Pharmaceutical Rejuvenation of Age-Associated Decline in Spatial Memory

Rejuvenation Research

Volumn 19, Issue 6, 2016, Pages 521-524

  Mendelsohn, Andrew R ^a,b   Larrick, James W ^a,b  

^a Panorama Research Institute   (United States)

^b Regenerative Sciences Institute   (United States)

Author keywords

aging; neurogenesis; neuroinflammation; rejuvenation

Indexed keywords

BETA 2 MICROGLOBULIN; MONTELUKAST; ACETIC ACID DERIVATIVE; G PROTEIN COUPLED RECEPTOR; GPR17 PROTEIN, RAT; LEUKOTRIENE D4; QUINOLINE DERIVATIVE;

AGING; BLOOD BRAIN BARRIER; COGNITION; COGNITIVE DEFECT; DEGENERATIVE DISEASE; DENTATE GYRUS; HIPPOCAMPUS; IN VIVO STUDY; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; REJUVENATION; REVIEW; SPATIAL MEMORY; ANIMAL; DRUG EFFECTS; PHYSIOLOGY; PSYCHOLOGY; RAT;

ACETATES; AGING; ANIMALS; BLOOD-BRAIN BARRIER; HIPPOCAMPUS; LEUKOTRIENE D4; NEUROGENESIS; QUINOLINES; RATS; RECEPTORS, G-PROTEIN-COUPLED; REJUVENATION; SPATIAL MEMORY;

EID: 85007047128     PISSN: 15491684     EISSN: 15578577     Source Type: Journal    
DOI: 10.1089/rej.2016.1903     Document Type: Review

References (29)

1. Sierra A, Gottfried-Blackmore AC, McEwen BS, Bulloch K. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 2007;55:412-424.
2. Hefendehl JK. Homeostatic and injury-induced microglia behavior in the aging brain. Aging Cell 2014;13:60-69.
3. Mosher KI, Wyss-Coray T. Microglial dysfunction in brain aging and Alzheimer's disease. Biochem Pharmacol 2014;88: 594-604.
4. Villeda SA. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 2011;477: 90-94.
5. Morrison JH, Baxter MG. The ageing cortical synapse: Hallmarks and implications for cognitive decline. Nat Rev Neurosci 2012;13:240-250.
6. Bake S, Sohrabji F. 17beta-estradiol differentially regulates blood-brain barrier permeability in young and aging female rats. Endocrinology 2004;145:5471-5475.
7. Kuhn HG, Dickinson-Anson H, Gage FH. Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation. J Neurosci 1996;16:2027-2033.
8. Villeda SA. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med 2014;20:659-66
9. Conboy IM, Conboy MJ, Rebo J. Systemic problems: A perspective on stem cell aging and rejuvenation. Aging 2015;7:754-765.
10. Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, et al. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science 2014;344:630-634.
11. Smith LK, He Y, Park J-S, Bieri G, Snethlage CE, Lin K, et al. b2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nat Med 2015;21:932-937.
12. Saad MA, Abdelsalam RM, Kenawy SA, Attia AS. Montelukast, a cysteinyl leukotriene receptor-1 antagonist protects against hippocampal injury induced by transient global cerebral ischemia and reperfusion in rats. Neurochem Res 2015;40:139-150.
13. Lecca D. The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. PLoS One 2008;3:e3579.
14. Zhang XY. HAMI 3379, a CysLT2 receptor antagonist, attenuates ischemia-like neuronal injury by inhibiting microglial activation. J Pharmacol Exp Ther 2013;346:328-341.
15. Huber C. Inhibition of leukotriene receptors boosts neural progenitor proliferation. Cell Physiol Biochem 2011;28: 793-804.
16. Kohman RA, Bhattacharya TK, Kilby C, Bucko P, Rhodes JS. Effects of minocycline on spatial learning, hippocampal neurogenesis and microglia in aged and adult mice. Behav Brain Res 2013;242:17-24.
17. Marschallinger J, Schäffner I, Klein B, Gelfert R, Rivera FJ, Illes S, et al. Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug. Nat Commun 2015;6. doi:10.1038/ncomms9466.
18. Marchesini M, Matocci R, Tasselli L, Cambiaghi V, OrlethOrleth A, Furia L, et al. PML is required for telomere stability in non-neoplastic human cells. Oncogene 2015. DOI:10.1038/onc.2015.246
19. Dobolyi A, Vincze C, Pál G, Lovas G. The neuroprotective functions of transforming growth factor beta proteins. Int J Mol Sci 2012;13:8219-8258.
20. Paik JH. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 2009;5:540-553.
21. Kumar A, Prakash A, Pahwa D, Mishra J. Montelukast potentiates the protective effect of rofecoxib against kainic acid-induced cognitive dysfunction in rats. Pharmacol Biochem Behav 2012;103:43-52.
22. Kalonia H, Kumar P, Kumar A, Nehru B. Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: Possible behavioral, biochemical, mitochondrial and tumor necrosis factor-alpha level alterations in rats. Neuroscience 2010;171:284-299.
23. Lai J. Montelukast rescues primary neurons against Abeta1-42-induced toxicity through inhibiting CysLT1R-mediated NF-kappaB signaling. Neurochem Int 2014;75:26-31.
24. Yagami T, Yamamoto Y, Kohma H. Leukotriene receptor antagonists, LY293111 and ONO-1078, protect neurons from the sPLA2-IB-induced neuronal cell death independently of blocking their receptors. Neurochem Int 2013; 63:163-171.
25. Aldea Perona A, Garcá-Sáiz M, Sanzálvarez E. Psychiatric disorders and montelukast in children: A disproportionality analysis of the VigiBase(-). Drug Saf 2016;39:69-78.
26. Parravicini C, Daniele S, Palazzolo L, Trincavelli ML, Martini C, Zaratin P, et al. A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights. Cell Signal 2016;28:631-642.
27. Qi AD, Harden TK, Nicholas RA. Is GPR17 a P2Y/leukotriene receptor examination of uracil nucleotides, nucleotide sugars, and cysteinyl leukotrienes as agonists of GPR17. J Pharmacol Exp Ther 2013;347:38-46.
28. Hennen S. Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist. Sci Signal 2013;6:ra93.
29. Rebo J, Mehdipour M, Gathwala R, Causey K, Liu Y, Conboy MJ, et al. A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood. Nat Commun 2016;7:13363.