-
2
-
-
0032508046
-
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
-
Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG. 1998. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393:537-544.
-
(1998)
Nature
, vol.393
, pp. 537-544
-
-
Cole, S.T.1
Brosch, R.2
Parkhill, J.3
Garnier, T.4
Churcher, C.5
Harris, D.6
Gordon, S.V.7
Eiglmeier, K.8
Gas, S.9
Barry, C.E.10
Tekaia, F.11
Badcock, K.12
Basham, D.13
Brown, D.14
Chillingworth, T.15
Connor, R.16
Davies, R.17
Devlin, K.18
Feltwell, T.19
Gentles, S.20
Hamlin, N.21
Holroyd, S.22
Hornsby, T.23
Jagels, K.24
Krogh, A.25
McLean, J.26
Moule, S.27
Murphy, L.28
Oliver, K.29
Osborne, J.30
Quail, M.A.31
Rajandream, M.A.32
Rogers, J.33
Rutter, S.34
Seeger, K.35
Skelton, J.36
Squares, R.37
Squares, S.38
Sulston, J.E.39
Taylor, K.40
Whitehead, S.41
Barrell, B.G.42
more..
-
3
-
-
0001903401
-
DNA replication
-
Hatfull G, Jacobs WR Jr (ed), ASM Press, Washington, DC
-
Mizrahi V, Dawes SS, Rubin H. 2000. DNA replication, p 159-172. In Hatfull G, Jacobs WR Jr (ed), Molecular Genetics of Mycobacteria. ASM Press, Washington, DC.
-
(2000)
Molecular Genetics of Mycobacteria
, pp. 159-172
-
-
Mizrahi, V.1
Dawes, S.S.2
Rubin, H.3
-
4
-
-
81755189021
-
Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide
-
Le Nours J, Bulloch EM, Zhang Z, Greenwood DR, Middleditch MJ, Dickson JM, Baker EN. 2011. Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide. J Biol Chem 286:40706-40716.
-
(2011)
J Biol Chem
, vol.286
, pp. 40706-40716
-
-
Le Nours, J.1
Bulloch, E.M.2
Zhang, Z.3
Greenwood, D.R.4
Middleditch, M.J.5
Dickson, J.M.6
Baker, E.N.7
-
5
-
-
84862697944
-
Wild-type phosphoribosylpyrophosphate synthase (PRS) from Mycobacterium tuberculosis: a bacterial class II PRS?
-
Breda A, Martinelli LK, Bizarro CV, Rosado LA, Borges CB, Santos DS, Basso LA. 2012. Wild-type phosphoribosylpyrophosphate synthase (PRS) from Mycobacterium tuberculosis: a bacterial class II PRS? PLoS One 7:e39245.
-
(2012)
PLoS One
, vol.7
-
-
Breda, A.1
Martinelli, L.K.2
Bizarro, C.V.3
Rosado, L.A.4
Borges, C.B.5
Santos, D.S.6
Basso, L.A.7
-
6
-
-
79952543554
-
Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase
-
Alderwick LJ, Lloyd GS, Lloyd AJ, Lovering AL, Eggeling L, Besra GS. 2011. Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase. Glycobiology 21: 410-425.
-
(2011)
Glycobiology
, vol.21
, pp. 410-425
-
-
Alderwick, L.J.1
Lloyd, G.S.2
Lloyd, A.J.3
Lovering, A.L.4
Eggeling, L.5
Besra, G.S.6
-
7
-
-
0023967996
-
Mutation in the phosphoribosylpyrophosphate synthetase gene (prs) that results in simultaneous requirements for purine and pyrimidine nucleosides, nicotinamide nucleotide, histidine, and tryptophan in Escherichia coli
-
Hove-Jensen B. 1988. Mutation in the phosphoribosylpyrophosphate synthetase gene (prs) that results in simultaneous requirements for purine and pyrimidine nucleosides, nicotinamide nucleotide, histidine, and tryptophan in Escherichia coli. J Bacteriol 170:1148-1152.
-
(1988)
J Bacteriol
, vol.170
, pp. 1148-1152
-
-
Hove-Jensen, B.1
-
8
-
-
0037407702
-
Escherichia coli phnN, encoding ribose 1, 5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways
-
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL. 2003. Escherichia coli phnN, encoding ribose 1, 5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways. J Bacteriol 185:2793-2801.
-
(2003)
J Bacteriol
, vol.185
, pp. 2793-2801
-
-
Hove-Jensen, B.1
Rosenkrantz, T.J.2
Haldimann, A.3
Wanner, B.L.4
-
9
-
-
43549101762
-
Biosynthesis of D-arabinose in mycobacteria: a novel bacterial pathway with implications for antimycobacterial therapy
-
Wolucka BA. 2008. Biosynthesis of D-arabinose in mycobacteria: a novel bacterial pathway with implications for antimycobacterial therapy. FEBS J 275:2691-2711.
-
(2008)
FEBS J
, vol.275
, pp. 2691-2711
-
-
Wolucka, B.A.1
-
10
-
-
78649731694
-
Mycobacterium tuberculosis phosphoribosylpyrophosphate synthetase: biochemical features of a crucial enzyme for mycobacterial cell wall biosynthesis
-
Lucarelli AP, Buroni S, Pasca MR, Rizzi M, Cavagnino A, Valentini G, Riccardi G, Chiarelli LR. 2010. Mycobacterium tuberculosis phosphoribosylpyrophosphate synthetase: biochemical features of a crucial enzyme for mycobacterial cell wall biosynthesis. PLoS One 5:e15494.
-
(2010)
PLoS One
, vol.5
-
-
Lucarelli, A.P.1
Buroni, S.2
Pasca, M.R.3
Rizzi, M.4
Cavagnino, A.5
Valentini, G.6
Riccardi, G.7
Chiarelli, L.R.8
-
11
-
-
0035135556
-
A purF mutant of Mycobacterium smegmatis has impaired survival during oxygen-starved stationary phase
-
Keer J, Smeulders MJ, Williams HD. 2001. A purF mutant of Mycobacterium smegmatis has impaired survival during oxygen-starved stationary phase. Microbiology 147:473-481.
-
(2001)
Microbiology
, vol.147
, pp. 473-481
-
-
Keer, J.1
Smeulders, M.J.2
Williams, H.D.3
-
12
-
-
65849218106
-
Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery
-
Zhang Z, Caradoc-Davies TT, Dickson JM, Baker, Squire CJ. 2009. Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery. J Mol Biol 389:722-733.
-
(2009)
J Mol Biol
, vol.389
, pp. 722-733
-
-
Zhang, Z.1
Caradoc-Davies, T.T.2
Dickson, J.M.3
Baker, S.C.J.4
-
13
-
-
0035704319
-
DNA replication in Mycobacterium leprae
-
Dawes SS, Mizrahi V. 2001. DNA replication in Mycobacterium leprae. Lepr Rev 72:408.
-
(2001)
Lepr Rev
, vol.72
, pp. 408
-
-
Dawes, S.S.1
Mizrahi, V.2
-
14
-
-
4043093379
-
The formylglycinamide ribonucleotide amidotransferase complex from Bacillus subtilis: metabolite-mediated complex formation
-
Hoskins AA, Anand R, Ealick SE, Stubbe J. 2004. The formylglycinamide ribonucleotide amidotransferase complex from Bacillus subtilis: metabolite-mediated complex formation. Biochemistry 43: 10314-10327.
-
(2004)
Biochemistry
, vol.43
, pp. 10314-10327
-
-
Hoskins, A.A.1
Anand, R.2
Ealick, S.E.3
Stubbe, J.4
-
15
-
-
4043110518
-
A model for the Bacillus subtilis formylglycinamide ribonucleotide amidotransferase multiprotein complex
-
Anand R, Hoskins AA, Bennett EM, Sintchak MD, Stubbe J, Ealick SE. 2004. A model for the Bacillus subtilis formylglycinamide ribonucleotide amidotransferase multiprotein complex. Biochemistry 43:10343-10352.
-
(2004)
Biochemistry
, vol.43
, pp. 10343-10352
-
-
Anand, R.1
Hoskins, A.A.2
Bennett, E.M.3
Sintchak, M.D.4
Stubbe, J.5
Ealick, S.E.6
-
16
-
-
4043055054
-
Domain organization of Salmonella typhimurium formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography
-
Anand R, Hoskins AA, Stubbe J, Ealick SE. 2004. Domain organization of Salmonella typhimurium formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography. Biochemistry 43: 10328-10342.
-
(2004)
Biochemistry
, vol.43
, pp. 10328-10342
-
-
Anand, R.1
Hoskins, A.A.2
Stubbe, J.3
Ealick, S.E.4
-
17
-
-
0034651835
-
The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine biosynthetic pathway
-
Toth EA, Yeates TO. 2000. The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine biosynthetic pathway. Structure 8:163-174.
-
(2000)
Structure
, vol.8
, pp. 163-174
-
-
Toth, E.A.1
Yeates, T.O.2
-
18
-
-
0142106016
-
Nucleoside diphosphate kinase-like activity in adenylate kinase of Mycobacterium tuberculosis
-
Meena LS, Chopra P, Bedwal RS, Singh Y. 2003. Nucleoside diphosphate kinase-like activity in adenylate kinase of Mycobacterium tuberculosis. Biotechnol Appl Biochem 38:169-174.
-
(2003)
Biotechnol Appl Biochem
, vol.38
, pp. 169-174
-
-
Meena, L.S.1
Chopra, P.2
Bedwal, R.S.3
Singh, Y.4
-
19
-
-
0037293032
-
Cytotoxic activity of nucleoside diphosphate kinase secreted from Mycobacterium tuberculosis
-
Chopra P, Singh A, Koul A, Ramachandran S, Drlica K, Tyagi AK, Singh Y. 2003. Cytotoxic activity of nucleoside diphosphate kinase secreted from Mycobacterium tuberculosis. Eur J Biochem 270:625-634.
-
(2003)
Eur J Biochem
, vol.270
, pp. 625-634
-
-
Chopra, P.1
Singh, A.2
Koul, A.3
Ramachandran, S.4
Drlica, K.5
Tyagi, A.K.6
Singh, Y.7
-
20
-
-
78650744683
-
Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis
-
Usha V, Gurcha S, Lovering AL, Lloyd AJ, Papaemmanouil A, Reynolds RC, Besra GS. 2011. Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis. Microbiology 157:290-299.
-
(2011)
Microbiology
, vol.157
, pp. 290-299
-
-
Usha, V.1
Gurcha, S.2
Lovering, A.L.3
Lloyd, A.J.4
Papaemmanouil, A.5
Reynolds, R.C.6
Besra, G.S.7
-
21
-
-
30144443246
-
Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase
-
Hible G, Christova P, Renault L, Seclaman E, Thompson A, Girard E, Munier-Lehmann H, Cherfils J. 2006. Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase. Proteins 62:489-500.
