Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

Cell Reports

Volumn 19, Issue 4, 2017, Pages 719-732

  Zhou, Tongqing ^a   Doria Rose, Nicole A ^a   Cheng, Cheng ^a   Stewart Jones, Guillaume B E ^a   Chuang, Gwo Yu ^a   Chambers, Michael ^a   Druz, Aliaksandr ^a   Geng, Hui ^a   McKee, Krisha ^a   Kwon, Young Do ^a   O'Dell, Sijy ^a   Sastry, Mallika ^a   Schmidt, Stephen D ^a   Xu, Kai ^a   Chen, Lei ^a   Chen, Rita E ^a   Louder, Mark K ^a   Pancera, Marie ^a   Wanninger, Timothy G ^a   Zhang, Baoshan ^a   Zheng, Anqi ^a   Farney, S Katie ^a   Foulds, Kathryn E ^a   Georgiev, Ivelin S ^a   Joyce, M Gordon ^a   Lemmin, Thomas ^a   Narpala, Sandeep ^a   Rawi, Reda ^a   Soto, Cinque ^a   Todd, John Paul ^a   Shen, Chen Hsiang ^a   Tsybovsky, Yaroslav ^b   Yang, Yongping ^a   Zhao, Peng ^c,f   Haynes, Barton F ^d   Stamatatos, Leonidas ^e   Tiemeyer, Michael ^c,f   Wells, Lance ^c   Scorpio, Diana G ^a   Shapiro, Lawrence ^a,g   McDermott, Adrian B ^a   Mascola, John R ^a   Kwong, Peter D ^a,g   more..

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^c UNIVERSITY OF GEORGIA   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e USA   (United States)

^f University of Georgia   (United States)

^g NONE   (United States)

Author keywords

CD4 binding site; crystal structure; envelope glycoprotein; glycan shield; glycomics; HIV 1; immunogen design; immunogenicity; targeted deglycosylation; vaccine design

Indexed keywords

BG505 DS SOSIP ANTIBODY; CD4 ANTIGEN; GLYCAN DERIVATIVE; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; EPITOPE; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; POLYSACCHARIDE; VIRUS ENVELOPE PROTEIN;

ANIMAL EXPERIMENT; ANTIBODY DETECTION; ANTIBODY TITER; ANTIGENICITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; DEGLYCOSYLATION; GLYCOSYLATION; GUINEA PIG; HUMAN IMMUNODEFICIENCY VIRUS 1; ID50; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; MOLECULAR DYNAMICS; NONHUMAN; RECEPTOR BINDING; RHESUS MONKEY; ANIMAL; ANTIBODY SPECIFICITY; BLOOD; CHEMISTRY; DEFICIENCY; HUMAN; IMMUNOLOGY; METABOLISM; PROTEIN QUATERNARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODY SPECIFICITY; BINDING SITES; CD4 ANTIGENS; CRYSTALLOGRAPHY, X-RAY; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; EPITOPES; GLYCOSYLATION; GUINEA PIGS; HIV ANTIBODIES; HIV-1; HUMANS; IMMUNIZATION; MACACA MULATTA; MOLECULAR DYNAMICS SIMULATION; POLYSACCHARIDES; PROTEIN STRUCTURE, QUATERNARY;

EID: 85018708194     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.04.013     Document Type: Article

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