Status epilepticus

Cold Spring Harbor Perspectives in Medicine

Volumn 6, Issue 3, 2016, Pages

  Seinfeld, Syndi ^a   Goodkin, Howard P ^b   Shinnar, Shlomo ^c  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT;

AGE DISTRIBUTION; ARTICLE; BRAIN INJURY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; EMERGENCY CARE; EPILEPTIC STATE; HIPPOCAMPUS INJURY; HUMAN; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PROGNOSIS; SEIZURE; TEMPORAL LOBE EPILEPSY; TREATMENT OUTCOME; ANIMAL; BRAIN; DISEASE MODEL; EPILEPSY, TEMPORAL LOBE; HIPPOCAMPUS; INJURIES; STATUS EPILEPTICUS;

ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; EPILEPSY, TEMPORAL LOBE; HIPPOCAMPUS; HUMANS; SEIZURES; STATUS EPILEPTICUS;

EID: 84959517503     PISSN: None     EISSN: 21571422     Source Type: Journal    
DOI: 10.1101/cshperspect.a022830     Document Type: Article

References (103)

1. Alldredge BK, Gelb AM, Isaacs SM, Corry MD, Allen F, Ulrich S, Gottwald MD, O’Neil N, Neuhaus JM, Segal MR, et al. 2001. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med 345: 631-637
2. Aminoff MJ, Simon RP. 1980. Status epilepticus. Causes, clinical features and consequences in 98 patients. Am J Med 69: 657-666
3. Arcieri S, Velotti R, Noe F, Carriero G, Cattalini A, Galbardi B, Gnatkovsky V, de Curtis M. 2014. Variable electrobehavioral patterns during focal nonconvulsive status epilepticus induced by unilateral intrahippocampal injection of kainic acid. Epilepsia 55: 1978-1985
4. Barry E, Hauser WA. 1994. Pleocytosis after status epilepticus. Arch Neurol 51: 190-193
5. Berg AT, Shinnar S. 1996. Complex febrile seizures. Epilepsia 37: 126-133
6. Berg AT, Shinnar S, Testa FM, Levy SR, Frobish D, Smith SN, Beckerman B. 2004. Status epilepticus after the initial diagnosis of epilepsy in children. Neurology 63: 1027-1034
7. Bleck T, Cock H, Chamberlain J, Cloyd J, Connor J, Elm J, Fountain N, Jones E, Lowenstein D, Shinnar S, et al. 2013. The established status epilepticus trial 2013. Epilepsia 54: 89-92
8. Broomall E, Natale JE, Grimason M, Goldstein J, Smith CM, Chang C, Kanes S, Rogawski MA, Wainwright MS. 2014. Pediatric super-refractory status epilepticus treated with allopregnanolone. Ann Neurol 76: 911-915
9. Chamberlain JM, Okada P, Holsti M, Mahajan P, Brown KM, Vance C, Gonzalez V, Lichenstein R, Stanley R, Brousseau DC, et al. 2014. Lorazepam vs diazepam for pediatric status epilepticus: A randomized clinical trial. JAMA 311: 1652-1660
10. Coeytaux A, Jallon P, Galobardes B, Morabia A. 2000. Incidence of status epilepticus in French-speaking Switzerland: (EPISTAR). Neurology 55: 693-697
11. Commission on Epidemiology and Prognosis, International League Against Epilepsy. 1993. Guidelines for epidemiologic studies on epilepsy. Epilepsia 34: 592-596
12. Corey LA, Pellock JM, DeLorenzo RJ. 2004. Status epilepticus in a population-based Virginia twin sample. Epilepsia 45: 159-165
13. Deeb TZ, Maguire J, Moss SJ. 2012. Possible alterations in GABAA receptor signaling that underlie benzodiazepineresistant seizures. Epilepsia 53: 79-88
14. DeLorenzo RJ, Towne AR, Pellock JM, Ko D. 1992. Status epilepticus in children, adults, and the elderly. Epilepsia 33: S15-25
