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Volumn 62, Issue 10, 2014, Pages 1724-1735

In acute experimental autoimmune encephalomyelitis, infiltrating macrophages are immune activated, whereas microglia remain immune suppressed

Author keywords

EAE; Ly 6C; Macrophage; Microglia; Multiple sclerosis

Indexed keywords

B7 ANTIGEN; CD11B ANTIGEN; CD40 ANTIGEN; CD45 ANTIGEN; CD86 ANTIGEN; INTERLEUKIN 1BETA; LYMPHOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN 6 COMPLEX; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CASP6 PROTEIN, MOUSE; CASPASE 6; CYTOKINE; IL1B PROTEIN, MOUSE; LY ANTIGEN; LY-6C ANTIGEN, MOUSE; PTPRC PROTEIN, MOUSE;

EID: 84906313533     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22711     Document Type: Article
Times cited : (79)

References (38)
  • 1
    • 80052246111 scopus 로고    scopus 로고
    • Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
    • Ajami B, Bennett JL, Krieger C, McNagny KM, Rossi FM. 2011. Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool. Nat Neurosci 14:1142-1149.
    • (2011) Nat Neurosci , vol.14 , pp. 1142-1149
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    McNagny, K.M.4    Rossi, F.M.5
  • 2
    • 34248997759 scopus 로고    scopus 로고
    • Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis
    • Arnold L, Henry A, Poron F, Baba-Amer Y, van Rooijen N, Plonquet A, Gherardi RK, Chazaud B. 2007. Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J Exp Med 204:1057-1069.
    • (2007) J Exp Med , vol.204 , pp. 1057-1069
    • Arnold, L.1    Henry, A.2    Poron, F.3    Baba-Amer, Y.4    van Rooijen, N.5    Plonquet, A.6    Gherardi, R.K.7    Chazaud, B.8
  • 3
    • 0029451821 scopus 로고
    • The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental autoimmune encephalomyelitis
    • Bauer J, Huitinga I, Zhao W, Lassmann H, Hickey WF, Dijkstra CD. 1995. The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental autoimmune encephalomyelitis. Glia 15:437-446.
    • (1995) Glia , vol.15 , pp. 437-446
    • Bauer, J.1    Huitinga, I.2    Zhao, W.3    Lassmann, H.4    Hickey, W.F.5    Dijkstra, C.D.6
  • 4
    • 33745631754 scopus 로고    scopus 로고
    • Antigen presentation in autoimmunity and CNS inflammation: How T lymphocytes recognize the brain
    • Becher B, Bechmann I, Greter M. 2006. Antigen presentation in autoimmunity and CNS inflammation: How T lymphocytes recognize the brain. J Mol Med 84:532-543.
    • (2006) J Mol Med , vol.84 , pp. 532-543
    • Becher, B.1    Bechmann, I.2    Greter, M.3
  • 5
    • 0030970058 scopus 로고    scopus 로고
    • Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis
    • Benveniste EN. 1997a. Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J Mol Med 75:165-173.
    • (1997) J Mol Med , vol.75 , pp. 165-173
    • Benveniste, E.N.1
  • 6
    • 0030970058 scopus 로고    scopus 로고
    • Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis
    • Benveniste EN. 1997b. Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J Mol Med 75:165-173.
    • (1997) J Mol Med , vol.75 , pp. 165-173
    • Benveniste, E.N.1
  • 7
    • 84898028606 scopus 로고    scopus 로고
    • What is microglia neurotoxicity (Not)?
    • Biber K, Owens T, Boddeke E. 2014. What is microglia neurotoxicity (Not)? Glia. 62:841-854.
    • (2014) Glia , vol.62 , pp. 841-854
    • Biber, K.1    Owens, T.2    Boddeke, E.3
  • 8
    • 0019468319 scopus 로고
    • The effects of macrophage depletion on the clinical and pathologic expression of experimental allergic encephalomyelitis
    • Brosnan CF, Bornstein MB, Bloom BR. 1981. The effects of macrophage depletion on the clinical and pathologic expression of experimental allergic encephalomyelitis. J Immunol 126:614-620.
    • (1981) J Immunol , vol.126 , pp. 614-620
    • Brosnan, C.F.1    Bornstein, M.B.2    Bloom, B.R.3
  • 9
    • 0036847841 scopus 로고    scopus 로고
    • Microglia as liaisons between the immune and central nervous systems: Functional implications for multiple sclerosis
    • Carson MJ. 2002. Microglia as liaisons between the immune and central nervous systems: Functional implications for multiple sclerosis. Glia 40:218-231.
