Thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor haemostatic treatment versus usual care in adults or children with bleeding

Cochrane Database of Systematic Reviews

Volumn 2016, Issue 8, 2016, Pages

  Wikkelsø, Anne ^a   Wetterslev, Jørn ^b   Møller, Ann Merete ^c   Afshari, Arash ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

^c GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOSTATIC AGENT;

BLEEDING; BLOOD CLOTTING; BLOOD TRANSFUSION; HEMATOLOGICAL PROCEDURE; HUMAN; PATIENT MONITORING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK BENEFIT ANALYSIS; SEQUENTIAL ANALYSIS; SYSTEMATIC REVIEW; THROMBOELASTOGRAPHY; THROMBOELASTOMETRY; TREATMENT OUTCOME; ADULT; ADVERSE EFFECTS; BLOOD; BLOOD COAGULATION DISORDERS; CHILD; ERYTHROCYTE TRANSFUSION; HEART SURGERY; HEMORRHAGE; LIVER TRANSPLANTATION; META ANALYSIS; MORTALITY; OUTCOME ASSESSMENT; PLASMA; PROCEDURES;

ADULT; BLOOD COAGULATION DISORDERS; CARDIAC SURGICAL PROCEDURES; CHILD; ERYTHROCYTE TRANSFUSION; HEMORRHAGE; HUMANS; LIVER TRANSPLANTATION; OUTCOME ASSESSMENT (HEALTH CARE); PLASMA; RANDOMIZED CONTROLLED TRIALS AS TOPIC; THROMBELASTOGRAPHY;

EID: 84983347895     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD007871.pub3     Document Type: Review

References (119)

1. Ak K, Isbir CS, Tetik S, Atalan N, Tekeli A, Aljodi M, et al. Thromboelastography-based transfusion algorithm reduces blood product use after elective CABG: a prospective randomized study. Journal of Cardiac Surgery 2009;24(4):404-10. [PUBMED: 19583608]
2. Avidan MS, Alcock EL, Da Fonseca J, Ponte J, Desai JB, Despotis GJ, et al. Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery. British Journal of Anaesthesia 2004;92(2):178-86. [PUBMED: 14722166 ]
3. Cui Y, Hei F, Long C, Feng Z, Zhao J, Yan F, et al. Perioperative monitoring of thromboelastograph on blood protection and recovery for severely cyanotic patients undergoing complex cardiac surgery. Artificial Organs 2010;34(11):955-60. [PUBMED: 21092037]
4. Girdauskas E, Kempfert J, Kuntze T, Borger MA, Enders J, Fassl J, et al. Thromboelastometrically guided transfusion protocol during aortic surgery with circulatory arrest: a prospective, randomized trial. Journal of Thoracic and Cardiovascular Surgery 2010;140(5):1117-24. [PUBMED: 20951260]
5. Kempfert J. Thromboelastography-guided blood component therapy after cardiac surgery: A randomised study. Interactive Cardiovascular and Thoracic Surgery 2011;13:S106-7.
6. Kultufan Turan S, Aydinli B, Ayik H, Yaar S, Kazanci D, Karadenz Ü, et al. The role of rotational thromboelastgraphy on decision of blood transfusion in open heart surgery [Açik Kalp Cerrahisinde TromboelastografininTransfüzyon Karari Üzerine Etkisi]. Göğüs-Kalp-Damar Anestezi ve Yoğun Bakim Derneği Dergisi 2006;12(4):154-9.
7. Nakayama Y, Nakajima Y, Tanaka KA, Sessler DI, Maeda S, Iida J, et al. Thromboelastometry-guided intraoperative haemostatic management reduces bleeding and red cell transfusion after paediatric cardiac surgery. British Journal of Anaesthesia 2015;114(1):91-102. [PUBMED: 25303988]
8. NCT00772239 Perioperative coagulation management in cardiac surgery. (ROTEM). clinicaltrials.gov/ct2/show/NCT00772239 (first received 13 October 2008).