15. DeLorenzo RJ, Hauser WA, Towne AR, Boggs JG, Pellock JM, Penberthy L, Garnett L, Fortner CA, Ko D. 1996. A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology 46: 1029-1035
16. DeLorenzo RJ, Waterhouse EJ, Towne AR, Boggs JG, Ko D, DeLorenzo GA, Brown A, Garnett L. 1998. Persistent nonconvulsive status epilepticus after the control of convulsive status epilepticus. Epilepsia 39: 833-840
17. Dodson WE, DeLorenzo RJ, Pedley TA, Shinnar S, Treiman DM, Wannamker BB. 1993. Treatment of convulsive status epilepticus. Recommendations of the Epilepsy Foundation of America’s Working Group on Status Epilepticus. JAMA 270: 854-859
18. Dube CM, Ravizza T, Hamamura M, Zha Q, Keebaugh A, Fok K, Andres AL, Nalcioglu O, Obenaus A, Vezzani A, et al. 2010. Epileptogenesis provoked by prolonged experimental febrile seizures: Mechanisms and biomarkers. J Neurosci 30: 7484-7494
19. Eckel R, Szulc B, Walker MC, Kittler JT. 2015. Activation of calcineurin underlies altered trafficking of a2 subunit containing GABAA receptors during prolonged epileptiform activity. Neuropharmacology 88: 82-90
20. Feng HJ, Macdonald RL. 2004.Multiple actions of propofol on abg and abd GABAA receptors. Mol Pharmacol 66: 1517-1524
21. Feng HJ, Bianchi MT, Macdonald RL. 2004. Pentobarbital differentially modulates a1b3d and a1b3g2L GABAA receptor currents. Mol Pharmacol 66: 988-1003
22. Frank LM, Shinnar S, Hesdorffer DC, Shinnar RC, Pellock JM, Gallentine W, Nordli DR Jr, Epstein LG, Moshe SL, Lewis DV, et al. 2012. Cerebrospinal fluid findings in children with fever-associated status epilepticus: Results of the consequences of prolonged febrile seizures (FEBSTAT) study. J Pediatr 161: 1169-1171
23. Fujikawa DG, Itabashi HH, Wu A, Shinmei SS. 2000. Status epilepticus-induced neuronal loss in humans without systemic complications or epilepsy. Epilepsia 41: 981-991
24. Gastaut H. 1983. Classification of status epilepticus. Adv Neurol 34: 15-35
25. Gomes WA, Shinnar S. 2011. Prospects for imaging-related biomarkers of human epileptogenesis: A critical review. Biomark Med 5: 599-606
26. Goodkin HP, Yeh JL, Kapur J. 2005. Status epilepticus increases the intracellular accumulation of GABAA receptors. J Neurosci 25: 5511-5520
27. Goodkin HP, Joshi S, Mtchedlishvili Z, Brar J, Kapur J. 2008. Subunit-specific trafficking of GABAA receptors during status epilepticus. J Neurosci 28: 2527-2538
28. Grosenbaugh DK, Mott DD. 2013. Stiripentol is anticonvulsant by potentiating GABAergic transmission in a model of benzodiazepine-refractory status epilepticus. Neuropharmacology 67: 136-143
29. Guilliams K, Rosen M, Buttram S, Zempel J, Pineda J, Miller B, Shoykhet M. 2013. Hypothermia for pediatric refractory status epilepticus. Epilepsia 54: 1586-1594
30. Hesdorffer DC, Logroscino G, Cascino G, Annegers JF, Hauser WA. 1998. Incidence of status epilepticus in Rochester, Minnesota, 1965-1984. Neurology 50: 735-741
31. Hesdorffer DC, Benn EK, Bagiella E, Nordli D, Pellock J, Hinton V, Shinnar S, Team FS. 2011. Distribution of febrile seizure duration and associations with development. Ann Neurol 70: 93-100
32. Hesdorffer DC, Shinnar S, Lewis DV, Moshe SL, Nordli DR Jr, Pellock JM, MacFall J, Shinnar RC, Masur D, Frank LM, et al. 2012. Design and phenomenology of the FEBSTAT study. Epilepsia 53: 1471-1480