-
(2006)
Proteins
, vol.62
, pp. 489-500
-
-
Hible, G.1
Christova, P.2
Renault, L.3
Seclaman, E.4
Thompson, A.5
Girard, E.6
Munier-Lehmann, H.7
Cherfils, J.8
-
22
-
-
18744383065
-
Nucleoside diphosphate kinase from Mycobacterium tuberculosis cleaves single strand DNA within the human c-myc promoter in an enzyme-catalyzed reaction
-
Kumar P, Verma A, Saini AK, Chopra P, Chakraborti PK, Singh Y, Chowdhury S. 2005. Nucleoside diphosphate kinase from Mycobacterium tuberculosis cleaves single strand DNA within the human c-myc promoter in an enzyme-catalyzed reaction. Nucleic Acids Res 33: 2707-2714.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 2707-2714
-
-
Kumar, P.1
Verma, A.2
Saini, A.K.3
Chopra, P.4
Chakraborti, P.K.5
Singh, Y.6
Chowdhury, S.7
-
23
-
-
9644259051
-
Nuclear localization and in situ DNA damage by Mycobacterium tuberculosis nucleoside-diphosphate kinase
-
Saini AK, Maithal K, Chand P, Chowdhury S, Vohra R, Goyal A, Dubey GP, Chopra P, Chandra R, Tyagi AK, Singh Y, Tandon V. 2004. Nuclear localization and in situ DNA damage by Mycobacterium tuberculosis nucleoside-diphosphate kinase. J Biol Chem 279:50142-50149.
-
(2004)
J Biol Chem
, vol.279
, pp. 50142-50149
-
-
Saini, A.K.1
Maithal, K.2
Chand, P.3
Chowdhury, S.4
Vohra, R.5
Goyal, A.6
Dubey, G.P.7
Chopra, P.8
Chandra, R.9
Tyagi, A.K.10
Singh, Y.11
Tandon, V.12
-
24
-
-
77649306523
-
Mycobacterial nucleoside diphosphate kinase blocks phagosome maturation in murine RAW 264.7 macrophages
-
Sun J, Wang X, Lau A, Liao TY, Bucci C, Hmama Z. 2010. Mycobacterial nucleoside diphosphate kinase blocks phagosome maturation in murine RAW 264.7 macrophages. PLoS One 5:e8769.
-
(2010)
PLoS One
, vol.5
-
-
Sun, J.1
Wang, X.2
Lau, A.3
Liao, T.Y.4
Bucci, C.5
Hmama, Z.6
-
25
-
-
80155200967
-
Secretory nucleoside diphosphate kinases from both intra-and extracellular pathogenic bacteria are functionally indistinguishable
-
Dar HH, Prasad D, Varshney GC, Chakraborti PK. 2011. Secretory nucleoside diphosphate kinases from both intra-and extracellular pathogenic bacteria are functionally indistinguishable. Microbiology 157: 3024-3035.
-
(2011)
Microbiology
, vol.157
, pp. 3024-3035
-
-
Dar, H.H.1
Prasad, D.2
Varshney, G.C.3
Chakraborti, P.K.4
-
27
-
-
70349307297
-
Phosphate depletion: a novel trigger for Mycobacterium tuberculosis persistence
-
Rifat D, Bishai WR, Karakousis PC. 2009. Phosphate depletion: a novel trigger for Mycobacterium tuberculosis persistence. J Infect Dis 200:1126-1135.
-
(2009)
J Infect Dis
, vol.200
, pp. 1126-1135
-
-
Rifat, D.1
Bishai, W.R.2
Karakousis, P.C.3
-
28
-
-
0043192889
-
The role of RelMtbmediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice
-
Dahl JL, Kraus CN, Boshoff HI, Doan B, Foley K, Avarbock D, Kaplan G, Mizrahi V, Rubin H, Barry CE 3rd. 2003. The role of RelMtbmediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice. Proc Natl Acad Sci USA 100: 10026-10031.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 10026-10031
-
-
Dahl, J.L.1
Kraus, C.N.2
Boshoff, H.I.3
Doan, B.4
Foley, K.5
Avarbock, D.6
Kaplan, G.7
Mizrahi, V.8
Rubin, H.9
Barry, C.E.10
-
29
-
-
15244353229
-
The relA homolog of Mycobacterium smegmatis affects cell appearance, viability, and gene expression
-
Dahl JL, Arora K, Boshoff HI, Whiteford DC, Pacheco SA, Walsh OJ, Lau-Bonilla D, Davis WB, Garza AG. 2005. The relA homolog of Mycobacterium smegmatis affects cell appearance, viability, and gene expression. J Bacteriol 187:2439-2447.
-
(2005)
J Bacteriol
, vol.187
, pp. 2439-2447
-
-
Dahl, J.L.1
Arora, K.2
Boshoff, H.I.3
Whiteford, D.C.4
Pacheco, S.A.5
Walsh, O.J.6
Lau-Bonilla, D.7
Davis, W.B.8
Garza, A.G.9
-
30
-
-
0033872759
-
The stringent response of Mycobacterium tuberculosis is required for long-term survival
-
Primm TP, Andersen SJ, Mizrahi V, Avarbock D, Rubin H, Barry CE 3rd. 2000. The stringent response of Mycobacterium tuberculosis is required for long-term survival. J Bacteriol 182:4889-4898.
-
(2000)
J Bacteriol
, vol.182
, pp. 4889-4898
-
-
Primm, T.P.1
Andersen, S.J.2
Mizrahi, V.3
Avarbock, D.4
Rubin, H.5
Barry, C.E.6
-
31
-
-
0034718458
-
Differential regulation of opposing RelMtb activities by the aminoacylation state of a tRNA. ribosome.mRNA.RelMtb complex
-
Avarbock D, Avarbock A, Rubin H. 2000. Differential regulation of opposing RelMtb activities by the aminoacylation state of a tRNA. ribosome.mRNA.RelMtb complex. Biochemistry 39:11640-11648.
-
(2000)
Biochemistry
, vol.39
, pp. 11640-11648
-
-
Avarbock, D.1
Avarbock, A.2
Rubin, H.3
-
32
-
-
22744459778
-
Functional regulation of the opposing (p)ppGpp synthetase/hydrolase activities of RelMtb from Mycobacterium tuberculosis
-
Avarbock A, Avarbock D, Teh JS, Buckstein M, Wang ZM, Rubin H. 2005. Functional regulation of the opposing (p)ppGpp synthetase/hydrolase activities of RelMtb from Mycobacterium tuberculosis. Biochemistry 44:9913-9923.
-
(2005)
Biochemistry
, vol.44
, pp. 9913-9923
-
-
Avarbock, A.1
Avarbock, D.2
Teh, J.S.3
Buckstein, M.4
Wang, Z.M.5
Rubin, H.6
-
33
-
-
77958102894
-
The stringent response is required for full virulence of Mycobacterium tuberculosis in guinea pigs
-
Klinkenberg LG, Lee JH, Bishai WR, Karakousis PC. 2010. The stringent response is required for full virulence of Mycobacterium tuberculosis in guinea pigs. J Infect Dis 202:1397-1404.
-
(2010)
J Infect Dis
, vol.202
, pp. 1397-1404
-
-
Klinkenberg, L.G.1
Lee, J.H.2
Bishai, W.R.3
Karakousis, P.C.4
-
34
-
-
34447311357
-
Polyphosphate kinase is involved in stress-induced mprAB-sigE-rel signalling in mycobacteria
-
Sureka K, Dey S, Datta P, Singh AK, Dasgupta A, Rodrigue S, Basu J, Kundu M. 2007. Polyphosphate kinase is involved in stress-induced mprAB-sigE-rel signalling in mycobacteria. Mol Microbiol 65:261-276.
-
(2007)
Mol Microbiol
, vol.65
, pp. 261-276
-
-
Sureka, K.1
Dey, S.2
Datta, P.3
Singh, A.K.4
Dasgupta, A.5
Rodrigue, S.6
Basu, J.7
Kundu, M.8
-
35
-
-
46349090277
-
Positive feedback and noise activate the stringent response regulator rel in mycobacteria
-
Sureka K, Ghosh B, Dasgupta A, Basu J, Kundu M, Bose I. 2008. Positive feedback and noise activate the stringent response regulator rel in mycobacteria. PLoS One 3:e1771.
-
(2008)
PLoS One
, vol.3
-
-
Sureka, K.1
Ghosh, B.2
Dasgupta, A.3
Basu, J.4
Kundu, M.5
Bose, I.6
-
36
-
-
4043108470
-
Regulation through the secondary channel-structural framework for ppGpp-DksA synergism during transcription
-
Perederina A, Svetlov V, Vassylyeva MN, Tahirov TH, Yokoyama S, Artsimovitch I, Vassylyev DG. 2004. Regulation through the secondary channel-structural framework for ppGpp-DksA synergism during transcription. Cell 118:297-309.
-
(2004)
Cell
, vol.118
, pp. 297-309
-
-
Perederina, A.1
Svetlov, V.2
Vassylyeva, M.N.3
Tahirov, T.H.4
Yokoyama, S.5
Artsimovitch, I.6
Vassylyev, D.G.7
-
37
-
-
67649660560
-
CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence
-
Stallings CL, Stephanou NC, Chu L, Hochschild A, Nickels BE, Glickman MS. 2009. CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence. Cell 138:146-159.
-
(2009)
Cell
, vol.138
, pp. 146-159
-
-
Stallings, C.L.1
Stephanou, N.C.2
Chu, L.3
Hochschild, A.4
Nickels, B.E.5
Glickman, M.S.6
-
38
-
-
84866334556
-
MS-RHII-RSD, a dual-function RNase HII-(p)ppGpp synthetase from Mycobacterium smegmatis
-
Murdeshwar MS, Chatterji D. 2012. MS_RHII-RSD, a dual-function RNase HII-(p)ppGpp synthetase from Mycobacterium smegmatis. J Bacteriol 194:4003-4014.
-
(2012)
J Bacteriol
, vol.194
, pp. 4003-4014
-
-
Murdeshwar, M.S.1
Chatterji, D.2
-
39
-
-
0345701347
-
Genes required for mycobacterial growth defined by high density mutagenesis
-
Sassetti CM, Boyd DH, Rubin EJ. 2003. Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol 48:77-84.
-
(2003)
Mol Microbiol
, vol.48
, pp. 77-84
-
-
Sassetti, C.M.1
Boyd, D.H.2
Rubin, E.J.3
-
40
-
-
84864411484
-
Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase
-
Breda A, Machado P, Rosado LA, Souto AA, Santos DS, Basso LA. 2012. Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase. Eur J Med Chem 54:113-122.
-
(2012)
Eur J Med Chem
, vol.54
, pp. 113-122
-
-
Breda, A.1
Machado, P.2
Rosado, L.A.3
Souto, A.A.4
Santos, D.S.5
Basso, L.A.6
-
41
-
-
79955630791
-
Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation
-
Labesse G, Benkali K, Salard-Arnaud I, Gilles AM, Munier-Lehmann H. 2011. Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation. Nucleic Acids Res 39:3458-3472.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 3458-3472
-
-
Labesse, G.1
Benkali, K.2
Salard-Arnaud, I.3
Gilles, A.M.4
Munier-Lehmann, H.5
-
42
-
-
78651254744
-
UMP kinase from Mycobacterium tuberculosis: mode of action and allosteric interactions, and their likely role in pyrimidine metabolism regulation
-
Rostirolla DC, Breda A, Rosado LA, Palma MS, Basso LA, Santos DS. 2011. UMP kinase from Mycobacterium tuberculosis: mode of action and allosteric interactions, and their likely role in pyrimidine metabolism regulation. Arch Biochem Biophys 505:202-212.
-
(2011)
Arch Biochem Biophys
, vol.505
, pp. 202-212
-
-
Rostirolla, D.C.1
Breda, A.2
Rosado, L.A.3
Palma, M.S.4
Basso, L.A.5
Santos, D.S.6
-
43
-
-
34548478561
-
Regulation of pyr gene expression in Mycobacterium smegmatis by PyrR-dependent translational repression
-
Fields CJ, Switzer RL. 2007. Regulation of pyr gene expression in Mycobacterium smegmatis by PyrR-dependent translational repression. J Bacteriol 189:6236-6245.