9. Nuttall GA, Oliver WC, Santrach PJ, Bryant S, Dearani JA, Schaff HV, et al. Efficacy of a simple intraoperative transfusion algorithm for nonerythrocyte component utilization after cardiopulmonary bypass. Anesthesiology 2001;94(5):773-81. [PUBMED: 11388527]
10. Paniagua P, Koller T, Requena T, Gil JM, Campos JM, Galan J. Randomized controlled trial to evaluate postoperative coagulation management with bed-side trombelastometry (Rotem) compared with a transfusion protocol based on laboratory measurements in bleeding patients after cardiac surgery: Preliminary data. European Journal of Anaesthesiology 2011;28:94.
11. Rauter M, Kästenbauer T, Schwarz S, Fitzgerald R. Reduced number of red blood cell transfusions in cardiac surgery due to perioperative coagulation testing by thromboelastometry. Acta Anaesthesiologica Scandinavica. 2007; Vol. 51 (Suppl 118):40.
12. Royston D, von Kier S. Reduced haemostatic factor transfusion using heparinase-modified thrombelastography during cardiopulmonary bypass. British Journal of Anaesthesia 2001;86(4):575-8. [PUBMED: 11573637]
13. Schaden E, Kimberger O, Kraincuk P, Baron DM, Metnitz PG, Kozek-Langenecker S. Perioperative treatment algorithm for bleeding burn patients reduces allogeneic blood product requirements. British Journal of Anaesthesia 2012;109(3):376-81. [PUBMED: 22719014]
14. Shore-Lesserson L, Manspeizer HE, DePerio M, Francis S, Vela-Cantos F, Ergin MA. Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery. Anesthesia and Analgesia 1999;88(2):312-9. [PUBMED: 9972747]
15. Wang SC, Shieh JF, Chang KY, Chu YC, Liu CS, Loong CC. Thromboelastography-guided transfusion decreases intraoperative blood transfusion during orthotopic liver transplantation: randomized clinical trial. Transplant Proceedings 2010;42(7):2590-3. [PUBMED: 20832550]
16. Weber CF, Goerlinger K, Meininger D, Herrmann E, Bingold T, Moritz A, et al. Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology 2012;117(3):531-47. [ClinicalTrials.gov: NCT00997841; PUBMED: 22914710]
17. Westbrook AJ, Olsen J, Bailey M, Bates J, Scully M, Salamonsen RF. Protocol based on thromboelastograph (TEG) out-performs physician preference using laboratory coagulation tests to guide blood replacement during and after cardiac surgery: a pilot study. Heart Lung and Circulation 2009;18(4):277-88. [PUBMED: 19117801]
18. Anderson L, Quasim I, Soutar R, Steven M, Macfie A, Korte W. An audit of red cell and blood product use after the institution of thrombelastometry in cardiac intensive care unit. Transfusion Medicine 2006;16:31-9. [PUBMED: 16480437 ]
19. Anderson L, Quasim I, Steven M, Soutar R, Macfie A. An audit of red cell and blood products use after institution of thrombelastography in cardiac intensive care unit. British Journal of Haematology 2003;121(Suppl 1):80.
