AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD+ elevation

Aging Cell

Volumn 15, Issue 3, 2016, Pages 416-427

  Han, Xiaojuan ^a   Tai, Haoran ^a   Wang, Xiaobo ^a   Wang, Zhe ^a   Zhou, Jiao ^a   Wei, Xiawei ^a   Ding, Yi ^a   Gong, Hui ^a   Mo, Chunfen ^a   Zhang, Jie ^a   Qin, Jianqiong ^a   Ma, Yuanji ^a   Huang, Ning ^a   Xiang, Rong ^b   Xiao, Hengyi ^a  

^a SICHUAN UNIVERSITY   (China)

^b NANKAI UNIVERSITY   (China)

Author keywords

AMPK; Autophagy; NAD+; Oxidative stress; Senescence

Indexed keywords

ADENOSINE 5' MONOPHOSPHATE ACTIVATED PROTEIN KINASE; BERBERINE; HYDROGEN PEROXIDE; HYDROLASE; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; PHOSPHOTRANSFERASE; PROTEIN KINASE; PROTEIN P62; SIRTUIN 1; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; TARGET OF RAPAMYCIN KINASE; TCFEB PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL AGING; CELL PROTECTION; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME SYNTHESIS; HOMEOSTASIS; HUMAN; HUMAN CELL; LYSOSOME; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; ANIMAL; CELL NUCLEUS; DRUG EFFECTS; INTRACELLULAR SPACE; METABOLISM; MOUSE; NIH 3T3 CELL LINE; PROTEIN TRANSPORT; UMBILICAL VEIN ENDOTHELIAL CELL;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL AGING; CELL NUCLEUS; CYTOPROTECTION; ENZYME ACTIVATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROGEN PEROXIDE; INTRACELLULAR SPACE; LYSOSOMES; MICE; NAD; NIH 3T3 CELLS; OXIDATIVE STRESS; PROTEIN TRANSPORT; TOR SERINE-THREONINE KINASES;

EID: 84964706600     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12446     Document Type: Article

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