Beyond knockout: A novel homodimerization-targeting MyD88 inhibitor prevents and cures type 1 diabetes in NOD mice

Metabolism: Clinical and Experimental

Volumn 65, Issue 9, 2016, Pages 1267-1277

  Zhang, Xue ^a   Xing, Shuai ^a   Li, Mingqiang ^a,b   Zhang, Limin ^a   Xie, Lin ^a   He, Wentao ^a   Liu, Jianhua ^a   Chang, Sheng ^a   Jiang, Fengchao ^a   Zhou, Ping ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b TAIAN CITY CENTRAL HOSPITAL   (China)

Author keywords

DC; MyD88; MyD88 inhibitor; Therapeutics; Type 1 diabetes

Indexed keywords

AMINO ACID; GAMMA INTERFERON; GLUCOSE; INTERLEUKIN 10; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN INHIBITOR; TJ M 2010 6; UNCLASSIFIED DRUG; 5-(3-(4-(4-BENZYLPIPERAZIN-1-YL)-N-(4-PHENYLTHIAZOL-2-YL))PROPANAMIDE; ANTIDIABETIC AGENT; CYTOKINE; GLUCOSE BLOOD LEVEL; MYD88 PROTEIN, MOUSE; PIPERAZINE DERIVATIVE; THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MATURATION; CONTINUOUS INFUSION; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DIMERIZATION; DRUG MECHANISM; FEMALE; GLUCOSE BLOOD LEVEL; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LYMPHOCYTE PROLIFERATION; MOLECULAR DOCKING; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SPLEEN; T LYMPHOCYTE ACTIVATION; THERAPY EFFECT; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DIABETES MELLITUS, TYPE 1; DRUG EFFECTS; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM; MOLECULAR MODEL; NONOBESE DIABETIC MOUSE; PANCREAS; PATHOLOGY; T LYMPHOCYTE;

AMINO ACIDS; ANIMALS; BLOOD GLUCOSE; CYTOKINES; DENDRITIC CELLS; DIABETES MELLITUS, TYPE 1; FEMALE; HYPOGLYCEMIC AGENTS; IMMUNITY, INNATE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; MYELOID DIFFERENTIATION FACTOR 88; PANCREAS; PIPERAZINES; T-LYMPHOCYTES; THIAZOLES;

EID: 84973561545     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2016.05.005     Document Type: Article

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