33. Hocker SE, Britton JW, Mandrekar JN, Wijdicks EF, Rabinstein AA. 2013. Predictors of outcome in refractory status epilepticus. JAMA Neurol 70: 72-77
34. Hosie AM, Wilkins ME, da Silva HMA, Smart TG. 2006. Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites. Nature 444: 486-489
35. Joshi S, Rajasekaran K, Hawk KM, Brar J, Ross BM, Tran CA, Chester SJ, Goodkin HP. 2015. Phosphatase inhibition prevents the activity-dependent trafficking of GABAA receptors during status epilepticus in the young animal. Epilepsia 56: 1355-1365
36. Kapur J, Coulter DA. 1995. Experimental status epilepticus alters g-aminobutyric acid type A receptor function in CA1 pyramidal neurons. Ann Neurol 38: 893-900
37. Kapur J, Lothman EW. 1989. Loss of inhibition precedes delayed spontaneous seizures in the hippocampus after tetanic electrical stimulation. J Neurophysiol 61: 427-434
38. Kapur J, Macdonald RL. 1997. Rapid seizure-induced reduction of benzodiazepine and Zn2þ sensitivity of hippocampal dentate granule cellGABAA receptors. JNeurosci 17: 7532-7540
39. Kapur J, Stringer JL, Lothman EW. 1989. Evidence that repetitive seizures in the hippocampus cause a lasting reduction of GABAergic inhibition. J Neurophysiol 61: 417-426
40. Knake S, Rosenow F, Vescovi M, Oertel WH, Mueller HH, Wirbatz A, Katsarou N, Hamer HM, Status Epilepticus Study Group H. 2001. Incidence of status epilepticus in adults in Germany: A prospective, population-based study. Epilepsia 42: 714-718
41. Kokate TG, Cohen AL, Karp E, Rogawski MA. 1996. Neuroactive steroids protect against pilocarpine-and kainic acid-induced limbic seizures and status epilepticus in mice. Neuropharmacology 35: 1049-1056
42. Kowalski RG, Ziai WC, Rees RN, Werner JK Jr, Kim G, Goodwin H, Geocadin RG. 2012. Third-line antiepileptic therapy and outcome in status epilepticus: The impact of vasopressor use and prolonged mechanical ventilation. Crit Care Med 40: 2677-2684
43. Kowski AB, Kanaan H, Schmitt FC, Holtkamp M. 2012. Deep hypothermia terminates status epilepticus—An experimental study. Brain Res 1446: 119-126
44. Kramer U, Chi CS, Lin KL, Specchio N, Sahin M, Olson H, Nabbout R, Kluger G, Lin JJ, van Baalen A. 2011. Febrile infection-related epilepsy syndrome (FIRES): Pathogenesis, treatment, and outcome: A multicenter study on 77 children. Epilepsia 52: 1956-1965
45. Krsek P, Mikulecka A, Druga R, Hlinak Z, Kubova H, Mares P. 2001. An animal model of nonconvulsive status epilepticus: A contribution to clinical controversies. Epilepsia 42: 171-180
46. Lee HH, Jurd R, Moss SJ. 2010. Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2. Mol Cell Neurosci 45: 173-179
47. Lees G, Edwards MD, Hassoni AA, Ganellin CR, Galanakis D. 1998.Modulation of GABAA receptors and inhibitory synaptic currents by the endogenous CNS sleep regulator cis-9,10-octadecenoamide (cOA). Br J Pharmacol 124: 873-882
48. Lewis DV, Shinnar S, Hesdorffer DC, Bagiella E, Bello JA, Chan S, Xu Y, MacFall J, Gomes WA, Moshe SL, et al. 2014. Hippocampal sclerosis after febrile status epilepticus: The FEBSTAT study. Ann Neurol 75: 178-185
49. Logroscino G, Hesdorffer DC, Cascino GD, Annegers JF, Bagiella E, Hauser WA. 2002. Long-term mortality after a first episode of status epilepticus. Neurology 58: 537-541
