Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations

PLoS Genetics

Volumn 13, Issue 4, 2017, Pages

  Nielsen, Sofie V ^a   Stein, Amelie ^a   Dinitzen, Alexander B ^a   Papaleo, Elena ^b   Tatham, Michael H ^c   Poulsen, Esben G ^a   Kassem, Maher M ^a   Rasmussen, Lene J ^a   Lindorff Larsen, Kresten ^a   Hartmann Petersen, Rasmus ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEASOME; PROTEIN MSH2; DNA BINDING PROTEIN; MSH2 PROTEIN, HUMAN;

ARTICLE; BIOPHYSICS; CARCINOGENESIS; COMPUTER MODEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; GENETIC VARIATION; GENOTYPE PHENOTYPE CORRELATION; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; METABOLIC STABILITY; MISSENSE MUTATION; MUTAGENESIS; PREDICTION; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY; THERMODYNAMICS; CHEMISTRY; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; COMPUTER SIMULATION; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; HIGH THROUGHPUT SEQUENCING; HUMAN GENOME; MICROSATELLITE INSTABILITY; PATHOLOGY; PROTEIN CONFORMATION;

COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; COMPUTER SIMULATION; DNA-BINDING PROTEINS; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MICROSATELLITE INSTABILITY; MUTATION, MISSENSE; MUTS HOMOLOG 2 PROTEIN; PROTEIN CONFORMATION; PROTEIN FOLDING;

EID: 85018453754     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1006739     Document Type: Article

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