-
(2007)
J Bacteriol
, vol.189
, pp. 6236-6245
-
-
Fields, C.J.1
Switzer, R.L.2
-
44
-
-
23844434045
-
Structure of pyrR (Rv1379) from Mycobacterium tuberculosis: a persistence gene and protein drug target
-
Kantardjieff KA, Vasquez C, Castro P, Warfel NM, Rho BS, Lekin T, Kim CY, Segelke BW, Terwilliger TC, Rupp B. 2005. Structure of pyrR (Rv1379) from Mycobacterium tuberculosis: a persistence gene and protein drug target. Acta Crystallogr D Biol Crystallogr 61:355-364.
-
(2005)
Acta Crystallogr D Biol Crystallogr
, vol.61
, pp. 355-364
-
-
Kantardjieff, K.A.1
Vasquez, C.2
Castro, P.3
Warfel, N.M.4
Rho, B.S.5
Lekin, T.6
Kim, C.Y.7
Segelke, B.W.8
Terwilliger, T.C.9
Rupp, B.10
-
45
-
-
44949214942
-
Regulation of pyrimidine biosynthetic gene expression in bacteria: repression without repressors
-
Turnbough CL Jr, Switzer RL. 2008. Regulation of pyrimidine biosynthetic gene expression in bacteria: repression without repressors. Microbiol Mol Biol Rev 72:266-300.
-
(2008)
Microbiol Mol Biol Rev
, vol.72
, pp. 266-300
-
-
Turnbough, C.L.1
Switzer, R.L.2
-
46
-
-
46249108568
-
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates
-
Via LE, Lin PL, Ray SM, Carrillo J, Allen SS, Eum SY, Taylor K, Klein E, Manjunatha U, Gonzales J, Lee EG, Park SK, Raleigh JA, Cho SN, McMurray DN, Flynn JL, Barry CE 3rd. 2008. Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates. Infect Immun 76:2333-2340.
-
(2008)
Infect Immun
, vol.76
, pp. 2333-2340
-
-
Via, L.E.1
Lin, P.L.2
Ray, S.M.3
Carrillo, J.4
Allen, S.S.5
Eum, S.Y.6
Taylor, K.7
Klein, E.8
Manjunatha, U.9
Gonzales, J.10
Lee, E.G.11
Park, S.K.12
Raleigh, J.A.13
Cho, S.N.14
McMurray, D.N.15
Flynn, J.L.16
Barry, C.E.17
-
47
-
-
0242659213
-
Identification and characterization of a unique adenosine kinase from Mycobacterium tuberculosis
-
Long MC, Escuyer V, Parker WB. 2003. Identification and characterization of a unique adenosine kinase from Mycobacterium tuberculosis. J Bacteriol 185:6548-6555.
-
(2003)
J Bacteriol
, vol.185
, pp. 6548-6555
-
-
Long, M.C.1
Escuyer, V.2
Parker, W.B.3
-
48
-
-
0023597994
-
Enzymes for purine synthesis and scavenging in pathogenic mycobacteria and their distribution in Mycobacterium leprae
-
Wheeler PR. 1987. Enzymes for purine synthesis and scavenging in pathogenic mycobacteria and their distribution in Mycobacterium leprae. J Gen Microbiol 133:3013-3018.
-
(1987)
J Gen Microbiol
, vol.133
, pp. 3013-3018
-
-
Wheeler, P.R.1
-
49
-
-
80053459692
-
High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism
-
Griffin JE, Gawronski JD, Dejesus MA, Ioerger TR, Akerley BJ, Sassetti CM. 2011. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathog 7:e1002251.
-
(2011)
PLoS Pathog
, vol.7
-
-
Griffin, J.E.1
Gawronski, J.D.2
Dejesus, M.A.3
Ioerger, T.R.4
Akerley, B.J.5
Sassetti, C.M.6
-
50
-
-
20444419421
-
Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages
-
Rengarajan J, Bloom BR, Rubin EJ. 2005. Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. Proc Natl Acad Sci USA 102:8327-8332.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 8327-8332
-
-
Rengarajan, J.1
Bloom, B.R.2
Rubin, E.J.3
-
51
-
-
0242268400
-
Genetic requirements for mycobacterial survival during infection
-
Sassetti CM, Rubin EJ. 2003. Genetic requirements for mycobacterial survival during infection. Proc Natl Acad Sci USA 100:12989-12994.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 12989-12994
-
-
Sassetti, C.M.1
Rubin, E.J.2
-
52
-
-
67349253088
-
Hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv: cloning, expression, and biochemical characterization
-
Biazus G, Schneider CZ, Palma MS, Basso LA, Santos DS. 2009. Hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv: cloning, expression, and biochemical characterization. Protein Expr Purif 66:185-190.
-
(2009)
Protein Expr Purif
, vol.66
, pp. 185-190
-
-
Biazus, G.1
Schneider, C.Z.2
Palma, M.S.3
Basso, L.A.4
Santos, D.S.5
-
53
-
-
67349183401
-
Substrate specificity and kinetic mechanism of purine nucleoside phosphorylase from Mycobacterium tuberculosis
-
Ducati RG, Santos DS, Basso LA. 2009. Substrate specificity and kinetic mechanism of purine nucleoside phosphorylase from Mycobacterium tuberculosis. Arch Biochem Biophys 486:155-164.
-
(2009)
Arch Biochem Biophys
, vol.486
, pp. 155-164
-
-
Ducati, R.G.1
Santos, D.S.2
Basso, L.A.3
-
54
-
-
0035902502
-
Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces
-
Shi W, Basso LA, Santos DS, Tyler PC, Furneaux RH, Blanchard JS, Almo SC, Schramm VL. 2001. Structures of purine nucleoside phosphorylase from Mycobacterium tuberculosis in complexes with immucillin-H and its pieces. Biochemistry 40:8204-8215.
-
(2001)
Biochemistry
, vol.40
, pp. 8204-8215
-
-
Shi, W.1
Basso, L.A.2
Santos, D.S.3
Tyler, P.C.4
Furneaux, R.H.5
Blanchard, J.S.6
Almo, S.C.7
Schramm, V.L.8
-
55
-
-
34848907756
-
High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme
-
Reddy MC, Palaninathan SK, Shetty ND, Owen JL, Watson MD, Sacchettini JC. 2007. High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme. J Biol Chem 282:27334-27342.
-
(2007)
J Biol Chem
, vol.282
, pp. 27334-27342
-
-
Reddy, M.C.1
Palaninathan, S.K.2
Shetty, N.D.3
Owen, J.L.4
Watson, M.D.5
Sacchettini, J.C.6
-
56
-
-
33646534929
-
Overexpression, purification and crystallographic analysis of a unique adenosine kinase from Mycobacterium tuberculosis
-
Wang Y, Long MC, Ranganathan S, Escuyer V, Parker WB, Li R. 2005. Overexpression, purification and crystallographic analysis of a unique adenosine kinase from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 61:553-557.
-
(2005)
Acta Crystallogr Sect F Struct Biol Cryst Commun
, vol.61
, pp. 553-557
-
-
Wang, Y.1
Long, M.C.2
Ranganathan, S.3
Escuyer, V.4
Parker, W.B.5
Li, R.6
-
57
-
-
77953651125
-
Use of pleural fluid levels of adenosine deaminase and interferon gamma in the diagnosis of tuberculous pleuritis
-
Krenke R, Korczynski P. 2010. Use of pleural fluid levels of adenosine deaminase and interferon gamma in the diagnosis of tuberculous pleuritis. Curr Opin Pulm Med 16:367-375.
-
(2010)
Curr Opin Pulm Med
, vol.16
, pp. 367-375
-
-
Krenke, R.1
Korczynski, P.2
-
58
-
-
40949138190
-
Structure-activity relationship for adenosine kinase from Mycobacterium tuberculosis II. Modifications to the ribofuranosyl moiety
-
Long MC, Shaddix SC, Moukha-Chafiq O, Maddry JA, Nagy L, Parker WB. 2008. Structure-activity relationship for adenosine kinase from Mycobacterium tuberculosis II. Modifications to the ribofuranosyl moiety. Biochem Pharmacol 75:1588-1600.
-
(2008)
Biochem Pharmacol
, vol.75
, pp. 1588-1600
-
-
Long, M.C.1
Shaddix, S.C.2
Moukha-Chafiq, O.3
Maddry, J.A.4
Nagy, L.5
Parker, W.B.6
-
59
-
-
0037177231
-
Kinetic mechanism of adenine phosphoribosyltransferase from Leishmania donovani
-
Bashor C, Denu JM, Brennan RG, Ullman B. 2002. Kinetic mechanism of adenine phosphoribosyltransferase from Leishmania donovani. Biochemistry 41:4020-4031.
-
(2002)
Biochemistry
, vol.41
, pp. 4020-4031
-
-
Bashor, C.1
Denu, J.M.2
Brennan, R.G.3
Ullman, B.4
-
60
-
-
0029919169
-
Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata
-
Degano M, Gopaul DN, Scapin G, Schramm VL, Sacchettini JC. 1996. Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata. Biochemistry 35:5971-5981.
-
(1996)
Biochemistry
, vol.35
, pp. 5971-5981
-
-
Degano, M.1
Gopaul, D.N.2
Scapin, G.3
Schramm, V.L.4
Sacchettini, J.C.5
-
61
-
-
79952788822
-
Pyrimidine salvage pathway in Mycobacterium tuberculosis
-
Villela AD, Sanchez-Quitian ZA, Ducati RG, Santos DS, Basso LA. 2011. Pyrimidine salvage pathway in Mycobacterium tuberculosis. Curr Med Chem 18:1286-1298.
-
(2011)
Curr Med Chem
, vol.18
, pp. 1286-1298
-
-
Villela, A.D.1
Sanchez-Quitian, Z.A.2
Ducati, R.G.3
Santos, D.S.4
Basso, L.A.5
-
62
-
-
84861438630
-
The dUTPase enzyme is essential in Mycobacterium smegmatis
-
Pecsi I, Hirmondo R, Brown AC, Lopata A, Parish T, Vertessy BG, Toth J. 2012. The dUTPase enzyme is essential in Mycobacterium smegmatis. PLoS One 7:e37461.
-
(2012)
PLoS One
, vol.7
-
-
Pecsi, I.1
Hirmondo, R.2
Brown, A.C.3
Lopata, A.4
Parish, T.5
Vertessy, B.G.6
Toth, J.7
-
63
-
-
3342875968
-
Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism
-
Chan S, Segelke B, Lekin T, Krupka H, Cho US, Kim MY, So M, Kim CY, Naranjo CN, Rogers YC, Park MS, Waldo GS, Pashkov I, Cascio D, Perry JL, Sawaya MR. 2004. Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism. J Mol Biol 341:503-517.
-
(2004)
J Mol Biol
, vol.341
, pp. 503-517
-
-
Chan, S.1
Segelke, B.2
Lekin, T.3
Krupka, H.4
Cho, U.S.5
Kim, M.Y.6
So, M.7
Kim, C.Y.8
Naranjo, C.N.9
Rogers, Y.C.10
Park, M.S.11
Waldo, G.S.12
Pashkov, I.13
Cascio, D.14
Perry, J.L.15
Sawaya, M.R.16
-
64
-
-
61849128423
-
Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases
-
Vertessy BG, Toth J. 2009. Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases. Acc Chem Res 42: 97-106.