20. Andreasen JB, Hvas AM, Christiansen K, Ravn HB. Can RoTEM analysis be applied for haemostatic monitoring in paediatric congenital heart surgery?. Cardiology in the Young 2011;21(06):684-91. [PUBMED: 21729518]
21. Aoki K, Sugimoto A, Nagasawa A, Saito M, Ohzeki H. Optimization of thromboelastography-guided platelet transfusion in cardiovascular surgery. General Thoracic and Cardiovascular Surgery 2012;60(7):411-6. [PUBMED: 22566265]
22. Blasi A, Beltran J, Pereira A, Martinez-Palli G, Torrents A, Balust J, et al. An assessment of thromboelastometry to monitor blood coagulation and guide transfusion support in liver transplantation. Transfusion 2012;52(9):1989-98. [PUBMED: 22304465]
23. Coakley M, Reddy K, Mackie I, Mallett S. Transfusion triggers in orthotopic liver transplantation: a comparison of the thromboelastometry analyzer, the thromboelastogram, and conventional coagulation tests. Journal of Cardiothoracic and Vascular Anesthesia 2006;20(4):548-53. [PUBMED: 16884987]
24. Cui Y, Hei F, Long C, Feng Z, Zhao J, Yan F, et al. Perioperative monitoring of thromboelastograph on hemostasis and therapy for cyanotic infants undergoing complex cardiac surgery. Artificial Organs 2009;33(11):909-14. [PUBMED: 20021469]
25. Bianchini M, De Pietri L, Di Maira T, De Maria N, Begliomini B, Gerunda GE, et al. Thrombelastography decreases hemoderivates requirement before invasive procedures in cirrhotic patients with coagulation disorders. A randomized controlled trial. Hepatology. John Wiley and Sons Inc., 2013, issue 4 Suppl 1:292A-3A.
26. De Pietri L, Bianchini M, Montalti R, De Maria N, Di Maira T, Begliomini B, et al. Thrombelastography (TEG) decreases blood products requirement before invasive procedures in cirrhotic patients with coagulation tests derangement. A randomized controlled trial. Digestive and Liver Disease. 2014; Vol. 46:e5-6.
27. De Pietri L, Bianchini M, Montalti R, Di Maira T, De Maria N, Begliomini B, et al. 194 Thrombelastography before invasive procedures reduces hemoderivates requirements in cirrhotic patients with coagulation disorders. a randomized controlled trial. Journal of Hepatology 2013;58:S85-6.
28. Dirkmann D, Gorlinger K, Dusse F, Kottenberg E, Peters J. Early thromboelastometric variables reliably predict maximum clot firmness in patients undergoing cardiac surgery: A step towards earlier decision making. Acta Anaesthesiologica Scandinavica 2013;5:594-603. [PUBMED: 23240733]
29. Doran CM, Woolley T, Midwinter MJ. Feasibility of using rotational thromboelastometry to assess coagulation status of combat casualties in a deployed setting. Journal of Trauma 2010;69:S40-8. [PUBMED: 20622618 ]
30. Dua K, Singh J, Chatterji C, Makroo R, Das BS. Blood component therapy in postoperative OBCAB (off pump coronary artery bypass surgery) patients: Our experiences with thromboelastography (TEG). Vox Sanguinis 2005;89 Suppl 2:5P-144.
31. El Kady N, Khedr H, Yosry M, El Mekawi S. Perioperative assessment of coagulation in paediatric neurosurgical patients using thromboelastography. European Journal of Anaesthesiology 2009;26(4):293-7. [PUBMED: 19401660]
32. Faraoni D, Savan V, Levy JH, Theusinger OM. Goal-directed coagulation management in the perioperative period of cardiac surgery. Journal of Cardiothoracic and Vascular Anesthesia 2013;27(6):1347-54. [PUBMED: 24103717]
33. Gorlinger K, Dirkmann D, Hanke AA, Kamler M, Kottenberg E, Thielmann M, et al. First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing Is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study. Anesthesiology 2011;115(6):1179-91. [PUBMED: 21970887]
34. Gorlinger K, Dirkmann D, Rahe-Meyer N, Weber CF, Hanke AA. Algorithms for transfusion and coagulation management in massive haemorrhage. Anasthesiologie und Intensivmedizin 2011;52(2):145-59.
35. Gronchi F, Perret A, Ferrari E, Marcucci CM, Fleche J, Crosset M, et al. Validation of rotational thromboelastometry during cardiopulmonary bypass: A prospective, observational in-vivo study. European Journal of Anaesthesiology 2014;31(2):68-75.