    • (2002) Glia , vol.40 , pp. 218-231
    • Carson, M.J.1
  • 10
    • 84869178487 scopus 로고    scopus 로고
    • Microglia and neurodegeneration: The role of systemic inflammation
    • Cunningham C. 2013. Microglia and neurodegeneration: The role of systemic inflammation. Glia 61:71-90.
    • (2013) Glia , vol.61 , pp. 71-90
    • Cunningham, C.1
  • 11
    • 46749115222 scopus 로고    scopus 로고
    • Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS
    • de Haas AH, Boddeke HW, Biber K. 2008. Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS. Glia 56:888-894.
    • (2008) Glia , vol.56 , pp. 888-894
    • de Haas, A.H.1    Boddeke, H.W.2    Biber, K.3
  • 12
    • 0033807680 scopus 로고    scopus 로고
    • CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis
    • Fife BT, Huffnagle GB, Kuziel W a, Karpus WJ. 2000. CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis. J Exp Med 192:899-905.
    • (2000) J Exp Med , vol.192 , pp. 899-905
    • Fife, B.T.1    Huffnagle, G.B.2    Kuziel, W.a.3    Karpus, W.J.4
  • 13
    • 77951214891 scopus 로고    scopus 로고
    • Role of the innate immune system in the pathogenesis of multiple sclerosis
    • Gandhi R, Laroni A, Weiner HL. 2010. Role of the innate immune system in the pathogenesis of multiple sclerosis. J Neuroimmunol 221:7-14.
    • (2010) J Neuroimmunol , vol.221 , pp. 7-14
    • Gandhi, R.1    Laroni, A.2    Weiner, H.L.3
  • 14
    • 33746729791 scopus 로고    scopus 로고
    • Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research
    • Gold R, Linington C, Lassmann H. 2006. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 129:1953-1971.
    • (2006) Brain , vol.129 , pp. 1953-1971
    • Gold, R.1    Linington, C.2    Lassmann, H.3
  • 17
    • 0035911254 scopus 로고    scopus 로고
    • Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis
    • Huang DR, Wang J, Kivisakk P, Rollins BJ, Ransohoff RM. 2001. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J Exp Med 193:713-726.
    • (2001) J Exp Med , vol.193 , pp. 713-726
    • Huang, D.R.1    Wang, J.2    Kivisakk, P.3    Rollins, B.J.4    Ransohoff, R.M.5
  • 18
    • 0025015655 scopus 로고
    • Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages
    • Huitinga I, van Rooijen N, de Groot CJ, Uitdehaag BM, Dijkstra CD. 1990. Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages. J Exp Med 172:1025-1033.
    • (1990) J Exp Med , vol.172 , pp. 1025-1033
    • Huitinga, I.1    van Rooijen, N.2    de Groot, C.J.3    Uitdehaag, B.M.4    Dijkstra, C.D.5
  • 19
    • 0034596949 scopus 로고    scopus 로고
    • Resistance to experimental autoimmune encephalomyelitis in mice lacking the Cc chemokine receptor (CCR2)
    • Izikson L, Klein RS, Charo IF, Weiner HL, Luster AD. 2000. Resistance to experimental autoimmune encephalomyelitis in mice lacking the Cc chemokine receptor (CCR2). J Exp Med 192:1075-1080.
    • (2000) J Exp Med , vol.192 , pp. 1075-1080
    • Izikson, L.1    Klein, R.S.2    Charo, I.F.3    Weiner, H.L.4    Luster, A.D.5
  • 21
    • 0033961796 scopus 로고    scopus 로고
    • Kinetics and cellular origin of cytokines in the central nervous system: Insight into mechanisms of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis
    • Juedes AE, Hjelmström P, Bergman CM, Neild AL, Ruddle NH. 2000. Kinetics and cellular origin of cytokines in the central nervous system: Insight into mechanisms of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. J Immunol 164:419-426.
    • (2000) J Immunol , vol.164 , pp. 419-426
    • Juedes, A.E.1    Hjelmström, P.2    Bergman, C.M.3    Neild, A.L.4    Ruddle, N.H.5
  • 22
    • 0035871635 scopus 로고    scopus 로고
    • Resident and infiltrating central nervous system APCs regulate the emergence and resolution of experimental autoimmune encephalomyelitis
    • Juedes AE, Ruddle NH. 2001. Resident and infiltrating central nervous system APCs regulate the emergence and resolution of experimental autoimmune encephalomyelitis. J Immunol 166:5168-5175.
    • (2001) J Immunol , vol.166 , pp. 5168-5175
    • Juedes, A.E.1    Ruddle, N.H.2
  • 23
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: A sensor for pathological events in the CNS
