Essential but not vulnerable: Indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

ACS Infectious Diseases

Volumn 3, Issue 1, 2017, Pages 18-33

  Park, Yumi ^a   Pacitto, Angela ^b   Bayliss, Tracy ^c   Cleghorn, Laura A T ^c   Wang, Zhe ^d   Hartman, Travis ^d   Arora, Kriti ^a   Ioerger, Thomas R ^e   Sacchettini, Jim ^f   Rizzi, Menico ^g   Donini, Stefano ^g   Blundell, Tom L ^b   Ascher, David B ^b   Rhee, Kyu ^d   Breda, Ardala ^f   Zhou, Nian ^f   Dartois, Veronique ^h   Jonnala, Surendranadha Reddy ^a   Via, Laura E ^a,i   Mizrahi, Valerie ⁱ   Epemolu, Ola ^c   Stojanovski, Laste ^c   Simeons, Fred ^c   Osuna Cabello, Maria ^c   Ellis, Lucy ^c   MacKenzie, Claire J ^c   Smith, Alasdair R C ^c   Davis, Susan H ^c   Murugesan, Dinakaran ^c   Buchanan, Kirsteen I ^c   Turner, Penelope A ^c   Huggett, Margaret ^c   Zuccotto, Fabio ^c   Rebollo Lopez, Maria Jose ^j   Lafuente Monasterio, Maria Jose ^j   Sanz, Olalla ^j   Diaz, Gracia Santos ^j   Lelièvre, Joël ^j   Ballell, Lluis ^j   Selenski, Carolyn ^k   Axtman, Matthew ^k   Ghidelli Disse, Sonja ^l   Pflaumer, Hannah ^l   Bösche, Markus ^l   Drewes, Gerard ^l   Freiberg, Gail M ^m   Kurnick, Matthew D ^m   Srikumaran, Myron ^m   Kempf, Dale J ^m   Green, Simon R ^c   Ray, Peter C ^c   Read, Kevin ^c   Wyatt, Paul ^c   Barry, Clifton E ^a,i   Boshoff, Helena I ^a   more..

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d WEILL CORNELL MEDICAL COLLEGE   (United States)

^e Texas AandM University   (United States)

^f TEXAS A AND M UNIVERSITY   (United States)

^g UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^h PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

ⁱ UNIVERSITY OF CAPE TOWN   (South Africa)

^j GLAXOSMITHKLINE   (Spain)

^k GLAXOSMITHKLINE   (United States)

^l GLAXOSMITHKLINE   (Germany)

^m ABBVIE INC   (United States)

more..

Author keywords

Guanine; IMPDH; Indazole sulfonamide; Mycobacterium tuberculosis; Purine salvage; Target validation

Indexed keywords

BACTERIAL DNA; CLAVULANIC ACID; GENOMIC DNA; GREEN FLUORESCENT PROTEIN; GUANINE; INDAZOLE DERIVATIVE; INOSINATE DEHYDROGENASE INHIBITOR; ISONIAZID; MEROPENEM; METRONIDAZOLE; SULFONAMIDE; TUBERCULOSTATIC AGENT; TUNICAMYCIN; INOSINATE DEHYDROGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; AREA UNDER THE CURVE; ARTICLE; BACTERIAL CELL WALL; BACTERIAL GENOME; BACTERIAL GROWTH; BACTERIAL MUTATION; BACTERIUM ISOLATION; BIOGENESIS; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME INHIBITION; EXPERIMENTAL TUBERCULOSIS; FEMALE; GENE AMPLIFICATION; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; LUNG LAVAGE; LUNG RESECTION; MAXIMUM PLASMA CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NEW ZEALAND WHITE (RABBIT); NONHUMAN; PHARMACOKINETIC PARAMETERS; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; TISSUES; WHOLE GENOME SEQUENCING; X RAY CRYSTALLOGRAPHY; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; HUMAN; LEPORIDAE; MUTATION; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; DRUG DESIGN; DRUG DISCOVERY; DRUG RESISTANCE, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; IMP DEHYDROGENASE; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TUBERCULOSIS;

EID: 85018480535     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.6b00103     Document Type: Article

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