36. Haas T, Spielmann N, Restin T, Seifert B, Henze G, Obwegeser J, et al. Higher fibrinogen concentrations for reduction of transfusion requirements during major paediatric surgery: A prospective randomised controlled trial. British Journal of Anaesthesia 2015;115(2):234-43. [PUBMED: 25982134]
37. Hanke AA, Herold U, Dirkmann D, Tsagakis K, Jakob H, Gorlinger K. Thromboelastometry based early goal-directed coagulation management reduces blood transfusion requirements, adverse events, and costs in acute Type A aortic dissection: A pilot study. Transfusion Medicine and Hemotherapy 2012;39(2):121-8. [PUBMED: 22670130]
38. Hanke AA, Herold U, Dirkmann D, Tsagakis K, Jakob H, Gorlinger K. Thromboelastometry based early goal-directed coagulation management reduces blood transfusion requirements, adverse events, and costs in acute type A aortic dissection: A pilot study. Transfusion Medicine and Hemotherapy 2012;39(2):121-8. [PUBMED: 22670130]
39. Hill JS, Devenie G, Powell M. Point-of-care testing of coagulation and fibrinolytic status during postpartum haemorrhage: developing a thrombelastography-guided transfusion algorithm. Anaesthesia and Intensive Care 2012;40(6):1007-15. [PUBMED: 23194210]
40. Howland WS, Schweizer O, Gould P. A comparison of intraoperative measurements of coagulation. Anesthesia and Analgesia 1974;53(5):657-63. [PUBMED: 4606102]
41. Hvas A-M, Boas TW, Jensen M, Lindskov C, Folkersen L, Ravn HB. Change in hemostatic intervention after implementation of thromboelastometry. Journal of Cardiothoracic and Vascular Anesthesia 2012, issue 2:227-31. [PUBMED: 21924638]
42. Jambor C, Spannagl M, Zwissler B. Perioperative management of patients with coronary stents in non-cardiac surgery. Anaesthesist 2009;58(10):971-85. [PUBMED: 19823781]
43. Johansson PIM. The blood bank: From provider to partner in treatment of massively bleeding patients. Transfusion 2007;47 Suppl(2):176-81. [PUBMED: 17651347]
44. Johansson PI, Stensballe J. Effect of Haemostatic Control Resuscitation on mortality in massively bleeding patients: A before and after study. Vox Sanguinis 2009;96(2):111-8. [PUBMED: 19152603]
45. Kunio NR, Differding JA, Watson KM, Stucke RS, Schreiber MA. Thrombelastography-identified coagulopathy Is associated with increased morbidity and mortality after traumatic brain injury. American Journal of Surgery 2012;203(5):584-8. [PUBMED: 22425448]
46. Mendeloff EN, Glenn GF, Tavakolian P, Lin E, Leonard A, Prince SL, et al. The role of thromboelastography in directing blood product usage in infant open heart surgery. Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 2009;4(5):282-90. [DOI: 10.1097/IMI.0b013e3181bbd4ff]
47. Naik BI, Pajewski TN, Bogdonoff DI, Zuo Z, Clark P, Terkawi Abdullah S, et al. Rotational thromboelastometry-guided blood product management in major spine surgery. Journal of Neurosurgery. Spine 2015;23(2):239-49. [PUBMED: 26053893]
48. NCT01218074 Platelets antiaggregation control enhancement (PACE) study. clinicaltrials.gov/ct2/show/NCT01218074 (first received 5 October 2010).