-
(2009)
Acc Chem Res
, vol.42
, pp. 97-106
-
-
Vertessy, B.G.1
Toth, J.2
-
65
-
-
38349191358
-
Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis
-
Helt SS, Thymark M, Harris P, Aagaard C, Dietrich J, Larsen S, Willemoes M. 2008. Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis. J Mol Biol 376:554-569.
-
(2008)
J Mol Biol
, vol.376
, pp. 554-569
-
-
Helt, S.S.1
Thymark, M.2
Harris, P.3
Aagaard, C.4
Dietrich, J.5
Larsen, S.6
Willemoes, M.7
-
66
-
-
0037025191
-
An alternative flavin-dependent mechanism for thymidylate synthesis
-
Myllykallio H, Lipowski G, Leduc D, Filee J, Forterre P, Liebl U. 2002. An alternative flavin-dependent mechanism for thymidylate synthesis. Science 297:105-107.
-
(2002)
Science
, vol.297
, pp. 105-107
-
-
Myllykallio, H.1
Lipowski, G.2
Leduc, D.3
Filee, J.4
Forterre, P.5
Liebl, U.6
-
67
-
-
24944591878
-
Structure of the Mycobacterium tuberculosis flavin dependent thymidylate synthase (MtbThyX) at 2.0A resolution
-
Sampathkumar P, Turley S, Ulmer JE, Rhie HG, Sibley CH, Hol WG. 2005. Structure of the Mycobacterium tuberculosis flavin dependent thymidylate synthase (MtbThyX) at 2.0A resolution. J Mol Biol 352: 1091-1104.
-
(2005)
J Mol Biol
, vol.352
, pp. 1091-1104
-
-
Sampathkumar, P.1
Turley, S.2
Ulmer, J.E.3
Rhie, H.G.4
Sibley, C.H.5
Hol, W.G.6
-
68
-
-
84856754603
-
Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid
-
Fivian-Hughes AS, Houghton J, Davis EO. 2012. Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid. Microbiology 158:308-318.
-
(2012)
Microbiology
, vol.158
, pp. 308-318
-
-
Fivian-Hughes, A.S.1
Houghton, J.2
Davis, E.O.3
-
70
-
-
48249126476
-
Kinetics and ligandbinding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX
-
Hunter JH, Gujjar R, Pang CK, Rathod PK. 2008. Kinetics and ligandbinding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX. PLoS One 3:e2237.
-
(2008)
PLoS One
, vol.3
-
-
Hunter, J.H.1
Gujjar, R.2
Pang, C.K.3
Rathod, P.K.4
-
71
-
-
84877724213
-
Mechanistic and structural basis for inhibition of thymidylate synthase ThyX
-
Basta T, Boum Y, Briffotaux J, Becker HF, Lamarre-Jouenne I, Lambry JC, Skouloubris S, Liebl U, Graille M, van Tilbeurgh H, Myllykallio H. 2012. Mechanistic and structural basis for inhibition of thymidylate synthase ThyX. Open Biol 2:120120.
-
(2012)
Open Biol
, vol.2
-
-
Basta, T.1
Boum, Y.2
Briffotaux, J.3
Becker, H.F.4
Lamarre-Jouenne, I.5
Lambry, J.C.6
Skouloubris, S.7
Liebl, U.8
Graille, M.9
van Tilbeurgh, H.10
Myllykallio, H.11
-
72
-
-
79960190026
-
Synthesis and evaluation of 5-substituted 2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis
-
Kogler M, Vanderhoydonck B, De Jonghe S, Rozenski J, Van Belle K, Herman J, Louat T, Parchina A, Sibley C, Lescrinier E, Herdewijn P. 2011. Synthesis and evaluation of 5-substituted 2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis. J Med Chem 54:4847-4862.
-
(2011)
J Med Chem
, vol.54
, pp. 4847-4862
-
-
Kogler, M.1
Vanderhoydonck, B.2
De Jonghe, S.3
Rozenski, J.4
Van Belle, K.5
Herman, J.6
Louat, T.7
Parchina, A.8
Sibley, C.9
Lescrinier, E.10
Herdewijn, P.11
-
73
-
-
76749150421
-
Structural and functional analyses of Mycobacterium tuberculosis Rv3315c-encoded metal-dependent homotetrameric cytidine deaminase
-
Sanchez-Quitian ZA, Schneider CZ, Ducati RG, de Azevedo WF Jr, Bloch C Jr, Basso LA, Santos DS. 2010. Structural and functional analyses of Mycobacterium tuberculosis Rv3315c-encoded metal-dependent homotetrameric cytidine deaminase. J Struct Biol 169:413-423.
-
(2010)
J Struct Biol
, vol.169
, pp. 413-423
-
-
Sanchez-Quitian, Z.A.1
Schneider, C.Z.2
Ducati, R.G.3
de Azevedo, W.F.4
Bloch, C.5
Basso, L.A.6
Santos, D.S.7
-
74
-
-
79954447859
-
Crystal structure determination and dynamic studies of Mycobacterium tuberculosis cytidine deaminase in complex with products
-
Sanchez-Quitian ZA, Timmers LF, Caceres RA, Rehm JG, Thompson CE, Basso LA, de Azevedo WF Jr, Santos DS. 2011. Crystal structure determination and dynamic studies of Mycobacterium tuberculosis cytidine deaminase in complex with products. Arch BiochemBiophys 509:108-115.
-
(2011)
Arch BiochemBiophys
, vol.509
, pp. 108-115
-
-
Sanchez-Quitian, Z.A.1
Timmers, L.F.2
Caceres, R.A.3
Rehm, J.G.4
Thompson, C.E.5
Basso, L.A.6
de Azevedo, W.F.7
Santos, D.S.8
-
75
-
-
65249143233
-
The Rv1712 locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP
-
Thum C, Schneider CZ, Palma MS, Santos DS, Basso LA. 2009. The Rv1712 locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP. J Bacteriol 191:2884-2887.
-
(2009)
J Bacteriol
, vol.191
, pp. 2884-2887
-
-
Thum, C.1
Schneider, C.Z.2
Palma, M.S.3
Santos, D.S.4
Basso, L.A.5
-
76
-
-
41549087785
-
Molecular modeling and dynamics studies of cytidylate kinase from Mycobacterium tuberculosis H37Rv
-
Caceres RA, Macedo Timmers LF, Vivan AL, Schneider CZ, Basso LA, De Azevedo WF Jr, Santos DS. 2008. Molecular modeling and dynamics studies of cytidylate kinase from Mycobacterium tuberculosis H37Rv. J Mol Model 14:427-434.
-
(2008)
J Mol Model
, vol.14
, pp. 427-434
-
-
Caceres, R.A.1
Macedo Timmers, L.F.2
Vivan, A.L.3
Schneider, C.Z.4
Basso, L.A.5
De Azevedo, W.F.6
Santos, D.S.7
-
77
-
-
0242381240
-
Ribonucleotide reduction in Mycobacterium tuberculosis: function and expression of genes encoding class Ib and class II ribonucleotide reductases
-
Dawes SS, Warner DF, Tsenova L, Timm J, McKinney JD, Kaplan G, Rubin H, Mizrahi V. 2003. Ribonucleotide reduction in Mycobacterium tuberculosis: function and expression of genes encoding class Ib and class II ribonucleotide reductases. Infect Immun 71:6124-6131.
-
(2003)
Infect Immun
, vol.71
, pp. 6124-6131
-
-
Dawes, S.S.1
Warner, D.F.2
Tsenova, L.3
Timm, J.4
McKinney, J.D.5
Kaplan, G.6
Rubin, H.7
Mizrahi, V.8
-
78
-
-
63449142502
-
Function and regulation of class I ribonucleotide reductase-encoding genes in mycobacteria
-
Mowa MB, Warner DF, Kaplan G, Kana BD, Mizrahi V. 2009. Function and regulation of class I ribonucleotide reductase-encoding genes in mycobacteria. J Bacteriol 191:985-995.
-
(2009)
J Bacteriol
, vol.191
, pp. 985-995
-
-
Mowa, M.B.1
Warner, D.F.2
Kaplan, G.3
Kana, B.D.4
Mizrahi, V.5
-
79
-
-
48649109470
-
Secondary structure conversions of Mycobacterium tuberculosis ribonucleotide reductase protein R2 under varying pH and temperature conditions
-
Georgieva ER, Narvaez AJ, Hedin N, Graslund A. 2008. Secondary structure conversions of Mycobacterium tuberculosis ribonucleotide reductase protein R2 under varying pH and temperature conditions. Biophys Chem 137:43-48.
-
(2008)
Biophys Chem
, vol.137
, pp. 43-48
-
-
Georgieva, E.R.1
Narvaez, A.J.2
Hedin, N.3
Graslund, A.4
-
80
-
-
76749149023
-
Identification of small peptides mimicking the R2 C-terminus of Mycobacterium tuberculosis ribonucleotide reductase
-
Ericsson DJ, Nurbo J, Muthas D, Hertzberg K, Lindeberg G, Karlen A, Unge T. 2010. Identification of small peptides mimicking the R2 C-terminus of Mycobacterium tuberculosis ribonucleotide reductase. J Pept Sci 16:159-164.
-
(2010)
J Pept Sci
, vol.16
, pp. 159-164
-
-
Ericsson, D.J.1
Nurbo, J.2
Muthas, D.3
Hertzberg, K.4
Lindeberg, G.5
Karlen, A.6
Unge, T.7
-
81
-
-
84875216302
-
Novel pseudopeptides incorporating a benzodiazepine-based turn mimetic-targeting Mycobacterium tuberculosis ribonucleotide reductase
-
Nurbo J, Ericsson DJ, Rosenstrom U, Muthas D, Jansson AM, Lindeberg G, Unge T, Karlen A. 2013. Novel pseudopeptides incorporating a benzodiazepine-based turn mimetic-targeting Mycobacterium tuberculosis ribonucleotide reductase. Bioorg Med Chem 21:1992-2000.
-
(2013)
Bioorg Med Chem
, vol.21
, pp. 1992-2000
-
-
Nurbo, J.1
Ericsson, D.J.2
Rosenstrom, U.3
Muthas, D.4
Jansson, A.M.5
Lindeberg, G.6
Unge, T.7
Karlen, A.8
-
82
-
-
37349063385
-
Design, synthesis and evaluation of peptide inhibitors of Mycobacterium tuberculosis ribonucleotide reductase
-
Nurbo J, Roos AK, Muthas D, Wahlstrom E, Ericsson DJ, Lundstedt T, Unge T, Karlen A. 2007. Design, synthesis and evaluation of peptide inhibitors of Mycobacterium tuberculosis ribonucleotide reductase. J Pept Sci 13:822-832.
-
(2007)
J Pept Sci
, vol.13
, pp. 822-832
-
-
Nurbo, J.1
Roos, A.K.2
Muthas, D.3
Wahlstrom, E.4
Ericsson, D.J.5
Lundstedt, T.6
Unge, T.7
Karlen, A.8
-
83
-
-
0043142536
-
Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: insights into the phagosomal environment
-
Schnappinger D, Ehrt S, Voskuil MI, Liu Y, Mangan JA, Monahan IM, Dolganov G, Efron B, Butcher PD, Nathan C, Schoolnik GK. 2003. Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: insights into the phagosomal environment. J Exp Med 198: 693-704.
