014) Hum Cell , vol.27 , pp. 137-150
    • Amorin, B.1    Alegretti, A.P.2    Valim, V.3
  • 66
    • 84949626181 scopus 로고    scopus 로고
    • Mesenchymal stromal cells and the innate immune response
    • [Epub ahead of print]
    • Le Blanc K, Davies LC. Mesenchymal stromal cells and the innate immune response. Immunol Lett 2015. [Epub ahead of print]
    • (2015) Immunol Lett
    • Le Blanc, K.1    Davies, L.C.2
  • 67
    • 84887066242 scopus 로고    scopus 로고
    • A perspective on mesenchymal stromal cell transplantation in the treatment of sepsis
    • Kusadasi N, Groeneveld AB. A perspective on mesenchymal stromal cell transplantation in the treatment of sepsis. Shock 2013;40:352-357.
    • (2013) Shock , vol.40 , pp. 352-357
    • Kusadasi, N.1    Groeneveld, A.B.2
  • 68
    • 2942595706 scopus 로고    scopus 로고
    • Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenasemediated tryptophan degradation
    • Meisel R, Zibert A, Laryea M, et al. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenasemediated tryptophan degradation. Blood 2004; 103:4619-4621.
    • (2004) Blood , vol.103 , pp. 4619-4621
    • Meisel, R.1    Zibert, A.2    Laryea, M.3
  • 69
    • 34447298069 scopus 로고    scopus 로고
    • Interferongamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells
    • Ryan JM, Barry F, Murphy JM, et al. Interferongamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells. Clin Exp Immunol 2007; 149:353-363.
    • (2007) Clin Exp Immunol , vol.149 , pp. 353-363
    • Ryan, J.M.1    Barry, F.2    Murphy, J.M.3
  • 70
    • 34548833007 scopus 로고    scopus 로고
    • Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFNgammaR1 signaling and IDO expression
    • Gieseke F, Schutt B, Viebahn S, et al. Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFNgammaR1 signaling and IDO expression. Blood 2007;110:2197-2200.
    • (2007) Blood , vol.110 , pp. 2197-2200
    • Gieseke, F.1    Schutt, B.2    Viebahn, S.3
  • 71
    • 84896727247 scopus 로고    scopus 로고
    • IDOindependent suppression of T cell effector function by IFN-gamma-licensed human mesenchymal stromal cells
    • Chinnadurai R, Copland IB, Patel SR, et al. IDOindependent suppression of T cell effector function by IFN-gamma-licensed human mesenchymal stromal cells. J Immunol 2014;192:1491-1501.
    • (2014) J Immunol , vol.192 , pp. 1491-1501
    • Chinnadurai, R.1    Copland, I.B.2    Patel, S.R.3
  • 72
    • 33846006154 scopus 로고    scopus 로고
    • Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells
    • Sato K, Ozaki K, Oh I, et al. Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood 2007;109: 228-234.
    • (2007) Blood , vol.109 , pp. 228-234
    • Sato, K.1    Ozaki, K.2    Oh, I.3
  • 73
    • 84877626335 scopus 로고    scopus 로고
    • Reciprocal crosstalk between dendritic cells and natural killer cells under the effects of PGE2 in immunity and immunopathology
    • Harizi H. Reciprocal crosstalk between dendritic cells and natural killer cells under the effects of PGE2 in immunity and immunopathology. Cell Mol Immunol 2013;10:213-221.
    • (2013) Cell Mol Immunol , vol.10 , pp. 213-221
    • Harizi, H.1
  • 74
    • 77955464551 scopus 로고    scopus 로고
    • Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis
    • Esaki Y, Li Y, Sakata D, et al. Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 2010;107:12233-12238.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 12233-12238
    • Esaki, Y.1    Li, Y.2    Sakata, D.3
  • 76
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005;105:1815-1822.
    • (2005) Blood , vol.105 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 77
    • 22544436066 scopus 로고    scopus 로고
    • Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4 + T cells
    • Baratelli F, Lin Y, Zhu L, et al. Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4 + T cells. J Immunol 2005;175:1483-1490.
    • (2005) J Immunol , vol.175 , pp. 1483-1490
    • Baratelli, F.1    Lin, Y.2    Zhu, L.3
  • 78
    • 67349127266 scopus 로고    scopus 로고
    • Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion
    • Yao C, Sakata D, Esaki Y, et al. Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion. Nat Med 2009;15:633-640.
