Neuroprotective Efficacy of an Aminopropyl Carbazole Derivative P7C3-A20 in Ischemic Stroke

CNS Neuroscience and Therapeutics

Volumn 22, Issue 9, 2016, Pages 782-788

  Wang, Shu Na ^a   Xu, Tian Ying ^a   Wang, Xia ^a   Guan, Yun Feng ^a   Zhang, Sai Long ^a   Wang, Pei ^a   Miao, Chao Yu ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b BEIJING INSTITUTE FOR BRAIN DISORDERS   (China)

Author keywords

Aminopropyl carbazole chemical; Ischemic stroke; Neuroprotection; Nicotinamide adenine dinucleotide; Nicotinamide phosphoribosyltransferase; P7C3 A20

Indexed keywords

AMINOPROPYL CARBAZOLE DERIVATIVE; CARBAZOLE DERIVATIVE; ENZYME ACTIVATOR; NEUROPROTECTIVE AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE ACTIVATOR; P 7C3 A20; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN TISSUE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFICACY; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; RAT; REPERFUSION INJURY;

EID: 84982980363     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12576     Document Type: Article

References (47)

1. Langhorne P, Bernhardt J, Kwakkel G. Stroke rehabilitation. Lancet 2011;377:1693–1702.
2. Su Y, Cheng X, Dong Q. Dual antiplatelet therapy of clopidogrel and aspirin in secondary prevention of ischemic stroke: Evidence and indications. CNS Neurosci Ther 2015;21:870–876.
3. Chen J, Leak RK, Yang GY. Perspective for stroke and brain injury research: Mechanisms and potential therapeutic targets. CNS Neurosci Ther 2015;21:301–303.
4. Dirnagl U, Endres M. Found in translation: Preclinical stroke research predicts human pathophysiology, clinical phenotypes, and therapeutic outcomes. Stroke 2014;45:1510–1518.
5. Yang D, Kuan CY. Anti-tissue plasminogen activator (tPA) as an effective therapy of neonatal hypoxia-ischemia with and without inflammation. CNS Neurosci Ther 2015;21:367–373.
6. Wang P, Miao CY. NAMPT as a therapeutic target against stroke. Trends Pharmacol Sci 2015;36:891–905.
7. Wang P, Xu TY, Guan YF, et al. Nicotinamide Phosphoribosyltransferase Protects Against Ischemic Stroke Through SIRT1-Dependent Adenosine Monophosphate-Activated Kinase Pathway. Ann Neurol 2011;69:360–374.
8. Zhao Y, Liu XZ, Tian WW, Guan YF, Wang P, Miao CY. Extracellular visfatin has nicotinamide phosphoribosyltransferase enzymatic activity and is neuroprotective against ischemic injury. CNS Neurosci Ther 2014;20:539–547.
9. Zhao Y, Guan YF, Zhou XM, et al. Regenerative neurogenesis after ischemic stroke promoted by nicotinamide phosphoribosyltransferase-nicotinamide adenine dinucleotide cascade. Stroke 2015;46:1966–1974.
10. Wang P, Xu TY, Guan YF, Su DF, Fan GR, Miao CY. Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: Role of nicotinamide mononucleotide. Cardiovasc Res 2009;81:370–380.
11. Wang P, Guan YF, Li WL, Lu GC, Liu JM, Miao CY. Nicotinamide phosphoribosyltransferase facilitates post-stroke angiogenesis. CNS Neurosci Ther 2015;21:475–477.
12. Wang P, Du H, Zhou CC, et al. Intracellular NAMPT-NAD+-SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors. Cardiovasc Res 2014;104:477–488.
13. Wang P, Vanhoutte PM, Miao CY. Visfatin and cardio-cerebro-vascular disease. J Cardiovasc Pharmacol 2012;59:1–9.
14. Zhang RY, Qin Y, Lv XQ, et al. A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase. Anal Biochem 2011;412:18–25.
15. Xu TY, Zhang SL, Dong GQ, et al. Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase. Sci Rep 2015;5:10043.
16. Wang X, Xu TY, Liu XZ, et al. Discovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT. Sci Rep 2015;5:12657.
17. Sampath D, Zabka TS, Misner DL, O'Brien T, Dragovich PS. Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer. Pharmacol Ther 2015;151:16–31.
18. Wang G, Han T, Nijhawan D, et al. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell 2014;158:1324–1334.
19. Shen L, Cui WY, Chen RZ, Wang H. Differential modulation of GABAA and NMDA receptors by alpha7-nicotinic receptor desensitization in cultured rat hippocampal neurons. Acta Pharmacol Sin 2016;37:312–321.
20. Wang P, Guan YF, Du H, Zhai QW, Su DF, Miao CY. Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemic stroke. Autophagy 2012;8:77–87.
21. Li Y, Xu XL, Zhao D, et al. TLR3 ligand Poly IC Attenuates Reactive Astrogliosis and Improves Recovery of Rats after Focal Cerebral Ischemia. CNS Neurosci Ther 2015;21:905–913.