49. Ogawa S, Szlam F, Chen EP, Nishimura T, Kim H, Roback JD, et al. A comparative evaluation of rotation thromboelastometry and standard coagulation tests in hemodilution-induced coagulation changes after cardiac surgery. Transfusion 2012;52(1):14-22. [PUBMED: 21756263]
50. Ploppa A, Unertl KE, Nohe B. Thrombelastometry-guided thrombolytic therapy in massive pulmonary artery embolism. Acta Anaesthesiologica Scandinavica 2010;54(9):1145-8. [PUBMED: 20670312]
51. Rafiq S, Johansson PI, Zacho M, Stissing T, Kofoed K, Lilleor NB, et al. Thrombelastographic haemostatic status and antiplatelet therapy after coronary artery bypass surgery (TEG-CABG trial): assessing and monitoring the antithrombotic effect of clopidogrel and aspirin versus aspirin alone in hypercoagulable patients. Trials. BioMed Central Ltd. (Floor 6, 236 Gray's Inn Road, London WC1X 8HB, United Kingdom), 2012; Vol. 13:48. [Clinical trials NCT01046942.; PUBMED: 22540524]
52. Rahe-Meyer N, Pichlmaier M, Haverich A, Solomon C, Winterhalter M, Piepenbrock S, et al. Bleeding management with fibrinogen concentrate targeting a high-normal plasma fibrinogen level: a pilot study. British Journal of Anaesthesia 2009;102(6):785-92. [PUBMED: 19698858]
53. Rahe-Meyer N, Solomon C, Winterhalter M, Piepenbrock S, Tanaka K, Haverich A, et al. Thromboelastometry-guided administration of fibrinogen concentrate for the treatment of excessive intraoperative bleeding in thoracoabdominal aortic aneurysm surgery. Journal of Thoracic and Cardiovascular Surgery 2009;138(3):694-702. [PUBMED: 19698858]
54. Roullet S, Freyburger G, Cruc M, Quinart A, Stecken L, Audy M, et al. Management of bleeding and transfusion during liver transplantation before and after the introduction of a ROTEM-based algorithm. Liver Transplantation 2014;21(2):169-79. [PUBMED: 25331016]
55. Schochl H, Nienaber U, Hofer G, Voelckel W, Jambor C, Scharbert G, et al. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Critical Care 2010;14(2):R55. [PUBMED: 20374650]
56. Scochl H, Nienaber U, Maegele M, Hochleitner G, Primavesi F, Steitz B, et al. Transfusion in trauma: thromboelastometry-guided coagulation factor concentrate-based therapy versus standard fresh frozen plasma-based therapy. Critical Care 2011;15(2):R83. [PUBMED: 21375741]
57. Schochl H, Schlimp CJ, Voelckel W. Perioperative coagulation management in multiple trauma patients based on viscoelastic test results. Unfallchirurg 2014;117(2):111-7. [PUBMED: 24482057]
58. Smart L, Scharpf DT, Gray NO, Traetow D, Black S, Michaels A, et al. Rotational thromboelastometry (ROTEM) versus conventional coagulation tests during orthotopic liver transplantation: Comparison of intra-operative blood loss, transfusion requirements, and cost. Hepatology. 2015; Vol. 62 Suppl 1:832A.
59. Solomon C, Schoechl H, Hagl C, Rahe-Meyer N. Fibrinogen concentrate as first-line haemostatic therapy during aortic replacement surgery. A randomised trial. Journal of Thrombosis and Haemostasis 2012, issue 6:e7.
60. Spalding GJ, Hartrumpf M, Sierig T, Oesberg N, Kirschke CG, Albes JM. Cost reduction of perioperative coagulation management in cardiac surgery: value of 'bedside' thrombelastography (ROTEM). European Journal of Cardio-thoracic Surgery 2007;31(6):1052-7. [PUBMED: 17516038]
61. Spiess BD, Gillies BS, Chandler W, Verrier E. Changes in transfusion therapy and reexploration rate after institution of a blood management program in cardiac surgical patients. Journal of Cardiothoracic and Vascular Anesthesia 1995;9(2):168-73. [PUBMED: 7780073 ]
62. Tapia NM, Chang A, Norman M, Welsh F, Scott B, Wall MJ Jr, et al. TEG-guided resuscitation is superior to standardized MTP resuscitation in massively transfused penetrating trauma patients. Journal of Trauma and Acute Care Surgery 2013;74(2):378-86.