50. Lowenstein DH, Alldredge BK. 1993. Status epilepticus at an urban public hospital in the 1980s. Neurology 43: 483-488
51. Lowenstein DH, Bleck T, Macdonald RL. 1999. It’s time to revise the definition of status epilepticus. Epilepsia 40: 120-122
52. Lugo JN, Barnwell LF, Ren Y, Lee WL, Johnston LD, Kim R, Hrachovy RA, Sweatt JD, Anderson AE. 2008. Altered phosphorylation and localization of the A-type channel, Kv4.2 in status epilepticus. J Neurochem 106: 1929-1940
53. Mayer SA, Claassen J, Lokin J, Mendelsohn F, Dennis LJ, Fitzsimmons BF. 2002. Refractory status epilepticus: Frequency, risk factors, and impact on outcome. ArchNeurol 59: 205-210
54. Maytal J, Shinnar S. 1990. Febrile status epilepticus. Pediatrics 86: 611-616
55. Maytal J, Shinnar S, Moshe SL, Alvarez LA. 1989. Low morbidity and mortality of status epilepticus in children. Pediatrics 83: 323-331
56. Mazarati AM, Wasterlain CG. 1999. N-methyl-D-asparate receptor antagonists abolish the maintenance phase of self-sustaining status epilepticus in rat. Neurosci Lett 265: 187-190
57. Mazarati AM, Liu H, DN, Wasterlain C. 2006. Self-sustaining status epilepticus. In Status epileptius: Mechanisms and management, pp. 209-228. The MIT Press, London.
58. Meldrum BS, Horton RW. 1973. Physiology of status epilepticus in primates. Arch Neurol 28: 1-9
59. Mikati MA, Werner S, Gatt A, Liu Z, Rahmeh AA, Rachid RA, Stafstrom CE, Holmes GL. 1999. Consequences of aamino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor blockade during status epilepticus in the developing brain. Brain Res Dev Brain Res 113: 139-142
60. Naylor DE, Liu H, Wasterlain CG. 2005. Trafficking of GABAA receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus. J Neurosci 25: 7724-7733
61. Naylor DE, Liu H, Niquet J, Wasterlain CG. 2013. Rapid surface accumulation of NMDA receptors increases glutamatergic excitation during status epilepticus. Neurobiol Dis 54: 225-238
62. Nigrovic LE, Kuppermann N, Macias CG, Cannavino CR, Moro-Sutherland DM, Schremmer RD, Schwab SH, Agrawal D, Mansour KM, Bennett JE, et al. 2007. Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis. JAMA 297: 52-60
63. Nordli DR Jr, Moshe SL, Shinnar S, Hesdorffer DC, Sogawa Y, Pellock JM, Lewis DV, Frank LM, Shinnar RC, Sun S, et al. 2012. Acute EEG findings in children with febrile status epilepticus: Results of the FEBSTAT study. Neurology 79: 2180-2186
64. Novy J, Logroscino G, Rossetti AO. 2010. Refractory status epilepticus: A prospective observational study. Epilepsia 51: 251-256
65. Patterson KP, Baram TZ, Shinnar S. 2014. Origins of temporal lobe epilepsy: Febrile seizures and febrile status epilepticus. Neurotherapeutics 11: 242-250
66. Rajasekaran K, Todorovic M, Kapur J. 2012. Calcium-permeable AMPA receptors are expressed in a rodent model of status epilepticus. Ann Neurol 72: 91-102
67. Rider LG, Thapa PB, Del Beccaro MA, Gale JL, Foy HM, Farwell JR, Mendelman PM. 1995. Cerebrospinal fluid analysis in children with seizures. Pediatr Emerg Care 11: 226-229
68. Rossetti AO, Milligan TA, Vulliemoz S, Michaelides C, Bertschi M, Lee JW. 2011. A randomized trial for the treatment of refractory status epilepticus. Neurocrit Care 14: 4-10