    • (2009) Nat Med , vol.15 , pp. 633-640
    • Yao, C.1    Sakata, D.2    Esaki, Y.3
  • 79
    • 84884929175 scopus 로고    scopus 로고
    • Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia
    • Johansson JU, Pradhan S, Lokteva LA, et al. Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia. J Neurosci 2013;33:16016-16032.
    • (2013) J Neurosci , vol.33 , pp. 16016-16032
    • Johansson, J.U.1    Pradhan, S.2    Lokteva, L.A.3
  • 81
    • 79952779639 scopus 로고    scopus 로고
    • MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases
    • Dai R, Ahmed SA. MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases. Transl Res 2011; 157:163-179.
    • (2011) Transl Res , vol.157 , pp. 163-179
    • Dai, R.1    Ahmed, S.A.2
  • 82
    • 84899029161 scopus 로고    scopus 로고
    • Concise review: MicroRNA function in multipotent mesenchymal stromal cells
    • Clark EA, Kalomoiris S, Nolta JA, et al. Concise review: microRNA function in multipotent mesenchymal stromal cells. Stem Cells 2014;32: 1074-1082.
    • (2014) Stem Cells , vol.32 , pp. 1074-1082
    • Clark, E.A.1    Kalomoiris, S.2    Nolta, J.A.3
  • 83
    • 84868517795 scopus 로고    scopus 로고
    • MiRNA-146a expression positively regulates tumor necrosis factor-alpha-induced interleukin-8 production in mesenchymal stem cells and differentiated lung epithelial-like cells
    • Perng DW, Yang DM, Hsiao YH, et al. miRNA-146a expression positively regulates tumor necrosis factor-alpha-induced interleukin-8 production in mesenchymal stem cells and differentiated lung epithelial-like cells. Tissue Eng Part A 2012;18:2259-2267.
    • (2012) Tissue Eng Part A , vol.18 , pp. 2259-2267
    • Perng, D.W.1    Yang, D.M.2    Hsiao, Y.H.3
  • 84
    • 77954223697 scopus 로고    scopus 로고
    • IL-10 inhibits MIR-155 induction by toll-like receptors
    • McCoy CE, Sheedy FJ, Qualls JE, et al. IL-10 inhibits miR-155 induction by toll-like receptors. J Biol Chem 2010;285:20492-20498.
    • (2010) J Biol Chem , vol.285 , pp. 20492-20498
    • McCoy, C.E.1    Sheedy, F.J.2    Qualls, J.E.3
  • 85
    • 79952186298 scopus 로고    scopus 로고
    • MicroRNAs: The fine-tuners of Toll-like receptor signalling
    • O'Neill LA, Sheedy FJ, McCoy CE. MicroRNAs: the fine-tuners of Toll-like receptor signalling. Nat Rev Immunol 2011;11:163-175.
    • (2011) Nat Rev Immunol , vol.11 , pp. 163-175
    • O'neill, L.A.1    Sheedy, F.J.2    McCoy, C.E.3
  • 86
    • 76749099778 scopus 로고    scopus 로고
    • Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha
    • Koh W, Sheng CT, Tan B, et al. Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of hepatic nuclear factor 4 alpha. BMC Genomics 2010;11 Suppl 1:S6.
    • (2010) BMC Genomics , vol.11 , pp. S6
    • Koh, W.1    Sheng, C.T.2    Tan, B.3
  • 87
    • 79960565215 scopus 로고    scopus 로고
    • Small RNA sequencing reveals MIR-642a-3p as a novel adipocyte-specific microRNA and MIR-30 as a key regulator of human adipogenesis
    • Zaragosi LE, Wdziekonski B, Brigand KL, et al. Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis. Genome Biol 2011;12:R64.
    • (2011) Genome Biol , vol.12 , pp. R64
    • Zaragosi, L.E.1    Wdziekonski, B.2    Brigand, K.L.3
  • 88
    • 84890013875 scopus 로고    scopus 로고
    • MIR-146a-5p circuitry uncouples cell proliferation and migration, but not differentiation, in human mesenchymal stem cells
    • Hsieh JY, Huang TS, Cheng SM, et al. miR-146a-5p circuitry uncouples cell proliferation and migration, but not differentiation, in human mesenchymal stem cells. Nucleic Acids Res 2013;41:9753-9763.