-
(2003)
J Exp Med
, vol.198
, pp. 693-704
-
-
Schnappinger, D.1
Ehrt, S.2
Voskuil, M.I.3
Liu, Y.4
Mangan, J.A.5
Monahan, I.M.6
Dolganov, G.7
Efron, B.8
Butcher, P.D.9
Nathan, C.10
Schoolnik, G.K.11
-
84
-
-
0042140672
-
Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program
-
Voskuil MI, Schnappinger D, Visconti KC, Harrell MI, Dolganov GM, Sherman DR, Schoolnik GK. 2003. Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program. J Exp Med 198:705-713.
-
(2003)
J Exp Med
, vol.198
, pp. 705-713
-
-
Voskuil, M.I.1
Schnappinger, D.2
Visconti, K.C.3
Harrell, M.I.4
Dolganov, G.M.5
Sherman, D.R.6
Schoolnik, G.K.7
-
85
-
-
77649186393
-
Comparative genomics analysis of mycobacterium NrdH-redoxins
-
Leiting WU, Jianping XI. 2010. Comparative genomics analysis of mycobacterium NrdH-redoxins. Microb Pathog 48:97-102.
-
(2010)
Microb Pathog
, vol.48
, pp. 97-102
-
-
Leiting, W.U.1
Jianping, X.I.2
-
86
-
-
0030829520
-
Characterization of Escherichia coli NrdH. A glutaredoxin-like protein with a thioredoxin-like activity profile
-
Jordan A, Aslund F, Pontis E, Reichard P, Holmgren A. 1997. Characterization of Escherichia coli NrdH. A glutaredoxin-like protein with a thioredoxin-like activity profile. J Biol Chem 272:18044-18050.
-
(1997)
J Biol Chem
, vol.272
, pp. 18044-18050
-
-
Jordan, A.1
Aslund, F.2
Pontis, E.3
Reichard, P.4
Holmgren, A.5
-
87
-
-
77957270576
-
High-resolution crystal structures of the flavoprotein NrdI in oxidized and reduced states: an unusual flavodoxin. Structural biology
-
Johansson R, Torrents E, Lundin D, Sprenger J, Sahlin M, Sjoberg BM, Logan DT. 2010. High-resolution crystal structures of the flavoprotein NrdI in oxidized and reduced states: an unusual flavodoxin. Structural biology. FEBS J 277:4265-4277.
-
(2010)
FEBS J
, vol.277
, pp. 4265-4277
-
-
Johansson, R.1
Torrents, E.2
Lundin, D.3
Sprenger, J.4
Sahlin, M.5
Sjoberg, B.M.6
Logan, D.T.7
-
88
-
-
47349123990
-
NrdI essentiality for class Ib ribonucleotide reduction in Streptococcus pyogenes
-
Roca I, Torrents E, Sahlin M, Gibert I, Sjoberg BM. 2008. NrdI essentiality for class Ib ribonucleotide reduction in Streptococcus pyogenes. J Bacteriol 190:4849-4858.
-
(2008)
J Bacteriol
, vol.190
, pp. 4849-4858
-
-
Roca, I.1
Torrents, E.2
Sahlin, M.3
Gibert, I.4
Sjoberg, B.M.5
-
90
-
-
22244478079
-
Cellular DNA replicases: components and dynamics at the replication fork
-
Johnson A, O'Donnell M. 2005. Cellular DNA replicases: components and dynamics at the replication fork. Annu Rev Biochem 74:283-315.
-
(2005)
Annu Rev Biochem
, vol.74
, pp. 283-315
-
-
Johnson, A.1
O'Donnell, M.2
-
91
-
-
77951537332
-
Stoichiometry and architecture of active DNA replication machinery in Escherichia coli
-
Reyes-Lamothe R, Sherratt DJ, Leake MC. 2010. Stoichiometry and architecture of active DNA replication machinery in Escherichia coli. Science 328:498-501.
-
(2010)
Science
, vol.328
, pp. 498-501
-
-
Reyes-Lamothe, R.1
Sherratt, D.J.2
Leake, M.C.3
-
92
-
-
74749100156
-
Reconstitution of the B. subtilis replisome with 13 proteins including two distinct replicases
-
Sanders GM, Dallmann HG, McHenry CS. 2010. Reconstitution of the B. subtilis replisome with 13 proteins including two distinct replicases. Mol Cell 37:273-281.
-
(2010)
Mol Cell
, vol.37
, pp. 273-281
-
-
Sanders, G.M.1
Dallmann, H.G.2
McHenry, C.S.3
-
93
-
-
79959431646
-
DNA replicases from a bacterial perspective
-
McHenry CS. 2011. DNA replicases from a bacterial perspective. Annu Rev Biochem 80:403-436.
-
(2011)
Annu Rev Biochem
, vol.80
, pp. 403-436
-
-
McHenry, C.S.1
-
95
-
-
84855453503
-
Single-molecule studies reveal the function of a third polymerase in the replisome
-
Georgescu RE, Kurth I, O'Donnell ME. 2012. Single-molecule studies reveal the function of a third polymerase in the replisome. Nat Struct Mol Biol 19:113-116.
-
(2012)
Nat Struct Mol Biol
, vol.19
, pp. 113-116
-
-
Georgescu, R.E.1
Kurth, I.2
O'Donnell, M.E.3
-
96
-
-
84857134358
-
Architecture and conservation of the bacterial DNA replication machinery, an underexploited drug target
-
Robinson A, Causer RJ, Dixon NE. 2012. Architecture and conservation of the bacterial DNA replication machinery, an underexploited drug target. Curr Drug Targets 13:352-372.
-
(2012)
Curr Drug Targets
, vol.13
, pp. 352-372
-
-
Robinson, A.1
Causer, R.J.2
Dixon, N.E.3
-
97
-
-
0037453719
-
DnaE2 polymerase contributes to in vivo survival and the emergence of drug resistance in Mycobacterium tuberculosis
-
Boshoff HI, Reed MB, Barry CE 3rd, Mizrahi V. 2003. DnaE2 polymerase contributes to in vivo survival and the emergence of drug resistance in Mycobacterium tuberculosis. Cell 113:183-193.
-
(2003)
Cell
, vol.113
, pp. 183-193
-
-
Boshoff, H.I.1
Reed, M.B.2
Barry, C.E.3
Mizrahi, V.4
-
98
-
-
77955632920
-
Essential roles for imuA'-and imuBencoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis
-
Warner DF, Ndwandwe DE, Abrahams GL, Kana BD, Machowski EE, Venclovas C, Mizrahi V. 2010. Essential roles for imuA'-and imuBencoded accessory factors in DnaE2-dependent mutagenesis in Mycobacterium tuberculosis. Proc Natl Acad Sci USA 107:13093-13098.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 13093-13098
-
-
Warner, D.F.1
Ndwandwe, D.E.2
Abrahams, G.L.3
Kana, B.D.4
Machowski, E.E.5
Venclovas, C.6
Mizrahi, V.7
-
99
-
-
78049233666
-
The role of DNA repair in M. tuberculosis pathogenesis
-
Warner DF. 2010. The role of DNA repair in M. tuberculosis pathogenesis. Drug Discov Today Dis Mech 7:e5-e11.
-
(2010)
Drug Discov Today Dis Mech
, vol.7
, pp. e5-e11
-
-
Warner, D.F.1
-
100
-
-
79955549803
-
Breaking the rules: bacteria that use several DNA polymerase IIIs
-
McHenry CS. 2011. Breaking the rules: bacteria that use several DNA polymerase IIIs. EMBO Rep 12:408-414.
-
(2011)
EMBO Rep
, vol.12
, pp. 408-414
-
-
McHenry, C.S.1
-
101
-
-
0036452693
-
Selective identification of new therapeutic targets of Mycobacterium tuberculosis by IVIAT approach
-
Deb DK, Dahiya P, Srivastava KK, Srivastava R, Srivastava BS. 2002. Selective identification of new therapeutic targets of Mycobacterium tuberculosis by IVIAT approach. Tuberculosis (Edinb) 82:175-182.
-
(2002)
Tuberculosis (Edinb)
, vol.82
, pp. 175-182
-
-
Deb, D.K.1
Dahiya, P.2
Srivastava, K.K.3
Srivastava, R.4
Srivastava, B.S.5
-
102
-
-
84866930664
-
DNA replication fidelity in Escherichia coli: a multi-DNA polymerase affair
-
Fijalkowska IJ, Schaaper RM, Jonczyk P. 2012. DNA replication fidelity in Escherichia coli: a multi-DNA polymerase affair. FEMS Microbiol Rev 36:1105-1121.
-
(2012)
FEMS Microbiol Rev
, vol.36
, pp. 1105-1121
-
-
Fijalkowska, I.J.1
Schaaper, R.M.2
Jonczyk, P.3
-
103
-
-
84864871068
-
MsDpo4-a DinB homolog from Mycobacterium smegmatis is an error-prone DNA polymerase that can promote G:T and T:G mismatches
-
Sharma A, Nair DT. 2012. MsDpo4-a DinB homolog from Mycobacterium smegmatis is an error-prone DNA polymerase that can promote G:T and T:G mismatches. J Nucleic Acids 2012:285481.
-
(2012)
J Nucleic Acids
, vol.2012
-
-
Sharma, A.1
Nair, D.T.2
-
104
-
-
77950673080
-
Role of the DinB homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis
-
Kana BD, Abrahams GL, Sung N, Warner DF, Gordhan BG, Machowski EE, Tsenova L, Sacchettini JC, Stoker NG, Kaplan G, Mizrahi V. 2010. Role of the DinB homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis. J Bacteriol 192:2220-2227.
-
(2010)
J Bacteriol
, vol.192
, pp. 2220-2227
-
-
Kana, B.D.1
Abrahams, G.L.2
Sung, N.3
Warner, D.F.4
Gordhan, B.G.5
Machowski, E.E.6
Tsenova, L.7
Sacchettini, J.C.8
Stoker, N.G.9
Kaplan, G.10
Mizrahi, V.11
-
106
-
-
80053266375
-
Regulation of DnaA assembly and activity: taking directions from the genome
-
Leonard AC, Grimwade JE. 2011. Regulation of DnaA assembly and activity: taking directions from the genome. Annu Rev Microbiol 65:19-35.
-
(2011)
Annu Rev Microbiol
, vol.65
, pp. 19-35
-
-
Leonard, A.C.1
Grimwade, J.E.2
-
107
-
-
58149293213
-
Synchronous replication initiation in novel Mycobacterium tuberculosis dnaA cold-sensitive mutants
-
Nair N, Dziedzic R, Greendyke R, Muniruzzaman S, Rajagopalan M, Madiraju MV. 2009. Synchronous replication initiation in novel Mycobacterium tuberculosis dnaA cold-sensitive mutants. Mol Microbiol 71:291-304.
-
(2009)
Mol Microbiol
, vol.71
, pp. 291-304
-
-
Nair, N.1
Dziedzic, R.2
Greendyke, R.3
Muniruzzaman, S.4
Rajagopalan, M.5
Madiraju, M.V.6
-
108
-
-
62149121400
-
Characterization of IS6110 insertions in the dnaA-dnaN intergenic region of Mycobacterium tuberculosis clinical isolates
-
Turcios L, Casart Y, Florez I, de Waard J, Salazar L. 2009. Characterization of IS6110 insertions in the dnaA-dnaN intergenic region of Mycobacterium tuberculosis clinical isolates. Clin Microbiol Infect 15: 200-203.