69. Rossi LN, Brunelli G, Duzioni N, Rossi G. 1986. Lumbar puncture and febrile convulsions. Helv Paediatr Acta 41: 19-24
70. Sanchez Fernandez I, Abend NS, Agadi S, An S, Arya R, Carpenter JL, Chapman KE, Gaillard WD, Glauser TA, Goldstein DB, et al. 2014a. Gaps and opportunities in refractory status epilepticus research in children: A multi-center approach by the Pediatric Status Epilepticus Research Group (pSERG). Seizure 23: 87-97
71. Sanchez Fernandez I, Abend NS, Arndt DH, Carpenter JL, Chapman KE, Cornett KM, Dlugos DJ, Gallentine WB, Giza CC, Goldstein JL, et al. 2014b. Electrographic seizures after convulsive status epilepticus in children and young adults: A retrospective multicenter study. J Pediatr 164: 339-346 e331-332
72. Sanchez Fernandez I, Abend NS, Agadi S, An S, Arya R, Brenton JN, Carpenter JL, Chapman KE, Gaillard WD, Glauser TA, et al. 2015. Time from convulsive status epilepticus onset to anticonvulsant administration in children. Neurology 84: 2304-2311
73. Schmitt FC, Buchheim K, Meierkord H, Holtkamp M. 2006. Anticonvulsant properties of hypothermia in experimental status epilepticus. Neurobiol Dis 23: 689-696
74. Schmutzhard E, Pfausler B. 2011. Complications of the management of status epilepticus in the intensive care unit. Epilepsia 52: 39-41
75. Seinfeld S, Shinnar S, Sun S, Hesdorffer DC, Deng X, Shinnar RC, O’Hara K, Nordli DR Jr, Frank LM, Gallentine W, et al. 2014. Emergency management of febrile status epilepticus: Results of the FEBSTAT study. Epilepsia 55: 388-395
76. Shinnar S. 2003. Febrile seizures and mesial temporal sclerosis. Epilepsy Curr 3: 115-118
77. Shinnar S, Pellock JM, Moshe SL, Maytal J, O’Dell C, Driscoll SM, Alemany M, Newstein D, DeLorenzo RJ. 1997. In whom does status epilepticus occur: Age-related differences in children. Epilepsia 38: 907-914
78. Shinnar S, Berg AT, Moshe SL, Shinnar R. 2001a. How long do new-onset seizures in children last? Ann Neurol 49: 659-664
79. Shinnar S, Pellock JM, Berg AT, O’Dell C, Driscoll SM, Maytal J, Moshe SL, DeLorenzo RJ. 2001b. Short-term outcomes of childrenwith febrile status epilepticus. Epilepsia 42: 47-53
80. Shinnar S, Hesdorffer DC, Nordli DR Jr, Pellock JM, O’Dell C, Lewis DV, Frank LM, Moshe SL, Epstein LG, Marmarou A, et al. 2008. Phenomenology of prolonged febrile seizures: results of the FEBSTATstudy. Neurology 71: 170-176
81. Shinnar S, Bello JA, Chan S, Hesdorffer DC, Lewis DV, Macfall J, Pellock JM, Nordli DR, Frank LM, Moshe SL, et al. 2012. MRI abnormalities following febrile status epilepticus in children: The FEBSTATstudy. Neurology 79: 871-877
82. Shorvon S. 2011. Super-refractory status epilepticus: An approach to therapy in this difficult clinical situation. Epilepsia 52: 53-56
83. Shorvon S, Ferlisi M. 2011. The treatment of super-refractory status epilepticus: A critical review of available therapies and a clinical treatment protocol. Brain 134: 2802-2818
84. Sieghart W. 2006. Structure, pharmacology, and function of GABAA receptor subtypes. Adv Pharmacol 54: 231-263
85. Silayeva L, Deeb TZ, Hines RM, Kelley MR, Munoz MB, Lee HH, Brandon NJ, Dunlop J, Maguire J, Davies PA, et al. 2015. KCC2 activity is critical in limiting the onset and severity of status epilepticus. Proc Natl Acad Sci 112: 3523-3528