63. Urwyler N, Theiler L, Hirschberg M, Kleine-Brueggeney M, Colucci G, Greif R. Standard vs. point-of-care measurement of fibrinogen: Potential impact on clinical decisions. Minerva Anestesiologica 2012; Vol. 78, issue 5:550-5.
64. Vaidya A, Muthusamy AS, Hadjianastassiou VG, Roy D, Elker DE, Moustafellos P, et al. Simultaneous pancreas-kidney transplantation: To anticoagulate or not? Is that a question?. Clinical Transplantation 2007;21(4):554-7. [PUBMED: 17645719]
65. Wang SC, Lin HT, Chang KY, Mandell MS, Ting CK, Chu YC, et al. Use of higher thromboelastogram transfusion values is not associated with greater blood loss in liver transplant surgery. Liver Transplantation 2012;18(10):1254-8. [PUBMED: 22730210]
66. NCT01402739 Algorithm-guided transfusions in cardiac surgery patients for reduction of drainage blood losses (HEART-PoC). clinicaltrials.gov/ct2/show/NCT01402739 (first received 25 July 2011).
67. NCT01536496 Comparison of rapid thrombelastography and conventional coagulation testing for haemostatic resuscitation in trauma. clinicaltrials.gov/ct2/show/NCT01536496 (first received 19 July 2011).
68. NCT02352181 Management of coagulopathy during orthotopic liver transplantation. comparison between ROTEM-based management and standard biological assessment. clinicaltrials.gov/ct2/show/NCT02352181 (first received 18 December 2014).
69. NCT02416817 Strategy of transfusion in trauma patients - STATA trial (STATA). clinicaltrials.gov/ct2/show/NCT02416817 (first received 28 August 2014).
70. NCT02461251 Thromboelastometry-guided treatment protocol versus standard care of major haemorrhage in obstetric patients (ROTEM-PPH). clinicaltrials.gov/ct2/show/NCT02461251 (first received 29 May 2015).
71. NCT02593877 Implementing treatment algorithms for the correction of trauma induced coagulopathy (iTACTIC). clinicaltrials.gov/ct2/show/NCT02593877 (first received 15 October 2015).
72. Thomas D, Wee M, Clyburn P, Walker I, Brohi K, Collins P, et al. AAGBI (Association of Anaesthetists of Great Britain and Ireland). Blood transfusion and the anaesthetist: management of massive haemorrhage. Anaesthesia 2010;65(11):1153-61. [PUBMED: 20963925]
73. Altman DG, Bland JM. Interaction revisited: the difference between two estimates. BMJ 2003;326(7382):219. [PUBMED: 12543843]
74. Benes J, Zatloukal J, Kletecka J. Viscoelastic methods of blood clotting assessment - a multidisciplinary review. Frontiers in Medicine 2015;2:62. [PUBMED: 26442265]
75. Besser MW, Klein AA. The coagulopathy of cardiopulmonary bypass. Critical Reviews in Clinical Laboratory Sciences 2010;47(5-6):197-212. [PUBMED: 21391830]
76. Bolliger D, Tanaka KA. Roles of thrombelastography and thromboelastometry for patient blood management in cardiac surgery. Transfusion Medicine Reviews 2013;27(4):213-20. [PUBMED: 24075802]
77. Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, et al. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. The Journal of Trauma 2008;64(5):1211-7. [PUBMED: 18469643]
78. Brok J, Thorlund K, Wetterslev J, Gluud C. Apparently conclusive meta-analyses may be inconclusive-Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses. Journal of Clinical Epidemiology 2009;38(1):287-98. [PUBMED: 18824466]
79. Chan AW, Hróbjartsson A, Haahr MT, Gøtzsche PC, Altman DG. Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles. JAMA 2004;291(20):2457-65. [PUBMED: 15161896]
80. Chee YL, Greaves M. Role of coagulation testing in predicting bleeding risk. The Hematology Journal 2003;4(6):373-8. [PUBMED: 14671609]
81. Corredor C, Wasowicz M, Karkouti K, Sharma V. The role of point-of-care platelet function testing in predicting postoperative bleeding following cardiac surgery: a systematic review and meta-analysis. Anaesthesia 2015;70(6):715-31. [PUBMED: 25916344]
82. Craig J, Aguiar-Ibanez R, Bhattacharya S, Downie S, Duffy S, Kohli H, et al. The clinical and cost effectiveness of thromboelastography/thromboelastometry. Health Technology Assessment, Report 11. www.nhshealthquality.org (accessed January 2016).
