Heparinase thromboelastography compared with activated coagulation time for protamine titration after cardiopulmonary bypass

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 28, Issue 2, 2014, Pages 224-229

  Levin, Andrew Ian ^a   Heine, Adriaan Martin ^b   Coetzee, Johan Francois ^a   Coetzee, André ^a  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

^b Private Practice   (South Africa)

Author keywords

activated coagulation time; cardiopulmonary bypass; heparin; heparinase; point of care test; postoperative bleeding; protamine; thromboelastography

Indexed keywords

HEPARIN; HEPARIN LYASE; KAOLIN; PROTAMINE; TRANEXAMIC ACID;

ADULT; AGED; ANALYZER; ANESTHESIST; ARTICLE; BLOOD CLOTTING TIME; BLOOD SAMPLING; BLOOD TRANSFUSION; CARDIOPULMONARY BYPASS; COMPARATIVE STUDY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE TITRATION; FEMALE; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; ON PUMP CORONARY ARTERY BYPASS; POINT OF CARE TESTING; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TEACHING HOSPITAL; THROMBOELASTOGRAPHY; TUBE; YOUNG ADULT; ANTICOAGULATION; CORONARY ARTERY BYPASS GRAFT; HEART VALVE SURGERY; HEPARINASE KAOLIN THROMBOELASTOGRAPHY; POSTOPERATIVE CARE; POSTOPERATIVE COMPLICATION; PROSPECTIVE STUDY; REACTION TIME; SINGLE BLIND PROCEDURE; THROMBOCYTE AGGREGATION; THROMBOELASTOGRAPH; TITRIMETRY;

ACTIVATED COAGULATION TIME; CARDIOPULMONARY BYPASS; HEPARIN; HEPARINASE; POINT-OF-CARE TEST; POSTOPERATIVE BLEEDING; PROTAMINE; THROMBOELASTOGRAPHY;

AGED; BLOOD TRANSFUSION; CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; ENDPOINT DETERMINATION; FEMALE; HEART VALVES; HEPARIN ANTAGONISTS; HEPARIN LYASE; HUMANS; INTENSIVE CARE; KAOLIN; LENGTH OF STAY; MALE; MIDDLE AGED; POINT-OF-CARE SYSTEMS; POSTOPERATIVE HEMORRHAGE; PROSPECTIVE STUDIES; PROTAMINES; THROMBELASTOGRAPHY; WHOLE BLOOD COAGULATION TIME;

EID: 84896403003     PISSN: 10530770     EISSN: 15328422     Source Type: Journal    
DOI: 10.1053/j.jvca.2013.10.026     Document Type: Article

References (28)

