Cellular NAD depletion and decline of SIRT1 activity play critical roles in PARP-1-mediated acute epileptic neuronal death in vitro

Brain Research

Volumn 1535, Issue , 2013, Pages 14-23

  Wang, Shengjun ^a   Yang, Xue ^a   Lin, Youting ^b   Qiu, Xiaoxue ^a   Li, Hui ^c   Zhao, Xiuhe ^a   Cao, Lili ^a   Liu, Xuewu ^a   Pang, Yuejiu ^b   Wang, Xuping ^a   Chi, Zhaofu ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^c The Fourth People s Hospital of Ji an   (China)

Author keywords

Apoptosis inducing factor; Epilepsy; NAD; Neuronal death; Poly(ADP ribose)polymerase 1; SIRT1

Indexed keywords

MAGNESIUM ION; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; SIRTUIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; ELECTROPHYSIOLOGY; ENZYME ACTIVATION; EPILEPSY; HIPPOCAMPAL NEURONAL CULTURE; IN VITRO STUDY; MITOCHONDRION; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXY]-1(2H)-ISOQUINOLINONE; ACQUIRED EPILEPSY; AE; AIF; APOPTOSIS-INDUCING FACTOR; COXIV; CYTOCHROME OXIDASE SUBUNIT IV; DPQ; EPILEPSY; HIPPOCAMPAL NEURONAL CULTURE; HNC; MITOCHONDRIAL PERMEABILITY TRANSITION; MPT; NAD; NEURONAL DEATH; NICOTINAMIDE ADENINE DINUCLEOTIDE; PAR; PARP-1; POLY(ADP-RIBOSE); POLY(ADP-RIBOSE) POLYMERASE-1; POLY(ADP-RIBOSE)POLYMERASE-1; SIRT1; SPONTANEOUS RECURRENT EPILEPTIFORM DISCHARGES; SREDS; TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE-MEDIATED DUTP NICK END LABELING; TUNEL; WCC; WHOLE-CELL CURRENT-CLAMP;

ANIMALS; APOPTOSIS INDUCING FACTOR; CELL DEATH; EPILEPSY; HIPPOCAMPUS; NAD; NEURONS; POLY(ADP-RIBOSE) POLYMERASES; RATS; SIRTUIN 1;

EID: 84884702166     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.08.038     Document Type: Article

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