-
(2009)
Clin Microbiol Infect
, vol.15
, pp. 200-203
-
-
Turcios, L.1
Casart, Y.2
Florez, I.3
de Waard, J.4
Salazar, L.5
-
109
-
-
4344703895
-
Mycobacterium tuberculosis DnaA initiator protein: purification and DNA-binding requirements
-
Zawilak A, Kois A, Konopa G, Smulczyk-Krawczyszyn A, Zakrzewska-Czerwinska J. 2004. Mycobacterium tuberculosis DnaA initiator protein: purification and DNA-binding requirements. Biochem J 382:247-252.
-
(2004)
Biochem J
, vol.382
, pp. 247-252
-
-
Zawilak, A.1
Kois, A.2
Konopa, G.3
Smulczyk-Krawczyszyn, A.4
Zakrzewska-Czerwinska, J.5
-
110
-
-
79959511903
-
Structural and thermodynamic signatures of DNA recognition by Mycobacterium tuberculosis DnaA
-
Tsodikov OV, Biswas T. 2011. Structural and thermodynamic signatures of DNA recognition by Mycobacterium tuberculosis DnaA. J Mol Biol 410:461-476.
-
(2011)
J Mol Biol
, vol.410
, pp. 461-476
-
-
Tsodikov, O.V.1
Biswas, T.2
-
111
-
-
34247271405
-
DNA replication initiation: mechanisms and regulation in bacteria
-
Mott ML, Berger JM. 2007. DNA replication initiation: mechanisms and regulation in bacteria. Nat Rev Microbiol 5:343-354.
-
(2007)
Nat Rev Microbiol
, vol.5
, pp. 343-354
-
-
Mott, M.L.1
Berger, J.M.2
-
112
-
-
33645462018
-
The intrinsic ATPase activity of Mycobacterium tuberculosis DnaA promotes rapid oligomerization of DnaA on oriC
-
Madiraju MV, Moomey M, Neuenschwander PF, Muniruzzaman S, Yamamoto K, Grimwade JE, Rajagopalan M. 2006. The intrinsic ATPase activity of Mycobacterium tuberculosis DnaA promotes rapid oligomerization of DnaA on oriC. Mol Microbiol 59:1876-1890.
-
(2006)
Mol Microbiol
, vol.59
, pp. 1876-1890
-
-
Madiraju, M.V.1
Moomey, M.2
Neuenschwander, P.F.3
Muniruzzaman, S.4
Yamamoto, K.5
Grimwade, J.E.6
Rajagopalan, M.7
-
113
-
-
29744460566
-
Hda inactivation of DnaA is the predominant mechanism preventing hyperinitiation of Escherichia coli DNA replication
-
Camara JE, Breier AM, Brendler T, Austin S, Cozzarelli NR, Crooke E. 2005. Hda inactivation of DnaA is the predominant mechanism preventing hyperinitiation of Escherichia coli DNA replication. EMBO Rep 6:736-741.
-
(2005)
EMBO Rep
, vol.6
, pp. 736-741
-
-
Camara, J.E.1
Breier, A.M.2
Brendler, T.3
Austin, S.4
Cozzarelli, N.R.5
Crooke, E.6
-
114
-
-
58349095446
-
In-vitro helix opening of M. tuberculosis oriC by DnaA occurs at precise location and is inhibited by IciA like protein
-
Kumar S, Farhana A, Hasnain SE. 2009. In-vitro helix opening of M. tuberculosis oriC by DnaA occurs at precise location and is inhibited by IciA like protein. PLoS One 4:e4139.
-
(2009)
PLoS One
, vol.4
-
-
Kumar, S.1
Farhana, A.2
Hasnain, S.E.3
-
115
-
-
77956586435
-
The characterization of conserved binding motifs and potential target genes for M. tuberculosis MtrAB reveals a link between the two-component system and the drug resistance of M. smegmatis
-
Li Y, Zeng J, Zhang H, He ZG. 2010. The characterization of conserved binding motifs and potential target genes for M. tuberculosis MtrAB reveals a link between the two-component system and the drug resistance of M. smegmatis. BMC Microbiol 10:242.
-
(2010)
BMC Microbiol
, vol.10
, pp. 242
-
-
Li, Y.1
Zeng, J.2
Zhang, H.3
He, Z.G.4
-
116
-
-
84863618399
-
Septal localization of the Mycobacterium tuberculosis MtrB sensor kinase promotes MtrA regulon expression
-
Plocinska R, Purushotham G, Sarva K, Vadrevu IS, Pandeeti EV, Arora N, Plocinski P, Madiraju MV, Rajagopalan M. 2012. Septal localization of the Mycobacterium tuberculosis MtrB sensor kinase promotes MtrA regulon expression. J Biol Chem 287:23887-23899.
-
(2012)
J Biol Chem
, vol.287
, pp. 23887-23899
-
-
Plocinska, R.1
Purushotham, G.2
Sarva, K.3
Vadrevu, I.S.4
Pandeeti, E.V.5
Arora, N.6
Plocinski, P.7
Madiraju, M.V.8
Rajagopalan, M.9
-
117
-
-
77951189021
-
A lipoprotein modulates activity of the MtrAB two-component system to provide intrinsic multidrug resistance, cytokinetic control and cell wall homeostasis in Mycobacterium
-
Nguyen HT, Wolff KA, Cartabuke RH, Ogwang S, Nguyen L. 2010. A lipoprotein modulates activity of the MtrAB two-component system to provide intrinsic multidrug resistance, cytokinetic control and cell wall homeostasis in Mycobacterium. Mol Microbiol 76:348-364.
-
(2010)
Mol Microbiol
, vol.76
, pp. 348-364
-
-
Nguyen, H.T.1
Wolff, K.A.2
Cartabuke, R.H.3
Ogwang, S.4
Nguyen, L.5
-
119
-
-
84856385334
-
A novel high-throughput B1HChIP method for efficiently validating and screening specific regulatortarget promoter interactions
-
Zeng J, Li Y, Zhang S, He ZG. 2012. A novel high-throughput B1HChIP method for efficiently validating and screening specific regulatortarget promoter interactions. Appl Microbiol Biotechnol 93:1257-1269.
-
(2012)
Appl Microbiol Biotechnol
, vol.93
, pp. 1257-1269
-
-
Zeng, J.1
Li, Y.2
Zhang, S.3
He, Z.G.4
-
120
-
-
84866133084
-
A genome-wide regulator-DNA interaction network in the human pathogen Mycobacterium tuberculosis H37Rv
-
Zeng J, Cui T, He ZG. 2012. A genome-wide regulator-DNA interaction network in the human pathogen Mycobacterium tuberculosis H37Rv. J Proteome Res 11:4682-4692.
-
(2012)
J Proteome Res
, vol.11
, pp. 4682-4692
-
-
Zeng, J.1
Cui, T.2
He, Z.G.3
-
121
-
-
74849098714
-
Characterization of physical interaction between replication initiator protein DnaA and replicative helicase from Mycobacterium tuberculosis H37Rv
-
Xie Y, He ZG. 2009. Characterization of physical interaction between replication initiator protein DnaA and replicative helicase from Mycobacterium tuberculosis H37Rv. Biochemistry (Mosc) 74:1320-1327.
-
(2009)
Biochemistry (Mosc)
, vol.74
, pp. 1320-1327
-
-
Xie, Y.1
He, Z.G.2
-
122
-
-
84857989760
-
Architecture of a dodecameric bacterial replicative helicase
-
Stelter M, Gutsche I, Kapp U, Bazin A, Bajic G, Goret G, Jamin M, Timmins J, Terradot L. 2012. Architecture of a dodecameric bacterial replicative helicase. Structure 20:554-564.
-
(2012)
Structure
, vol.20
, pp. 554-564
-
-
Stelter, M.1
Gutsche, I.2
Kapp, U.3
Bazin, A.4
Bajic, G.5
Goret, G.6
Jamin, M.7
Timmins, J.8
Terradot, L.9
-
123
-
-
84876380310
-
A novel non-radioactive primase-pyrophosphatase activity assay and its application to the discovery of inhibitors of Mycobacterium tuberculosis primase DnaG
-
Biswas T, Resto-Roldan E, Sawyer SK, Artsimovitch I, Tsodikov OV. 2013. A novel non-radioactive primase-pyrophosphatase activity assay and its application to the discovery of inhibitors of Mycobacterium tuberculosis primase DnaG. Nucleic Acids Res 41:e56.
-
(2013)
Nucleic Acids Res
, vol.41
-
-
Biswas, T.1
Resto-Roldan, E.2
Sawyer, S.K.3
Artsimovitch, I.4
Tsodikov, O.V.5
-
124
-
-
77952569915
-
Structural and functional characterization of an RNase HI domain from the bifunctional protein Rv2228c from Mycobacterium tuberculosis
-
Watkins HA, Baker EN. 2010. Structural and functional characterization of an RNase HI domain from the bifunctional protein Rv2228c from Mycobacterium tuberculosis. J Bacteriol 192:2878-2886.
-
(2010)
J Bacteriol
, vol.192
, pp. 2878-2886
-
-
Watkins, H.A.1
Baker, E.N.2
-
125
-
-
0031407768
-
DNA gyrase, topoisomerase IV, and the 4-quinolones
-
Drlica K, Zhao X. 1997. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev 61:377-392.
-
(1997)
Microbiol Mol Biol Rev
, vol.61
, pp. 377-392
-
-
Drlica, K.1
Zhao, X.2
-
126
-
-
44349172245
-
Hexameric ring structure of the N-terminal domain of Mycobacterium tuberculosis DnaB helicase
-
Biswas T, Tsodikov OV. 2008. Hexameric ring structure of the N-terminal domain of Mycobacterium tuberculosis DnaB helicase. FEBS J 275:3064-3071.
-
(2008)
FEBS J
, vol.275
, pp. 3064-3071
-
-
Biswas, T.1
Tsodikov, O.V.2
-
127
-
-
69449095740
-
Singlemolecule analysis reveals that the lagging strand increases replisome processivity but slows replication fork progression
-
Yao NY, Georgescu RE, Finkelstein J, O'Donnell ME. 2009. Singlemolecule analysis reveals that the lagging strand increases replisome processivity but slows replication fork progression. Proc Natl Acad Sci USA 106:13236-13241.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 13236-13241
-
-
Yao, N.Y.1
Georgescu, R.E.2
Finkelstein, J.3
O'Donnell, M.E.4
-
128
-
-
84868453744
-
Characterization of DNA topoisomerase I from Mycobacterium tuberculosis: DNA cleavage and religation properties and inhibition of its activity
-
Godbole AA, Leelaram MN, Bhat AG, Jain P, Nagaraja V. 2012. Characterization of DNA topoisomerase I from Mycobacterium tuberculosis: DNA cleavage and religation properties and inhibition of its activity. Arch Biochem Biophys 528:197-203.
-
(2012)
Arch Biochem Biophys
, vol.528
, pp. 197-203
-
-
Godbole, A.A.1
Leelaram, M.N.2
Bhat, A.G.3
Jain, P.4
Nagaraja, V.5
-
129
-
-
79960444531
-
Physical and functional interaction between D-ribokinase and topoisomerase I has opposite effects on their respective activity in Mycobacterium smegmatis and Mycobacterium tuberculosis
-
Yang Q, Liu Y, Huang F, He ZG. 2011. Physical and functional interaction between D-ribokinase and topoisomerase I has opposite effects on their respective activity in Mycobacterium smegmatis and Mycobacterium tuberculosis. Arch Biochem Biophys 512:135-142.