86. Silbergleit R, Durkalski V, Lowenstein D, Conwit R, Pancioli A, Palesch Y, Barsan W, Investigators N. 2012. Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med 366: 591-600
87. Sillanpaa M, Shinnar S. 2002. Status epilepticus in a population-based cohort with childhood-onset epilepsy in Finland. Ann Neurol 52: 303-310
88. Sillanpaa M, Shinnar S. 2010. Long-term mortality in childhood-onset epilepsy. N Engl J Med 363: 2522-2529
89. Sillanpaa M, Jalava M, Kaleva O, Shinnar S. 1998. Longterm prognosis of seizures with onset in childhood. N Engl J Med 338: 1715-1722
90. Sivakumaran S, Cardarelli RA, Maguire J, Kelley MR, Silayeva L, Morrow DH, Mukherjee J, Moore YE, Mather RJ, Duggan ME, et al. 2015. Selective Inhibition of KCC2 Leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo. J Neurosci 35: 8291-8296
91. Sutter R, Marsch S, Fuhr P, Kaplan PW, Ruegg S. 2014. Anesthetic drugs in status epilepticus: risk or rescue? A 6-year cohort study. Neurology 82: 656-664
92. Tay SK, Hirsch LJ, Leary L, Jette N, Wittman J, Akman CI. 2006. Nonconvulsive status epilepticus in children: Clinical and EEG characteristics. Epilepsia 47: 1504-1509
93. Terunuma M, Xu J, Vithlani M, Sieghart W, Kittler J, Pangalos M, Haydon PG, Coulter DA, Moss SJ. 2008. Deficits in phosphorylation of GABAA receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus. J Neurosci 28: 376-384
94. Towne AR, Pellock JM, Ko D, DeLorenzo RJ. 1994. Determinants of mortality in status epilepticus. Epilepsia 35: 27-34
95. Treiman DM, Meyers PD, Walton NY, Collins JF, Colling C, Rowan AJ, Handforth A, Faught E, Calabrese VP, Uthman BM, et al. 1998. A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. N Engl J Med 339: 792-798
96. Trinka E, Cock H, Hesdorffer D, Rossetti AO, Scheffer IE, Shinnar S, Shorvon S, Lowenstein DH. 2015. A definition and classification of status epilepticus:Report of the ILAE Task Force on classification of status epilepticus. Epilepsia 56: 1515-1523
97. Tsetsou S, Novy J, Rossetti AO. 2015. Recurrence of status epilepticus: Prognostic role and outcome predictors. Epilepsia 56: 473-478
98. Vespa PM, McArthur DL, Xu Y, Eliseo M, Etchepare M, Dinov I, Alger J, Glenn TP, Hovda D. 2010. Nonconvulsive seizures after traumatic brain injury are associated with hippocampal atrophy. Neurology 75: 792-798
99. Vignatelli L, Tonon C, D’Alessandro R; Bologna Group for the Study of Status E. 2003. Incidence and short-term prognosis of status epilepticus in adults in Bologna, Italy. Epilepsia 44: 964-968
100. Wasterlain CG, Naylor DE, Liu H, Niquet J, Baldwin R. 2013. Trafficking of NMDA receptors during status epilepticus: Therapeutic implications. Epilepsia 54: 78-80
101. Wong M, Wozniak DF, Yamada KA. 2003. An animal model of generalized nonconvulsive status epilepticus: Immediate characteristics and long-term effects. Exp Neurol 183: 87-99
102. Woody RC, Yamauchi T, Bolyard K. 1988. Cerebrospinal fluid cell counts in childhood idiopathic status epilepticus. Pediatr Infect Dis J 7: 298-299
103. Wu YW, Shek DW, Garcia PA, Zhao S, Johnston SC. 2002. Incidence and mortality of generalized convulsive status epilepticus in California. Neurology 58: 1070-1076