22. Pieper AA, Xie S, Capota E, et al. Discovery of a proneurogenic, neuroprotective chemical. Cell 2010;142:39–51.
23. Lin Y, Wang P, Liu YH, Shang XL, Chen LY, Xue YX. DT, a Truncated Diphtheria Toxin, Increases Blood-Tumor Barrier Permeability by Upregulating the Expression of Caveolin-1. CNS Neurosci Ther 2016;22:477–487.
24. Guo XB, Chen XJ, Tong LJ, et al. DCLAK11, a multi-tyrosine kinase inhibitor, exhibits potent antitumor and antiangiogenic activity in vitro. Acta Pharmacol Sin 2015;36:1266–1276.
25. Chen WF, Chen CH, Chen NF, Sung CS, Wen ZH. Neuroprotective effects of direct intrathecal administration of granulocyte colony-stimulating factor in rats with spinal cord injury. CNS Neurosci Ther 2015;21:698–707.
26. Jiang BM, Zhang B, Liang PF, et al. Nucleolin protects the heart from ischaemia reperfusion injury by up-regulating heat shock protein 32. Cardiovasc Res 2013;99:92–101.
27. Zhang XH, Lei H, Liu AJ, Zou YX, Shen FM, Su DF. Increased oxidative stress is responsible for severer cerebral infarction in stroke-prone spontaneously hypertensive rats. CNS Neurosci Ther 2011;17:590–598.
28. Liu ZJ, Chen C, Li XR, et al. Remote ischemic preconditioning-mediated neuroprotection against stroke is associated with significant alterations in peripheral immune responses. CNS Neurosci Ther 2016;22:43–52.
29. Guo ZL, Zhu Y, Su XT, et al. DanHong injection dose-dependently varies amino acid metabolites and metabolic pathways in the treatment of rats with cerebral ischemia. Acta Pharmacol Sin 2015;36:748–757.
30. Xie H, Zhang J, Zhu J, et al. Sevoflurane post-conditioning protects isolated rat hearts against ischemia-reperfusion injury via activation of the ERK1/2 pathway. Acta Pharmacol Sin 2014;35:1504–1513.
31. Xu TY, Lan XH, Guan YF, Zhang SL, Wang X, Miao CY. Chronic nicotine treatment enhances vascular smooth muscle relaxation in rats. Acta Pharmacol Sin 2015;36:429–439.
32. Wang P, Xu TY, Wei K, et al. ARRB1/beta-arrestin-1 mediates neuroprotection through coordination of BECN1-dependent autophagy in cerebral ischemia. Autophagy 2014;10:1535–1548.
33. Wang P, Zhang RY, Song J, et al. Loss of AMP-activated protein kinase-alpha2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle. Diabetes 2012;61:1051–1061.
34. De Jesus-Cortes H, Xu P, Drawbridge J, et al. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease. Proc Natl Acad Sci USA 2012;109:17010–17015.
35. Naidoo J, De Jesus-Cortes H, Huntington P, et al. Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties. J Med Chem 2014;57:3746–3754.
36. Tesla R, Wolf HP, Xu P, et al. Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis. Proc Natl Acad Sci USA 2012;109:17016–17021.
37. Walker AK, Rivera PD, Wang Q, et al. The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis. Mol Psychiatry 2015;20:500–508.
38. Blaya MO, Bramlett HM, Naidoo J, Pieper AA, Dietrich WD. Neuroprotective efficacy of a proneurogenic compound after traumatic brain injury. J Neurotrauma 2014;31:476–486.
39. Dutca LM, Stasheff SF, Hedberg-Buenz A, et al. Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243. Invest Ophthalmol Vis Sci 2014;55:8330–8341.
40. Yin TC, Britt JK, De Jesus-Cortes H, et al. P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury. Cell Rep 2014;8:1731–1740.
41. Latchney SE, Jaramillo TC, Rivera PD, Eisch AJ, Powell CM. Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down Syndrome [Corrected]. Neurosci Lett 2015;591:86–92.
42. Kemp SW, Szynkaruk M, Stanoulis KN, et al. Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury. Neuroscience 2015;284:202–216.
43. Wang SN, Xu TY, Li WL, Miao CY. Targeting Nicotinamide Phosphoribosyltransferase as a Potential Therapeutic Strategy to Restore Adult Neurogenesis. CNS Neurosci Ther 2016;22:431–439.
44. Endres M, Wang ZQ, Namura S, Waeber C, Moskowitz MA. Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. J Cereb Blood Flow Metab 1997;17:1143–1151.
45. Yang J, Klaidman LK, Nalbandian A, et al. The effects of nicotinamide on energy metabolism following transient focal cerebral ischemia in Wistar rats. Neurosci Lett 2002;333:91–94.
46. Pacher P, Liaudet L, Bai P, et al. Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure. J Pharmacol Exp Ther 2002;300:862–867.
47. Munoz-Gomez JA, Rodriguez-Vargas JM, Quiles-Perez R, et al. PARP-1 is involved in autophagy induced by DNA damage. Autophagy 2009;5:61–74.