    • (2013) Nucleic Acids Res , vol.41 , pp. 9753-9763
    • Hsieh, J.Y.1    Huang, T.S.2    Cheng, S.M.3
  • 89
    • 84891885126 scopus 로고    scopus 로고
    • Loss of let-7 microRNA upregulates IL-6 in bone marrowderived mesenchymal stem cells triggering a reactive stromal response to prostate cancer
    • Sung SY, Liao CH, Wu HP, et al. Loss of let-7 microRNA upregulates IL-6 in bone marrowderived mesenchymal stem cells triggering a reactive stromal response to prostate cancer. PLoS One 2013;8:e71637.
    • (2013) PLoS One , vol.8 , pp. e71637
    • Sung, S.Y.1    Liao, C.H.2    Wu, H.P.3
  • 90
    • 84860483049 scopus 로고    scopus 로고
    • MicroRNA-27b suppresses mouse MSC migration to the liver by targeting SDF-1alphain vitro
    • Lu MH, Li CZ, Hu CJ, et al. microRNA-27b suppresses mouse MSC migration to the liver by targeting SDF-1alphain vitro. Biochem Biophys Res Commun 2012;421:389-395.
    • (2012) Biochem Biophys Res Commun , vol.421 , pp. 389-395
    • Lu, M.H.1    Li, C.Z.2    Hu, C.J.3
  • 91
    • 80052550487 scopus 로고    scopus 로고
    • MIR-1 is a tumor suppressor in thyroid carcinogenesis targeting CCND2, CXCR4, and SDF-1alpha
    • Leone V, D'Angelo D, Rubio I, et al. MiR-1 is a tumor suppressor in thyroid carcinogenesis targeting CCND2, CXCR4, and SDF-1alpha. J Clin Endocrinol Metab 2011;96:E1388-E1398.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. E1388-E1398
    • Leone, V.1    D'angelo, D.2    Rubio, I.3
  • 92
    • 84874629992 scopus 로고    scopus 로고
    • MIR-126 and MIR-126 repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis
    • Zhang Y, Yang P, Sun T, et al. miR-126 and miR-126 repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol 2013;15: 284-294.
    • (2013) Nat Cell Biol , vol.15 , pp. 284-294
    • Zhang, Y.1    Yang, P.2    Sun, T.3
  • 93
    • 57049089111 scopus 로고    scopus 로고
    • Experimental identification of microRNA-140 targets by silencing and overexpressing MIR-140
    • Nicolas FE, Pais H, Schwach F, et al. Experimental identification of microRNA-140 targets by silencing and overexpressing miR-140. RNA 2008;14:2513-2520.
    • (2008) RNA , vol.14 , pp. 2513-2520
    • Nicolas, F.E.1    Pais, H.2    Schwach, F.3
  • 94
    • 79952192872 scopus 로고    scopus 로고
    • MiRNA regulation of Sdf1 chemokine signaling provides genetic robustness to germ cell migration
    • Staton AA, Knaut H, Giraldez AJ. miRNA regulation of Sdf1 chemokine signaling provides genetic robustness to germ cell migration. Nat Genet 2011;43:204-211.
    • (2011) Nat Genet , vol.43 , pp. 204-211
    • Staton, A.A.1    Knaut, H.2    Giraldez, A.J.3
  • 96
    • 0023645106 scopus 로고
    • Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)
    • Johnstone RM, Adam M, Hammond JR, et al. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J Biol Chem 1987; 262:9412-9420.
    • (1987) J Biol Chem , vol.262 , pp. 9412-9420
    • Johnstone, R.M.1    Adam, M.2    Hammond, J.R.3
  • 97
    • 0029989258 scopus 로고    scopus 로고
    • B lymphocytes secrete antigen-presenting vesicles
    • Raposo G, Nijman HW, Stoorvogel W, et al. B lymphocytes secrete antigen-presenting vesicles. J Exp Med 1996;183:1161-1172.
    • (1996) J Exp Med , vol.183 , pp. 1161-1172
    • Raposo, G.1    Nijman, H.W.2    Stoorvogel, W.3
  • 98
    • 23944509766 scopus 로고    scopus 로고
    • Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation
    • Del Conde I, Shrimpton CN, Thiagarajan P, et al. Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood 2005;106:1604-1611.
    • (2005) Blood , vol.106 , pp. 1604-1611
    • Del Conde, I.1    Shrimpton, C.N.2    Thiagarajan, P.3
  • 99
    • 79955571241 scopus 로고    scopus 로고
    • Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusioninduced acute and chronic kidney injury
    • Gatti S, Bruno S, Deregibus MC, et al. Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusioninduced acute and chronic kidney injury. Nephrol Dial Transplant 2011;26:1474-1483.