1. M. Mittermayr, J. Margreiter, and C. Velik-Salchner et al. Effects of protamine and heparin can be detected and easily differentiated by modified thrombelastography (Rotem): An in vitro study Br J Anaesth 95 2005 310 316
2. T. Mochizuki, P.J. Olson, and F. Szlam et al. Protamine reversal of heparin affects platelet aggregation and activated clotting time after cardiopulmonary bypass Anesth Analg 87 1998 781 785
3. R.M. Barstad, R.W. Stephens, and M.J. Hamers et al. Protamine sulphate inhibits platelet membrane glycoprotein Ib-von Willebrand factor activity Thromb Haemost 83 2000 334 337
4. B.S. Bull, R.A. Korpman, and W.M. Huse et al. Heparin therapy during extracorporeal circulation. I. Problems inherent in existing heparin protocols Heparin therapy during extracorporeal circulation J Thorac Cardiovasc Surg 69 1975 674 684
5. S. Dalbert, M.T. Ganter, and L. Furrer et al. Effects of heparin, haemodilution and aprotinin on kaolin-based activated clotting time: in vitro comparison of two different point of care devices Acta Anaesthesiol Scand 50 2006 461 468
6. G.P. Gravlee, C.L. Whitaker, and L.J. Mark et al. Baseline activated coagulation time should be measured after surgical incision Anesth Analg 71 1990 549 553
7. J.S. Wang, C.Y. Lin, and W.T. Hung et al. Monitoring of heparin-induced anticoagulation with kaolin-activated clotting time in cardiac surgical patients treated with aprotinin Anesthesiology 77 1992 1080 1084
8. I.J. Welsby, E. McDonnell, and H. El-Moalem et al. Activated clotting time systems vary in precision and bias and are not interchangeable when following heparin management protocols during cardiopulmonary bypass J Clin Monit Comput 17 2002 287 292
9. M.T. Ganter, A. Monn, and R. Tavakoli et al. Kaolin-based activated coagulation time measured by sonoclot in patients undergoing cardiopulmonary bypass J Cardiothorac Vasc Anesth 21 2007 524 528
10. P.D. Raymond, M.J. Ray, and S.N. Callen et al. Heparin monitoring during cardiac surgery. Part 2: Calculating the overestimation of heparin by the activated clotting time Perfusion 18 2003 277 281
11. S.A. Spinler, A.K. Wittkowsky, and E.A. Nutescu et al. Anticoagulation monitoring part 2: Unfractionated heparin and low-molecular-weight heparin Ann Pharmacother 39 2005 1275 1285
12. S.A. Kozek-Langenecker Perioperative coagulation monitoring Best Pract Res Clin Anaesthesiol 24 2010 27 40
13. M. Mittermayr, C. Velik-Salchner, and B. Stalzer et al. Detection of protamine and heparin after termination of cardiopulmonary bypass by thrombelastometry (ROTEM): Results of a pilot study Anesth Analg 108 2009 743 750
14. A. Galeone, C. Rotunno, and P. Guida et al. Monitoring incomplete heparin reversal and heparin rebound after cardiac surgery J Cardiothorac Vasc Anesth 27 2013 853 858
15. D.J. Murray, W.J. Brosnahan, and B. Pennell et al. Heparin detection by the activated coagulation time: A comparison of the sensitivity of coagulation tests and heparin assays J Cardiothorac Vasc Anesth 11 1997 24 28
16. L.K. Ti, K.F. Cheong, and F.G. Chen Prediction of excessive bleeding after coronary artery bypass graft surgery: The influence of timing and heparinase on thromboelastography J Cardiothorac Vasc Anesth 16 2002 545 550
17. J.J. Chavez, D.E. Foley, and C.C. Snider et al. A novel thrombelastograph tissue factor/kaolin assay of activated clotting times for monitoring heparin anticoagulation during cardiopulmonary bypass Anesth Analg 99 2004 1290 1294
18. B.D. Spiess, K.J. Tuman, and R.J. McCarthy et al. Thromboelastography as an indicator of post-cardiopulmonary bypass coagulopathies J Clin Monit 3 1987 25 30
19. G. Berlot, F. Tartamella, and R. Bussani et al. An uncommon cause of postoperative bleeding Blood Coagul Fibrinolysis 22 2011 231 233
20. M. Coakley, K. Reddy, and I. Mackie et al. Transfusion triggers in orthotopic liver transplantation: A comparison of the thromboelastometry analyzer, the thromboelastogram, and conventional coagulation tests J Cardiothorac Vasc Anesth 20 2006 548 553
21. Altman DG, Machin D, Bryant TN, et al. Statistics with Confidence. (ed 2). London, BMJ Books, 2000
22. P.J. Kesteven, A. Ahmed, and C. Aps et al. Protamine sulphate and heparin rebound following open-heart surgery J Cardiovasc Surg (Torino) 27 1986 600 603
23. Ganter MT, Dalbert S, Graves K, et al. Monitoring activated clotting time for combined heparin and aprotinin application: An in vitro evaluation of a new aprotinin-insensitive test using SONOCLOT. Anesth Analg 101:308-314, table of contents, 2005
24. L. Shore-Lesserson, H.E. Manspeizer, and M. DePerio et al. Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery Anesth Analg 88 1999 312 319
25. D. Bolliger, M.D. Seeberger, and K.A. Tanaka Principles and practice of thromboelastography in clinical coagulation management and transfusion practice Transfus Med Rev 26 2012 1 13
26. TEG 5000 Users Manual. Hemoscope Corporation, Niles, IL, USA. May 2004.
27. M.T. Ganter, and C.K. Hofer Coagulation monitoring: Current techniques and clinical use of viscoelastic point-of-care coagulation devices Anesth Analg 106 2008 1366 1375
28. M.R. Pitney, S.A. Kelly, and R.M. Allan et al. Activated clotting time differential is a superior method of monitoring anticoagulation following coronary angioplasty Catheterization and cardiovascular diagnosis 37 1996 145 150