    • Kreutzberg GW. 1996. Microglia: A sensor for pathological events in the CNS. Trends Neurosci 19:312-318.
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 25
    • 0027436887 scopus 로고
    • Radiation bone marrow chimeras as a tool to study microglia turnover in normal brain and inflammation
    • Lassmann H, Hickey WF. 1993. Radiation bone marrow chimeras as a tool to study microglia turnover in normal brain and inflammation. Clin Neuropathol 12:284-285.
    • (1993) Clin Neuropathol , vol.12 , pp. 284-285
    • Lassmann, H.1    Hickey, W.F.2
  • 26
    • 33947509525 scopus 로고    scopus 로고
    • The immunopathology of multiple sclerosis: An overview
    • Lassmann H, Brück W, Lucchinetti CF. 2007. The immunopathology of multiple sclerosis: An overview. Brain Pathol 17:210-218.
    • (2007) Brain Pathol , vol.17 , pp. 210-218
    • Lassmann, H.1    Brück, W.2    Lucchinetti, C.F.3
  • 27
    • 81555223903 scopus 로고    scopus 로고
    • The molecular basis of neurodegeneration in multiple sclerosis
    • Lassmann H, van Horssen J. 2011. The molecular basis of neurodegeneration in multiple sclerosis. FEBS Lett 585:3715-3723.
    • (2011) FEBS Lett , vol.585 , pp. 3715-3723
    • Lassmann, H.1    van Horssen, J.2
  • 29
    • 71549167047 scopus 로고    scopus 로고
    • CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system
    • Mildner A, Mack M, Schmidt H, Brück W, Djukic M, Zabel MD, Hille A, Priller J, Prinz M. 2009. CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system. Brain 132:2487-2500.
    • (2009) Brain , vol.132 , pp. 2487-2500
    • Mildner, A.1    Mack, M.2    Schmidt, H.3    Brück, W.4    Djukic, M.5    Zabel, M.D.6    Hille, A.7    Priller, J.8    Prinz, M.9
  • 31
    • 84855384345 scopus 로고    scopus 로고
    • The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood
    • Mizutani M, Pino PA, Saederup N, Charo IF, Ransohoff RM, Cardona AE. 2012. The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood. J Immunol 188:29-36.
    • (2012) J Immunol , vol.188 , pp. 29-36
    • Mizutani, M.1    Pino, P.A.2    Saederup, N.3    Charo, I.F.4    Ransohoff, R.M.5    Cardona, A.E.6
  • 32
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A, Kirchhoff F, Helmchen F. 2005. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308:1314-1318.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 34
    • 25444484079 scopus 로고    scopus 로고
    • Microglial cell activation and proliferation precedes the onset of CNS autoimmunity
    • Ponomarev ED, Shriver LP, Maresz K, Dittel BN. 2005. Microglial cell activation and proliferation precedes the onset of CNS autoimmunity. J Neurosci Res 81:374-389.
    • (2005) J Neurosci Res , vol.81 , pp. 374-389
    • Ponomarev, E.D.1    Shriver, L.P.2    Maresz, K.3    Dittel, B.N.4
  • 35
    • 78651247933 scopus 로고    scopus 로고
    • MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway
    • Ponomarev ED, Veremeyko T, Barteneva N, Krichevsky AM, Weiner HL. 2011. MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway. Nat Med 17:64-70.
    • (2011) Nat Med , vol.17 , pp. 64-70
    • Ponomarev, E.D.1    Veremeyko, T.2    Barteneva, N.3    Krichevsky, A.M.4    Weiner, H.L.5
  • 37
    • 81955164222 scopus 로고    scopus 로고
    • Characterisation of microglia during de- and remyelination: Can they create a repair promoting environment?
    • Voss EV, Škuljec J, Gudi V, Skripuletz T, Pul R, Trebst C, Stangel M. 2012. Characterisation of microglia during de- and remyelination: Can they create a repair promoting environment? Neurobiol Dis 45:519-528.
    • (2012) Neurobiol Dis , vol.45 , pp. 519-528
    • Voss, E.V.1    Škuljec, J.2    Gudi, V.3    Skripuletz, T.4    Pul, R.5    Trebst, C.6    Stangel, M.7
  • 38
    • 40349096095 scopus 로고    scopus 로고
    • A shift from adaptive to innate immunity: A potential mechanism of disease progression in multiple sclerosis
    • Weiner HL. 2008. A shift from adaptive to innate immunity: A potential mechanism of disease progression in multiple sclerosis. J Neurol 255 Suppl:3-11.
    • (2008) J Neurol , vol.255 , Issue.Suppl , pp. 3-11
    • Weiner, H.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.