83. De Robertis E, Kozek-Langenecker SA, Tufano R, Romano GM, Piazza O, Zito Marinosci G. Coagulopathy induced by acidosis, hypothermia and hypocalcaemia in severe bleeding. Minerva Anestesiologica 2015;81(1):65-75. [PUBMED: 24608516]
84. Dickersin K. The existence of publication bias and risk factors for its occurrence. JAMA 1990;263(10):1359-85. [PUBMED: 2406472]
85. Gluud C, Gluud LL. Evidence based diagnostics. BMJ 2005;330(7493):724-6. [PUBMED: 15790646]
86. Gotzsche PC. Why we need a broad perspective on meta-analysis. It may be crucially important for patients. BMJ 2000;321(7261):585-6. [PUBMED: 10977820]
87. Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ (Clinical research ed.) 2008;336(7650):924-6. [PUBMED: 18436948]
88. Hardy JF, De Moerloose P, Samama M, Groupe d'intérêt en Hémostase Périopératoire. Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Canadian Journal of Anaesthesia 2004;51(4):293-310. [PUBMED: 15064258]
89. Hardy JF, de Moerloose P, Samama CM. The coagulopathy of massive transfusion. Vox Sanguinis 2005;89(3):123-7. [PUBMED: 16146503]
90. Hartert Blutgerinnungsstudien mit der Thrombelastographie, einem neuen Untersuchungsverfahren. Klinische Wochenschrift 1948;26(37-38):577-83. [PUBMED: 18101974]
91. Hartmann M, Sucker C, Boehm O, Koch A, Loer S, Zacharowski K. Effects of cardiac surgery on hemostasis. Transfusion Medicine Reviews 2006;20(3):230-41. [PUBMED: 16787830]
92. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327(7414):557-60. [PUBMED: 12958120]
93. Higgins JP, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.handbook.cochrane.org.
94. Hiippala ST, Myllyla GJ, Vahtera EM. Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesthesia and Analgesia 1995;81(2):360-5. [PUBMED: 7542432]
95. Hunt H, Stanworth S, Curry N, Woolley T, Cooper C, Ukoumunne O, et al. Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma-induced coagulopathy in adult trauma patients with bleeding. Cochrane Database of Systematic Reviews 2015, Issue 2. [DOI: 10.1002/14651858.CD010438.pub2; PUBMED: 25686465]
96. Hutton JL, Williamson PR. Bias in meta-analysis due to outcome variable selection within studies. Journal of the Royal Statistical Society Series C 2000;49:359-70. [PUBMED: 16248351]
97. Johansson PI, Stensballe J, Ostrowski SR. Current management of massive hemorrhage in trauma. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2012;20(1):47. [PUBMED: 22776724]
98. Johansson PI, Stensballe J, Oliveri R, Wade CE, Ostrowski SR, Holcomb JB. How I treat patients with massive hemorrhage. Blood 2014;124(20):3052-8. [PUBMED: 25293771]
99. Kozek-Langenecker S. Management of massive operative blood loss. Minerva Anestesiologica 2007;73(7-8):401-15. [PUBMED: 17380100]