    • (2011) Nephrol Dial Transplant , vol.26 , pp. 1474-1483
    • Gatti, S.1    Bruno, S.2    Deregibus, M.C.3
  • 100
    • 33646146422 scopus 로고    scopus 로고
    • Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: Evidence for horizontal transfer of mRNA and protein delivery
    • Ratajczak J, Miekus K, Kucia M, et al. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia 2006;20:847-856.
    • (2006) Leukemia , vol.20 , pp. 847-856
    • Ratajczak, J.1    Miekus, K.2    Kucia, M.3
  • 101
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • Skog J, Wurdinger T, van Rijn S, et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008;10: 1470-1476.
    • (2008) Nat Cell Biol , vol.10 , pp. 1470-1476
    • Skog, J.1    Wurdinger, T.2    Van Rijn, S.3
  • 102
    • 84877585949 scopus 로고    scopus 로고
    • Extracellular vesicles: Biology and emerging therapeutic opportunities
    • Andaloussi SEL, Mager I, Breakefield XO, et al. Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov 2013; 12:347-357.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 347-357
    • Andaloussi, S.E.L.1    Mager, I.2    Breakefield, X.O.3
  • 103
    • 84858185865 scopus 로고    scopus 로고
    • Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury
    • Bruno S, Grange C, Collino F, et al. Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PLoS One 2012;7:e33115.
    • (2012) PLoS One , vol.7 , pp. e33115
    • Bruno, S.1    Grange, C.2    Collino, F.3
  • 104
    • 65649089130 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived microvesicles protect against acute tubular injury
    • Bruno S, Grange C, Deregibus MC, et al. Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol 2009;20:1053-1067.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 1053-1067
    • Bruno, S.1    Grange, C.2    Deregibus, M.C.3
  • 105
    • 84862981326 scopus 로고    scopus 로고
    • Bone marrow stem cells-derived microvesicles protect against renal injury in the mouse remnant kidney model
    • He J, Wang Y, Sun S, et al. Bone marrow stem cells-derived microvesicles protect against renal injury in the mouse remnant kidney model. Nephrology (Carlton) 2012;17:493-500.
    • (2012) Nephrology (Carlton) , vol.17 , pp. 493-500
    • He, J.1    Wang, Y.2    Sun, S.3
  • 106
    • 84876875077 scopus 로고    scopus 로고
    • Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro
    • Zhou Y, Xu H, Xu W, et al. Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro. Stem Cell Res Ther 2013;4:34.
    • (2013) Stem Cell Res Ther , vol.4 , pp. 34
    • Zhou, Y.1    Xu, H.2    Xu, W.3
  • 107
    • 84873919177 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury
    • Arslan F, Lai RC, Smeets MB, et al. Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Res 2013;10:301-312.
    • (2013) Stem Cell Res , vol.10 , pp. 301-312
    • Arslan, F.1    Lai, R.C.2    Smeets, M.B.3
  • 108
    • 77952293014 scopus 로고    scopus 로고
    • Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
    • Lai RC, Arslan F, Lee MM, et al. Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res 2010;4:214-222.
    • (2010) Stem Cell Res , vol.4 , pp. 214-222
    • Lai, R.C.1    Arslan, F.2    Lee, M.M.3
  • 109
    • 77952673860 scopus 로고    scopus 로고
    • Derivation and characterization of human fetal MSCs: An alternative cell source for large-scale production of cardioprotective microparticles
    • Lai RC, Arslan F, Tan SS, et al. Derivation and characterization of human fetal MSCs: an alternative cell source for large-scale production of cardioprotective microparticles. J Mol Cell Cardiol 2010;48:1215-1224.
    • (2010) J Mol Cell Cardiol , vol.48 , pp. 1215-1224
    • Lai, R.C.1    Arslan, F.2    Tan, S.S.3
  • 110
    • 75649119273 scopus 로고    scopus 로고
    • Mesenchymal stem cell secretes microparticles enriched in premicroRNAs
    • Chen TS, Lai RC, Lee MM, et al. Mesenchymal stem cell secretes microparticles enriched in premicroRNAs. Nucleic Acids Res 2010;38:215-224.
