Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

Neurobiology of Aging

Volumn 55, Issue , 2017, Pages 115-122

  Yin, Zhuoran ^a,b   Raj, Divya ^a   Saiepour, Nasrin ^c   Van Dam, Debby ^a,d   Brouwer, Nieske ^a   Holtman, Inge R ^a   Eggen, Bart J L ^a   Möller, Thomas ^e   Tamm, Joseph A ^e   Abdourahman, Aicha ^e   Hol, Elly M ^f,g,h   Kamphuis, Willem ^g   Bayer, Thomas A ^c   De Deyn, Peter P ^a,d   Boddeke, Erik ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^d UNIVERSITY OF ANTWERP   (Belgium)

^e LUNDBECK RESEARCH USA   (United States)

^f UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^g NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^h UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Beta amyloid; Early onset Alzheimer's disease; Late onset Alzheimer's disease; Microglia; Neurodegeneration; Neuroinflammation

Indexed keywords

AMYLOID BETA PROTEIN; CD63 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; EARLY GROWTH RESPONSE FACTOR 2; HLA DR ANTIGEN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; OSTEOPONTIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL M1; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; APOLIPOPROTEIN E; AXL RECEPTOR TYROSINE KINASE; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; ONCOPROTEIN; PROTEIN TYROSINE KINASE; TREM2 PROTEIN, HUMAN;

ADULT; AGED; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOE GENE; ARTICLE; AXL GENE; CCL3 GENE; CCL4 GENE; CD63 GENE; CELL DIFFERENTIATION; CELL MOTILITY; CONTROLLED STUDY; CXCR4 GENE; EGR2 GENE; FEMALE; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE ONTOLOGY; HLA DRA GENE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; LGALS3 GENE; MALE; MICROGLIA; MIDDLE AGED; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PATHOGENESIS; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL; SDC3 GENE; SPP1 GENE; ST14 GENE; TREM2 GENE; TRPM1 GENE; TYROBP GENE; UPREGULATION; VERY ELDERLY; AMYLOID PLAQUE; ANIMAL; BRAIN; CELL MOTION; DISEASE MODEL; GENETICS; IMMUNOLOGY; INFLAMMATION; TRANSGENIC MOUSE;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; APOLIPOPROTEINS E; BRAIN; CELL DIFFERENTIATION; CELL MOVEMENT; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; HUMANS; INFLAMMATION; MALE; MEMBRANE GLYCOPROTEINS; MICE, TRANSGENIC; MICROGLIA; MIDDLE AGED; PHAGOCYTOSIS; PLAQUE, AMYLOID; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, IMMUNOLOGIC;

EID: 85018624693     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2017.03.021     Document Type: Article

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