100. Lan KKG, DeMets DL. Discrete sequential boundaries for clinical trials. Biometrika 1983;70:659-63.
101. Lang T, Bauters A, Braun SL, Pötzsch B, von Pape KW, Kolde HJ, et al. Multi-centre investigation on reference ranges for ROTEM thromboelastometry. Blood Coagulation & Fibrinolysis 2005;16(4):301-10. [PUBMED: 15870552]
102. Levrat A, Gros A, Rugeri L, Inaba K, Floccard B, Negrier C, et al. Evaluation of rotation thrombelastography for the diagnosis of hyperfibrinolysis in trauma patients. British Journal of Anaesthesia 2008;100(6):792-7. [PUBMED: 18440953]
103. Luddington RJ. Thrombelastography/thromboelastometry. Clinical and Laboratory Haematology 2005;27(2):81-90. [PUBMED: 15784122]
104. Paparella D, Brister SJ, Buchanan MR. Coagulation disorders of cardiopulmonary bypass: a review. Intensive Care Medicine 2004;30(10):1873-81. [PUBMED: 15278267]
105. Pogue JM, Yusuf S. Cumulating evidence from randomized trials: Utilizing sequential monitoring boundaries for cumulative meta-analysis. Controlled Clinical Trials 1997;18(6):580-93. [PUBMED: 9408720]
106. Pogue J, Yusuf S. Overcoming the limitations of current meta-analysis of randomized controlled trials. Lancet 1998;351(9095):45-52. [PUBMED: 9433436]
107. Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
108. Roth D, Heidinger B, Havel C, Herkner H. Different mortality time points in critical care trials: current practice and influence on effect estimates in meta-analyses. Critical Care Medicine 2016;44(8):e737-41. [PUBMED: 26963325]
109. Rugeri L, Levrat A, David JS, Delecroix E, Floccard B, Gros A, et al. Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography. Journal of Thrombosis and Haemostasis 2007;5(2):289-95. [PUBMED: 17109736]
110. Sabate A, Dalmau A, Koo M, Aparicio I, Costa M, Contreras L. Coagulopathy management in liver transplantation. Transplantation Proceedings 2012;44(6):1523-5. [PUBMED: 22841202]
111. Segal JB, Dzik WH. Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: an evidence-based review. Transfusion 2005;45(9):1413-25. [PUBMED: 16131373]
112. Sutton AJ, Cooper NJ, Lambert PC, Jones DR, Abrams KR, Sweeting MJ. Meta-analysis of rare and adverse event data. Expert Review of Pharmacoeconomics and Outcomes Research 2002;2(4):367-79. [PUBMED: 19807443]
113. Thorlund K, Devereaux PJ, Wetterslev J, Guyatt G, Ioannidis JP, Thabane L, et al. Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?. International Journal of Clinical Epidemiology 2009;38(1):276-86. [PUBMED: 18824467]
114. Wetterslev J, Thorlund K, Brok J, Gluud C. Trial Sequential Analysis. Version 0.8. Copenhagen: Copenhagn Trial Unit, 2010.
115. Wetterslev J, Thorlund K, Brok J, Gluud C. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. International Journal of Clinical Epidemiology 2008;61(1):64-75. [PUBMED: 18083463]
116. Wetterslev J, Thorlund K, Brok J, Gluud C. Estimating required information size by quantifying diversity in random-effects model meta-analyses. Bio Medical Central: Medical Research Methodology 2009;30(9):86. [PUBMED: 20042080]
117. Whiting P, Al M, Westwood M, Ramos IC, Ryder S, Armstrong N, et al. Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis. Health Technology Assessment 2015;19(58):1-228. [PUBMED: 26215747]
118. Afshari A, Wikkelsø A, Brok J, Møller AM, Wetterslev J. Thrombelastography (TEG) or Thrombelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion. Cochrane Database of Systematic Reviews 2009, Issue 3. [DOI: 10.1002/14651858.CD007871]
119. Afshari A, Wikkelsø A, Brok J, Møller AM, Wetterslev J. Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion. Cochrane Database of Systematic Reviews 2011, Issue 3. [DOI: 10.1002/14651858.CD007871.pub2]