-
(2011)
Arch Biochem Biophys
, vol.512
, pp. 135-142
-
-
Yang, Q.1
Liu, Y.2
Huang, F.3
He, Z.G.4
-
130
-
-
78650443178
-
Characterization of an interplay between a Mycobacterium tuberculosis MazF homolog, Rv1495 and its sole DNA topoisomerase I
-
Huang F, He ZG. 2010. Characterization of an interplay between a Mycobacterium tuberculosis MazF homolog, Rv1495 and its sole DNA topoisomerase I. Nucleic Acids Res 38:8219-8230.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 8219-8230
-
-
Huang, F.1
He, Z.G.2
-
131
-
-
33745845467
-
Characterization of mRNA interferases from Mycobacterium tuberculosis
-
Zhu L, Zhang Y, Teh JS, Zhang J, Connell N, Rubin H, Inouye M. 2006. Characterization of mRNA interferases from Mycobacterium tuberculosis. J Biol Chem 281:18638-18643.
-
(2006)
J Biol Chem
, vol.281
, pp. 18638-18643
-
-
Zhu, L.1
Zhang, Y.2
Teh, J.S.3
Zhang, J.4
Connell, N.5
Rubin, H.6
Inouye, M.7
-
132
-
-
0031692027
-
DNA repair in Mycobacterium tuberculosis. What have we learnt from the genome sequence?
-
Mizrahi V, Andersen SJ. 1998. DNA repair in Mycobacterium tuberculosis. What have we learnt from the genome sequence? Mol Microbiol 29:1331-1339.
-
(1998)
Mol Microbiol
, vol.29
, pp. 1331-1339
-
-
Mizrahi, V.1
Andersen, S.J.2
-
133
-
-
79955460244
-
Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection
-
Ford CB, Lin PL, Chase MR, Shah RR, Iartchouk O, Galagan J, Mohaideen N, Ioerger TR, Sacchettini JC, Lipsitch M, Flynn JL, Fortune SM. 2011. Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection. Nat Genet 43: 482-486.
-
(2011)
Nat Genet
, vol.43
, pp. 482-486
-
-
Ford, C.B.1
Lin, P.L.2
Chase, M.R.3
Shah, R.R.4
Iartchouk, O.5
Galagan, J.6
Mohaideen, N.7
Ioerger, T.R.8
Sacchettini, J.C.9
Lipsitch, M.10
Flynn, J.L.11
Fortune, S.M.12
-
134
-
-
4644335120
-
Lack of mismatch correction facilitates genome evolution in mycobacteria
-
Springer B, Sander P, Sedlacek L, Hardt WD, Mizrahi V, Schar P, Bottger EC. 2004. Lack of mismatch correction facilitates genome evolution in mycobacteria. Mol Microbiol 53:1601-1609.
-
(2004)
Mol Microbiol
, vol.53
, pp. 1601-1609
-
-
Springer, B.1
Sander, P.2
Sedlacek, L.3
Hardt, W.D.4
Mizrahi, V.5
Schar, P.6
Bottger, E.C.7
-
135
-
-
45749085292
-
Stabilization of the genome of the mismatch repair deficient Mycobacterium tuberculosis by context-dependent codon choice
-
Wanner RM, Guthlein C, Springer B, Bottger D, Ackermann M. 2008. Stabilization of the genome of the mismatch repair deficient Mycobacterium tuberculosis by context-dependent codon choice. BMC Genomics 9:249.
-
(2008)
BMC Genomics
, vol.9
, pp. 249
-
-
Wanner, R.M.1
Guthlein, C.2
Springer, B.3
Bottger, D.4
Ackermann, M.5
-
136
-
-
33947408132
-
In vitro analysis of rates and spectra of mutations in a polymorphic region of the Rv0746 PE_PGRS gene of Mycobacterium tuberculosis
-
Machowski EE, Barichievy S, Springer B, Durbach SI, Mizrahi V. 2007. In vitro analysis of rates and spectra of mutations in a polymorphic region of the Rv0746 PE_PGRS gene of Mycobacterium tuberculosis. J Bacteriol 189:2190-2195.
-
(2007)
J Bacteriol
, vol.189
, pp. 2190-2195
-
-
Machowski, E.E.1
Barichievy, S.2
Springer, B.3
Durbach, S.I.4
Mizrahi, V.5
-
137
-
-
58649089147
-
Characterization of the mycobacterial NER system reveals novel functions of the uvrD1 helicase
-
Guthlein C, Wanner RM, Sander P, Davis EO, Bosshard M, Jiricny J, Bottger EC, Springer B. 2009. Characterization of the mycobacterial NER system reveals novel functions of the uvrD1 helicase. J Bacteriol 191:555-562.
-
(2009)
J Bacteriol
, vol.191
, pp. 555-562
-
-
Guthlein, C.1
Wanner, R.M.2
Sander, P.3
Davis, E.O.4
Bosshard, M.5
Jiricny, J.6
Bottger, E.C.7
Springer, B.8
-
138
-
-
84874989093
-
Reduction of dNTP levels enhances DNA replication fidelity in vivo
-
Laureti L, Selva M, Dairou J, Matic I. 2013. Reduction of dNTP levels enhances DNA replication fidelity in vivo. DNA Repair (Amst) 12:300-305.
-
(2013)
DNA Repair (Amst)
, vol.12
, pp. 300-305
-
-
Laureti, L.1
Selva, M.2
Dairou, J.3
Matic, I.4
-
139
-
-
0022569937
-
Deoxyribonucleic acid replication time in Mycobacterium tuberculosis H37 Rv
-
Hiriyanna KT, Ramakrishnan T. 1986. Deoxyribonucleic acid replication time in Mycobacterium tuberculosis H37 Rv. Arch Microbiol 144:105-109.
-
(1986)
Arch Microbiol
, vol.144
, pp. 105-109
-
-
Hiriyanna, K.T.1
Ramakrishnan, T.2
-
140
-
-
79651474490
-
Crystal structure of DNA polymerase III β sliding clamp from Mycobacterium tuberculosis
-
Gui WJ, Lin SQ, Chen YY, Zhang XE, Bi LJ, Jiang T. 2011. Crystal structure of DNA polymerase III β sliding clamp from Mycobacterium tuberculosis. Biochem Biophys Res Commun 405:272-277.
-
(2011)
Biochem Biophys Res Commun
, vol.405
, pp. 272-277
-
-
Gui, W.J.1
Lin, S.Q.2
Chen, Y.Y.3
Zhang, X.E.4
Bi, L.J.5
Jiang, T.6
-
141
-
-
84855195248
-
Characterization and transcriptome analysis of Mycobacterium tuberculosis persisters
-
Keren I, Minami S, Rubin E, Lewis K. 2011. Characterization and transcriptome analysis of Mycobacterium tuberculosis persisters. MBio 2: e00100-00111.
-
(2011)
MBio
, vol.2
-
-
Keren, I.1
Minami, S.2
Rubin, E.3
Lewis, K.4
-
142
-
-
84868007876
-
Streptomycin-starved Mycobacterium tuberculosis 18b, a drug discovery tool for latent tuberculosis
-
Zhang, M, Sala C, Hartkoorn RC, Dhar N, Mendoza-Losana A, Cole ST. 2012. Streptomycin-starved Mycobacterium tuberculosis 18b, a drug discovery tool for latent tuberculosis. Antimicrob Agents Chemother 56:5782-5789.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 5782-5789
-
-
Zhang, M.1
Sala, C.2
Hartkoorn, R.C.3
Dhar, N.4
Mendoza-Losana, A.5
Cole, S.T.6
-
143
-
-
0029976980
-
An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence
-
Wayne LG, Hayes LG. 1996. An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence. Infect Immun 64:2062-2069.
-
(1996)
Infect Immun
, vol.64
, pp. 2062-2069
-
-
Wayne, L.G.1
Hayes, L.G.2
-
144
-
-
50149113470
-
The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis
-
Rao SP, Alonso S, Rand L, Dick T, Pethe K. 2008. The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis. Proc Natl Acad Sci USA 105:11945-11950.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 11945-11950
-
-
Rao, S.P.1
Alonso, S.2
Rand, L.3
Dick, T.4
Pethe, K.5
-
145
-
-
84876253419
-
Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis
-
Eoh H, Rhee KY. 2013. Multifunctional essentiality of succinate metabolism in adaptation to hypoxia in Mycobacterium tuberculosis. Proc Natl Acad Sci USA 110:6554-6559.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 6554-6559
-
-
Eoh, H.1
Rhee, K.Y.2
-
146
-
-
0017758101
-
Synchronized replication of Mycobacterium tuberculosis
-
Wayne LG. 1977. Synchronized replication of Mycobacterium tuberculosis. Infect Immun 17:528-530.
-
(1977)
Infect Immun
, vol.17
, pp. 528-530
-
-
Wayne, L.G.1
-
147
-
-
11144339323
-
Replication dynamics of Mycobacterium tuberculosis in chronically infected mice
-
Munoz-Elias EJ, Timm J, Botha T, Chan WT, Gomez JE, McKinney JD. 2005. Replication dynamics of Mycobacterium tuberculosis in chronically infected mice. Infect Immun 73:546-551.
-
(2005)
Infect Immun
, vol.73
, pp. 546-551
-
-
Munoz-Elias, E.J.1
Timm, J.2
Botha, T.3
Chan, W.T.4
Gomez, J.E.5
McKinney, J.D.6
-
148
-
-
59649119960
-
A replication clock for Mycobacterium tuberculosis
-
Gill WP, Harik NS, Whiddon MR, Liao RP, Mittler JE, Sherman DR. 2009. A replication clock for Mycobacterium tuberculosis. Nat Med 15: 211-214.
-
(2009)
Nat Med
, vol.15
, pp. 211-214
-
-
Gill, W.P.1
Harik, N.S.2
Whiddon, M.R.3
Liao, R.P.4
Mittler, J.E.5
Sherman, D.R.6
-
149
-
-
84859364840
-
Bacterial DNA replication enzymes as targets for antibacterial drug discovery
-
Sanyal G, Doig P. 2012. Bacterial DNA replication enzymes as targets for antibacterial drug discovery. Expert Opin Drug Discov 7:327-339.
-
(2012)
Expert Opin Drug Discov
, vol.7
, pp. 327-339
-
-
Sanyal, G.1
Doig, P.2
-
150
-
-
77949513909
-
Parallel multiplicative target screening against divergent bacterial replicases: identification of specific inhibitors with broad spectrum potential
-
Dallmann HG, Fackelmayer OJ, Tomer G, Chen J, Wiktor-Becker A, Ferrara T, Pope C, Oliveira MT, Burgers PM, Kaguni LS, McHenry CS. 2010. Parallel multiplicative target screening against divergent bacterial replicases: identification of specific inhibitors with broad spectrum potential. Biochemistry 49:2551-2562.
-
(2010)
Biochemistry
, vol.49
, pp. 2551-2562
-
-
Dallmann, H.G.1
Fackelmayer, O.J.2
Tomer, G.3
Chen, J.4
Wiktor-Becker, A.5
Ferrara, T.6
Pope, C.7
Oliveira, M.T.8
Burgers, P.M.9
Kaguni, L.S.10
McHenry, C.S.11
-
151
-
-
73549117492
-
Targeting the replication initiator of the second Vibrio chromosome: towards generation of Vibrionaceae-specific antimicrobial agents
-
Yamaichi Y, Duigou S, Shakhnovich EA, Waldor MK. 2009. Targeting the replication initiator of the second Vibrio chromosome: towards generation of Vibrionaceae-specific antimicrobial agents. PLoS Pathog 5:e1000663.