    • (2010) Nucleic Acids Res , vol.38 , pp. 215-224
    • Chen, T.S.1    Lai, R.C.2    Lee, M.M.3
  • 111
    • 84870807127 scopus 로고    scopus 로고
    • Microvesicles derived from human umbilical cord mesenchymal stem cells stimulated by hypoxia promote angiogenesis both in vitro and in vivo
    • Zhang HC, Liu XB, Huang S, et al. Microvesicles derived from human umbilical cord mesenchymal stem cells stimulated by hypoxia promote angiogenesis both in vitro and in vivo. Stem Cells Dev 2012;21:3289-3297.
    • (2012) Stem Cells Dev , vol.21 , pp. 3289-3297
    • Zhang, H.C.1    Liu, X.B.2    Huang, S.3
  • 112
    • 84876241933 scopus 로고    scopus 로고
    • Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis
    • Li T, Yan Y, Wang B, et al. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis. Stem Cells Dev 2013;22:845-854.
    • (2013) Stem Cells Dev , vol.22 , pp. 845-854
    • Li, T.1    Yan, Y.2    Wang, B.3
  • 113
    • 84870239895 scopus 로고    scopus 로고
    • Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension
    • Lee C, Mitsialis SA, Aslam M, et al. Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension. Circulation 2012;126:2601-2611.
    • (2012) Circulation , vol.126 , pp. 2601-2611
    • Lee, C.1    Mitsialis, S.A.2    Aslam, M.3
  • 114
    • 84939893615 scopus 로고    scopus 로고
    • A systematic review of preclinical studies on the therapeutic potential of mesenchymal stromal cell-derived microvesicles
    • Akyurekli C, Le Y, Richardson RB, et al. A systematic review of preclinical studies on the therapeutic potential of mesenchymal stromal cell-derived microvesicles. Stem Cell Rev 2015; 11:150-160.
    • (2015) Stem Cell Rev , vol.11 , pp. 150-160
    • Akyurekli, C.1    Le, Y.2    Richardson, R.B.3
  • 115
    • 84929050359 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived extracellular vesicles: Toward cell-free therapeutic applications
    • Rani S, Ryan AE, Griffin MD, et al. Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications. Mol Ther 2015; 23:812-823.
    • (2015) Mol Ther , vol.23 , pp. 812-823
    • Rani, S.1    Ryan, A.E.2    Griffin, M.D.3
  • 116
    • 84865355844 scopus 로고    scopus 로고
    • Microvesicles derived from mesenchymal stem cells: Potent organelles for induction of tolerogenic signaling
    • Mokarizadeh A, Delirezh N, Morshedi A, et al. Microvesicles derived from mesenchymal stem cells: potent organelles for induction of tolerogenic signaling. Immunol Lett 2012;147:47-54.
    • (2012) Immunol Lett , vol.147 , pp. 47-54
    • Mokarizadeh, A.1    Delirezh, N.2    Morshedi, A.3
  • 117
    • 84874831536 scopus 로고    scopus 로고
    • Mesenchymal stem cell exosome ameliorates reperfusion injury through proteomic complementation
    • Lai RC, Yeo RW, Tan KH, et al. Mesenchymal stem cell exosome ameliorates reperfusion injury through proteomic complementation. Regen Med 2013;8:197-209.
    • (2013) Regen Med , vol.8 , pp. 197-209
    • Lai, R.C.1    Yeo, R.W.2    Tan, K.H.3
  • 118
    • 79955031226 scopus 로고    scopus 로고
    • Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs
    • Chen TS, Arslan F, Yin Y, et al. Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs. J Transl Med 2011; 9:47.
    • (2011) J Transl Med , vol.9 , pp. 47
    • Chen, T.S.1    Arslan, F.2    Yin, Y.3
  • 119
    • 84929380225 scopus 로고    scopus 로고
    • Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties
    • Nordin JZ, Lee Y, Vader P, et al. Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties. Nanomedicine 2015;11:879-883.
    • (2015) Nanomedicine , vol.11 , pp. 879-883
    • Nordin, J.Z.1    Lee, Y.2    Vader, P.3
  • 120
    • 84898039042 scopus 로고    scopus 로고
    • MSCderived exosomes: A novel tool to treat therapyrefractory graft-versus-host disease
    • Kordelas L, Rebmann V, Ludwig AK, et al. MSCderived exosomes: a novel tool to treat therapyrefractory graft-versus-host disease. Leukemia 2014;28:970-973.
    • (2014) Leukemia , vol.28 , pp. 970-973
    • Kordelas, L.1    Rebmann, V.2    Ludwig, A.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.