-
(2009)
PLoS Pathog
, vol.5
-
-
Yamaichi, Y.1
Duigou, S.2
Shakhnovich, E.A.3
Waldor, M.K.4
-
152
-
-
78249279388
-
Novel inhibitors of E. coli RecA ATPase activity
-
Sexton JZ, Wigle TJ, He Q, Hughes MA, Smith GR, Singleton SF, Williams AL, Yeh LA. 2010. Novel inhibitors of E. coli RecA ATPase activity. Curr Chem Genomics 4:34-42.
-
(2010)
Curr Chem Genomics
, vol.4
, pp. 34-42
-
-
Sexton, J.Z.1
Wigle, T.J.2
He, Q.3
Hughes, M.A.4
Smith, G.R.5
Singleton, S.F.6
Williams, A.L.7
Yeh, L.A.8
-
153
-
-
84874050246
-
The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action
-
Karkare S, Chung TT, Collin F, Mitchenall LA, McKay AR, Greive SJ, Meyer JJ, Lall N, Maxwell A. 2013. The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action. J Biol Chem 288:5149-5156.
-
(2013)
J Biol Chem
, vol.288
, pp. 5149-5156
-
-
Karkare, S.1
Chung, T.T.2
Collin, F.3
Mitchenall, L.A.4
McKay, A.R.5
Greive, S.J.6
Meyer, J.J.7
Lall, N.8
Maxwell, A.9
-
154
-
-
49649087259
-
Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp
-
Georgescu RE, Yurieva O, Kim SS, Kuriyan J, Kong XP, O'Donnell M. 2008. Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp. Proc Natl Acad Sci USA 105:11116-11121.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 11116-11121
-
-
Georgescu, R.E.1
Yurieva, O.2
Kim, S.S.3
Kuriyan, J.4
Kong, X.P.5
O'Donnell, M.6
-
155
-
-
79960198988
-
Structure-based design of short peptide ligands binding onto the E. coli processivity ring
-
Wolff P, Olieric V, Briand JP, Chaloin O, Dejaegere A, Dumas P, Ennifar E, Guichard G, Wagner J, Burnouf DY. 2011. Structure-based design of short peptide ligands binding onto the E. coli processivity ring. J Med Chem 54:4627-4637.
-
(2011)
J Med Chem
, vol.54
, pp. 4627-4637
-
-
Wolff, P.1
Olieric, V.2
Briand, J.P.3
Chaloin, O.4
Dejaegere, A.5
Dumas, P.6
Ennifar, E.7
Guichard, G.8
Wagner, J.9
Burnouf, D.Y.10
-
156
-
-
79960180851
-
Binding inhibitors of the bacterial sliding clamp by design
-
Wijffels G, Johnson WM, Oakley AJ, Turner K, Epa VX, Briscoe SJ, Polley M, Liepa AJ, Hofmann A, Buchardt J, Christensen C, Prosselkov P, Dalrymple BP, Alewood PF, Jennings PA, Dixon NE, Winkler DA. 2011. Binding inhibitors of the bacterial sliding clamp by design. J Med Chem 54:4831-4838.
-
(2011)
J Med Chem
, vol.54
, pp. 4831-4838
-
-
Wijffels, G.1
Johnson, W.M.2
Oakley, A.J.3
Turner, K.4
Epa, V.X.5
Briscoe, S.J.6
Polley, M.7
Liepa, A.J.8
Hofmann, A.9
Buchardt, J.10
Christensen, C.11
Prosselkov, P.12
Dalrymple, B.P.13
Alewood, P.F.14
Jennings, P.A.15
Dixon, N.E.16
Winkler, D.A.17
-
157
-
-
84874826659
-
Protein interactions in genome maintenance as novel antibacterial targets
-
Marceau AH, Bernstein DA, Walsh BW, Shapiro W, Simmons LA, Keck JL. 2013. Protein interactions in genome maintenance as novel antibacterial targets. PLoS One 8:e58765.
-
(2013)
PLoS One
, vol.8
-
-
Marceau, A.H.1
Bernstein, D.A.2
Walsh, B.W.3
Shapiro, W.4
Simmons, L.A.5
Keck, J.L.6
-
158
-
-
65349157710
-
Uncovering new signaling proteins and potential drug targets through the interactome analysis of Mycobacterium tuberculosis
-
Cui T, Zhang L, Wang X, He ZG. 2009. Uncovering new signaling proteins and potential drug targets through the interactome analysis of Mycobacterium tuberculosis. BMC Genomics 10:118.
-
(2009)
BMC Genomics
, vol.10
, pp. 118
-
-
Cui, T.1
Zhang, L.2
Wang, X.3
He, Z.G.4
-
159
-
-
78649849857
-
Global protein-protein interaction network in the human pathogen Mycobacterium tuberculosis H37Rv
-
Wang Y, Cui T, Zhang C, Yang M, Huang Y, Li W, Zhang L, Gao C, He Y, Li Y, Huang F, Zeng J, Huang C, Yang Q, Tian Y, Zhao C, Chen H, Zhang H, He ZG. 2010. Global protein-protein interaction network in the human pathogen Mycobacterium tuberculosis H37Rv. J Proteome Res 9:6665-6677.
-
(2010)
J Proteome Res
, vol.9
, pp. 6665-6677
-
-
Wang, Y.1
Cui, T.2
Zhang, C.3
Yang, M.4
Huang, Y.5
Li, W.6
Zhang, L.7
Gao, C.8
He, Y.9
Li, Y.10
Huang, F.11
Zeng, J.12
Huang, C.13
Yang, Q.14
Tian, Y.15
Zhao, C.16
Chen, H.17
Zhang, H.18
He, Z.G.19
-
160
-
-
18344385508
-
Protein-protein interactions in the eubacterial replisome
-
Schaeffer PM, Headlam MJ, Dixon NE. 2005. Protein-protein interactions in the eubacterial replisome. IUBMB Life 57:5-12.
-
(2005)
IUBMB Life
, vol.57
, pp. 5-12
-
-
Schaeffer, P.M.1
Headlam, M.J.2
Dixon, N.E.3
-
161
-
-
0037062435
-
An expanded view of bacterial DNA replication
-
Noirot-Gros MF, Dervyn E, Wu LJ, Mervelet P, Errington J, Ehrlich SD, Noirot P. 2002. An expanded view of bacterial DNA replication. Proc Natl Acad Sci USA 99:8342-8347.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 8342-8347
-
-
Noirot-Gros, M.F.1
Dervyn, E.2
Wu, L.J.3
Mervelet, P.4
Errington, J.5
Ehrlich, S.D.6
Noirot, P.7
-
162
-
-
84877727980
-
Evidence for diversifying selection in a set of Mycobacterium tuberculosis genes in response to antibiotic-and nonantibiotic-related pressure
-
Osorio NS, Rodrigues F, Gagneux S, Pedrosa J, Pinto-Carbo M, Castro AG, Young D, Comas I, Saraiva M. 2013. Evidence for diversifying selection in a set of Mycobacterium tuberculosis genes in response to antibiotic-and nonantibiotic-related pressure. Mol Biol Evol 30:1326-1336.
-
(2013)
Mol Biol Evol
, vol.30
, pp. 1326-1336
-
-
Osorio, N.S.1
Rodrigues, F.2
Gagneux, S.3
Pedrosa, J.4
Pinto-Carbo, M.5
Castro, A.G.6
Young, D.7
Comas, I.8
Saraiva, M.9
-
163
-
-
45249087278
-
Evolution and diversity of clonal bacteria: the paradigm of Mycobacterium tuberculosis
-
Dos Vultos T, Mestre O, Rauzier J, Golec M, Rastogi N, Rasolofo V, Tonjum T, Sola C, Matic I, Gicquel B. 2008. Evolution and diversity of clonal bacteria: the paradigm of Mycobacterium tuberculosis. PLoS One 3:e1538.
-
(2008)
PLoS One
, vol.3
-
-
Dos Vultos, T.1
Mestre, O.2
Rauzier, J.3
Golec, M.4
Rastogi, N.5
Rasolofo, V.6
Tonjum, T.7
Sola, C.8
Matic, I.9
Gicquel, B.10
-
164
-
-
38749142232
-
Characterization of nucleotide pools as a function of physiological state in Escherichia coli
-
Buckstein MH, He J, Rubin H. 2008. Characterization of nucleotide pools as a function of physiological state in Escherichia coli. J Bacteriol 190:718-726.
-
(2008)
J Bacteriol
, vol.190
, pp. 718-726
-
-
Buckstein, M.H.1
He, J.2
Rubin, H.3
-
165
-
-
84855505260
-
Asymmetry and aging of mycobacterial cells lead to variable growth and antibiotic susceptibility
-
Aldridge BB, Fernandez-Suarez M, Heller D, Ambravaneswaran V, Irimia D, Toner M, Fortune SM. 2012. Asymmetry and aging of mycobacterial cells lead to variable growth and antibiotic susceptibility. Science 335:100-104.
-
(2012)
Science
, vol.335
, pp. 100-104
-
-
Aldridge, B.B.1
Fernandez-Suarez, M.2
Heller, D.3
Ambravaneswaran, V.4
Irimia, D.5
Toner, M.6
Fortune, S.M.7
-
166
-
-
84871859996
-
Dynamic persistence of antibiotic-stressed mycobacteria
-
Wakamoto Y, Dhar N, Chait R, Schneider K, Signorino-Gelo F, Leibler S, McKinney JD. 2013. Dynamic persistence of antibiotic-stressed mycobacteria. Science 339:91-95.
-
(2013)
Science
, vol.339
, pp. 91-95
-
-
Wakamoto, Y.1
Dhar, N.2
Chait, R.3
Schneider, K.4
Signorino-Gelo, F.5
Leibler, S.6
McKinney, J.D.7
-
167
-
-
0035822573
-
Increased levels of sigJ mRNA in late stationary phase cultures of Mycobacterium tuberculosis detected by DNA array hybridisation
-
Hu Y, Coates AR. 2001. Increased levels of sigJ mRNA in late stationary phase cultures of Mycobacterium tuberculosis detected by DNA array hybridisation. FEMS Microbiol Lett 202:59-65.
-
(2001)
FEMS Microbiol Lett
, vol.202
, pp. 59-65
-
-
Hu, Y.1
Coates, A.R.2
-
168
-
-
84870880581
-
Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing
-
Fang G, Munera D, Friedman DI, Mandlik A, Chao MC, BanerjeeO, Feng Z, Losic B, Mahajan MC, Jabado OJ, Deikus G, Clark TA, Luong K, Murray IA, Davis BM, Keren-Paz A, Chess A, Roberts RJ, Korlach J, Turner SW, Kumar V, Waldor MK, Schadt EE. 2012. Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing. Nat Biotechnol 30:1232-1239.
-
(2012)
Nat Biotechnol
, vol.30
, pp. 1232-1239
-
-
Fang, G.1
Munera, D.2
Friedman, D.I.3
Mandlik, A.4
Chao, M.C.5
Banerjee, O.6
Feng, Z.7
Losic, B.8
Mahajan, M.C.9
Jabado, O.J.10
Deikus, G.11
Clark, T.A.12
Luong, K.13
Murray, I.A.14
Davis, B.M.15
Keren-Paz, A.16
Chess, A.17
Roberts, R.J.18
Korlach, J.19
Turner, S.W.20
Kumar, V.21
Waldor, M.K.22
Schadt, E.E.23
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